{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:11:35Z","timestamp":1784977895735,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.cyto.2013.01.019","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T06:33:42Z","timestamp":1362465222000},"page":"146-150","source":"Crossref","is-referenced-by-count":16,"title":["The effect of granulocyte and monocyte adsorptive apheresis on serum cytokine levels in patients with ulcerative colitis"],"prefix":"10.1016","volume":"62","author":[{"given":"Yosuke","family":"Toya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kasugai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Orikasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukito","family":"Abiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risaburo","family":"Akasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Oana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2013.01.019_b0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/gut.25.1.32","article-title":"Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistochemical and cell isolation techniques","volume":"25","author":"Selby","year":"1984","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2013.01.019_b0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/gast.2000.8523","article-title":"Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease","volume":"119","author":"Tibble","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2013.01.019_b0015","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0016-5085(98)70381-6","article-title":"Inflammatory bowel disease: etiology and pathogenesis","volume":"115","author":"Fiocchi","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2013.01.019_b0020","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1023\/A:1020159932758","article-title":"Therapeutic efficacy of granulocyte and monocyte adsorption apheresis in severe active ulcerative colitis","volume":"47","author":"Hanai","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cyto.2013.01.019_b0025","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/gut.42.4.470","article-title":"Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation","volume":"42","author":"Nikolaus","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2013.01.019_b0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0167-5699(95)80066-2","article-title":"The production of cytokines by polymorphonuclear neutrophils","volume":"16","author":"Cassatella","year":"1995","journal-title":"Immunol. Today"},{"key":"10.1016\/j.cyto.2013.01.019_b0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0167-5699(97)01087-6","article-title":"Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis","volume":"18","author":"Edwards","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1016\/j.cyto.2013.01.019_b0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0952-7915(99)00051-5","article-title":"The role of IL-18 in innate immunity","volume":"12","author":"Akira","year":"2000","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cyto.2013.01.019_b0045","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/378088a0","article-title":"Cloning of a new cytokine that induces IFN-gamma production by T cells","volume":"378","author":"Okamura","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2013.01.019_b0050","first-page":"66","article-title":"Emerging biologic therapies in inflammatory bowel disease","volume":"4","author":"Lim","year":"2004","journal-title":"Gastroenterol. Disord."},{"key":"10.1016\/j.cyto.2013.01.019_b0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.transci.2007.08.003","article-title":"Therapeutic leucocytapheresis for inflammatory bowel disease","volume":"37","author":"Saniabadi","year":"2007","journal-title":"Transfus. Apheresis Sci."},{"key":"10.1016\/j.cyto.2013.01.019_b0060","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jca.20046","article-title":"Adacolumn for selective leucocytapheresis as a non-pharmacological treatment for patients with disorders of the immune system: an adjunct or an alternative to drug therapy?","volume":"20","author":"Saniabadi","year":"2005","journal-title":"J. Clin. Apheresis"},{"key":"10.1016\/j.cyto.2013.01.019_b0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1526-0968.2003.00012.x","article-title":"Adacolumn, an adsorptive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory diseases associated with leukocytes","volume":"7","author":"Saniabadi","year":"2003","journal-title":"Ther. Apheresis Dial."},{"key":"10.1016\/j.cyto.2013.01.019_b0070","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/jcgh.2003.50005","article-title":"Takeuchi k, et al. Leucocyte adsorptive apheresis for the treatment of active ulcerative colitis: a prospective, uncontrolled, pilot study","volume":"1","author":"Hanai","year":"2003","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cyto.2013.01.019_b0075","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1023\/B:DDAS.0000026299.43792.ae","article-title":"Selective granulocyte and monocyte adsorptive apheresis as a first-line treatment for steroid naive patients with active ulcerative colitis: a prospective uncontrolled study","volume":"49","author":"Suzuki","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cyto.2013.01.019_b0080","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.3748\/wjg.v12.i21.3393","article-title":"Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis","volume":"12","author":"Hanai","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cyto.2013.01.019_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jca.1000","article-title":"Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: a multicenter study","volume":"16","author":"Shimoyama","year":"2001","journal-title":"J. Clin. Apheresis"},{"key":"10.1016\/j.cyto.2013.01.019_b0090","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1007\/s00535-004-1465-z","article-title":"Adsorptive granulocyte and monocyte apheresis for refractory Crohn\u2019s disease: an open multicenter prospective study","volume":"39","author":"Fukuda","year":"2004","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.cyto.2013.01.019_b0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00054725-200405000-00012","article-title":"Granulocytapheresis is useful as an alternative therapy in patients with steroid-refractory or dependent ulcerative colitis","volume":"10","author":"Naganuma","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.cyto.2013.01.019_b0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0022-1759(00)00238-6","article-title":"Multiplexed particle-based flow cytometric assays","volume":"243","author":"Vignali","year":"2000","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cyto.2013.01.019_b0105","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nri1132","article-title":"The immunological and genetic basis of inflammatory bowel disease","volume":"3","author":"Bouma","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2013.01.019_b0110","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human Th17 cells","volume":"204","author":"Annunziato","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2013.01.019_b0115","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1572-0241.2007.01714.x","article-title":"Adsorptive depletion of elevated proinflammatory CD14+CD16+DR++ monocytes in patients with inflammatory bowel disease","volume":"103","author":"Hanai","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.cyto.2013.01.019_b0120","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1744-9987.2009.00668.x","article-title":"Granulocyte and monocyte adsorption apheresis therapy modulates monocyte-derived dendritic cell function in patients with ulcerative colitis","volume":"13","author":"Iwakami","year":"2009","journal-title":"Ther. Apheresis Dial."},{"key":"10.1016\/j.cyto.2013.01.019_b0125","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s10620-006-9406-8","article-title":"Adacolumn selective leukocyte adsorption apheresis in patients with active ulcerative colitis: clinical efficacy, effects on plasma IL-8, and expression of Toll-like receptor 2 on granulocytes","volume":"52","author":"Aoki","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cyto.2013.01.019_b0130","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00535-007-2118-9","article-title":"The production of interferon-\u03b3-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity","volume":"42","author":"Noguchi","year":"2007","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.cyto.2013.01.019_b0135","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.3748\/wjg.14.1521","article-title":"Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis","volume":"14","author":"Cuadrado","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cyto.2013.01.019_b0140","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1159\/000335316","article-title":"Peripheral blood CD64 levels decrease in Crohn\u2019s disease following granulocyte and monocyte adsorptive apheresis","volume":"5","author":"Chiba","year":"2011","journal-title":"Case Rep. Gastroenterol."},{"key":"10.1016\/j.cyto.2013.01.019_b0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1744-9987.2011.00970.x","article-title":"Immunoregulatory effects of adsorptive granulocyte and monocyte apheresis in patients with drug refractory Crohn\u2019s disease","volume":"15","author":"Nagase","year":"2011","journal-title":"Ther. Apheresis Dial."},{"key":"10.1016\/j.cyto.2013.01.019_b0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00054725-199606000-00004","article-title":"Chemokines in IBD mucosa: expression of RANTES, MIP-1\u03b1, MIP-1\u03b2 and interferon inducible protein 10 by macrophages, lymphocytes, endothelial cells and granulomas","volume":"2","author":"Grimm","year":"1996","journal-title":"Inflamm. Bowel Dis."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T12:16:54Z","timestamp":1562761014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466613000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S1043466613000537"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2013.01.019","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}