{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:19:27Z","timestamp":1773015567013,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"RMRIMS"},{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"publisher","award":["3\/1\/3\/JRF-2011\/HRD-68"],"award-info":[{"award-number":["3\/1\/3\/JRF-2011\/HRD-68"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.cyto.2015.01.011","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T13:16:03Z","timestamp":1424092563000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Leishmania donovani skews the CD56+ Natural Killer T cell response during human visceral leishmaniasis"],"prefix":"10.1016","volume":"73","author":[{"given":"Sarita","family":"Kumari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fauzia","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pushkar","family":"Shivam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiva","family":"Bimal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.N.R.","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubhankar K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2015.01.011_b0005","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0165-2478(98)00132-1","article-title":"T-cell response in human leishmaniasis","volume":"65","author":"Kharazmi","year":"1999","journal-title":"Immunol Lett"},{"key":"10.1016\/j.cyto.2015.01.011_b0010","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1172\/JCI112209","article-title":"Absence of gamma interferon and interleukin-2 production during active visceral leishmaniasis","volume":"76","author":"Carvalho","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2015.01.011_b0015","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1006\/cyto.2000.0694","article-title":"IL-10 and IL-12 are main regulatory cytokines in visceral leishmaniasis","volume":"12","author":"Bacellar","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2015.01.011_b0020","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.trim.2014.03.002","article-title":"Transforming growth factor beta (TGF-\u03b2) plays a crucial role in prolonging allograft survival in an allodepletion (\u201cpruning\u201d) skin transplant model","volume":"30","author":"Watson","year":"2014","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.immuni.2006.04.015","article-title":"Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation","volume":"25","author":"Mempel","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2015.01.011_b0030","doi-asserted-by":"crossref","first-page":"e31551","DOI":"10.1371\/journal.pone.0031551","article-title":"Regulatory T cells suppress T cell activation at the pathogenic site of human visceral leishmaniasis","volume":"7","author":"Rai","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cyto.2015.01.011_b0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT cell family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0040","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.4049\/jimmunol.181.5.3268","article-title":"Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors","volume":"181","author":"Patterson","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1568014053005282","article-title":"NKT cells: a regulator in both innate and acquired immunity, laboratory or immune regulation","volume":"4","author":"Seino","year":"2005","journal-title":"Curr Med Chem Anti Inflam Anti Allergy Agents"},{"key":"10.1016\/j.cyto.2015.01.011_b0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000090193","article-title":"Natural killer T cells: roles in tumor immunosurveillance and tolerance","volume":"33","author":"Jerud","year":"2006","journal-title":"Transfus Med Hemoth"},{"key":"10.1016\/j.cyto.2015.01.011_b0055","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.179.4.1285","article-title":"CD4 positive, NK1.1 positive T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3","volume":"179","author":"Yashimoto","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2015.01.011_b0060","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.ijpara.2011.05.010","article-title":"Early activated Th-1 type and dominantly diverse natural killer T (CD3+CD161+V\u03b124\u2212) cells in bone marrow among visceral leishmaniasis patients","volume":"41","author":"Rai","year":"2011","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.cyto.2015.01.011_b0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1084\/jem.189.1.103","article-title":"Distnct subsets of CD1d restricted T cells recognize self-antigens loaded in different cellular compartments","volume":"189","author":"Chiu","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.cyto.2015.01.011_b0070","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.4049\/jimmunol.162.11.6410","article-title":"Tissue-specific segregation of CD1d-dependent and CD1d-independent NKT cells","volume":"162","author":"Eberl","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0075","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0198-8859(98)00098-6","article-title":"Natural T cells in human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include V\u03b124-J\u03b1Q and \u03b3\u03b4 T cell receptor bearing cells","volume":"60","author":"Norris","year":"1999","journal-title":"Hum Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri1309","article-title":"NKT cells: facts, functions and