{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:32:13Z","timestamp":1783078333539,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.cyto.2016.02.015","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T12:49:10Z","timestamp":1457959750000},"page":"122-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["White adipose tissue IFN-\u03b3 expression and signalling along the progression of rodent cancer cachexia"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4998-0989","authenticated-orcid":false,"given":"Alex Shimura","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Xavier","family":"das Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Cesar","family":"Rosa-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio dos Santos","family":"Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-5131","authenticated-orcid":false,"suffix":"Jr.","given":"Miguel Lu\u00eds","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S\u00e9rgio","family":"Alcantara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pinhata","family":"Otoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia","family":"Seelaender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cyto.2016.02.015_b0005","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1038\/sj.bjc.6601781","article-title":"Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers?","volume":"90","author":"Ross","year":"2004","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.cyto.2016.02.015_b0010","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.cyto.2016.02.015_b0015","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.cyto.2016.02.015_b0020","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.cyto.2012.10.023","article-title":"Adipose tissue-derived factors as potential biomarkers in cachectic cancer patients","volume":"61","author":"Batista","year":"2013","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.cyto.2016.02.015_b0025","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.3390\/nu7064465","article-title":"NF-kappaBp65 and expression of its pro-inflammatory target genes are upregulated in the subcutaneous adipose tissue of cachectic cancer patients","volume":"7","author":"Camargo","year":"2015","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.cyto.2016.02.015_b0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1055\/s-0031-1299694","article-title":"Exercise training decreases adipose tissue inflammation in cachectic rats","volume":"44","author":"Lira","year":"2012","journal-title":"Horm. Metab. Res."},{"issue":"3","key":"10.1016\/j.cyto.2016.02.015_b0035","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00441-004-0987-2","article-title":"Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration","volume":"318","author":"Machado","year":"2004","journal-title":"Cell Tissue Res."},{"issue":"3","key":"10.1016\/j.cyto.2016.02.015_b0040","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/JOE-12-0307","article-title":"Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia","volume":"215","author":"Batista","year":"2012","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.cyto.2016.02.015_b0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4149\/neo_2009_01_56","article-title":"Tumor necrosis factor alpha and interferon gamma genes polymorphisms and serum levels in pancreatic adenocarcinoma","volume":"56","author":"Talar-Wojnarowska","year":"2009","journal-title":"Neoplasma"},{"issue":"6","key":"10.1016\/j.cyto.2016.02.015_b0050","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/PPO.0b013e3181594940","article-title":"How relevant are cytokines in colorectal cancer wasting?","volume":"13","author":"Ravasco","year":"2007","journal-title":"Cancer J."},{"issue":"5","key":"10.1016\/j.cyto.2016.02.015_b0055","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3892\/etm.2011.286","article-title":"Serum cytokine profiles in patients with prostate carcinoma","volume":"2","author":"Tazaki","year":"2011","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.cyto.2016.02.015_b0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.cyto.2016.02.015_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2009.11.021","article-title":"Gene modulation and immunoregulatory roles of interferon gamma","volume":"50","author":"Saha","year":"2010","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.cyto.2016.02.015_b0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ijc.2910490115","article-title":"Severe cachexia in mice inoculated with interferon-gamma-producing tumor cells","volume":"49","author":"Matthys","year":"1991","journal-title":"Int. J. Cancer"},{"issue":"9","key":"10.1016\/j.cyto.2016.02.015_b0075","first-page":"2302","article-title":"The roles of gamma-interferon and tumor necrosis factor alpha in an experimental rat model of cancer cachexia","volume":"51","author":"Langstein","year":"1991","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.cyto.2016.02.015_b0080","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1080\/01635580902825548","article-title":"Effect of fish oil supplementation for two generations on changes of lymphocyte function induced by Walker 256 cancer cachexia in rats","volume":"61","author":"Folador","year":"2009","journal-title":"Nutr. Cancer"},{"issue":"6","key":"10.1016\/j.cyto.2016.02.015_b0085","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/cbf.1495","article-title":"Effect of endurance training upon lipid metabolism in the liver of cachectic tumour-bearing rats","volume":"26","author":"Lira","year":"2008","journal-title":"Cell Biochem. Funct."