{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:56:51Z","timestamp":1778655411811,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.cyto.2017.04.025","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T21:47:37Z","timestamp":1494107257000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Possible link of Interleukin-6 and Interleukin-2 with psychiatric diagnosis, ethnicity, disaster or BMI"],"prefix":"10.1016","volume":"96","author":[{"given":"Phebe","family":"Tucker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Pfefferbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Niti\u00e9ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qaiser","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchi","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin E.","family":"Walling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2017.04.025_b0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0033-3182(99)71238-7","article-title":"Phenotype of blood lympohcytes in PTSD suggests chronic immune activation","volume":"40","author":"Wilson","year":"1999","journal-title":"Psychosomatics"},{"key":"10.1016\/j.cyto.2017.04.025_b0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/00006842-199703000-00003","article-title":"Posttraumatic stress symptoms, intrusive thoughts, loss of immune function after Hurricane Andrew","volume":"59","author":"Ironson","year":"1997","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.cyto.2017.04.025_b0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000112050","article-title":"Disturbance of serum interleukin-2 and interleukin-8 levels in posttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China","volume":"14","author":"Song","year":"2007","journal-title":"NeuroImmunoModulation"},{"key":"10.1016\/j.cyto.2017.04.025_b0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF02193091","article-title":"Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble Interleukin-2 receptor, prolactin and cortisol","volume":"245","author":"Maes","year":"1995","journal-title":"Eur. Arch. Psychiatry. Clin. Neurosci."},{"key":"10.1016\/j.cyto.2017.04.025_b0025","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/978-1-61779-458-2_27","article-title":"Interleukin-2 and the septohippocampal system: intrinsic actions and autoimmune processes relevant to neuropsychiatric disorders","volume":"829","author":"Petitto","year":"2012","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.cyto.2017.04.025_b0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1176\/appi.ajp.2014.14020263","article-title":"Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiologic responses in a civilian population with high levels of trauma","volume":"172","author":"Michopoulos","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.cyto.2017.04.025_b0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-244X-13-40","article-title":"Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells","volume":"13","author":"Gola","year":"2013","journal-title":"BMC Psychiatry"},{"issue":"6","key":"10.1016\/j.cyto.2017.04.025_b0040","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni.2030","article-title":"Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages","volume":"12","author":"Liao","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2017.04.025_b0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biopsych.2004.03.009","article-title":"Neuroimmune and cortisol changes in selective serotonin reuptake inhibitor and placebo treatment of chronic posttraumatic stress disorder","volume":"56","author":"Tucker","year":"2004","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.cyto.2017.04.025_b0050","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1590\/S0100-879X2002000500011","article-title":"Immune and hormonal activity in adults suffering from depression","volume":"35","author":"Nunes","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.cyto.2017.04.025_b0055","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2007.09.024","article-title":"Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review","volume":"63","author":"PotvinS","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cyto.2017.04.025_b0060","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cyto.2017.04.025_b0065","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jmv.2065","article-title":"Ethnicity and cytokine production gauge response of patients with hepatitis C to Interferon-\u03b1 therapy","volume":"65","author":"Kimball","year":"2001","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.cyto.2017.04.025_b0070","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1034\/j.1600-6143.2002.20611.x","article-title":"Ethnicity greatly influences cytokine gene polymorphism distribution","volume":"2","author":"Hoffman","year":"2002","journal-title":"Am. J. Transplantation"},{"issue":"4","key":"10.1016\/j.cyto.2017.04.025_b0075","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/00007890-200108270-00027","article-title":"Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of Interleukin-2 and Interleukin-6","volume":"72","author":"Cox","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.cyto.2017.04.025_b0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.gene.2012.08.021","article-title":"Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination","volume":"510","author":"Ovsyannikova","year":"2012","journal-title":"Gene"},{"issue":"12","key":"10.1016\/j.cyto.2017.04.025_b0085","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/archpediatrics.2009.214","article-title":"Adverse childhood experiences and adult risk factors for age-related disease","volume":"163","author":"Danese","year":"2009","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"1","key":"10.1016\/j.cyto.2017.04.025_b0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpsychires.2009.06.002","article-title":"Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population","volume":"44","author":"Spitzer","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.cyto.2017.04.025_b0095","doi-asserted-by":"crossref","DOI":"10.1001\/jamapsychiatry.2013.4374","article-title":"Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk","author":"Eraly","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"10.1016\/j.cyto.2017.04.025_b0100","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ni.3153","article-title":"IL-6 as a keystone cytokine in health and disease","volume":"16","author":"Hunter","year":"2015","journal-title":"Nature Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2017.04.025_b0105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5055\/ajdm.2010.0013","article-title":"Emotional and biological stress measures in Katrina survivors relocated to Oklahoma","volume":"5","author":"Tucker","year":"2010","journal-title":"Am. J. Disaster Med."},{"key":"10.1016\/j.cyto.2017.04.025_b0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbi.2013.01.081","article-title":"Association between posttraumatic stress disorder and inflammation: a twin study","volume":"30","author":"Plantings","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cyto.2017.04.025_b0115","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0006-3223(98)00131-0","article-title":"Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events","volume":"45","author":"Maes","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cyto.2017.04.025_b0120","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/cyto.1997.0290","article-title":"The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety","volume":"10","author":"Maes","year":"1998","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2017.04.025_b0125","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/PSY.0b013e318240a7d8","article-title":"Early trauma and inflammation: role of familial factors in a study of twins","volume":"74","author":"Rooks","year":"2012","journal-title":"Psychosom. Med."