fallacies","volume":"4","author":"Godfrey","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/IR:35:1:13","article-title":"NKR-P1 biology: from prototype to missing self","volume":"35","author":"Mesci","year":"2006","journal-title":"Immunol Res"},{"key":"10.1016\/j.cyto.2015.01.011_b0090","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.4049\/jimmunol.178.9.5524","article-title":"CD56 marks an effector T cell subset in the human intestine","volume":"178","author":"Cohavy","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0095","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1016\/S0021-9258(17)39926-X","article-title":"Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina","volume":"252","author":"Thiery","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cyto.2015.01.011_b0100","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.164.3.1148","article-title":"Cutting edge: cytolytic effector function in human circulating CD8+T cells closely correlates with CD56 surface expression","volume":"164","author":"Pittet","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0105","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1182\/blood-2005-02-0479","article-title":"The antileukemia effect of HLA-matched NK and NK-T cells in chronic Myelogenous leukemia involves NKG2D-target-cell interactions","volume":"106","author":"Sconocchia","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2015.01.011_b0110","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","article-title":"CD56bright natural killer (NK) cells: an important NK cell subset","volume":"126","author":"Poli","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2015.01.011_b0115","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1073\/pnas.0601335103","article-title":"Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2R targeted therapy (daclizumab) in multiple sclerosis","volume":"103","author":"Bielekova","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2015.01.011_b0120","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/intimm\/dxr122","article-title":"Increased numbers but functional defects of CD56+CD3+ cells in lung cancer","volume":"24","author":"Omar","year":"2012","journal-title":"Int Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0125","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1083\/jcb.98.6.2077","article-title":"Biosynthesis of the D2 cell adhesion molecule: pulse-chase studies in cultured fetal rat neuronal cells","volume":"98","author":"Lyles","year":"1984","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cyto.2015.01.011_b0130","first-page":"3680","article-title":"Lymphokine-activated killer activity induced by in vivo interleukin 2 therapy: predominant role for lymphocytes with increased expression of CD2 and leu19 antigens but negative expression of CD16 antigens","volume":"49","author":"Weil-Hillman","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.cyto.2015.01.011_b0135","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.4049\/jimmunol.138.7.2019","article-title":"Expression of Leu-19(NKH-1) antigen on IL2-dependent cytotoxic and non-cytotoxic T cell lines","volume":"138","author":"Lanier","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0140","first-page":"97","article-title":"Activity of neural cell adhesion molecule (N-CAM) components: a review","volume":"79","author":"Daniloff","year":"1994","journal-title":"Cytobios"},{"key":"10.1016\/j.cyto.2015.01.011_b0145","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1146\/annurev.immunol.23.021704.115742","article-title":"Towards an understanding of NKT cell biology: progress and paradoxes","volume":"23","author":"Kronenberg","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0150","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1073\/pnas.0409449102","article-title":"Mesenteric B cells centrally inhibit CD4+T cell colitis through interaction with regulatory T cell subsets","volume":"102","author":"Wei","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2015.01.011_b0155","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0167-5699(95)80121-9","article-title":"Perforin: structure and function","volume":"16","author":"Liu","year":"1995","journal-title":"Immunol Today"},{"key":"10.1016\/j.cyto.2015.01.011_b0160","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0167-5699(95)80122-7","article-title":"Granzymes: exogenous proteinases that induce target cell apoptosis","volume":"16","author":"Smyth","year":"1995","journal-title":"Immunol Today"},{"key":"10.1016\/j.cyto.2015.01.011_b0165","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3768::AID-IMMU3768>3.0.CO;2-G","article-title":"NKT cells are phenotypically and functionally diverse","volume":"29","author":"Hammond","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0170","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/1521-4141(200203)32:3<848::AID-IMMU848>3.0.CO;2-I","article-title":"CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance","volume":"32","author":"Sonoda","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0175","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.4049\/jimmunol.1000359","article-title":"Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-\u03b2","volume":"185","author":"Monteiro","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0180","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.exppara.2010.10.014","article-title":"Leishmania