{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:29:41Z","timestamp":1781663381719,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.cyto.2013.10.004","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T21:34:13Z","timestamp":1383255253000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Changes in central and peripheral inflammatory responses to lipopolysaccharide in ovariectomized female rats"],"prefix":"10.1016","volume":"65","author":[{"given":"Takeshi","family":"Iwasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyo","family":"Kinouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganbat","family":"Gereltsetseg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munkhsaikhan","family":"Munkhzaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tungalagsuvd","family":"Altankhuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Irahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2013.10.004_b0005","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1210\/en.2010-0336","article-title":"Inflammation and obesity pathogenesis: the hypothalamus heats up","volume":"151","author":"Thaler","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2013.10.004_b0010","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1189\/jlb.0108028","article-title":"Adipose\u2013immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span","volume":"84","author":"Dixit","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cyto.2013.10.004_b0015","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S1473-3099(06)70523-0","article-title":"Obesity and injection","volume":"6","author":"Falagas","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cyto.2013.10.004_b0020","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1073\/pnas.0804091105","article-title":"Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice","volume":"105","author":"Sennello","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2013.10.004_b0025","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1210\/en.2009-0526","article-title":"Changes in hypothalamically mediated acute-phase inflammatory response to lipopolysaccharide in diet induced obese rats","volume":"150","author":"Pohl","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2013.10.004_b0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/jne.12023","article-title":"Effect of obesity on the acute inflammatory response in pregnant and cycling female rats","volume":"25","author":"Pohl","year":"2013","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.cyto.2013.10.004_b0035","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2826.2011.02269.x","article-title":"Postnatal overfeeding leads to obesity and exacerbated febrile responses to lipopolysaccharide throughout life","volume":"24","author":"Clarke","year":"2011","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.cyto.2013.10.004_b0040","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2337\/diabetes.53.8.2087","article-title":"Intra-abdominal fat is a major determinant of the national cholesterol education program adult treatment panel III criteria for the metabolic syndrome","volume":"53","author":"Carr","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2013.10.004_b0045","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1210\/jc.2001-012034","article-title":"Differences in adipose tissue metabolism between postmenopausal and perimenopausal women","volume":"87","author":"Ferrara","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cyto.2013.10.004_b0050","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1055\/s-2007-978681","article-title":"Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women","volume":"32","author":"Tchernof","year":"2000","journal-title":"Hormone Metab Res"},{"key":"10.1016\/j.cyto.2013.10.004_b0055","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-5122(03)00159-2","article-title":"Body composition, visceral fat distribution and fat oxidation in postmenopausal women using oral or transdermal oestrogen","volume":"46","author":"dos Reis","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.cyto.2013.10.004_b0060","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1210\/en.2008-1405","article-title":"Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity","volume":"150","author":"Rogers","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2013.10.004_b0065","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0031-9384(79)90028-3","article-title":"Gonadal effects on food intake and adiposity: a metabolic hypothesis","volume":"22","author":"Wade","year":"1979","journal-title":"Physiol Behav"},{"key":"10.1016\/j.cyto.2013.10.004_b0070","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1210\/en.2004-0129","article-title":"Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats","volume":"145","author":"Meli","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2013.10.004_b0075","first-page":"245","article-title":"Effects of ovarian hormones on energy balance and brown adipose tissue thermogenesis","volume":"250","author":"Richard","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cyto.2013.10.004_b0080","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2337\/db11-1718","article-title":"Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance","volume":"62","author":"Zhu","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2013.10.004_b0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jri.2011.05.010","article-title":"Effect of immune stress on body weight regulation is altered by ovariectomy in female rats","volume":"91","author":"Iwasa","year":"2011","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.cyto.2013.10.004_b0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.physbeh.2009.02.036","article-title":"Sex differences in stress responses: focus on ovarian hormones","volume":"97","author":"Ter Horst","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.cyto.2013.10.004_b0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/sj.ijo.0801911","article-title":"Cytokines and feeding","volume":"25","author":"Plata-Salaman","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.cyto.2013.10.004_b0100","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1210\/en.2002-0093","article-title":"Neuroimmune response to endogenous and exogenous pyrogens is differently modulated by sex