{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:19:27Z","timestamp":1767986367629,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["POIG.01.01.02-10-107\/09"],"award-info":[{"award-number":["POIG.01.01.02-10-107\/09"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.cyto.2016.01.017","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T15:15:26Z","timestamp":1454944526000},"page":"136-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Secretion of cytokines and heat shock protein (HspA1A) by ovarian cancer cells depending on the tumor type and stage of disease"],"prefix":"10.1016","volume":"89","author":[{"given":"Marek","family":"Nowak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Glowacka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Kielbik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Kulig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia","family":"Sulowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Klink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2016.01.017_b0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.critrevonc.2006.03.004","article-title":"Ovarian cancer","volume":"60","author":"Colombo","year":"2006","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.cyto.2016.01.017_b0010","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12672-010-0054-2","article-title":"Microenvironment and pathogenesis of epithelial ovarian cancer","volume":"1","author":"Saad","year":"2010","journal-title":"Horm. Cancer"},{"key":"10.1016\/j.cyto.2016.01.017_b0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0020-7292(00)90001-8","article-title":"FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers","volume":"70","author":"Benedet","year":"2000","journal-title":"Int. J. Gynecol. Obstet."},{"key":"10.1016\/j.cyto.2016.01.017_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","article-title":"Staging classification for cancer of the ovary, fallopian tube, and peritoneum","volume":"124","author":"Prat","year":"2014","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.cyto.2016.01.017_b0025","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00404-014-3364-8","article-title":"The new FIGO staging system for ovarian, fallopian tube, and primary peritoneal cancer","volume":"290","author":"Zeppernick","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"issue":"Suppl 1","key":"10.1016\/j.cyto.2016.01.017_b0030","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1016\/S0020-7292(06)60033-7","article-title":"Carcinoma of the ovary. FIGO 26th annual report on the results of treatment in gynecological cancer","volume":"95","author":"Heintz","year":"2006","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.cyto.2016.01.017_b0035","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","article-title":"Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer \u2013 shifting the paradigm","volume":"42","author":"Kurman","year":"2011","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.cyto.2016.01.017_b0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ajog.2008.01.005","article-title":"Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis","volume":"198","author":"Kurman","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cyto.2016.01.017_b0045","first-page":"151","article-title":"Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications","volume":"27","author":"Kurman","year":"2008","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.cyto.2016.01.017_b0050","doi-asserted-by":"crossref","first-page":"934261","DOI":"10.1155\/2014\/934261","article-title":"Recent concepts of ovarian carcinogenesis: type I and type II","volume":"2014","author":"Koshiyama","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cyto.2016.01.017_b0055","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.3390\/ijms14059536","article-title":"Targeting signaling pathways in epithelial ovarian cancer","volume":"14","author":"Smolle","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2016.01.017_b0060","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10585-012-9457-5","article-title":"Tumor microenvironment: a main actor in the metastasis process","volume":"29","author":"Spano","year":"2012","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.cyto.2016.01.017_b0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00005-006-0038-7","article-title":"Mechanisms of tumor escape: role of tumor microenvironment in inducing apoptosis of cytolytic effector cells","volume":"54","author":"Poggi","year":"2006","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.cyto.2016.01.017_b0070","doi-asserted-by":"crossref","first-page":"877","DOI":"10.4161\/cc.4.7.1838","article-title":"Hsp70-2 is required for tumor cell growth and survival","volume":"4","author":"Daugaard","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cyto.2016.01.017_b0075","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1196\/annals.1391.030","article-title":"Heat shock proteins in cancer","volume":"1113","author":"Sherman","year":"2007","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.cyto.2016.01.017_b0080","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0002-9440(10)63708-X","article-title":"Ovarian tumourigenesis: a proposed model based on morphological and molecular genetic analysis","volume":"164","author":"Shih","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cyto.2016.01.017_b0085","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-3083.2008.02139.x","article-title":"Ovarian cancer cells modulate human blood neutrophils response to activation in vitro","volume":"68","author":"Klink","year":"2008","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cyto.2016.01.017_b0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-3083.2009.02350.x","article-title":"Production of cytokines during interaction of peripheral blood mononuclear cells with autologous ovarian cancer cells or benign ovarian tumour cells","volume":"71","author":"Nowak","year":"2010","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cyto.2016.01.017_b0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s12192-012-0338-2","article-title":"The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian cancer cells in vitro","volume":"17","author":"Klink","year":"2012","journal-title":"Cell Stress Chaperon."