{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:59:12Z","timestamp":1790492352196,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.cyto.2012.12.031","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T21:48:20Z","timestamp":1360360100000},"page":"747-754","source":"Crossref","is-referenced-by-count":43,"title":["Multiplex analysis of cytokines\/chemokines as biomarkers that differentiate healthy contacts from tuberculosis patients in high endemic settings"],"prefix":"10.1016","volume":"61","author":[{"given":"D.","family":"Anbarasu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ponnu Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alamelu","family":"Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2012.12.031_b0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/146642400212200206","article-title":"The global emergency of tuberculosis: what is the cause?","volume":"122","author":"Grange","year":"2002","journal-title":"J Roy Soc Promot Health"},{"key":"10.1016\/j.cyto.2012.12.031_b0010","unstructured":"WHO: World Health Organization. Global Tuberculosis Control\u2013Surveillance, Planning, Financing. WHO Report; 2009."},{"key":"10.1016\/j.cyto.2012.12.031_b0015","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1086\/505877","article-title":"Global incidence of multidrug-resistant tuberculosis","volume":"194","author":"Zignol","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cyto.2012.12.031_b0020","first-page":"S384","article-title":"Tuberculosis contact investigations: outcomes in selected areas of the United States, 1999","volume":"7","author":"Jereb","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.cyto.2012.12.031_b0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.0903856","article-title":"Understanding latent tuberculosis: a moving target","volume":"185","author":"Lin","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/jama.282.7.677","article-title":"Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project","volume":"282","author":"Dye","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.cyto.2012.12.031_b0035","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrmicro2236","article-title":"The spectrum of latent tuberculosis: rethinking the biology and intervention strategies","volume":"7","author":"Barry","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.cyto.2012.12.031_b0040","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.drudis.2009.10.005","article-title":"The quest for biomarkers in tuberculosis","volume":"15","author":"Parida","year":"2010","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.cyto.2012.12.031_b0045","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri2960","article-title":"Immunological biomarkers of tuberculosis","volume":"11","author":"Walzl","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0050","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1074\/mcp.M900299-MCP200","article-title":"Immunoproteomic identification of human T cell antigens of Mycobacterium tuberculosis that differentiate healthy contacts from tuberculosis patients","volume":"9","author":"Deenadayalan","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.cyto.2012.12.031_b0055","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yexmp.2009.11.008","article-title":"Immunological and proteomic analysis of preparative isoelectric focusing separated culture filtrate antigens of Mycobacterium tuberculosis","volume":"88","author":"Deenadayalan","year":"2010","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.cyto.2012.12.031_b0060","first-page":"226","article-title":"Comparison of variants of carbol\u2013fuchsin solution in Ziehl\u2013Neelsen for detection of acid-fast bacilli","volume":"9","author":"Selvakumar","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.cyto.2012.12.031_b0065","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF02728860","article-title":"Tuberculin test","volume":"68","author":"Chadha","year":"2001","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.cyto.2012.12.031_b0070","first-page":"337","article-title":"Attack rate of tuberculosis in a 5-year period among close family contacts of tuberculosis patients under domiciliary treatment with isoniazid plus PAS or isoniazid alone","volume":"42","author":"Devadatta","year":"1970","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.cyto.2012.12.031_b0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.1124619","article-title":"Mass spectrometry and protein analysis","volume":"312","author":"Domon","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cyto.2012.12.031_b0080","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1183\/09031936.00055508","article-title":"Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis","volume":"32","author":"Ruhwald","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cyto.2012.12.031_b0085","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2466-9-21","article-title":"Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report","volume":"9","author":"Chegou","year":"2009","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.cyto.2012.12.031_b0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-0500-2-19","article-title":"IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay","volume":"2","author":"Ruhwald","year":"2009","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.cyto.2012.12.031_b0095","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1473-3099(07)70108-1","article-title":"Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development","volume":"7","author":"Gagneux","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cyto.2012.12.031_b0100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.chom.2008.08.002","article-title":"Tuberculosis in Africa: learning from pathogenesis for biomarker identification","volume":"4","author":"Kaufmann","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cyto.2012.12.031_b0105","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.meegid.2007.09.007","article-title":"Genomic interrogation of ancestral Mycobacterium tuberculosis from south India","volume":"8","author":"Narayanan","year":"2008","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.cyto.2012.12.031_b0110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.meegid.2008.10.001","article-title":"Ancestral Mycobacterium tuberculosis genotypes in India: implications for TB control programmes","volume":"9","author":"Ahmed","year":"2009","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.cyto.2012.12.031_b0115","doi-asserted-by":"crossref","first-page":"e25075","DOI":"10.1371\/journal.pone.0025075","article-title":"Reduced transmissibility of east African Indian strains of Mycobacterium tuberculosis","volume":"6","author":"Albanna","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2012.12.031_b0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0962-8479(94)90013-2","article-title":"A re-examination of the variations in the efficacy of BCG vaccination against tuberculosis in clinical trials","volume":"75","author":"Springett","year":"1994","journal-title":"Tuber Lung Dis"},{"key":"10.1016\/j.cyto.2012.12.031_b0125","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0264-410X(98)00124-8","article-title":"The effect of heterologous immunity upon the apparent efficacy of (e.g. BCG) vaccines","volume":"16","author":"Fine","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.cyto.2012.12.031_b0265","first-page":"814","article-title":"Pathogenesis, immunology, and diagnosis of latent Mycobacterium tuberculosis infection","author":"Ahmad","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0135","first-page":"93","article-title":"Rational use of immunodiagnostic tools for tuberculosis infection: guidelines and cost effectiveness