{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:07:47Z","timestamp":1787508467278,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.cyto.2012.02.018","type":"journal-article","created":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T15:01:24Z","timestamp":1331996484000},"page":"390-397","source":"Crossref","is-referenced-by-count":35,"title":["Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: Differential effect of cigarette smoking"],"prefix":"10.1016","volume":"58","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Dawes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek L.","family":"Mattey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2012.02.018_b0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2613.2009.00640.x","article-title":"The vasculature in rheumatoid arthritis: cause or consequence?","volume":"90","author":"Paleolog","year":"2009","journal-title":"Int J Exp Path"},{"key":"10.1016\/j.cyto.2012.02.018_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2009.02.002","article-title":"Angiogenesis and its targeting in rheumatoid arthritis","volume":"51","author":"Szekanecz","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.cyto.2012.02.018_b0015","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(89)92678-8","article-title":"Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells","volume":"161","author":"Ferrara","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cyto.2012.02.018_b0020","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1002\/j.1460-2075.1989.tb08557.x","article-title":"Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT20 cells","volume":"8","author":"Plo\u00fcet","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/j.cyto.2012.02.018_b0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.cyto.2012.02.018_b0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s001099900019","article-title":"Molecular and biological properties of vascular endothelial growth factor","volume":"77","author":"Ferrara","year":"1999","journal-title":"J Mol Med"},{"key":"10.1016\/j.cyto.2012.02.018_b0035","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0198-8859(99)00132-9","article-title":"Novel polymorphisms in the promoter and 5\u2032 UTR regions of the human vascular endothelial growth factor gene","volume":"60","author":"Brogan","year":"1999","journal-title":"Hum Immunol"},{"key":"10.1016\/j.cyto.2012.02.018_b0040","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1006\/cyto.2000.0692","article-title":"Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production","volume":"12","author":"Watson","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2012.02.018_b0045","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1159\/000054076","article-title":"A common 936 C\/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels","volume":"37","author":"Renner","year":"2000","journal-title":"J Vasc Res"},{"key":"10.1016\/j.cyto.2012.02.018_b0050","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.2337\/diabetes.51.5.1635","article-title":"A common polymorphism in the 5\u2032-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes","volume":"51","author":"Awata","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2012.02.018_b0055","first-page":"812","article-title":"Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter","volume":"63","author":"Stevens","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.cyto.2012.02.018_b0060","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.lungcan.2004.04.037","article-title":"VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer","volume":"46","author":"Koukourakis","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.cyto.2012.02.018_b0065","doi-asserted-by":"crossref","first-page":"H1848","DOI":"10.1152\/ajpheart.01033.2005","article-title":"DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption","volume":"290","author":"Prior","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cyto.2012.02.018_b0070","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/thx.2006.069393","article-title":"Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS","volume":"62","author":"Zhai","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.cyto.2012.02.018_b0075","first-page":"1382","article-title":"Local and genetic determinants of vascular endothelial growth factor expression in advanced proliferative diabetic retinopathy","volume":"14","author":"Petrovic","year":"2008","journal-title":"Mol Vis"},{"key":"10.1016\/j.cyto.2012.02.018_b0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ygyno.2009.11.011","article-title":"The relationship of VEGF polymorphisms with serum VEGF levels and progression-free survival in patients with epithelial ovarian cancer","volume":"117","author":"Steffensen","year":"2010","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.cyto.2012.02.018_b0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/tpj.2010.48","article-title":"VEGF-460\u2192C polymorphism and its association with VEGF expression and outcome to FOLFOX-4 treatment in patients with colorectal carcinoma","volume":"11","author":"Chen","year":"2011","journal-title":"Pharmacogenom J"},{"key":"10.1016\/j.cyto.2012.02.018_b0090","first-page":"321","article-title":"Vascular endothelial growth factor levels in the serum and synovial fluid of patients with rheumatoid arthritis","volume":"19","author":"Lee","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.cyto.2012.02.018_b0095","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10067-009-1343-4","article-title":"The relation of serum vascular endothelial growth factor level with disease duration and activity in patients with rheumatoid arthritis","volume":"29","author":"Ozgonenel","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.cyto.2012.02.018_b0100","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3899\/jrheum.090941","article-title":"Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis","volume":"37","author":"Kurosaka","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.cyto.2012.02.018_b0105","first-page":"86","article-title":"Serum