steroid","volume":"144","author":"Mouihate","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2013.10.004_b0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2170\/physiolsci.RP003407","article-title":"Time-course changes of hormones and cytokines by lipopolysaccharide and its relation with anorexia","volume":"57","author":"Kim","year":"2007","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.cyto.2013.10.004_b0110","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1172\/JCI118653","article-title":"Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters","volume":"97","author":"Grunfeld","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2013.10.004_b0115","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1073\/pnas.96.12.7047","article-title":"Leptin actions on food intake and body temperature are mediated by IL1","volume":"96","author":"Luheshi","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2013.10.004_b0120","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.074351","article-title":"Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats","volume":"561","author":"Sachot","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.cyto.2013.10.004_b0125","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0166-2236(95)93890-A","article-title":"Cytokines and the nervous system. II. Actions and mechanisms of action","volume":"18","author":"Rothwell","year":"1995","journal-title":"Trents Neurosci"},{"key":"10.1016\/j.cyto.2013.10.004_b0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0166-2236(95)93881-W","article-title":"Cytokines and the nervous system. I. Expression and recognition","volume":"18","author":"Hopkins","year":"1995","journal-title":"Trend Neurosci"},{"key":"10.1016\/j.cyto.2013.10.004_b0135","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1152\/ajpregu.1997.272.3.R862","article-title":"Febrile response to tissue inflammation involves both peripheral and brain IL-1 and TNF-\u03b1 in the rat","volume":"272","author":"Luheshi","year":"1997","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.cyto.2013.10.004_b0140","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ncprheum0338","article-title":"Interleukin 6: from bench to bedside","volume":"2","author":"Nishimoto","year":"2006","journal-title":"Nat Clin Prac Rheumatol"},{"key":"10.1016\/j.cyto.2013.10.004_b0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/infdis\/161.1.79","article-title":"Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever","volume":"161","author":"Cannon","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cyto.2013.10.004_b0150","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1056\/NEJM198806093182301","article-title":"Detection of circulating tumor necrosis factor after endotoxin administration","volume":"318","author":"Michie","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cyto.2013.10.004_b0155","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1152\/ajpregu.1993.265.3.R512","article-title":"Role of hypothalamic interleukin-6 and tumor necrosis factor-alpha in LPS fever in rat","volume":"265","author":"Klir","year":"1993","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.cyto.2013.10.004_b0160","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cyto.2012.08.027","article-title":"Obesity and IL-6 interact in modulating the response to endotoxemia in mice","volume":"61","author":"Pini","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2013.10.004_b0165","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2478\/v10039-009-0035-2","article-title":"Role of adipokines in complications related to obesity: a review","volume":"54","author":"Gnacinska","year":"2009","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.cyto.2013.10.004_b0170","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1210\/en.133.6.2574","article-title":"Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland and spleen","volume":"133","author":"Muramami","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2013.10.004_b0175","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0361-9230(97)00437-1","article-title":"Interleukin-1beta system (ligand, receptor type I, receptor accessory protein and receptor antagonist), TNF-alpha, TGF-beta1 and Neuropeptide Y mRNAs in specific brain regions during bacterial LPS-induced anorexia","volume":"45","author":"Ilyin","year":"1998","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.cyto.2013.10.004_b0180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0165-5728(99)00050-8","article-title":"Intracerebroventricular injection of interleukin-1 stimulates the release of high levels of interleukin-6 and interleukin-1 receptor antagonist into peripheral blood in the primate","volume":"97","author":"Xiao","year":"1999","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.cyto.2013.10.004_b0185","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00011-006-5194-z","article-title":"Estrogen attenuates vascular expression of inflammation associated genes and adhesion of monocytes to endothelial cells","volume":"55","author":"Gao","year":"2006","journal-title":"Inflamm Res"},{"key":"10.1016\/j.cyto.2013.10.004_b0190","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1365-2826.2007.01588.x","article-title":"Oestrogen and progesterone reduce lipopolysaccharide-induced expression of tumor necrosis factor-alpha and interleukin-18 in midbrain astrocytes","volume":"19","author":"Kipp","year":"2007","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.cyto.2013.10.004_b0195","doi-asserted-by":"crossref","first-page":"e1002149","DOI":"10.1371\/journal.ppat.1002149","article-title":"Elevated 17\u03b2-estradiol protects females from influenza a virus pathogenesis by suppressing inflammatory responses","volume":"7","author":"Robinson","year":"2011","journal-title":"PLoS Pathog"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613007175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613007175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T21:13:01Z","timestamp":1564607581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466613007175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S1043466613007175"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2013.10.004","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in central and peripheral inflammatory responses to lipopolysaccharide in ovariectomized female rats","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2013.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}