{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:51:02Z","timestamp":1789861862242,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.cyto.2017.07.009","type":"journal-article","created":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T05:17:34Z","timestamp":1500787054000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Association of the IL-15 and IL-15R\u03b1 genes with celiac disease"],"prefix":"10.1016","volume":"99","author":[{"given":"Celia","family":"Escudero-Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Plaza-Izurieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Garrote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Bilbao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Arranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cyto.2017.07.009_b0005","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/gut.52.7.960","article-title":"Seroprevalence, correlates, and characteristics of undetected coeliac disease in England","volume":"52","author":"West","year":"2003","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.cyto.2017.07.009_b0010","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1517\/13543780903369333","article-title":"Investigational therapies for celiac disease","volume":"18","author":"Rodrigo","year":"2009","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"6","key":"10.1016\/j.cyto.2017.07.009_b0015","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/j.gastro.2009.09.008","article-title":"Celiac disease: from pathogenesis to novel therapies","volume":"137","author":"Schuppan","year":"2009","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.cyto.2017.07.009_b0020","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/ng.3268","article-title":"Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease","volume":"47","author":"Gutierrez-Achury","year":"2015","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.cyto.2017.07.009_b0025","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng2058","article-title":"A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21","volume":"39","author":"van Heel","year":"2007","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.cyto.2017.07.009_b0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ng.102","article-title":"Newly identified genetic risk variants for celiac disease related to the immune response","volume":"40","author":"Hunt","year":"2008","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.cyto.2017.07.009_b0035","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ng.543","article-title":"Multiple common variants for celiac disease influencing immune gene expression","volume":"42","author":"Dubois","year":"2010","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.cyto.2017.07.009_b0040","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.cyto.2017.07.009_b0045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000369521","article-title":"Interleukin-15, a master piece in the immunological jigsaw of celiac disease","volume":"33","author":"Meresse","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.cyto.2017.07.009_b0050","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/1471-230X-14-176","article-title":"Potential blood-based markers of celiac disease","volume":"14","author":"Bragde","year":"2014","journal-title":"BMC Gastroenterol."},{"issue":"12","key":"10.1016\/j.cyto.2017.07.009_b0055","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nri3919","article-title":"IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction","volume":"15","author":"Jabri","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"21","key":"10.1016\/j.cyto.2017.07.009_b0060","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.febslet.2005.07.066","article-title":"Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins","volume":"579","author":"Sander","year":"2005","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.009_b0065","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/jidsymp.2013.8","article-title":"The biology of IL-15: implications for cancer therapy and the treatment of autoimmune disorders","volume":"16","author":"Waldmann","year":"2013","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"10.1016\/j.cyto.2017.07.009_b0070","first-page":"6","article-title":"Current and emerging therapy for celiac disease","volume":"1","author":"Makharia","year":"2014","journal-title":"Front Med (Lausanne)"},{"issue":"7","key":"10.1016\/j.cyto.2017.07.009_b0075","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.4049\/jimmunol.164.7.3608","article-title":"IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production","volume":"164","author":"Liu","year":"2000","journal-title":"J. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.cyto.2017.07.009_b0080","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.imlet.2011.04.013","article-title":"IL-15 promotes osteoclastogenesis via the PLD pathway in rheumatoid arthritis","volume":"139","author":"Park","year":"2011","journal-title":"Immunol. Lett."},{"issue":"4","key":"10.1016\/j.cyto.2017.07.009_b0085","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.4049\/jimmunol.165.4.2240","article-title":"Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis?","volume":"165","author":"Ruckert","year":"2000","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.009_b0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cytogfr.2010.09.003","article-title":"Role of IL-15 in immune-mediated and infectious diseases","volume":"22","author":"Di Sabatino","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"issue":"33","key":"10.1016\/j.cyto.2017.07.009_b0095","doi-asserted-by":"crossref","first-page":"13534","DOI":"10.1073\/pnas.1312911110","article-title":"Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Ralpha","volume":"110","author":"Chen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.cyto.2017.07.009_b0100","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/rheumatology\/40.8.876","article-title":"Serum interleukin-15 is elevated in systemic lupus erythematosus","volume":"40","author":"Aringer","year":"2001","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.cyto.2017.07.009_b0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.expneurol.2009.12.034","article-title":"Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice","volume":"222","author":"Gomez-Nicola","year":"2010","journal-title":"Exp. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.cyto.2017.07.009_b0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneuroim.2010.04.001","article-title":"Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis","volume":"223","author":"Wu","year":"2010","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.cyto.2017.07.009_b0115","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.0022-202X.2004.22607.x","article-title":"Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population","volume":"122","author":"Sagoo","year":"2004","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.cyto.2017.07.009_b0120","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1038\/sj.jid.5700896","article-title":"Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population","volume":"127","author":"Zhang","year":"2007","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.cyto.2017.07.009_b0125","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.gene.2013.12.008","article-title":"Association of BANK1 and cytokine gene polymorphisms with type 1 diabetes in Tunisia","volume":"536","author":"Zouidi","year":"2014","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.cyto.2017.07.009_b0130","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11033-014-3067-z","article-title":"Association of the interleukin 15 (IL-15) gene polymorphisms with the risk of developing ulcerative colitis in Mexican individuals","volume":"41","author":"Yamamoto-Furusho","year":"2014","journal-title":"Mol. Biol. Rep."},{"issue":"10","key":"10.1016\/j.cyto.2017.07.009_b0135","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1136\/annrheumdis-2011-200724","article-title":"Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study","volume":"71","author":"Knevel","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.cyto.2017.07.009_b0140","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Revised criteria for diagnosis of coeliac disease. Report of working group of European society of paediatric gastroenterology and nutrition","volume":"65","author":"Walker-Smith","year":"1990","journal-title":"Arch. Dis. Child"},{"issue":"2","key":"10.1016\/j.cyto.2017.07.009_b0145","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.cyto.2017.07.009_b0150","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.009_b0155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Royal Stat. Soc."},{"issue":"15","key":"10.1016\/j.cyto.2017.07.009_b0160","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1128\/MCB.02178-07","article-title":"How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)\/IL-15 receptor alpha","volume":"28","author":"Duitman","year":"2008","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.009_b0165","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/jmg.2008.061457","article-title":"Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease","volume":"46","author":"Romanos","year":"2009","journal-title":"J. Med. Genet."},{"issue":"9","key":"10.1016\/j.cyto.2017.07.009_b0170","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/jmg.2009.067041","article-title":"Association of IL18RAP and CCR3 with coeliac disease in the Spanish population","volume":"46","author":"Dema","year":"2009","journal-title":"J. Med. Genet."},{"issue":"7","key":"10.1016\/j.cyto.2017.07.009_b0175","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/jmg.2011.089714","article-title":"Revisiting genome wide association studies (GWAS) in coeliac disease: replication study in Spanish population and expression analysis of candidate genes","volume":"48","author":"Plaza-Izurieta","year":"2011","journal-title":"J. Med. Genet."},{"issue":"21","key":"10.1016\/j.cyto.2017.07.009_b0180","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1093\/hmg\/ddp364","article-title":"Replication of celiac disease UK genome-wide association study results in a US population","volume":"18","author":"Garner","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.009_b0185","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/gene.2009.67","article-title":"Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort","volume":"11","author":"Amundsen","year":"2010","journal-title":"Genes Immun."},{"key":"10.1016\/j.cyto.2017.07.009_b0190","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","article-title":"Integration of genetic and immunological insights into a model of celiac disease pathogenesis","volume":"29","author":"Abadie","year":"2011","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.009_b0195","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/imr.12191","article-title":"IL-15: a central regulator of celiac disease immunopathology","volume":"260","author":"Abadie","year":"2014","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.cyto.2017.07.009_b0200","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/ajh.20431","article-title":"Differential effect of IL-15 and IL-2 on survival of phytohemagglutinin-activated umbilical cord blood T cells","volume":"80","author":"Lin","year":"2005","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.cyto.2017.07.009_b0205","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2249.2008.03743.x","article-title":"Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients","volume":"154","author":"Bernardo","year":"2008","journal-title":"Clin. Exp. Immunol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617302090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617302090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T18:41:33Z","timestamp":1719340893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466617302090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":41,"alternative-id":["S1043466617302090"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2017.07.009","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of the IL-15 and IL-15R\u03b1 genes with celiac disease","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2017.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}