tumor necrosis factor alpha (TNF-alpha) concentration correlations with soluble adhesion molecules and vascular endothelial growth factor (VEGF) in rheumatoid arthritis","volume":"61","author":"Klimiuk","year":"2004","journal-title":"Przegl Lek"},{"key":"10.1016\/j.cyto.2012.02.018_b0110","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/1529-0131(200109)44:9<2055::AID-ART355>3.0.CO;2-2","article-title":"Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis","volume":"44","author":"Ballara","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cyto.2012.02.018_b0115","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/rheumatology\/keh281","article-title":"VEGF gene polymorphisms and susceptibility to rheumatoid arthritis","volume":"43","author":"Han","year":"2004","journal-title":"Rheumatology"},{"key":"10.1016\/j.cyto.2012.02.018_b0120","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.humimm.2005.05.004","article-title":"Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis","volume":"66","author":"Rueda","year":"2005","journal-title":"Hum Immunol"},{"key":"10.1016\/j.cyto.2012.02.018_b0125","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3899\/jrheum.101095","article-title":"Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis","volume":"38","author":"Chen","year":"2011","journal-title":"J Rheumatol"},{"issue":"1988","key":"10.1016\/j.cyto.2012.02.018_b0130","first-page":"315","article-title":"Revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cyto.2012.02.018_b0135","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/art.1780380107","article-title":"M.A. van\u2019t Hof, H.H. Kuper, M.A. van Leeuwen, L.B. van de Putte, P.L. van Riel, Modified disease activity scores that include twenty-eight-joints counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis","volume":"38","author":"Prevoo","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cyto.2012.02.018_b0140","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/gepi.20098","article-title":"Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies","volume":"29","author":"Lin","year":"2005","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.cyto.2012.02.018_b0145","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s10067-005-1081-1","article-title":"IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes","volume":"25","author":"Ryu","year":"2006","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.cyto.2012.02.018_b0150","doi-asserted-by":"crossref","unstructured":"Gullick NJ, Evans HG, Church LD, Jayaraj DM, Filer A, Kirkham BW, et al. Linking power doppler ultrasound to the presence of TH17 cells in the rheumatoid arthritis joint, PLoS ONE 2010;5:E12516.","DOI":"10.1371\/journal.pone.0012516"},{"key":"10.1016\/j.cyto.2012.02.018_b0155","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.4049\/jimmunol.0903271","article-title":"IL-17 contributes to angiogenesis in rheumatoid arthritis","volume":"184","author":"Pickens","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2012.02.018_b0160","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/sj.onc.1202019","article-title":"Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription","volume":"17","author":"Akiri","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2012.02.018_b0165","first-page":"35","article-title":"Hypoxia regulatory elements of the human vascular endothelial growth factor gene","volume":"40","author":"Minchenko","year":"1994","journal-title":"Cell Mol Biol Res"},{"key":"10.1016\/j.cyto.2012.02.018_b0170","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/01.RES.77.3.638","article-title":"Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5\u2019 enhancer","volume":"77","author":"Liu","year":"1995","journal-title":"Circ Res"},{"key":"10.1016\/j.cyto.2012.02.018_b0175","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/rheumatology\/kei240","article-title":"The effects of tobacco smoking and rheumatoid factor seropositivity on disease activity and joint damage in early rheumatoid arthritis","volume":"45","author":"Manfredsdottir","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cyto.2012.02.018_b0180","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/rheumatology\/ken057","article-title":"Rheumatoid arthritis patients who smoke have a higher need for DMARDs and feel worse, but they do not have more joint damage than non-smokers of the same serological group","volume":"47","author":"Westhoff","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cyto.2012.02.018_b0185","first-page":"820","article-title":"Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database","volume":"28","author":"Naranjo","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.cyto.2012.02.018_b0190","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/03009742.2010.541495","article-title":"BARFOT study group. Smoking at onset of rheumatoid arthritis (RA) and its effect on disease activity and functional status: experiences from BARFOT, a long-term observational study on early RA","volume":"40","author":"S\u00f6derlin","year":"2011","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.cyto.2012.02.018_b0195","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.3899\/jrheum.110410","article-title":"Effects of smoking on disease activity and radiographic progression in early rheumatoid arthritis","volume":"38","author":"Ruiz-Esquide","year":"2011","journal-title":"J Rheumatol"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466612000701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466612000701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T13:37:36Z","timestamp":1561469856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466612000701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1043466612000701"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2012.02.018","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}