{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T07:48:18Z","timestamp":1771746498778,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.cyto.2017.07.001","type":"journal-article","created":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T05:17:05Z","timestamp":1500787025000},"page":"80-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["M1 homeopathic complex trigger effective responses against Leishmania (L) amazonensis in vivo and in vitro"],"prefix":"10.1016","volume":"99","author":[{"given":"Katia Fialho","family":"Nascimento","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Rodrigues","family":"de Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleber Rafael Vieira","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Kaplum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helito","family":"Volpato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Vaturo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leoni Villano","family":"Bonamin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorly","family":"de Freitas Buchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2017.07.001_b0005","unstructured":"World Health Organization (WHO, 2010. Dispon\u00edvel em: http:\/\/www.who.int\/en\/Acess in: novembro, 2014."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.001_b0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/AAC.49.11.176-182.2005","article-title":"Antileishmanial activity of parthenolide, asesquiterpene lactone isolated from Tenacetum parthenium","volume":"49","author":"Tiuman","year":"2005","journal-title":"Antimicro Agents Chemoter"},{"issue":"Suppl 2","key":"10.1016\/j.cyto.2017.07.001_b0015","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1007\/s00436-002-0768-3","article-title":"Natural products as antiparasitic drugs","volume":"90","author":"Kayser","year":"2003","journal-title":"Parasitol. Res."},{"issue":"2\u20133","key":"10.1016\/j.cyto.2017.07.001_b0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-8741(01)00346-4","article-title":"Antiprotozoal activities of colombian plants","volume":"78","author":"Weniger","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cyto.2017.07.001_b0025","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1089\/jir.2015.0043","article-title":"IFN-c-dependent recruitment of CD4+T cells and macrophages contributes to pathogenesis during Leishmania amazonensis Infection","volume":"35","author":"Carneiro","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.cyto.2017.07.001_b0030","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0169-4758(00)01692-6","article-title":"Leishmania-host-cell interaction: complexities and alternative views","volume":"16","author":"Rittg","year":"2000","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.cyto.2017.07.001_b0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.freeradbiomed.2011.05.011","article-title":"Leishmania-macrophage interactions: Insights into the redox biology","volume":"51","author":"Assche","year":"2011","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.cyto.2017.07.001_b0040","first-page":"1","article-title":"The role of nitric oxide and reactive oxygen species in the killing of leishmania braziliensis by monocytes from patients with cutaneous leishmaniasis","author":"Carneiro","year":"2016","journal-title":"PloS ONE"},{"key":"10.1016\/j.cyto.2017.07.001_b0045","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.vetpar.2014.08.022","article-title":"Immunological profile of resistance and susceptibility in naturally infected dogs by Leishmania infantum","volume":"205","author":"Leal","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.cyto.2017.07.001_b0050","article-title":"Use of interleukin-10 blockade as a therapeutic strategy in human cutaneous leishmaniasis","volume":"152741","author":"Castellano","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.cyto.2017.07.001_b0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1472-6882-11-101","article-title":"Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers","volume":"11","author":"De Oliveira","year":"2011","journal-title":"BMC Complemen. Alternat. Med."},{"key":"10.1016\/j.cyto.2017.07.001_b0060","first-page":"1","article-title":"Inhalation therapy with M1 inhibits experimental melanoma development and metastases in mice","author":"de Andrade","year":"2015","journal-title":"Homeopathy"},{"issue":"8","key":"10.1016\/j.cyto.2017.07.001_b0065","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1128\/IAI.70.8.4571-4580.2002","article-title":"And N.W. Andrews. Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis","volume":"70","author":"Morehead","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cyto.2017.07.001_b0070","unstructured":"Brasil. ANVISA. Farmacopeia Homeopatica Brasileira, 3a. ed. 2011. http:\/\/www.anvisa.gov.br\/hotsite\/farmacopeiabrasileira\/conteudo\/3a_edicao.pdf."},{"key":"10.1016\/j.cyto.2017.07.001_b0075","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.micron.2005.08.005","article-title":"Phagocytosis, endosomal\/lisosomal system and other cellular aspects of macrophage activation by Canova medication","volume":"37","author":"Lopes","year":"2006","journal-title":"Micron"},{"issue":"6","key":"10.1016\/j.cyto.2017.07.001_b0080","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jinf.2005.08.017","article-title":"Canova, a Brazilian medical formulation, alters oxidative metabolism of mice macrophages","volume":"52","author":"De Oliveira","year":"2006","journal-title":"J. Infect."