{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:51:13Z","timestamp":1760921473041,"version":"build-2065373602"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Research Council of Lithuania for National Research Programme","award":["LIG 05\/2012"],"award-info":[{"award-number":["LIG 05\/2012"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.cyto.2017.11.019","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T02:38:30Z","timestamp":1512527910000},"page":"70-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Investigation of TGF\u03b2R2 SNP rs4522809, Osteopontin, TGF \u03b21 and their association with dilatative pathology of ascending thoracic aorta"],"prefix":"10.1016","volume":"107","author":[{"given":"Zivile","family":"Staneviciute","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramune","family":"Sepetiene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6117-6307","authenticated-orcid":false,"given":"Ingrida","family":"Grabauskyte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaiva","family":"Patamsyte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaiva","family":"Lesauskaite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"1997","series-title":"Pathophysiology of Heart Disease","author":"Lilly","key":"10.1016\/j.cyto.2017.11.019_b0005"},{"issue":"6","key":"10.1016\/j.cyto.2017.11.019_b0010","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/S0735-1097(03)00922-7","article-title":"Is aortic dilatation an atherosclerosis-related process? Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation","volume":"42","author":"Agmon","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.cyto.2017.11.019_b0015","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1083\/jcb.200608167","article-title":"Fibrillin-1 regulates the bioavailability of TGFbeta1","volume":"176","author":"Chaudhry","year":"2007","journal-title":"J. Cell Biol."},{"issue":"6027","key":"10.1016\/j.cyto.2017.11.019_b0020","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1192149","article-title":"Noncanonical TGF\u03b2 signaling contributes to aortic aneurysm progression in Marfan syndrome mice","volume":"332","author":"Holm","year":"2011","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.cyto.2017.11.019_b0025","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/CIRCULATIONAHA.108.841981","article-title":"Circulating transforming growth factor-\u03b2 in Marfan syndrome","volume":"120","author":"Matt","year":"2009","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.cyto.2017.11.019_b0030","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/clc.22320","article-title":"Total serum transforming growth factor-\u03b21 is elevated in the entire spectrum of genetic aortic syndromes","volume":"37","author":"Hillebrand","year":"2014","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.cyto.2017.11.019_b0035","doi-asserted-by":"crossref","unstructured":"B. Agg, K. Benke, B. Szilveszter, M. Polos, L. Daroczi, B. Odler et al., Possible extracardiac predictors of aortic dissection in Marfan syndrome. BMC Cardiovasc. Disord. 14 (2014) 47. Available from: http:\/\/www.biomedcentral.com\/1471-2261\/14\/47.","DOI":"10.1186\/1471-2261-14-47"},{"issue":"6","key":"10.1016\/j.cyto.2017.11.019_b0040","doi-asserted-by":"crossref","first-page":"e0129353","DOI":"10.1371\/journal.pone.0129353","article-title":"Blood plasma TGF- \u03b21 concentration in sporadic dilatative pathology of ascending aorta: more questions than answers","volume":"10","author":"Sepetiene","year":"2015","journal-title":"PLoS One"},{"issue":"6139","key":"10.1016\/j.cyto.2017.11.019_b0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/329539a0","article-title":"Two forms of transforming growth factor-beta distinguished by multipotential haematopoietic progenitor cells","volume":"329","author":"Ohta","year":"1987","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cyto.2017.11.019_b0050","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.exer.2004.08.018","article-title":"Comparative effects of TGF-beta 1 and TGF-beta 2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon\u2019s capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma","volume":"80","author":"Kottler","year":"2005","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.cyto.2017.11.019_b0055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1744-313X.2009.00855.x","article-title":"A genetic polymorphism in transforming growth factor beta receptor-2 is associated with serum osteopontin","volume":"36","author":"Biros","year":"2009","journal-title":"Int. J. Immunogenet."},{"issue":"1","key":"10.1016\/j.cyto.2017.11.019_b0060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/excr.2000.5074","article-title":"TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding elements","volume":"262","author":"Hullinger","year":"2001","journal-title":"Exp. Cell Res."},{"issue":"23","key":"10.1016\/j.cyto.2017.11.019_b0065","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1161\/CIRCULATIONAHA.108.802074","article-title":"Circulating markers of abdominal aortic aneurysm presence and progression","volume":"118","author":"Golledge","year":"2008","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.cyto.2017.11.019_b0070","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1053\/hupa.2001.27107","article-title":"Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors","volume":"32","author":"Lesauskaite","year":"2001","journal-title":"Hum. Pathol."},{"issue":"3","key":"10.1016\/j.cyto.2017.11.019_b0075","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucl. Acids Res."},{"issue":"2","key":"10.1016\/j.cyto.2017.11.019_b0080","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ejhg.2009.141","article-title":"Association of the TGF-\u03b2 receptor genes with abdominal aortic aneurysm","volume":"18","author":"Baas","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.cyto.2017.11.019_b0085","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5694\/j.1326-5377.2000.tb125684.x","article-title":"Screening for abdominal aortic aneurysm: lessons from a population-based study","volume":"173","author":"Jamrozik","year":"2000","journal-title":"Med. J. Aust."},{"issue":"12","key":"10.1016\/j.cyto.2017.11.019_b0090","doi-asserted-by":"crossref","first-page":"e8476","DOI":"10.1371\/journal.pone.0008476","article-title":"Plasma levels of transforming growth factor-\u03b21 reflect left ventricular remodeling in aortic stenosis","volume":"4","author":"Villar","year":"2009","journal-title":"PLoS One"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617303691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466617303691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:50:37Z","timestamp":1760907037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466617303691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":18,"alternative-id":["S1043466617303691"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2017.11.019","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of TGF\u03b2R2 SNP rs4522809, Osteopontin, TGF \u03b21 and their association with dilatative pathology of ascending thoracic aorta","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2017.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}