{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:44:19Z","timestamp":1774802659751,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.cyto.2016.03.003","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:14:56Z","timestamp":1458605696000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Expression of fibroblast growth factor 21 in patients with biliary atresia"],"prefix":"10.1016","volume":"83","author":[{"given":"Dawei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianfei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conghuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cyto.2016.03.003_b0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MPG.0000000000000755","article-title":"Biliary atresia: clinical lessons learned","volume":"61","author":"Feldman","year":"2015","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"3","key":"10.1016\/j.cyto.2016.03.003_b0010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jpeds.2014.05.038","article-title":"Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium","volume":"165","author":"Ng","year":"2014","journal-title":"J. Pediatr."},{"issue":"3","key":"10.1016\/j.cyto.2016.03.003_b0015","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/0884533612474043","article-title":"Nutrition assessment and support in children with end-stage liver disease","volume":"28","author":"Young","year":"2013","journal-title":"Nutr. Clin. Pract."},{"issue":"4","key":"10.1016\/j.cyto.2016.03.003_b0020","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0950-3528(98)90010-0","article-title":"Cholestasis and end-stage liver disease","volume":"12","author":"Protheroe","year":"1998","journal-title":"Baillieres Clin. Gastroenterol."},{"issue":"13","key":"10.1016\/j.cyto.2016.03.003_b0025","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/S0149-2918(11)00022-1","article-title":"A review of the treatment of chronic hepatitis C virus infection in cirrhosis","volume":"32","author":"Vezali","year":"2010","journal-title":"Clin. Ther."},{"issue":"6","key":"10.1016\/j.cyto.2016.03.003_b0030","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0899-9007(01)00521-4","article-title":"Nutrition and survival in patients with liver cirrhosis","volume":"17","author":"Alberino","year":"2001","journal-title":"Nutrition"},{"issue":"11\u201312","key":"10.1016\/j.cyto.2016.03.003_b0035","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.nut.2013.05.016","article-title":"Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis","volume":"29","author":"Iwasa","year":"2013","journal-title":"Nutrition"},{"issue":"3","key":"10.1016\/j.cyto.2016.03.003_b0040","first-page":"463","article-title":"Studies of Pediatric Liver Transplantation (SPLIT): year 2000 outcomes","year":"2001","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.cyto.2016.03.003_b0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/01.mpg.0000226378.03247.1f","article-title":"Impact of pretransplant growth retardation in pediatric liver transplantation","volume":"43","author":"Barshes","year":"2006","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"6","key":"10.1016\/j.cyto.2016.03.003_b0050","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/MPG.0000000000000547","article-title":"Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia","volume":"59","author":"Venkat","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"4","key":"10.1016\/j.cyto.2016.03.003_b0055","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0889-8553(21)00165-5","article-title":"Fat-soluble vitamins and their importance in patients with cholestatic liver diseases","volume":"23","author":"Sokol","year":"1994","journal-title":"Gastroenterol. Clin. North Am."},{"issue":"1","key":"10.1016\/j.cyto.2016.03.003_b0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00004836-200201000-00018","article-title":"Nutritional problems in end-stage liver disease: contribution of impaired gastric emptying and ascites","volume":"34","author":"Scolapio","year":"2002","journal-title":"J. Clin. Gastroenterol."},{"issue":"2","key":"10.1016\/j.cyto.2016.03.003_b0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/EJE-14-0539","article-title":"Circulating FGF21 levels are related to nutritional status and metabolic but not hormonal disturbances in polycystic ovary syndrome","volume":"172","author":"Olszanecka-Glinianowicz","year":"2015","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"10.1016\/j.cyto.2016.03.003_b0070","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1651-2227.2007.00596.x","article-title":"Circulating leptin levels and bone mineral density in children with biliary atresia","volume":"97","author":"Honsawek","year":"2008","journal-title":"Acta Paediatr."},{"issue":"9","key":"10.1016\/j.cyto.2016.03.003_b0075","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00042737-200509000-00007","article-title":"Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis","volume":"17","author":"Szalay","year":"2005","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.cyto.2016.03.003_b0080","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12519-012-0377-x","article-title":"+276 G\/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia","volume":"8","author":"Udomsinprasert","year":"2012","journal-title":"World J. Pediatr."},{"issue":"4","key":"10.1016\/j.cyto.2016.03.003_b0085","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1007\/s12072-011-9262-2","article-title":"Serum retinol binding protein 4 and clinical outcome in postoperative biliary atresia","volume":"5","author":"Chayanupatkul","year":"2011","journal-title":"Hepatol. Int."},{"issue":"1","key":"10.1016\/j.cyto.2016.03.003_b0090","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0167-4781(00)00067-1","article-title":"Identification of a novel FGF, FGF-21, preferentially expressed in the liver","volume":"1492","author":"Nishimura","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.cyto.2016.03.003_b0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tig.2004.08.007","article-title":"Evolution of the Fgf and Fgfr gene families","volume":"20","author":"Itoh","year":"2004","journal-title":"Trends Genet."