{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:02:09Z","timestamp":1777309329109,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371927"],"award-info":[{"award-number":["81371927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changzhou Foundation for Applied Basic Research","award":["CJ20130027"],"award-info":[{"award-number":["CJ20130027"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.cyto.2015.09.007","type":"journal-article","created":{"date-parts":[[2015,9,13]],"date-time":"2015-09-13T05:55:43Z","timestamp":1442123743000},"page":"363-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between polymorphisms of interleukin 12 and rheumatoid arthritis associated biomarkers in a Chinese population"],"prefix":"10.1016","volume":"76","author":[{"given":"Li","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2015.09.007_b0005","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"Mcinnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2015.09.007_b0010","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/03009742.2012.677063","article-title":"Association of the methionine sulfoxide reductase A rs10903323 gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis","volume":"41","author":"Garc\u00eda-Berm\u00fadez","year":"2012","journal-title":"Scand. J. Rheumatol."},{"issue":"3","key":"10.1016\/j.cyto.2015.09.007_b0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jbspin.2014.12.009","article-title":"Is the microRNA-146a (rs2910164) polymorphism associated with rheumatoid arthritis? Association of microRNA-146a (rs2910164) polymorphism and rheumatoid arthritis could depend on gender","volume":"82","author":"Zhou","year":"2015","journal-title":"Joint Bone Spine"},{"issue":"1","key":"10.1016\/j.cyto.2015.09.007_b0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13075-015-0574-9","article-title":"CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women","volume":"17","author":"Stark","year":"2015","journal-title":"Arthritis Res. Ther."},{"issue":"7","key":"10.1016\/j.cyto.2015.09.007_b0025","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.4049\/jimmunol.1402956","article-title":"Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis","volume":"194","author":"Giles","year":"2015","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2015.09.007_b0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.gene.2015.04.028","article-title":"Association between interleukin 17A polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population","volume":"566","author":"Shen","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.cyto.2015.09.007_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2015.03.020","article-title":"Evidence of association of interleukin-23 receptor gene polymorphisms with Egyptian rheumatoid arthritis patients","author":"Hamdy","year":"2015","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.cyto.2015.09.007_b0040","doi-asserted-by":"crossref","DOI":"10.1007\/s10067-015-2881-6","article-title":"Genetics of serum concentration of IL-6 and TNF\u03b1 in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis","author":"Solus","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.cyto.2015.09.007_b0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/cimm.1998.1363","article-title":"Interleukin-12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritis","volume":"188","author":"Sakkas","year":"1998","journal-title":"Cell Immunol."},{"key":"10.1016\/j.cyto.2015.09.007_b0050","first-page":"113","article-title":"The role of interleukin-12 in immune-mediated rheumatic diseases","volume":"54","author":"Spadaro","year":"2002","journal-title":"Reumatismo"},{"key":"10.1016\/j.cyto.2015.09.007_b0055","first-page":"S14","article-title":"Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthritis","volume":"27","author":"Alvarez-Rodriguez","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.cyto.2015.09.007_b0060","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00002371-200303000-00002","article-title":"Generating potent Th1\/Tc1 T cell adoptive immunotherapy doses using human IL-12: harnessing the immunomodulatory potential of IL-12 without the in vivo-associated toxicity","volume":"26","author":"Emtage","year":"2003","journal-title":"J. Immunother."},{"key":"10.1016\/j.cyto.2015.09.007_b0065","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/art.23492","article-title":"The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis","volume":"58","author":"Chang","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cyto.2015.09.007_b0070","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1002\/eji.1830261219","article-title":"Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice","volume":"26","author":"McIntyre","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2015.09.007_b0075","first-page":"536","article-title":"The role of IFN-gamma, IL-10, IL-12 and TRAIL in sera and synovium fluids from patients with rheumatoid arthritis","volume":"23","author":"Xie","year":"2007","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"10.1016\/j.cyto.2015.09.007_b0080","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1365-2249.2000.01095.x","article-title":"The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis (RA)","volume":"119","author":"Kim","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cyto.2015.09.007_b0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrrheum.2012.170","article-title":"Possible roles of IL-12-family cytokines in rheumatoid arthritis","volume":"9","author":"Pope","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.cyto.2015.09.007_b0090","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/dote.12189","article-title":"Interleukin 12B rs3212227 T>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population","volume":"28","author":"Yin","year":"2014","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.cyto.2015.09.007_b0095","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1158\/1078-0432.CCR-08-1829","article-title":"Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women","volume":"15","author":"Chen","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cyto.2015.09.007_b0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.gene.2012.08.019","article-title":"Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: evidence from a meta-analysis of 18 case-control studies","volume":"510","author":"Zhou","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.cyto.2015.09.007_b0105","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3892\/mco.2013.134","article-title":"Increased IL-17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers","volume":"1","author":"Yazawa","year":"2013","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.cyto.2015.09.007_b0110","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.humimm.2005.02.004","article-title":"Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis","volume":"66","author":"Orozco","year":"2005","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.cyto.2015.09.007_b0115","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/sj.gene.6363661","article-title":"Genetic polymorphism of IL-12 p40 gene in immune-mediated disease","volume":"1","author":"Hall","year":"2000","journal-title":"Genes Immun."},{"key":"10.1016\/j.cyto.2015.09.007_b0120","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/ard.2008.099275","article-title":"IL23R and IL12B genes: susceptibility analysis in rheumatoid arthritis","volume":"68","author":"Varade","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cyto.2015.09.007_b0125","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cyto.2015.09.007_b0130","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.clinbiochem.2013.05.050","article-title":"Interleukin 1B rs16944 G>A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population","volume":"46","author":"Zheng","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cyto.2015.09.007_b0135","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2249.1996.tb08288.x","article-title":"Expression of interferon-gamma (IFN-gamma), IL-10, IL-12 and transforming growth factor-beta (TGF-beta) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA)","volume":"103","author":"Bucht","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cyto.2015.09.007_b0140","first-page":"147","article-title":"Serum levels of TNF-alpha, TNF-alphaRI, TNF-alphaRII and IL-12 in treated rheumatoid arthritis patients","volume":"6","author":"Ebrahimi","year":"2009","journal-title":"Iran J. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2015.09.007_b0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/cei.12563","article-title":"Association of polymorphisms in interleukin (IL)-12A and -B genes with rheumatoid arthritis in a Chinese population","volume":"180","author":"Wang","year":"2015","journal-title":"Clin. Exp. Immunol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466615300600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466615300600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T12:29:12Z","timestamp":1537360152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466615300600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1043466615300600"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2015.09.007","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between polymorphisms of interleukin 12 and rheumatoid arthritis associated biomarkers in a Chinese population","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2015.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}