{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:27:59Z","timestamp":1759847279509,"version":"3.41.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["NN-401130 31\/2871"],"award-info":[{"award-number":["NN-401130 31\/2871"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.cyto.2015.10.012","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:33:14Z","timestamp":1456965194000},"page":"26-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1\u03b2 in the brain and plasma of rats"],"prefix":"10.1016","volume":"80","author":[{"given":"Ewa","family":"Obuchowicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Prymus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Bielecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Drzyzga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Paul-Samojedny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Kot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u0142adys\u0142awa A.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2015.10.012_b0005","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s11481-013-9462-8","article-title":"Evidence for a dysregulated immune system in the etiology of psychiatric disorders","volume":"8","author":"Gibney","year":"2013","journal-title":"J. Neuroimmune. Pharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cyto.2015.10.012_b0015","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1517\/14728222.2012.718331","article-title":"Targeting IL-1 in depression","volume":"16","author":"Maes","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.cyto.2015.10.012_b0020","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/sj.mp.4002055","article-title":"Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression","volume":"13","author":"Goshen","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cyto.2015.10.012_b0025","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1073\/pnas.0708092105","article-title":"IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress","volume":"105","author":"Koo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cyto.2015.10.012_b0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbi.2012.12.008","article-title":"The inflammasome: pathways linking psychological stress, depression, and systemic illnesses","volume":"31","author":"Iwata","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cyto.2015.10.012_b0035","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-0447.1991.tb03163.x","article-title":"Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1 beta and soluble interleukin-2 receptor production","volume":"84","author":"Maes","year":"1991","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.cyto.2015.10.012_b0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.cyto.2015.10.012_b0045","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cyto.2015.10.012_b0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/hup.1103","article-title":"A psychoneuroimmunological review on cytokines involved in antidepressant treatment response","volume":"25","author":"Janssen","year":"2010","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.cyto.2015.10.012_b0055","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/npp.2011.132","article-title":"The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis","volume":"36","author":"Hannestad","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cyto.2015.10.012_b0060","first-page":"7","article-title":"Depression\u2019s multiple comorbidities explained by (neuro) inflammatory and oxidative & nitrosative stress pathways","volume":"32","author":"Maes","year":"2011","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.cyto.2015.10.012_b0065","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/187152409787601897","article-title":"Anti-inflammatory effects of antidepressants: possibilities for preventives against Alzheimer\u2019s disease","volume":"9","author":"Hashioka","year":"2009","journal-title":"Centr. Nerv. Syst. Med. Chem."},{"key":"10.1016\/j.cyto.2015.10.012_b0070","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cyto.2015.10.012_b0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2007.12.037","article-title":"Repeated administration of mirtazapine inhibits development of hyperalgesia\/allodynia and activation of NF-kappa B in a rat model of neuropathic pain","volume":"433","author":"Zhu","year":"2008","journal-title":"Neurosci. Lett."},{"year":"2011","series-title":"Essential Psychopharmacology: The Prescriber\u2019s Guide. Antidepressants","author":"Stahl","key":"10.1016\/j.cyto.2015.10.012_b0080"},{"key":"10.1016\/j.cyto.2015.10.012_b0085","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.bjp.0707253","article-title":"Tricyclic antidepressant pharmacology and therapeutic drug interactions updated","volume":"151","author":"Gillman","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1556\/ABiol.53.2002.1-2.21","article-title":"Nonsynaptic noradrenaline release in neuro-immune responses","volume":"53","author":"Vizi","year":"2002","journal-title":"Acta Biol. Hung."},{"key":"10.1016\/j.cyto.2015.10.012_b0095","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1023\/A:1025084415833","article-title":"Intrinsic regulation of brain inflammatory responses","volume":"23","author":"Galea","year":"2003","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.cyto.2015.10.012_b0100","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0024-3205(99)00430-0","article-title":"Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat","volume":"65","author":"Shen","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.cyto.2015.10.012_b0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000026417","article-title":"Olfactory bulbectomy provokes a suppression of interleukin-1 beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment","volume":"7","author":"Connor","year":"2000","journal-title":"NeuroImmunoModulation"},{"key":"10.1016\/j.cyto.2015.10.012_b0110","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0306-4530(00)00026-3","article-title":"The effect of repeated amitryptyline and desipramine administration on cytokine release in C57BL\/6 mice","volume":"25","author":"Kubera","year":"2000","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.cyto.2015.10.012_b0115","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1017\/S146114570800967X","article-title":"Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration","volume":"12","author":"O\u2019Sullivan","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0120","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0306-4530(03)00142-2","article-title":"Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats","volume":"29","author":"Castanon","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.cyto.2015.10.012_b0125","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1177\/0269881107077165","article-title":"Role of paroxetine in interferon-alpha-induced immune and behavioural changes in male Wistar