{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:06:26Z","timestamp":1792069586203,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":348,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"EditalSa\u00fade\/2010 (CNPq)"},{"DOI":"10.13039\/501100005283","name":"FUNCAP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.cyto.2013.10.009","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T14:15:36Z","timestamp":1385561736000},"page":"217-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Chronic inflammatory state in sickle cell anemia patients is associated with HBB*S haplotype"],"prefix":"10.1016","volume":"65","author":[{"given":"Izabel C.J.","family":"Bandeira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillianne B.S.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza C.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcielle B.D.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.N.","family":"Querioz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max Vitor Carioca","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e9lia P.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2013.10.009_b0005","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1056\/NEJM199709113371107","article-title":"Pathogenesis and treatment of sickle cell disease","volume":"337","author":"Bunn","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cyto.2013.10.009_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03630260802625709","article-title":"Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion","volume":"33","author":"Conran","year":"2009","journal-title":"Hemoglobin"},{"issue":"7","key":"10.1016\/j.cyto.2013.10.009_b0015","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1182\/blood.V99.7.2297","article-title":"Hydroxyurea corrects the dysregulated L-selectin expression and increased H2O2 production of polymorphonuclear neutrophils from patients with sickle cell anemia","volume":"99","author":"Benkerrou","year":"2002","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.cyto.2013.10.009_b0020","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tips.2006.02.007","article-title":"Pathophysiologically based drug treatment of sickle cell disease","volume":"27","author":"Steinberg","year":"2006","journal-title":"Trends Pharmacol Sci"},{"issue":"8","key":"10.1016\/j.cyto.2013.10.009_b0025","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s002770000173","article-title":"The role of cytokines in sickle cell disease","volume":"79","author":"Makis","year":"2000","journal-title":"Ann Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0030","first-page":"611","article-title":"Elevated immunoreactive tumor necrosis factor and interleukin-1 in sickle cell disease","volume":"84","author":"Francis","year":"1992","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.cyto.2013.10.009_b0035","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000204452","article-title":"Level of tumor necrosis factor alpha\/cachectin (TNF alpha) in sera from patients with sickle cell disease","volume":"90","author":"Malave","year":"1993","journal-title":"Acta Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0040","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.163.6.1363","article-title":"Tumor necrosis factor\/cachectin interacts with endothelial cell receptors to induce release of interleukin-1","volume":"163","author":"Nawroyh","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2013.10.009_b0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ajh.20196","article-title":"Cytokine profile of sickle cell disease in Oman","volume":"77","author":"Pathare","year":"2004","journal-title":"Am J Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0050","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00277-010-0954-9","article-title":"Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients","volume":"89","author":"Vilas-Boas","year":"2010","journal-title":"Ann Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0055","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cyto.2011.08.013","article-title":"Increased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome","volume":"56","author":"Cerqueira","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2013.10.009_b0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1076029611420992","article-title":"Biomarkers of inflammation, growth factor, and coagulation activation in patients with sickle cell disease","volume":"18","author":"Qari","year":"2012","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.cyto.2013.10.009_b0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2141.2011.08961.x","article-title":"Biomarkers in sickle cell disease","volume":"156","author":"Rees","year":"2011","journal-title":"Brit J Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0070","first-page":"47","article-title":"Inflama\u00e7\u00e3o, citocinas, prote\u00ednas de fase aguda e implica\u00e7\u00f5es terap\u00eauticas","volume":"8","author":"Bilate","year":"2007","journal-title":"Temas de reumatologia cl\u00ednica"},{"key":"10.1016\/j.cyto.2013.10.009_b0075","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1365-2141.1994.tb08318.x","article-title":"Circulating cytokines in sickle cell patients during steady state","volume":"87","author":"Croziat","year":"1994","journal-title":"Brit J Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0080","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-0609.1998.tb01060.x","article-title":"Cytokines and acute-phase proteins during the steady state of sickle cell disease","volume":"61","author":"Bourantas","year":"1998","journal-title":"Eur J Hematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJM199107043250103","article-title":"Pain in sickle cell disease-rates and risk factors","volume":"325","author":"Platt","year":"1991","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.cyto.2013.10.009_b0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ajh.2830140412","article-title":"Clinical diversity of sickle cell anemia: genetic and cellular modulation of disease severity","volume":"14","author":"Steinberg","year":"1983","journal-title":"Am J Hematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0095","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1600-0609.2010.01528.x","article-title":"Oxidative stress status, clinical outcome, and \u03b2-globin gene cluster haplotypes in pediatric patients with sickle cell disease","volume":"85","author":"Rusanova","year":"2010","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/(SICI)1096-8652(199610)53:2<72::AID-AJH3>3.0.CO;2-0","article-title":"Effect of alpha-thalassemia and beta-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil","volume":"53","author":"Figueiredo","year":"1996","journal-title":"Am J Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0105","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1590\/S0100-879X2003001000001","article-title":"\u03b2S-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil","volume":"36","author":"Gon\u00e7alves","year":"2003","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.cyto.2013.10.009_b0110","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1590\/S1516-84842010005000005","article-title":"Caracter\u00edsticas fenot\u00edpicas dos pacientes com anemia falciforme de acordo com os hapl\u00f3tipos do gene da \u03b2S - globina em Fortaleza","volume":"32","author":"Silva","year":"2010","journal-title":"Cear\u00e1 Rev Braz Hematol Hemoter"},{"key":"10.1016\/j.cyto.2013.10.009_b0115","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1081\/HEM-120040310","article-title":"The beta-globin gene cluster haplotypes in sickle cell anemia patients from Northeast Brazil: a clinical and molecular view","volume":"28","author":"Adorno","year":"2004","journal-title":"Hemoglobin"},{"key":"10.1016\/j.cyto.2013.10.009_b0120","first-page":"202","article-title":"Sickle cell anemia: \u03b2S-gene-cluster haplotypes as prognostic indicators of vital organ failure","volume":"28","author":"Powars","year":"1991","journal-title":"Sem Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0125","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1100\/tsw.2009.10","article-title":"Genetic etiologies for phenotypic diversity in sickle cell anemia","volume":"9","author":"Steinberg","year":"2009","journal-title":"Sci World J"},{"key":"10.1016\/j.cyto.2013.10.009_b0130","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1590\/S1415-47572008000400003","article-title":"Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil","volume":"31","author":"Adorno","year":"2008","journal-title":"Genet Mol Biol"},{"key":"10.1016\/j.cyto.2013.10.009_b0135","first-page":"360","article-title":"The variable expression of sickle cell disease is genetically determined","volume":"27","author":"Powars","year":"1990","journal-title":"Sem Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0140","first-page":"53","article-title":"The origin of the hemoglobin S gene: clinical, genetic and anthropological consequences","volume":"2","author":"Nagel","year":"1994","journal-title":"Einstein Quart J Biol Med"},{"key":"10.1016\/j.cyto.2013.10.009_b0145","first-page":"142","article-title":"Rearrangements of the beta-globin gene cluster in apparently typical beta S haplotypes","volume":"86","author":"Zago","year":"2001","journal-title":"Haematology"},{"key":"10.1016\/j.cyto.2013.10.009_b0150","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/ajh.22259","article-title":"More definitions in sickle cell disease:steady state v base line data","volume":"87","author":"Ballas","year":"2012","journal-title":"Am J Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0155","series-title":"Molecular cloning: a laboratory manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.cyto.2013.10.009_b0160","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.2999980","article-title":"Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia","volume":"4732","author":"Saiki","year":"1985","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.cyto.2013.10.009_b0165","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/ajh.2830320113","article-title":"Polymerase chain reaction amplification applied to the determination of beta-like globin gene cluster haplotypes","volume":"32","author":"Sutton","year":"1989","journal-title":"Am J Haematol"},{"key":"10.1016\/j.cyto.2013.10.009_b0170","first-page":"1824","article-title":"Hemoglobin disorders and endothelial cell interactions","volume":"42","author":"Conran","year":"2009","journal-title":"Clin Biol Chem"},{"key":"10.1016\/j.cyto.2013.10.009_b0175","doi-asserted-by":"crossref","first-page":"9797","DOI":"10.1073\/pnas.85.24.9797","article-title":"Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium derived relaxing factor","volume":"85","author":"De Nucci","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2013.10.009_b0180","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.4049\/jimmunol.177.10.7211","article-title":"A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells","volume":"177","author":"Kim","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2013.10.009_b0185","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bja\/aeh163","article-title":"Physiology of the endothelium","volume":"93","author":"Galley","year":"2004","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.cyto.2013.10.009_b0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1189\/jlb.0708445","article-title":"Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy","volume":"85","author":"Lanaro","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cyto.2013.10.009_b0195","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1590\/S0100-879X2001001000011","article-title":"Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease","volume":"34","author":"Gon\u00e7alves","year":"2001","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"10.1016\/j.cyto.2013.10.009_b0200","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1172\/JCI10726","article-title":"Sickle cell anaemia as an inflammatory disease","volume":"106","author":"Platt","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2013.10.009_b0205","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.thromres.2007.04.002","article-title":"Evaluation of reticulated platelets in patients with sickle cell diseases","volume":"121","author":"Noronha","year":"2007","journal-title":"Thromb Res"},{"issue":"2","key":"10.1016\/j.cyto.2013.10.009_b0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1076029611420992","article-title":"Biomarkers of inflammation, growth factor, and coagulation activation in patients with sickle cell disease","volume":"18","author":"Qari","year":"2012","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.cyto.2013.10.009_b0215","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mrgentox.2012.08.003","article-title":"DNA damage in leukocytes of sickle cell anemia patients is associated with hydroxyurea therapy and with HBB*S haplotype","volume":"749","author":"Rocha","year":"2012","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613007503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466613007503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T05:03:27Z","timestamp":1564895007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466613007503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S1043466613007503"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2013.10.009","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic inflammatory state in sickle cell anemia patients is associated with HBB*S haplotype","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2013.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}