{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:12:41Z","timestamp":1778922761177,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31200875"],"award-info":[{"award-number":["31200875"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270402"],"award-info":[{"award-number":["81270402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shaanxi Province of China","award":["2013K132-02-06)"],"award-info":[{"award-number":["2013K132-02-06)"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.cyto.2014.08.004","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T03:46:50Z","timestamp":1410839210000},"page":"60-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lacidipine attenuates TNF-\u03b1-induced cardiomyocyte apoptosis"],"prefix":"10.1016","volume":"71","author":[{"given":"Qiu-Lin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Zeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Qiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding-Hua","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ming","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2014.08.004_b0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response inmyocardialinjury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cyto.2014.08.004_b0010","first-page":"83","article-title":"Insulin resistance and inflammation markers in myocardial infarction","volume":"6","author":"Gruzdeva","year":"2013","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.cyto.2014.08.004_b0015","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1253\/circj.CJ-12-1516","article-title":"Thromboxane A2 mediates iron-overload cardiomyopathy in mice through calcineurin-nuclear factor of activated T cells signaling pathway","volume":"77","author":"Lin","year":"2013","journal-title":"Circ J"},{"key":"10.1016\/j.cyto.2014.08.004_b0020","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1152\/jappl.1998.85.6.2005","article-title":"Tumor necrosis factor-alpha in ischemia and reperfusion injury in rat lungs","volume":"85","author":"Khimenko","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cyto.2014.08.004_b0025","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cyto.2006.04.010","article-title":"TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes","volume":"34","author":"Zhu","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2014.08.004_b0030","doi-asserted-by":"crossref","first-page":"e51223","DOI":"10.1371\/journal.pone.0051223","article-title":"Resveratrol attenuates ischemia\/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism","volume":"7","author":"Shen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2014.08.004_b0035","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.ijcard.2013.01.163","article-title":"Cardiomyocyte apoptosis in the failing heart\u2013a critical review from definition and classification of cell death","volume":"167","author":"Takemura","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cyto.2014.08.004_b0040","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"BCL-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Dev"},{"issue":"Suppl 1","key":"10.1016\/j.cyto.2014.08.004_b0045","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/onc.2009.39","article-title":"BH3-only proteins in apoptosis and beyond: an overview","volume":"27","author":"Lomonosova","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2014.08.004_b0050","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1038\/sj.onc.1202591","article-title":"Bcl-2 family proteins","volume":"17","author":"Reed","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2014.08.004_b0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.cyto.2014.08.004_b0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","article-title":"Cell death in the pathogenesis of heart disease: mechanisms and significance","volume":"72","author":"Whelan","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.cyto.2014.08.004_b0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.vph.2010.08.003","article-title":"Lacidipine has antiatherosclerotic effects independent of its actions on lipid metabolism and blood pressure","volume":"53","author":"Anacak","year":"2010","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.cyto.2014.08.004_b0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0753-3322(00)88858-7","article-title":"Anti-atherosclerotic activity of the calcium antagonist lacidipine in cholesterol-fed hamsters","volume":"54","author":"Cristofori","year":"2000","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.cyto.2014.08.004_b0075","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/01.fjc.0000211728.23304.ad","article-title":"Comparative study of the effects of lacidipine and enalapril on the left ventricular cardiomyocyte remodeling in spontaneously hypertensive rats","volume":"47","author":"Cagalinec","year":"2006","journal-title":"J Cardiovasc Pharmacol"},{"issue":"Pt 2","key":"10.1016\/j.cyto.2014.08.004_b0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/0264-6021:3440281","article-title":"Calreticulin: one protein, one gene, many functions","volume":"344","author":"Michalak","year":"1999","journal-title":"Biochem J"},{"issue":"Pt 3","key":"10.1016\/j.cyto.2014.08.004_b0085","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/bj2850681","article-title":"Calreticulin","volume":"285","author":"Michalak","year":"1992","journal-title":"Biochem J"},{"key":"10.1016\/j.cyto.2014.08.004_b0090","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0962-8924(01)01926-2","article-title":"The ins and outs of calreticulin: from the ER lumen to the extracellular space","volume":"11","author":"Johnson","year":"2001","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.cyto.2014.08.004_b0095","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0092-8674(00)81884-X","article-title":"Calreticulin","volume":"88","author":"Krause","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2014.08.004_b0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.152.1.127","article-title":"Calreticulin Is a receptor for nuclear export","volume":"152","author":"Holaska","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cyto.2014.08.004_b0105","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.86.6.692","article-title":"Inhibition of extracellular signal-regulated kinase enhances ischemia\/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart","volume":"86","author":"Yue","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.cyto.2014.08.004_b0110","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/cvr\/cvn327","article-title":"TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model","volume":"81","author":"Palomer","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cyto.2014.08.004_b0115","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1242\/jcs.01640","article-title":"Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors","volume":"118","author":"Depuydt","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cyto.2014.08.004_b0120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/hy0202.103482","article-title":"Lacidipine inhibits adhesion molecule and oxidase expression independent of blood pressure reduction in angiotensin-induced vascular injury","volume":"39","author":"Park","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.cyto.2014.08.004_b0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2165\/00003495-200262020-00003","article-title":"Effects of antihypertensive drugs on endothelial dysfunction: clinical implications","volume":"62","author":"Taddei","year":"2002","journal-title":"Drugs"},{"key":"10.1016\/j.cyto.2014.08.004_b0130","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ejphar.2013.07.040","article-title":"Lacidipine inhibits endoplasmic reticulum stress and myocardial remodeling induced by pressure overload in rat heart","volume":"718","author":"Huai","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.cyto.2014.08.004_b0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-2999(99)00880-8","article-title":"Nifedipine does not induce but rather prevents apoptosis in cardiomyocytes","volume":"388","author":"Rabkin","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.cyto.2014.08.004_b0140","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/01.RES.0000087542.26971.D4","article-title":"Role of the mitochondrial permeability transition in myocardial disease","volume":"93","author":"Weiss","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.cyto.2014.08.004_b0145","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1007\/s00018-006-6007-9","article-title":"Tribbles: novel regulators of cell function; evolutionary aspects","volume":"63","author":"Hegedus","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.cyto.2014.08.004_b0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF03032574","article-title":"Shared pathways: death receptors and cytotoxic drugs in cancer therapy","volume":"7","author":"Petak","year":"2001","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.cyto.2014.08.004_b0155","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/emboj\/17.6.1675","article-title":"Two CD95 (APO-1\/Fas) signaling pathways","volume":"17","author":"Scaffidi","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.cyto.2014.08.004_b0160","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1023\/A:1016167228059","article-title":"Initiator caspases in apoptosis signaling pathways","volume":"7","author":"Chen","year":"2002","journal-title":"Apoptosis"},{"key":"10.1016\/j.cyto.2014.08.004_b0165","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.cellbio.15.1.269","article-title":"Biochemical pathways of caspase activation during apoptosis","volume":"15","author":"Budihardjo","year":"1999","journal-title":"Annu Rev Cell Dev Biol"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466614005225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466614005225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T21:17:37Z","timestamp":1565817457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466614005225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1043466614005225"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2014.08.004","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lacidipine attenuates TNF-\u03b1-induced cardiomyocyte apoptosis","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2014.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}