rats","volume":"21","author":"Myint","year":"2007","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0130","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.euroneuro.2013.03.008","article-title":"Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine","volume":"23","author":"Molteni","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0135","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cyto.2015.10.012_b0140","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0028-3908(91)90010-9","article-title":"Chronic administration of desipramine and zimelidine changes the behavioural response in the formalin test","volume":"30","author":"Lund","year":"1991","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cyto.2015.10.012_b0145","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0028-3908(91)90080-U","article-title":"Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies","volume":"30","author":"Nelson","year":"1991","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cyto.2015.10.012_b0150","first-page":"179","article-title":"Synergistic effect of imipramine and amantadine in the forced swimming test in rats. Behavioral and pharmacokinetic studies","volume":"56","author":"Rog\u00f3\u017c","year":"2004","journal-title":"Pol. J. Pharmacol."},{"year":"2007","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.cyto.2015.10.012_b0155"},{"key":"10.1016\/j.cyto.2015.10.012_b0160","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.brainresbull.2004.11.003","article-title":"Stress-induced increases in hypothalamic IL-1: a systematic analysis of multiple stressor paradigms","volume":"64","author":"Deak","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.cyto.2015.10.012_b0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cyto.2015.10.012_b0170","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00210-010-0535-4","article-title":"Moclobemide exerts anti-inflammatory effect in lipopolysaccharide-activated primary mixed glial cell culture","volume":"382","author":"Bielecka","year":"2010","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.cyto.2015.10.012_b0175","article-title":"A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples","volume":"15","author":"Chomczynski","year":"1993","journal-title":"Biotechniques"},{"key":"10.1016\/j.cyto.2015.10.012_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00682-7","article-title":"Subtypes of functional alpha1- and alpha 2-adrenoceptors","volume":"361","author":"Docherty","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0185","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.neuropharm.2006.05.012","article-title":"Discriminative stimulus properties of the selective and highly potent alpha2-adrenoceptor agonist, S18616, in rats: mediation by the alpha2A subtype, and blockade by the atypical antidepressants, mirtazapine and mianserin","volume":"51","author":"Dekeyne","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cyto.2015.10.012_b0190","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.neuroscience.2005.06.090","article-title":"Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines","volume":"135","author":"Johnson","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.cyto.2015.10.012_b0195","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neurobiolaging.2009.01.012","article-title":"Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus","volume":"32","author":"Espinosa-Oliva","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cyto.2015.10.012_b0200","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneuroim.2007.02.008","article-title":"Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations","volume":"186","author":"Anisman","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cyto.2015.10.012_b0205","doi-asserted-by":"crossref","first-page":"e111665","DOI":"10.1371\/journal.pone.0111665","article-title":"Sertraline reduces IL-1\u03b2 and TNF-\u03b1 mRNA expression and overcomes their rise induced by seizures in the rat hippocampus","volume":"9","author":"Sitges","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cyto.2015.10.012_b0210","series-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","first-page":"681","article-title":"Blood\u2013brain\u2013cerebrospinal fluid barriers","author":"Betz","year":"1994"},{"key":"10.1016\/j.cyto.2015.10.012_b0215","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tox.2004.04.015","article-title":"How does peripheral lipopolysaccharide induce gene expression in the brain of rats?","volume":"201","author":"Singh","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.cyto.2015.10.012_b0220","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneuroim.2006.01.019","article-title":"Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen","volume":"174","author":"Johnson","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cyto.2015.10.012_b0225","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cyto.2015.10.012_b0230","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/brain\/awn345","article-title":"Live imaging of toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation","volume":"132","author":"Lalancette-H\u00e9bert","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.cyto.2015.10.012_b0235","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neubiorev.2005.03.010","article-title":"The olfactory bulbectomised rat as a model of depression","volume":"29","author":"Song","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cyto.2015.10.012_b0240","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-3956(01)00029-2","article-title":"Reduced olfactory performance in patients with major depression","volume":"35","author":"Pause","year":"2001","journal-title":"J. Psychiat. Res."},{"key":"10.1016\/j.cyto.2015.10.012_b0245","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.neuroscience.2010.05.012","article-title":"Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression","volume":"169","author":"Negoias","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.cyto.2015.10.012_b0250","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tins.2008.05.006","article-title":"Origin and function of olfactory bulb interneuron diversity","volume":"31","author":"Lledo","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cyto.2015.10.012_b0255","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.npp.1300924","article-title":"Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner","volume":"31","author":"Keilhoff","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cyto.2015.10.012_b0260","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0306-9877(03)00207-X","article-title":"Cytokine\u2013serotonin interaction through IDO: a neurodegeneration hypothesis of depression","volume":"61","author":"Myint","year":"2003","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.cyto.2015.10.012_b0265","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cnr.2006.04.002","article-title":"Effects of cytokines and infections on brain neurochemistry","volume":"6","author":"Dunn","year":"2006","journal-title":"Clin. Neurosci. Res."