{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:51:17Z","timestamp":1780066277348,"version":"3.54.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.cyto.2013.05.003","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T05:18:34Z","timestamp":1370323114000},"page":"427-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Coronary artery ectasia and inflammatory cytokines: Link with a predominant Th-2 immune response?"],"prefix":"10.1016","volume":"64","author":[{"given":"Andreas S.","family":"Triantafyllis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas S.","family":"Kalogeropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos G.","family":"Rigopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios A.","family":"Sakadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis K.","family":"Toumpoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Tsikrikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios T.","family":"Kremastinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Rizos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2013.05.003_b0005","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/01.CIR.0000165121.50527.DE","article-title":"Increased prevalence of coronary artery aneurysms among cocaine users","volume":"111","author":"Satran","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2013.05.003_b0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/01.CIR.67.1.134","article-title":"Aneurysmal coronary artery disease","volume":"67","author":"Swaye","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2013.05.003_b0015","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/eurheartj\/ehi725","article-title":"Coronary artery ectasia: imaging, functional assessment and clinical implications","volume":"27","author":"Manginas","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cyto.2013.05.003_b0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/clc.4960210304","article-title":"Current knowledge and significance of coronary artery ectasia: a chronologic review of the literature, recommendations for treatment, possible etiologies, and future considerations","volume":"21","author":"Sorrell","year":"1998","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.cyto.2013.05.003_b0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/hrt.40.4.393","article-title":"Coronary artery ectasia\u2013a variant of occlusive coronary arteriosclerosis","volume":"40","author":"Swanton","year":"1978","journal-title":"Brit Heart J"},{"key":"10.1016\/j.cyto.2013.05.003_b0030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0002-9149(76)90315-5","article-title":"Clinical significance of coronary arterial ectasia","volume":"37","author":"Markis","year":"1976","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cyto.2013.05.003_b0035","first-page":"1817","article-title":"Inflammation: an important mechanism for different clinical entities of coronary artery diseases","volume":"118","author":"Li","year":"2005","journal-title":"Chin Med J"},{"key":"10.1016\/j.cyto.2013.05.003_b0040","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2013.05.003_b0045","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2143\/AC.59.5.2005226","article-title":"Plasma interleukin-6 levels are increased in coronary artery ectasia","volume":"59","author":"Tokgozoglu","year":"2004","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.cyto.2013.05.003_b0050","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.amjcard.2004.07.120","article-title":"Comparison of C-reactive protein levels in patients with coronary artery ectasia versus patients with obstructive coronary artery disease","volume":"94","author":"Turhan","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cyto.2013.05.003_b0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.atherosclerosis.2004.10.020","article-title":"Temporal association between circulating proteolytic, inflammatory and neurohormonal markers in patients with coronary ectasia","volume":"179","author":"Finkelstein","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cyto.2013.05.003_b0060","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000091414","article-title":"Plasma soluble adhesion molecule levels in coronary artery ectasia","volume":"105","author":"Yilmaz","year":"2006","journal-title":"Cardiology"},{"key":"10.1016\/j.cyto.2013.05.003_b0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00019501-200502000-00009","article-title":"Plasma soluble adhesion molecules; intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin levels in patients with isolated coronary artery ectasia","volume":"16","author":"Turhan","year":"2005","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.cyto.2013.05.003_b0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/icb.2011.45","article-title":"Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase","volume":"90","author":"Miller","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.cyto.2013.05.003_b0075","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cyto.2007.08.013","article-title":"Interleukin-2 serum levels variations in recent onset atrial fibrillation are related with cardioversion outcome","volume":"40","author":"Rizos","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2013.05.003_b0080","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00019501-200309000-00003","article-title":"Serum tumour necrosis factor-alpha, interleukin-2 and interleukin-10 activation in stable angina and acute coronary syndromes","volume":"14","author":"Mizia-Stec","year":"2003","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.cyto.2013.05.003_b0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00547-001-0023-2","article-title":"Role of interleukins in atherogenesis","volume":"10","author":"Subramanya","year":"2001","journal-title":"Int J Angiol"},{"issue":"Suppl 4","key":"10.1016\/j.cyto.2013.05.003_b0090","first-page":"331","article-title":"Regulation of fibrinogen biosynthesis by cytokines, consequences on the vascular risk","volume":"26","author":"Vasse","year":"1996","journal-title":"Haemostasis"},{"key":"10.1016\/j.cyto.2013.05.003_b0095","doi-asserted-by":"crossref","first-page":"27631","DOI":"10.1016\/S0021-9258(18)47031-7","article-title":"Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes","volume":"269","author":"Nassar","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2013.05.003_b0100","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.4049\/jimmunol.159.9.4532","article-title":"TNF-alpha