{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:50:55Z","timestamp":1765486255351,"version":"build-2065373602"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsches Zentrum f\u00fcr Diabetesforschung","award":["82DZD00601"],"award-info":[{"award-number":["82DZD00601"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.cyto.2018.10.012","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T19:31:07Z","timestamp":1540409467000},"page":"400-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150\u202fweeks of treatment"],"prefix":"10.1016","volume":"113","author":[{"given":"Janett","family":"P\u00fcschel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstanze","family":"Miehle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Villringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stumvoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Fasshauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiko","family":"Schl\u00f6gl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2018.10.012_b0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00125-009-1502-9","article-title":"Efficacy of leptin therapy in the different forms of human lipodystrophy","volume":"53","author":"Chong","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.cyto.2018.10.012_b0010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00108-010-2711-5","article-title":"Lipodystrophy","volume":"52","author":"Miehle","year":"2011","journal-title":"Mech., Clin. Presentation, Therapy, Internist (Berl.)"},{"key":"10.1016\/j.cyto.2018.10.012_b0015","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1210\/jc.2003-031868","article-title":"Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency","volume":"89","author":"McDuffie","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2018.10.012_b0020","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.2337\/db15-1550","article-title":"Leptin substitution in patients with lipodystrophy: neural correlates for long-term success in the normalization of eating behavior","volume":"65","author":"Schl\u00f6gl","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2018.10.012_b0025","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2018.10.012_b0030","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm.4145","article-title":"Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice","volume":"22","author":"Lee","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2018.10.012_b0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0022-3999(85)90010-8","article-title":"The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger","volume":"29","author":"Stunkard","year":"1985","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.cyto.2018.10.012_b0040","unstructured":"V. Pudel, J. Westh\u00f6fer, Fragebogen zum E\u00dfverhalten (FEV), G\u00f6ttingen, Toronto, Z\u00fcrich: Verlag f\u00fcr Psychologie Dr. C.J. Hogrefe, 1989."},{"year":"2006","series-title":"Inventar zum Essverhalten und Gewichtsproblemen (IEG)","author":"Diehl","key":"10.1016\/j.cyto.2018.10.012_b0045"},{"key":"10.1016\/j.cyto.2018.10.012_b0050","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1056\/NEJM199909163411204","article-title":"Effects of recombinant leptin therapy in a child with congenital leptin deficiency","volume":"341","author":"Farooqi","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2018.10.012_b0055","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1056\/NEJMoa012437","article-title":"Leptin-replacement therapy for lipodystrophy","volume":"346","author":"Oral","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2018.10.012_b0060","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.appet.2005.01.002","article-title":"Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy","volume":"45","author":"Williamson","year":"2005","journal-title":"Appetite"},{"key":"10.1016\/j.cyto.2018.10.012_b0065","doi-asserted-by":"crossref","first-page":"18276","DOI":"10.1073\/pnas.0706481104","article-title":"Leptin replacement alters brain response to food cues in genetically leptin-deficient adults","volume":"104","author":"Baicy","year":"2007","journal-title":"P.N.A.S."},{"key":"10.1016\/j.cyto.2018.10.012_b0070","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s12020-018-1589-1","article-title":"Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy","volume":"60","author":"Brown","year":"2018","journal-title":"Endocrine"},{"key":"10.1016\/j.cyto.2018.10.012_b0075","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12020-014-0450-4","article-title":"Recombinant human leptin treatment in genetic lipodystrophic syndromes: the long-term Spanish experience","volume":"49","author":"Araujo-Vilar","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.cyto.2018.10.012_b0080","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1210\/jc.2014-4491","article-title":"Partial and generalized lipodystrophy: Comparison of baseline characteristics and response to metreleptin","volume":"100","author":"Diker-Cohen","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2018.10.012_b0085","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4158\/EP11229.OR","article-title":"Clinical effects of long-term metreleptin treatment in patients with lipodystrophy","volume":"17","author":"Chan","year":"2011","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.cyto.2018.10.012_b0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/cen.12980","article-title":"Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy","volume":"85","author":"Chan","year":"2016","journal-title":"Clin. Endocrinol. (Oxf)"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466618304009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466618304009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:51:37Z","timestamp":1760907097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466618304009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":18,"alternative-id":["S1043466618304009"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2018.10.012","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150\u202fweeks of treatment","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2018.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}