{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:47:07Z","timestamp":1789390027050,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.cyto.2013.07.021","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T21:00:38Z","timestamp":1379019638000},"page":"516-522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Change in inflammatory cytokine profiles after transarterial chemotherapy in patients with hepatocellular carcinoma"],"prefix":"10.1016","volume":"64","author":[{"given":"Min Ju","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Won","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong Sun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hyun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Won","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Suk","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Jekarl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2013.07.021_b0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/j.gastro.2004.09.032","article-title":"Chemoembolization for hepatocellular carcinoma","volume":"127","author":"Bruix","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2013.07.021_b0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1440-1746.2011.07003.x","article-title":"Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease","volume":"27","author":"Gao","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.cyto.2013.07.021_b0015","first-page":"2111","article-title":"Immunological and histological analyses of transarterial immuno-embolization therapy (TIE) in operable patients with hepatocellular carcinoma","volume":"21","author":"Yoshida","year":"1994","journal-title":"Gan to Kagaku Ryoho"},{"key":"10.1016\/j.cyto.2013.07.021_b0020","first-page":"1569","article-title":"Serum levels of interleukin-10, interleukin-12 and soluble interleukin-2 receptor in chronic liver disease type C","volume":"50","author":"Kitaoka","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.cyto.2013.07.021_b0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00280-008-0866-8","article-title":"Changes of host immunity in relation to efficacy in liver cirrhosis patients with advanced hepatocellular carcinoma treated by intra-arterial chemotherapy","volume":"64","author":"Momiyama","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.cyto.2013.07.021_b0030","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cyto.2012.07.017","article-title":"Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma","volume":"60","author":"Jang","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2013.07.021_b0035","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1189\/jlb.0506297","article-title":"The role of cytokines in hepatocellular carcinoma","volume":"80","author":"Budhu","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cyto.2013.07.021_b0040","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/annonc\/mdm448","article-title":"Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma","volume":"19","author":"Porta","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.cyto.2013.07.021_b0045","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00000658-200004000-00015","article-title":"Serum interleukin-10 but not interleukin-6 is related to clinical outcome in patients with resectable hepatocellular carcinoma","volume":"231","author":"Chau","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.cyto.2013.07.021_b0050","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.23291","article-title":"Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells","volume":"51","author":"Kuang","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cyto.2013.07.021_b0055","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/hep.24486","article-title":"Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3","volume":"54","author":"Jiang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.cyto.2013.07.021_b0060","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ejso.2006.10.036","article-title":"Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma","volume":"33","author":"Hsia","year":"2007","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.cyto.2013.07.021_b0065","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0167-5699(90)90173-7","article-title":"Biological and clinical aspects of interleukin 6","volume":"11","author":"Hirano","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/j.cyto.2013.07.021_b0070","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jhep.2007.11.007","article-title":"Inflammation, HCC and sex: IL-6 in the centre of the triangle","volume":"48","author":"Prieto","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.cyto.2013.07.021_b0075","first-page":"1711","article-title":"Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells","volume":"4","author":"Lee","year":"1998","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cyto.2013.07.021_b0080","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/147323000203000505","article-title":"Analysis of host response to hepatectomy by simultaneous measurement of cytokines in the portal vein, caval vein and radial artery","volume":"30","author":"Kanaoka","year":"2002","journal-title":"J Int Med Res"},{"key":"10.1016\/j.cyto.2013.07.021_b0085","first-page":"1048","article-title":"Levels of interleukin (IL)-6, IL-8, and IL-1 receptor antagonist in the hepatic vein following liver surgery","volume":"47","author":"Ueda","year":"2000","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.cyto.2013.07.021_b0090","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1152\/ajpgi.00075.2009","article-title":"IL-22 is involved in liver regeneration after hepatectomy","volume":"298","author":"Ren","year":"2010","journal-title":"Am J Physiol Gastroint Liver Physiol"},{"key":"10.1016\/j.cyto.2013.07.021_b0095","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.21087","article-title":"Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair","volume":"43","author":"Jin","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cyto.2013.07.021_b0100","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s002689900617","article-title":"Interleukin-6 and tumor necrosis factor-alpha levels following hepatic cryotherapy: association with volume and duration of freezing","volume":"23","author":"Seifert","year":"1999","journal-title":"World J Surg"},{"key":"10.1016\/j.cyto.2013.07.021_b0105","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.4049\/jimmunol.0904091","article-title":"IL-22 induces an acute-phase response","volume":"185","author":"Liang","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2013.07.021_b0110","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume":"39","author":"Radaeva","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cyto.2013.07.021_b0115","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume":"27","author":"Zenewicz","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2013.07.021_b0120","first-page":"7457","article-title":"Production of interleukin 6 from human liver cell lines: production of interleukin 6 is not concurrent with the production of alpha-fetoprotein","volume":"50","author":"Matsuguchi","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.cyto.2013.07.021_b0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2249.2007.03356.x","article-title":"The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease","volume":"148","author":"Afzali","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cyto.2013.07.021_b0130","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1182\/blood-2002-05-1461","article-title":"Interleukin-17 promotes angiogenesis and tumor growth","volume":"101","author":"Numasaki","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2013.07.021_b0140","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.immuni.2009.09.014","article-title":"T helper 17 cells promote cytotoxic T cell activation in tumor immunity","volume":"31","author":"M artin-Orozco","year":"2009","journal-title":"Immunity"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613006376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613006376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T00:23:28Z","timestamp":1539390208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466613006376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S1043466613006376"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2013.07.021","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Change in inflammatory cytokine profiles after transarterial chemotherapy in patients with hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2013.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}