},{"key":"10.1016\/j.cyto.2016.01.017_b0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1677\/erc.0.0060093","article-title":"The role of cytokines in both the normal and malignant ovary","volume":"6","author":"Nash","year":"1999","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.cyto.2016.01.017_b0105","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2567.2006.02321.x","article-title":"Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells","volume":"117","author":"Taylor","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2016.01.017_b0110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1447-0756.2008.00935.x","article-title":"Evaluation of immune inhibitory cytokine profiles in epithelial ovarian carcinoma","volume":"35","author":"Chen","year":"2009","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.cyto.2016.01.017_b0115","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/147323000703500302","article-title":"The expression of interleukin-10 in patients with primary ovarian epithelial carcinoma and in ovarian carcinoma cell lines","volume":"35","author":"Zhou","year":"2007","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.cyto.2016.01.017_b0120","first-page":"375","article-title":"Proinflammatory and immunosuppressive serum, ascites and cyst fluid cytokines in patients with early and advanced ovarian cancer and benign ovarian tumors","volume":"31","author":"Nowak","year":"2010","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.cyto.2016.01.017_b0125","first-page":"804","article-title":"Increased levels of interleukin-10 and transforming growth factor-beta in the plasma and ascitic fluid of patients with advanced ovarian cancer","volume":"108","author":"Santin","year":"2001","journal-title":"BJOG"},{"key":"10.1016\/j.cyto.2016.01.017_b0130","first-page":"1715","article-title":"Expression of IL-10 in patients with ovarian carcinoma","volume":"26","author":"Mustea","year":"2006","journal-title":"Anticancer Res."},{"key":"10.1016\/j.cyto.2016.01.017_b0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cyto.2008.10.019","article-title":"Monitoring of IL-10 in the serum of patients with advanced ovarian cancer: results from a prospective pilot-study","volume":"45","author":"Mustea","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2016.01.017_b0140","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1093\/humrep\/deg321","article-title":"Serum and cyst fluid levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-alpha in women with endometriomas and benign and malignant cystic ovarian tumours","volume":"18","author":"Dara\u00ef","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cyto.2016.01.017_b0145","first-page":"171","article-title":"Tumor necrosis factor-alpha and interleukin-6 are differently expressed by fresh human cancerous ovarian tissue and primary cell lines","volume":"9","author":"Glezerman","year":"1998","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.cyto.2016.01.017_b0150","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/1471-2164-14-508","article-title":"An IL6-correlated signature in serous epithelial ovarian cancer associates with growth factor response","volume":"14","author":"Pinciroli","year":"2013","journal-title":"BMC Genom."},{"key":"10.1016\/j.cyto.2016.01.017_b0155","doi-asserted-by":"crossref","first-page":"937s","DOI":"10.1158\/1078-0432.937s.11.2","article-title":"Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression","volume":"11","author":"Muraoka-Cook","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cyto.2016.01.017_b0160","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ejca.2006.01.012","article-title":"Tumour necrosis factor-alpha as a tumour promoter","volume":"42","author":"Szlosarek","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cyto.2016.01.017_b0165","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10555-006-9005-3","article-title":"TNF-alpha in promotion and progression of cancer","volume":"25","author":"Balkwill","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.cyto.2016.01.017_b0170","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1600-0897.2011.01068.x","article-title":"Distinct subpopulations of epithelial ovarian cancer cells can differentially induce macrophages and T regulatory cells toward a pro-tumor phenotype","volume":"67","author":"Alvero","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.cyto.2016.01.017_b0175","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.suronc.2011.09.001","article-title":"The tumor microenvironment","volume":"21","author":"Weber","year":"2012","journal-title":"Surg. Oncol."},{"key":"10.1016\/j.cyto.2016.01.017_b0180","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/scbi.2001.0419","article-title":"The role of cytokines in the epithelial cancer microenvironment","volume":"12","author":"Wilson","year":"2002","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cyto.2016.01.017_b0185","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1074\/jbc.M200497200","article-title":"Novel signal transduction pathway utilized by extracellular HSP70: role of Toll-like receptor (TLR) 2 and TLR4","volume":"277","author":"Asea","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2016.01.017_b0190","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/157339506778018514","article-title":"Initiation of the immune response by extracellular Hsp72: chaperokine activity of Hsp72","volume":"2","author":"Asea","year":"2006","journal-title":"Curr. Immunol. Rev."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466616300199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466616300199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T20:07:24Z","timestamp":1692216444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466616300199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":38,"alternative-id":["S1043466616300199"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2016.01.017","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secretion of cytokines and heat shock protein (HspA1A) by ovarian cancer cells depending on the tumor type and stage of disease","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2016.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}