},{"issue":"3","key":"10.1016\/j.cyto.2016.02.015_b0090","doi-asserted-by":"crossref","first-page":"e0122660","DOI":"10.1371\/journal.pone.0122660","article-title":"Pioglitazone treatment increases survival and prevents body weight loss in tumor-bearing animals: possible anti-cachectic effect","volume":"10","author":"Beluzi","year":"2015","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.cyto.2016.02.015_b0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1593\/tlo.12442","article-title":"Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation","volume":"6","author":"Yamashita","year":"2013","journal-title":"Transl. Oncol."},{"issue":"9","key":"10.1016\/j.cyto.2016.02.015_b0100","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucl. Acids Res."},{"issue":"2","key":"10.1016\/j.cyto.2016.02.015_b0105","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cyto.2012.10.021","article-title":"Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats","volume":"61","author":"Donatto","year":"2013","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.cyto.2016.02.015_b0110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1743-7075-8-60","article-title":"Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats","volume":"8","author":"Lira","year":"2011","journal-title":"Nutr. Metab. (Lond)"},{"key":"10.1016\/j.cyto.2016.02.015_b0115","article-title":"White adipose tissue cells and the progression of cachexia: inflammatory pathways","author":"Neves","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"5","key":"10.1016\/j.cyto.2016.02.015_b0120","doi-asserted-by":"crossref","first-page":"E1000","DOI":"10.1152\/ajpendo.90252.2008","article-title":"Neural control of the anorexia-cachexia syndrome","volume":"295","author":"Laviano","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.cyto.2016.02.015_b0125","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.clnu.2012.01.011","article-title":"Inflammation in cancer cachexia: to resolve or not to resolve (is that the question?)","volume":"31","author":"Seelaender","year":"2012","journal-title":"Clin. Nutr."},{"issue":"28","key":"10.1016\/j.cyto.2016.02.015_b0130","doi-asserted-by":"crossref","first-page":"20065","DOI":"10.1074\/jbc.R700003200","article-title":"The interferon regulatory factor family in host defense: mechanism of action","volume":"282","author":"Ozato","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cyto.2016.02.015_b0135","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2011.02.005","article-title":"Transcriptional control of adipose lipid handling by IRF4","volume":"13","author":"Eguchi","year":"2011","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.cyto.2016.02.015_b0140","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1158\/0008-5472.CAN-06-4585","article-title":"Mechanism of increased lipolysis in cancer cachexia","volume":"67","author":"Agustsson","year":"2007","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cyto.2016.02.015_b0145","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1210\/endo.131.4.1396316","article-title":"In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis","volume":"131","author":"Memon","year":"1992","journal-title":"Endocrinology"},{"issue":"21","key":"10.1016\/j.cyto.2016.02.015_b0150","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1073\/pnas.83.21.8313","article-title":"Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells","volume":"83","author":"Patton","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.cyto.2016.02.015_b0155","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1210\/en.2006-1760","article-title":"Acute and selective inhibition of adipocyte glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase by interferon gamma","volume":"148","author":"Khazen","year":"2007","journal-title":"Endocrinology"},{"issue":"46","key":"10.1016\/j.cyto.2016.02.015_b0160","doi-asserted-by":"crossref","first-page":"31936","DOI":"10.1074\/jbc.M109.061655","article-title":"Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK\/STAT pathway","volume":"284","author":"McGillicuddy","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cyto.2016.02.015_b0165","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13539-011-0051-5","article-title":"The role of insulin resistance in the development of muscle wasting during cancer cachexia","volume":"3","author":"Honors","year":"2012","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.cyto.2016.02.015_b0170","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cyto.2010.07.006","article-title":"Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction","volume":"52","author":"Yamashita","year":"2010","journal-title":"Cytokine"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466616300394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466616300394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T10:40:16Z","timestamp":1567680016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466616300394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":34,"alternative-id":["S1043466616300394"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2016.02.015","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White adipose tissue IFN-\u03b3 expression and signalling along the progression of rodent cancer cachexia","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2016.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}