donovani: assessment of leishmanicidal effects of herbal extracts obtained from plants in the visceral leishmaniasis endemic area of Bihar, India","volume":"127","author":"Singh","year":"2011","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.cyto.2015.01.011_b0185","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.exppara.2007.08.009","article-title":"Leishmania donovani: role of CD2 on CD4+ T-cell function in visceral leishmaniasis","volume":"118","author":"Bimal","year":"2008","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.cyto.2015.01.011_b0190","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2613.2001.00199.x","article-title":"Tissue granuloma structure\u2013function in experimental visceral leishmaniasis","volume":"82","author":"Murray","year":"2001","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.cyto.2015.01.011_b0195","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/IAI.73.7.3903-3911.2005","article-title":"Antagonising deactivating cytokines to enhance host defence and chemotherapy in experimental visceral leishmaniasis","volume":"73","author":"Murray","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.cyto.2015.01.011_b0200","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.exppara.2005.05.009","article-title":"Leishmania donovani: effect of therapy on expression of CD2 antigen and secretion of macrophage migration inhibition factor by T-cells in patients with visceral leishmaniasis","volume":"111","author":"Bimal","year":"2005","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.cyto.2015.01.011_b0205","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.humimm.2013.08.007","article-title":"Leishmania donovani: influence of anti-leishmanial therapy on expression of lymphocyte function-associated antigen-3 and its relevance to pathogenesis in visceral leishmaniasis","volume":"74","author":"Shivam","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0210","doi-asserted-by":"crossref","first-page":"924","DOI":"10.4049\/jimmunol.1102845","article-title":"Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response","volume":"189","author":"Shrivastav","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0215","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1348-0421.1998.tb02354.x","article-title":"Leishmania donovani infection of a susceptible host results in apoptosis of Th1-like cells: rescue of anti-leishmanial CMI by providing Th1-specific bystander costimulation","volume":"42","author":"Das","year":"1998","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0220","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/icb.2010.108","article-title":"TGF-\u03b2-regulated tyrosine phosphatages induce lymphocyte apoptosis in Leishmania donovani-infected hamsters","volume":"89","author":"Benerjee","year":"2011","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.cyto.2015.01.011_b0225","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1590\/S0001-37652004000300006","article-title":"The T-cell anergy induced by Leshmania amazonensis antigens is related with defective antigen presentation and apoptosis","volume":"76","author":"Pinheiro","year":"2004","journal-title":"Ann Braz Acad Sci"},{"key":"10.1016\/j.cyto.2015.01.011_b0230","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1128\/AAC.47.8.2513-2517.2003","article-title":"Immunoenhancement combined with amphotericn B as treatment for experimental visceral leishmaniasis","volume":"47","author":"Murray","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cyto.2015.01.011_b0235","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1471-4906(03)00162-5","article-title":"Liver NKT cells: an account of heterogeneity","volume":"24","author":"Emoto","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0240","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1073\/pnas.1019082108","article-title":"Killer cell Ig-like receptor (KIR) 3DL1 down-regulation enhances inhibition of type 1 diabetes by autoantigen-specific regulatory T cells","volume":"108","author":"Qin","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cyto.2015.01.011_b0245","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1365-2249.1999.00833.x","article-title":"Expression of killer inhibitory receptors on cytotoxic cells from HIV-1-infected individuals","volume":"115","author":"Galiani","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cyto.2015.01.011_b0250","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/cmi.2009.48","article-title":"EBV- induced human CD8+ NKT cells synergise CD4+ NKT cells suppressing EBV-associated tumours upon induction of Th1-bias","volume":"6","author":"Xiao","year":"2009","journal-title":"Cell Mol Immunol"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466615000150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466615000150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T21:21:15Z","timestamp":1691270475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466615000150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1043466615000150"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2015.01.011","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leishmania donovani skews the CD56+ Natural Killer T cell response during human visceral leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2015.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}