studies","volume":"33","author":"Amicosante","year":"2010","journal-title":"New Microbiol"},{"key":"10.1016\/j.cyto.2012.12.031_b0140","doi-asserted-by":"crossref","first-page":"e9051","DOI":"10.1371\/journal.pone.0009051","article-title":"Role of QuantiFERON-TB gold, interferon gamma inducible protein-10 and tuberculin skin test in active tuberculosis diagnosis","volume":"5","author":"Syed Ahamed Kabeer","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2012.12.031_b0145","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1055\/s-0028-1085707","article-title":"New diagnostics for latent and active tuberculosis: state of the art and future prospects","volume":"29","author":"Pai","year":"2008","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.cyto.2012.12.031_b0150","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/CVI.00132-07","article-title":"Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation","volume":"14","author":"Leyten","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0155","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.tube.2007.08.001","article-title":"Influence of HLA-DRB1 alleles on Th1 and Th2 cytokine response to Mycobacterium tuberculosis antigens in pulmonary tuberculosis","volume":"87","author":"Selvaraj","year":"2007","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.cyto.2012.12.031_b0270","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/intimm\/dxq429","article-title":"Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy","volume":"22","author":"Mattos","year":"2010","journal-title":"Int Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0165","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1128\/IAI.67.11.5747-5754.1999","article-title":"Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine","volume":"67","author":"Leal","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2012.12.031_b0170","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/IAI.65.11.4843-4849.1997","article-title":"Lethal tuberculosis in interleukin-6-deficient mutant mice","volume":"65","author":"Ladel","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2012.12.031_b0175","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","article-title":"Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease","volume":"129","author":"Onishi","year":"2010","journal-title":"Immunology"},{"issue":"July","key":"10.1016\/j.cyto.2012.12.031_b0180","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/eji.201040391","article-title":"IL-6: regulator of Treg\/Th17 balance","volume":"40","author":"Kimura","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0185","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.178.5.2661","article-title":"Cutting edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis","volume":"178","author":"Kursar","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0190","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.20030735","article-title":"Interleukin 7 regulates the survival and generation of memory CD4 cells","volume":"198","author":"Kondrack","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2012.12.031_b0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1365-2567.2004.01785.x","article-title":"Intracellular expression of interleukin-4 and interferon-gamma by a Mycobacterium tuberculosis antigen-stimulated CD4+ CD57+ T-cell subpopulation with memory phenotype in tuberculosis patients","volume":"111","author":"Jimenez-Martinez","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2012.12.031_b0200","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"Wilson C The interleukin-8 pathway in cancer","volume":"14","author":"Waugh","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cyto.2012.12.031_b0275","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1128\/IAI.73.3.1744-1753.2005","article-title":"Neutrophil response Mycobacterium tuberculosis infection in genetically susceptible and resistance mice","volume":"73","author":"Eruslanov","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2012.12.031_b0210","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.clim.2007.09.009","article-title":"IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis","volume":"126","author":"Wu","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.cyto.2012.12.031_b0215","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1164\/ajrccm.157.4.9709126","article-title":"Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tuberculosis","volume":"157","author":"Juffermans","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cyto.2012.12.031_b0220","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1378\/chest.117.1.103","article-title":"Imbalances between tumor necrosis factor-alpha and its soluble receptor forms, and interleukin-1beta and interleukin-1 receptor antagonist in BAL fluid of cavitary pulmonary tuberculosis","volume":"117","author":"Tsao","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.cyto.2012.12.031_b0225","doi-asserted-by":"crossref","first-page":"e8272","DOI":"10.1371\/journal.pone.0008272","article-title":"Immunological memory transferred with CD4 T cells specific for tuberculosis antigens Ag85B-TB10.4: persisting antigen enhances protection","volume":"4","author":"Duffy","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2012.12.031_b0280","first-page":"208371","article-title":"Assessment of the genetic diversity of Mycobacterium tuberculosis esxA, esxH, and fbpB genes among clinical isolates and its implication for the future immunization by new tuberculosis subunit vaccines Ag85B-ESAT-6 and Ag85B-TB10.4","author":"Davila","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.cyto.2012.12.031_b0235","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.vaccine.2010.12.135","article-title":"Ag85B-ESAT-6 adjuvanted with IC31(R) promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection","volume":"29","author":"van Dissel","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.cyto.2012.12.031_b0240","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.1128\/IAI.73.10.6846-6851.2005","article-title":"Antibody profiles characteristic of Mycobacterium tuberculosis infection state","volume":"73","author":"Davidow","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2012.12.031_b0245","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.micinf.2006.03.018","article-title":"Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis","volume":"8","author":"Leyten","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.cyto.2012.12.031_b0250","doi-asserted-by":"crossref","first-page":"e17813","DOI":"10.1371\/journal.pone.0017813","article-title":"Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states","volume":"6","author":"Sester","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2012.12.031_b0255","doi-asserted-by":"crossref","first-page":"e12577","DOI":"10.1371\/journal.pone.0012577","article-title":"Is IP-10 an accurate marker for detecting M. tuberculosis-specific response in HIV-infected persons?","volume":"5","author":"Goletti","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2012.12.031_b0260","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/31159","article-title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence","volume":"393","author":"Cole","year":"1998","journal-title":"Nature"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346661300032X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346661300032X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T03:01:23Z","timestamp":1595386883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104346661300032X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S104346661300032X"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2012.12.031","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}