{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:28:51Z","timestamp":1785364131535,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica de Argentina","doi-asserted-by":"publisher","award":["PICT 2014-866"],"award-info":[{"award-number":["PICT 2014-866"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010677","name":"INTA","doi-asserted-by":"publisher","award":["PNBIO 1131033"],"award-info":[{"award-number":["PNBIO 1131033"]}],"id":[{"id":"10.13039\/501100010677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.cyto.2018.11.024","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T09:32:15Z","timestamp":1542965535000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats"],"prefix":"10.1016","volume":"115","author":[{"given":"Ursula A.","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia C.","family":"Hasenauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E.","family":"Caffaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Raschia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Maurizio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector S.","family":"Cortez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto D.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A.","family":"Poli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-2521","authenticated-orcid":false,"given":"Carlos A.","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2018.11.024_b0005","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.ajpath.2015.03.003","article-title":"Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions","volume":"185","author":"de Figueiredo","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cyto.2018.11.024_b0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","article-title":"An overview of human brucellosis","volume":"21","author":"Young","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cyto.2018.11.024_b0015","article-title":"Caprine brucellosis: a historically neglected disease with significant impact on public health","volume":"11","author":"Rossetti","year":"2017","journal-title":"Rev. PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cyto.2018.11.024_b0020","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/QCO.0b013e3283638104","article-title":"Brucellosis in low-income and middle-income countries","volume":"26","author":"Rubach","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.cyto.2018.11.024_b0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1874318801004010061","article-title":"Natural resistance against brucellosis: a review","volume":"4","author":"Adams","year":"2010","journal-title":"Open Vet. Sci. J."},{"key":"10.1016\/j.cyto.2018.11.024_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023135","article-title":"MyD88 and STING signaling pathways are required for IRF3-mediated IFN-beta induction in response to Brucella abortus infection","volume":"6","author":"de Almeida","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2018.11.024_b0035","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.chom.2015.05.004","article-title":"The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy","volume":"17","author":"Watson","year":"2015","journal-title":"Cell Host Microbe."},{"key":"10.1016\/j.cyto.2018.11.024_b0040","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1371\/journal.pgen.0030152","article-title":"Irf3 polymorphism alters induction of interferon beta in response to Listeria monocytogenes infection","volume":"3","author":"Garifulin","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cyto.2018.11.024_b0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/hdy.2013.137","article-title":"Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis","volume":"112","author":"Bermingham","year":"2014","journal-title":"Heredity (Edinb)"},{"key":"10.1016\/j.cyto.2018.11.024_b0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vetmic.2017.06.001","article-title":"A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats","volume":"207","author":"Rossi","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.cyto.2018.11.024_b0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12711-016-0197-x","article-title":"A genome-wide association study for genetic susceptibility to Mycobacterium bovis infection in dairy cattle identifies a susceptibility QTL on chromosome 23","volume":"48","author":"Richardson","year":"2016","journal-title":"Genet. Sel. Evol."},{"key":"10.1016\/j.cyto.2018.11.024_b0060","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/gene.2013.48","article-title":"The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis","volume":"14","author":"Capparelli","year":"2013","journal-title":"Genes Immun."},{"key":"10.1016\/j.cyto.2018.11.024_b0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4238\/vol10-1gmr980","article-title":"Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population","volume":"10","author":"Zhang","year":"2011","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.cyto.2018.11.024_b0070","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2016.06.064","article-title":"Brucella TIR-like protein TcpB\/Btp1 specifically targets the host adaptor protein MAL\/TIRAP to promote infection","volume":"477","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cyto.2018.11.024_b0075","doi-asserted-by":"crossref","first-page":"956","DOI":"10.4049\/jimmunol.0902008","article-title":"Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL","volume":"184","author":"Sengupta","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2018.11.024_b0080","doi-asserted-by":"crossref","first-page":"28049","DOI":"10.1074\/jbc.M113.491555","article-title":"Interplay between clathrin and Rab5 controls the early phagocytic trafficking and intracellular survival of Brucella abortus within HeLa cells","volume":"288","author":"Lee","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2018.11.024_b0085","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1462-5822.2002.00221.x","article-title":"Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking","volume":"4","author":"Chaves-Olarte","year":"2002","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cyto.2018.11.024_b0090","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.vetimm.2014.05.007","article-title":"Polymorphisms at the 3\u2032 untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats","volume":"160","author":"Iacoboni","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.cyto.2018.11.024_b0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2915.2007.00677.x","article-title":"Using fluorescently labelled M13-tailed primers to isolate 45 novel microsatellite loci from the arboviral vector Culex tarsalis","volume":"21","author":"Venkatesan","year":"2007","journal-title":"Med. Vet. Entomol."