},{"issue":"6","key":"10.1016\/j.cyto.2016.03.003_b0100","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.cyto.2016.03.003_b0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1053\/j.gastro.2013.10.059","article-title":"Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21","volume":"146","author":"Li","year":"2014","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.cyto.2016.03.003_b0110","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1172\/JCI74915","article-title":"FGF21 is an endocrine signal of protein restriction","volume":"124","author":"Laeger","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.cyto.2016.03.003_b0115","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","article-title":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21","volume":"5","author":"Inagaki","year":"2007","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.cyto.2016.03.003_b0120","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jhep.2012.10.029","article-title":"High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China","volume":"58","author":"Li","year":"2013","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.cyto.2016.03.003_b0125","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/hep.27060","article-title":"Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1alpha-mediated antioxidant capacity in mice","volume":"60","author":"Ye","year":"2014","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.cyto.2016.03.003_b0130","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1053\/j.gastro.2010.04.054","article-title":"Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease","volume":"139","author":"Dushay","year":"2010","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.cyto.2016.03.003_b0135","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2010.05.018","article-title":"Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride","volume":"53","author":"Li","year":"2010","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.cyto.2016.03.003_b0140","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/mc.20241","article-title":"Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis","volume":"45","author":"Huang","year":"2006","journal-title":"Mol. Carcinog."},{"issue":"5","key":"10.1016\/j.cyto.2016.03.003_b0145","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"issue":"24","key":"10.1016\/j.cyto.2016.03.003_b0150","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/eurheartj\/ehs011","article-title":"Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia\/reperfusion injury","volume":"34","author":"Pu","year":"2013","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.cyto.2016.03.003_b0155","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1097-2765(00)80348-2","article-title":"Endogenous bile acids are ligands for the nuclear receptor FXR\/BAR","volume":"3","author":"Wang","year":"1999","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.cyto.2016.03.003_b0160","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/me.2010-0142","article-title":"Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse","volume":"24","author":"Fon Tacer","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.cyto.2016.03.003_b0165","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/db08-0392","article-title":"Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.cyto.2016.03.003_b0170","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/hep.24645","article-title":"Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking","volume":"54","author":"Wu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.cyto.2016.03.003_b0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-230X-13-67","article-title":"Activation of liver FGF21 in hepatocarcinogenesis and during hepatic stress","volume":"13","author":"Yang","year":"2013","journal-title":"BMC Gastroenterol."},{"issue":"3","key":"10.1016\/j.cyto.2016.03.003_b0180","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.metabol.2014.11.009","article-title":"The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy","volume":"64","author":"Liu","year":"2015","journal-title":"Metabolism"},{"issue":"11","key":"10.1016\/j.cyto.2016.03.003_b0185","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1517\/14728222.2014.944898","article-title":"The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target","volume":"18","author":"Liu","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.cyto.2016.03.003_b0190","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fendo.2013.00194","article-title":"Stressed liver and muscle call on adipocytes with FGF21","volume":"4","author":"Luo","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.cyto.2016.03.003_b0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jhep.2013.09.003","article-title":"Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure","volume":"60","author":"Mutanen","year":"2014","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.cyto.2016.03.003_b0200","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2014.07.044","article-title":"Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets","volume":"147","author":"Fisher","year":"2014","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.cyto.2016.03.003_b0205","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metab."},{"issue":"30","key":"10.1016\/j.cyto.2016.03.003_b0210","doi-asserted-by":"crossref","first-page":"25123","DOI":"10.1074\/jbc.M112.375907","article-title":"Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21","volume":"287","author":"Cyphert","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cyto.2016.03.003_b0215","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/j.sempedsurg.2012.05.010","article-title":"Biliary atresia: clinical aspects","volume":"21","author":"Davenport","year":"2012","journal-title":"Semin. Pediatr. Surg."},{"issue":"11","key":"10.1016\/j.cyto.2016.03.003_b0220","doi-asserted-by":"crossref","first-page":"e49270","DOI":"10.1371\/journal.pone.0049270","article-title":"Elevated bile acids in newborns with Biliary Atresia (BA)","volume":"7","author":"Zhou","year":"2012","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.cyto.2016.03.003_b0225","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1210\/me.2002-0120","article-title":"Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor","volume":"17","author":"Pineda Torra","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.cyto.2016.03.003_b0230","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.numecd.2011.06.008","article-title":"FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity","volume":"23","author":"Mencarelli","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.cyto.2016.03.003_b0235","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-230X-7-44","article-title":"Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study","volume":"7","author":"Cindoruk","year":"2007","journal-title":"BMC Gastroenterol."}],"updated-by":[{"DOI":"10.1016\/j.cyto.2024.156525","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000}}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466616300424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466616300424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T21:09:50Z","timestamp":1655327390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466616300424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":47,"alternative-id":["S1043466616300424"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2016.03.003","relation":{"expression_of_concern":[{"id-type":"doi","id":"10.1016\/j.cyto.2024.156525","asserted-by":"object"}]},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of fibroblast growth factor 21 in patients with biliary atresia","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2016.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}