and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells","volume":"159","author":"Barks","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2013.05.003_b0105","doi-asserted-by":"crossref","first-page":"799","DOI":"10.4049\/jimmunol.154.2.799","article-title":"IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells","volume":"154","author":"Bochner","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2013.05.003_b0110","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.4049\/jimmunol.165.5.2818","article-title":"The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13","volume":"165","author":"Fukushi","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2013.05.003_b0115","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9440(10)64206-X","article-title":"T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm","volume":"161","author":"Schonbeck","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cyto.2013.05.003_b0120","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00392-007-0521-0","article-title":"Novel insights into an old controversy: is coronary artery ectasia a variant of coronary atherosclerosis?","volume":"96","author":"Yetkin","year":"2007","journal-title":"Clin Res Cardiol: Off J Ger Card Soc"},{"key":"10.1016\/j.cyto.2013.05.003_b0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cyto.2008.12.012","article-title":"Chronic inflammatory status in patients with coronary artery ectasia","volume":"46","author":"Li","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2013.05.003_b0130","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/01.ATV.15.8.1145","article-title":"Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm","volume":"15","author":"Freestone","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cyto.2013.05.003_b0135","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/01.CIR.98.3.193","article-title":"Aortic aneurysm formation: lessons from human studies and experimental models","volume":"98","author":"Davies","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2013.05.003_b0140","doi-asserted-by":"crossref","first-page":"106145","DOI":"10.1155\/2009\/106145","article-title":"The levels of tumor necrosis factor-alpha and interleukin-6 in patients with isolated coronary artery ectasia","volume":"2009","author":"Aydin","year":"2009","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.cyto.2013.05.003_b0145","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.ATV.11.5.1223","article-title":"Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells","volume":"11","author":"Amento","year":"1991","journal-title":"Arterioscler Thromb: J Vasc Biol\/Am Heart Assoc"},{"key":"10.1016\/j.cyto.2013.05.003_b0150","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1073\/pnas.94.5.1931","article-title":"Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis","volume":"94","author":"Mach","year":"1997","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.cyto.2013.05.003_b0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0021-9150(99)00011-8","article-title":"Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines","volume":"145","author":"Frostegard","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cyto.2013.05.003_b0160","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/clc.4960240315","article-title":"Elevated plasma levels of interleukin-2 and soluble IL-2 receptor in ischemic heart disease","volume":"24","author":"Simon","year":"2001","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.cyto.2013.05.003_b0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/01.CIR.91.1.20","article-title":"T lymphocyte activation in stable angina pectoris and after percutaneous transluminal coronary angioplasty","volume":"91","author":"Blum","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2013.05.003_b0170","first-page":"161","article-title":"Interleukin-4 inhibits human smooth muscle cell proliferation","volume":"21","author":"Vadiveloo","year":"1994","journal-title":"Artery"},{"key":"10.1016\/j.cyto.2013.05.003_b0175","first-page":"75","article-title":"Human 15-lipoxygenase: induction by interleukin-4 and insights into positional specificity","volume":"6","author":"Sigal","year":"1993","journal-title":"J Lipid Mediators"},{"key":"10.1016\/j.cyto.2013.05.003_b0180","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/01.RES.0000160543.84254.f1","article-title":"Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT, and helper T cells","volume":"96","author":"Chan","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.cyto.2013.05.003_b0185","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0022-2275(20)31641-2","article-title":"Interleukin 4 induces transcription of the 15-lipoxygenase I gene in human endothelial cells","volume":"42","author":"Lee","year":"2001","journal-title":"J Lipid Res"},{"key":"10.1016\/j.cyto.2013.05.003_b0190","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2013.05.003_b0195","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4049\/jimmunol.149.1.107","article-title":"IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis","volume":"149","author":"Zubiaga","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2013.05.003_b0200","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1172\/JCI200419855","article-title":"Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas","volume":"114","author":"Shimizu","year":"2004","journal-title":"J Clin Investig"},{"key":"10.1016\/j.cyto.2013.05.003_b0205","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0021-9150(97)00296-7","article-title":"A role for interleukin 4 in production of matrix metalloproteinase 1 by human aortic smooth muscle cells","volume":"138","author":"Sasaguri","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cyto.2013.05.003_b0210","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.4049\/jimmunol.164.11.5952","article-title":"Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytes","volume":"164","author":"Chizzolini","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2013.05.003_b0215","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/1529-0131(199808)41:8<1398::AID-ART8>3.0.CO;2-B","article-title":"Interleukin-4 suppression of interleukin-1-induced transcription of collagenase (MMP-1) and stromelysin 1 (MMP-3) in human synovial fibroblasts","volume":"41","author":"Borghaei","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cyto.2013.05.003_b0220","article-title":"Suppression of matrix metalloproteinase-3 synthesis by interleukin-4 in human articular chondrocytes","volume":"24","author":"Nemoto","year":"1997","journal-title":"J Rheumatol"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613002202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613002202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T04:52:37Z","timestamp":1688273557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466613002202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S1043466613002202"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2013.05.003","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coronary artery ectasia and inflammatory cytokines: Link with a predominant Th-2 immune response?","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2013.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}