},{"key":"10.1016\/j.cyto.2018.11.024_b0100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nprot.2010.182","article-title":"Basic statistical analysis in genetic case-control studies","volume":"6","author":"Clarke","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cyto.2018.11.024_b0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cyto.2018.11.024_b0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0378-1119(02)00386-4","article-title":"Genomic organization and differential expression of Kalirin isoforms","volume":"284","author":"McPherson","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.cyto.2018.11.024_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101712","article-title":"MicroRNA in control of gene expression: an overview of nuclear functions","volume":"17","author":"Catalanotto","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2018.11.024_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003529","article-title":"Gene expression regulation by upstream open reading frames and human disease","volume":"9","author":"Barbosa","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cyto.2018.11.024_b0125","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1073\/pnas.0810916106","article-title":"Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans","volume":"106","author":"Calvo","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cyto.2018.11.024_b0130","doi-asserted-by":"crossref","first-page":"16927","DOI":"10.1074\/jbc.R116.733899","article-title":"Upstream open reading frames differentially regulate gene-specific translation in the integrated stress response","volume":"291","author":"Young","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2018.11.024_b0135","series-title":"Genetic Association Studies: Background, Conduct, Analysis, Interpretation, Garland Science","author":"Dorak","year":"2017"},{"key":"10.1016\/j.cyto.2018.11.024_b0140","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1128\/iai.58.4.879-886.1990","article-title":"Ability of mononuclear phagocytes from cattle naturally resistant or susceptible to brucellosis to control in vitro intracellular survival of Brucella abortus","volume":"58","author":"Price","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cyto.2018.11.024_b0145","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1128\/IAI.74.4.2115-2120.2006","article-title":"Genetic resistance to Brucella abortus in the water buffalo (Bubalus bubalis)","volume":"74","author":"Borriello","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cyto.2018.11.024_b0150","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cell.2015.12.027","article-title":"alpha and beta type 1 interferon signaling: Passage for diverse biologic outcomes","volume":"164","author":"Ng","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2018.11.024_b0155","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cyto.2015.11.012","article-title":"Interferon-\u03b2 gene transfer inhibits melanoma cells adhesion and migration","volume":"89","author":"Rossi","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2018.11.024_b0160","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri1684","article-title":"The Yin and Yang of type I interferon activity in bacterial infection","volume":"5","author":"Decker","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2018.11.024_b0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2005.12.003","article-title":"Recognition of cytosolic DNA activates an IRF3-dependent innate immune response","volume":"24","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2018.11.024_b0170","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I inteferon gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"Honda","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2018.11.024_b0175","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3389\/fmicb.2017.01275","article-title":"Systems biology analysis of temporal in vivo Brucella melitensis and bovine transcriptomes predicts host:pathogen protein\u2013protein interactions","volume":"8","author":"Rossetti","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cyto.2018.11.024_b0180","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.biocel.2013.04.020","article-title":"A perspective on mammalian upstream open reading frame function","volume":"45","author":"Somers","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cyto.2018.11.024_b0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrg1270","article-title":"The complex interplay among factors that influence allelic association","volume":"5","author":"Zondervan","year":"2004","journal-title":"Nat. Rev. Genet."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466618304423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466618304423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:51:54Z","timestamp":1760907114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466618304423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":37,"alternative-id":["S1043466618304423"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2018.11.024","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2018.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}