},{"issue":"4","key":"10.1016\/j.cyto.2017.04.025_b0130","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/01.PSY.0000062530.94551.EA","article-title":"Joint effect of hostility and severity of depressive symptoms on plasma Interleukin-6 concentration","volume":"65","author":"Suareza","year":"2003","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.cyto.2017.04.025_b0135","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainresrev.2011.01.002","article-title":"Interleukin-6, a mental Cytokine","volume":"67","author":"Spooren","year":"2011","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.cyto.2017.04.025_b0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-244X-13-40","article-title":"Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells","volume":"13","author":"Gola","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.cyto.2017.04.025_b0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2141.2001.03061.x","article-title":"Interleukin 6 and haemostasis","volume":"115","author":"Kerr","year":"2001","journal-title":"Br. J. Hematol."},{"issue":"3","key":"10.1016\/j.cyto.2017.04.025_b0150","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1440-1819.2010.02094.x","article-title":"Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models","volume":"64","author":"Watanabe","year":"2010","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.cyto.2017.04.025_b0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/157339510791823673","article-title":"Immune system and Schizophrenia","volume":"6","author":"M\u00fcller","year":"2010","journal-title":"CIR Curr. Immunol. Rev."},{"key":"10.1016\/j.cyto.2017.04.025_b0160","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-IV), Clinician Version (Administrative Booklet)","author":"First","year":"1997"},{"issue":"2","key":"10.1016\/j.cyto.2017.04.025_b0165","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-1781(98)00038-9","article-title":"Training and quality assurance with the Structured Clinical Interview for DSM-IV (SCID-IV)","volume":"79","author":"Ventura","year":"1998","journal-title":"Psychiat. Res."},{"key":"10.1016\/j.cyto.2017.04.025_b0170","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G\u2217Power 3.1: Tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.cyto.2017.04.025_b0175","series-title":"Statistical Power Analysis for the Behavioral Sciences","first-page":"412","author":"Cohen","year":"1988"},{"key":"10.1016\/j.cyto.2017.04.025_b0180","author":"National Institute of Mental Health"},{"key":"10.1016\/j.cyto.2017.04.025_b0185","series-title":"Diagnostic and Statistical Manual of Mental Disorders","first-page":"277","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.cyto.2017.04.025_b0190","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S0033291704003514","article-title":"Lifetime risk and persistence of psychiatric disorders across ethnic groups in the United States","volume":"35","author":"Breslau","year":"2005","journal-title":"Psychol. Med."},{"key":"10.1016\/j.cyto.2017.04.025_b0195","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF02900219","article-title":"Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission","volume":"247","author":"Frommberger","year":"1997","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"7","key":"10.1016\/j.cyto.2017.04.025_b0200","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1399-5618.2007.00444.x","article-title":"An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment","volume":"9","author":"Knijff","year":"2007","journal-title":"Bipolar Disord."},{"issue":"3","key":"10.1016\/j.cyto.2017.04.025_b0205","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.alcohol.2004.02.004","article-title":"Serum cytokine concentrations in alcohol-dependent individuals without liver disease","volume":"32","author":"Nicolaou","year":"2004","journal-title":"Alcohol"},{"issue":"2012","key":"10.1016\/j.cyto.2017.04.025_b0210","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuropharm.2011.02.027","article-title":"Biomarkers of PTSD: neuropeptides and immune signaling","volume":"62","author":"Baker","year":"2012","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.cyto.2017.04.025_b0215","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2012.10.022","article-title":"The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia","volume":"48","author":"Na","year":"2014","journal-title":"Prog. Neuro-Psychopharm. Biol. Psychiatry"},{"key":"10.1016\/j.cyto.2017.04.025_b0220","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.psyneuen.2014.09.024","article-title":"Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: a pilot study","volume":"51","author":"Tylee","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.cyto.2017.04.025_b0225","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.2044-8287.2012.02085.x","article-title":"Autonomy, positive relationships, and IL-6: evidence for gender-specific effects","volume":"18","author":"Eisenlohr-Moul","year":"2012","journal-title":"Br. J. Health Psychol."},{"issue":"6","key":"10.1016\/j.cyto.2017.04.025_b0230","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/0148607104028006410","article-title":"Serum levels of Interleukin-6 and C-reactive protein correlate with body mass index across the road range of obesity","volume":"28","author":"Khaodhiar","year":"2004","journal-title":"J. Parenteral. Enteral Nutrition"},{"issue":"12","key":"10.1016\/j.cyto.2017.04.025_b0235","first-page":"4196","article-title":"Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-a Vivo","volume":"82","author":"Mohamed-Ali","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2017.04.025_b0240","first-page":"878","article-title":"Rose-John S (2011): The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"5","author":"Scheller","year":"1813","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.cyto.2017.04.025_b0245","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1172\/JCI1368","article-title":"IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses","volume":"101","author":"Xing","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2017.04.025_b0250","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/mp.2013.35","article-title":"Long-term inflammation risk of common mental disorder: a cohort study","volume":"19","author":"Kivimaki","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.cyto.2017.04.025_b0255","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/08039488.2011.611894","article-title":"Role of cytokines in atypical depression","volume":"66","author":"Yoon","year":"2012","journal-title":"Nord. J. Psychiatry"},{"issue":"5","key":"10.1016\/j.cyto.2017.04.025_b0260","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2012.02.012","article-title":"Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation","volume":"36","author":"Ballesteros-Tato","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2017.04.025_b0265","doi-asserted-by":"crossref","first-page":"14716","DOI":"10.1073\/pnas.0902971106","article-title":"Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling","volume":"106","author":"Miller","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617301205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617301205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T02:53:00Z","timestamp":1535856780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466617301205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":53,"alternative-id":["S1043466617301205"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2017.04.025","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible link of Interleukin-6 and Interleukin-2 with psychiatric diagnosis, ethnicity, disaster or BMI","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2017.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}