},{"key":"10.1016\/j.cyto.2015.10.012_b0270","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3171\/jns.2000.92.1.0108","article-title":"Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis and vasogenic edema","volume":"92","author":"Holmin","year":"2000","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.cyto.2015.10.012_b0275","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1111\/j.1460-9568.2005.04067.x","article-title":"Interleukin-1beta exacerbates and interleukin-1receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures","volume":"21","author":"Hailer","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cyto.2015.10.012_b0280","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/npp.2011.277","article-title":"Interleukin-1beta: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis","volume":"37","author":"Zunszain","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.cyto.2015.10.012_b0285","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1749-6632.2009.04984.x","article-title":"Cytokines and glucocorticoid receptor signaling. Relevance to major depression","volume":"1179","author":"Pace","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cyto.2015.10.012_b0290","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejphar.2013.08.046","article-title":"Chronic antidepressant treatments resulted in altered expression of genes involved in inflammation in the rat hypothalamus","volume":"721","author":"Alboni","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0295","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1254\/jphs.FP0061255","article-title":"Desipramine activated Bcl-2 expression an inhibited lipopolysaccharide-induced apoptosis in hippocampus-derived adult neural stem cells","volume":"104","author":"Huang","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.cyto.2015.10.012_b0300","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neuroscience.2005.02.023","article-title":"An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission","volume":"133","author":"Reynolds","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.cyto.2015.10.012_b0305","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1471-4159.2000.740457.x","article-title":"\u201cInflammatory\u201d cytokines: neuromodulators in normal brain?","volume":"74","author":"Vitkovic","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cyto.2015.10.012_b0310","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0022-3565(25)20043-X","article-title":"Quantitative autoradiography of central beta adrenoceptor subtypes: comparison of the effects of chronic treatment with desipramine or centrally administered l-isoproterenol","volume":"247","author":"Ordway","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cyto.2015.10.012_b0315","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1124\/jpet.106.118935","article-title":"Differential effects of the tricyclic antidepressant desipramine on the density of adrenergic receptors in juvenile and adult rats","volume":"321","author":"Deupree","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cyto.2015.10.012_b0320","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0197-0186(03)00097-4","article-title":"Cortical alpha-adrenoceptor downregulation by tricyclic antidepressants in the rat brain","volume":"43","author":"Subhash","year":"2003","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cyto.2015.10.012_b0325","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1073\/pnas.77.3.1696","article-title":"Noradrenergic \u03b11 and \u03b12 receptors: light microscopic autoradiographic localization","volume":"77","author":"Young","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cyto.2015.10.012_b0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.903520102","article-title":"Distribution and development of beta-adrenergic receptors in the rat olfactory bulb","volume":"352","author":"Woo","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cyto.2015.10.012_b0335","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbi.2008.03.007","article-title":"Role of central beta-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge","volume":"22","author":"Johnson","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cyto.2015.10.012_b0340","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1096-9861(19960715)371:1<85::AID-CNE5>3.0.CO;2-H","article-title":"Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration","volume":"371","author":"Elmquist","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cyto.2015.10.012_b0345","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/cne.902850305","article-title":"Chemoanatomical organization of the noradrenergic input from locus coeruleus to the olfactory bulb of the adult rat","volume":"285","author":"McLean","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cyto.2015.10.012_b0350","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.psyneuen.2003.10.009","article-title":"Do antidepressants regulate how cortisol affects the brain?","volume":"29","author":"Pariante","year":"2004","journal-title":"Psychoneuroendocrinology"},{"issue":"168","key":"10.1016\/j.cyto.2015.10.012_b0355","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.neuroscience.2010.03.067","article-title":"Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity","volume":"2010","author":"Hutchinson","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.cyto.2015.10.012_b0360","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-2999(03)01721-7","article-title":"Intact noradrenaline transporter is needed for the sympathetic fine-tuning of cytokine balance","volume":"469","author":"Selmeczy","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cyto.2015.10.012_b0365","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000067178","article-title":"Lateralization and catecholaminergic neuroimmunomodulation: prazosin, an alpha1\/alpha2-adrenergic receptor antagonist, suppresses interleukin-1 and increases interleukin-10 production induced by lipopolysaccharides","volume":"10","author":"Dong","year":"2002","journal-title":"NeuroImmunoModulation"},{"key":"10.1016\/j.cyto.2015.10.012_b0370","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0031-6997(24)01470-4","article-title":"The sympathetic nerve \u2013 an integrative interface between two supersystems: the brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol. Rev."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466615300831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466615300831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T16:10:46Z","timestamp":1748794246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466615300831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":74,"alternative-id":["S1043466615300831"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2015.10.012","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1\u03b2 in the brain and plasma of rats","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2015.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}