},{"key":"10.1016\/j.cyto.2017.07.001_b0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1590\/S0037-86822005000200002","article-title":"Perfi l de isotipos de imunoglobulinas e subclasses de IgG na leishmaniose tegumentar americana","volume":"38","author":"Souza","year":"2005","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.cyto.2017.07.001_b0090","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0165-2478(99)00146-7","article-title":"The humoral immune response to the kinetoplastid membrane protein-11 in patients with American leishmaniasis and chagas disease: prevalence og IgG subclasses and mapping of epitopes","volume":"70","author":"Trujillo","year":"1999","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.cyto.2017.07.001_b0095","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/expr.1996.0104","article-title":"Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis","volume":"84","author":"Bomfim","year":"1996","journal-title":"Exp. Parasitology"},{"key":"10.1016\/j.cyto.2017.07.001_b0100","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2249.1993.tb05931.x","article-title":"Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction","volume":"91","author":"C\u00e1ceres-Dittmar","year":"1993","journal-title":"Clin Exp Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2017.07.001_b0105","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.4049\/jimmunol.176.3.1834","article-title":"Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of leishmania (L) amazonensis in mammalian hosts","volume":"176","author":"Wanderley","year":"2006","journal-title":"J. Immunol."},{"issue":"5447","key":"10.1016\/j.cyto.2017.07.001_b0110","first-page":"2098","article-title":"Using DNA microarrays to study hostmicrobe","volume":"286","author":"Cummings","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cyto.2017.07.001_b0115","unstructured":"I.D. Manger, D.A. Relman, How the host \u2018sees\u2019 pathogens: global gene 2000."},{"key":"10.1016\/j.cyto.2017.07.001_b0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1369-5274(00)00171-5","article-title":"Comparing functional genomic datasets: lessons from DNA microarray analyses of host-pathogen interactions","volume":"4","author":"Diehn","year":"2001","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.cyto.2017.07.001_b0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1590\/0037-8682-0007-2013","article-title":"Cutaneous and visceral leishmaniasis co-infection in dogs from Rio de Janeiro, Brazil: evaluation by specific PCR and RFLP-PCR essays","volume":"27","author":"Pires","year":"2014","journal-title":"Rev. Bras. Med. Trop."},{"key":"10.1016\/j.cyto.2017.07.001_b0130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/pim.12100","article-title":"Immunoregulation in human american leishmaniasis: balancing pathology and protection","volume":"36","author":"Gollob","year":"2014","journal-title":"Parasite Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2017.07.001_b0135","doi-asserted-by":"crossref","first-page":"e1518","DOI":"10.1371\/journal.pntd.0001518","article-title":"The Diverse and Dynamic Nature of Leishmania Parasitophorous Vacuoles Studied by Multidimensional Imaging","volume":"6","author":"Real","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cyto.2017.07.001_b0140","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijantimicag.2011.11.008","article-title":"Efficacy of miltefosine treatment in Leishmania amazonensis-infected BALB\/c mice","volume":"39","author":"Godinho","year":"2012","journal-title":"Internat. J. Antimicrobial Agents"},{"key":"10.1016\/j.cyto.2017.07.001_b0145","article-title":"Revising the pathogenesis of the American Tegumentary Leishmaniasis in Amazonian, with emphasis to the disease due to Leishmania (V.) braziliensis and Leishmania (L.)amazonensis","volume":"22","author":"Silveira","year":"2008","journal-title":"Rev. Para. Med"},{"key":"10.1016\/j.cyto.2017.07.001_b0150","first-page":"1","article-title":"Revis\u00e3o sobre a Patogenia da Leishmaniose Tegumentar Americana na Amaz\u00f4nia, com \u00eanfase \u00e0 doen\u00e7a causada por Leishmania (V.) braziliensis e Leishmania (L.) amazonensis","volume":"22","author":"Silveira","year":"2008","journal-title":"Revista Paraense deMed."},{"key":"10.1016\/j.cyto.2017.07.001_b0155","doi-asserted-by":"crossref","first-page":"1000179","DOI":"10.1371\/journal.ppat.1000179","article-title":"Control of parasitophorous vacuole expasion by LYST\/Beige restricts the intracellular growth of Leishmania amazonensis","volume":"4","author":"Wilson","year":"2008","journal-title":"Plos Pathog."},{"issue":"2","key":"10.1016\/j.cyto.2017.07.001_b0160","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1517\/14656566.2015.973850","article-title":"An Update on Pharmacotherapy for Leishmaniasis","volume":"16","author":"Sundar","year":"2015","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.cyto.2017.07.001_b0165","first-page":"13","article-title":"Immunology and Homeopathy. 2. Cells of the Immune System and Inflammation","volume":"3","author":"Bellavite","year":"2006","journal-title":"eCAM"},{"key":"10.1016\/j.cyto.2017.07.001_b0170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/ecam\/nel016","article-title":"Immunology and homeopathy. 3. Experimental studies on animal models","volume":"3","author":"Bellavite","year":"2006","journal-title":"Evid. Based. Complement Alternat. Med"},{"key":"10.1016\/j.cyto.2017.07.001_b0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cyto.2017.02.010","article-title":"Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB\/c mice infected with Leishmania infantum","volume":"95","author":"Cajueiro","year":"2017","journal-title":"Cytokine."},{"key":"10.1016\/j.cyto.2017.07.001_b0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cyto.2017.01.004","article-title":"High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro","volume":"92","author":"Santana","year":"2017","journal-title":"Cytokine."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617301941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617301941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T01:23:02Z","timestamp":1535592182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466617301941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":36,"alternative-id":["S1043466617301941"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2017.07.001","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"M1 homeopathic complex trigger effective responses against Leishmania (L) amazonensis in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2017.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}