{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:08:43Z","timestamp":1787756923337,"version":"build-2784847793"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2013 FAPESP","doi-asserted-by":"publisher","award":["2010\/16162-1"],"award-info":[{"award-number":["2010\/16162-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2013 FAPESP","doi-asserted-by":"publisher","award":["#2013\/26381-0"],"award-info":[{"award-number":["#2013\/26381-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.cyto.2018.12.019","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T17:45:56Z","timestamp":1548438356000},"page":"27-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis"],"prefix":"10.1016","volume":"116","author":[{"given":"E.S.","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B.","family":"C\u00e9sar-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7307-0283","authenticated-orcid":false,"given":"E.","family":"Albuquerque-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S.","family":"Rebeis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Holzhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Pannuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-7538","authenticated-orcid":false,"given":"L.","family":"Saraiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2018.12.019_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1902\/annals.1999.4.1.53","article-title":"Consensus report \u2013 aggressive periodontitis","volume":"4","author":"Lang","year":"1999","journal-title":"Ann. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0015","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1902\/jop.2011.110432","article-title":"Effectiveness of systemic amoxicillin\/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis","volume":"83","author":"Sgolastra","year":"2012","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0020","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/jre.12252","article-title":"Non-surgical periodontal therapy with systemic antibiotics in patients with untreatedaggressive periodontitis: a systematic review and meta-analysis","volume":"50","author":"Keestra","year":"2015","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.cyto.2018.12.019_b0025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/jcpe.12427","article-title":"Systemic antibiotics in the treatment of aggressive periodontitis. A systematic review and a Bayesian Network meta-analysis","volume":"42","author":"Rabelo","year":"2015","journal-title":"J. Clin. Periodontol."},{"issue":"65","key":"10.1016\/j.cyto.2018.12.019_b0030","first-page":"27","article-title":"Epidemiology and demographics of aggressive periodontitis","volume":"2014","author":"Susin","year":"2000","journal-title":"Periodontol"},{"issue":"75","key":"10.1016\/j.cyto.2018.12.019_b0035","first-page":"79","article-title":"Host response in aggressive periodontitis","volume":"2014","author":"Kulkarni","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.cyto.2018.12.019_b0040","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1902\/jop.2001.72.11.1463","article-title":"Associations between serum antibody levels to periodontal pathogens and early-onset periodontitis","volume":"72","author":"Albandar","year":"2001","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0045","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1399-302X.2008.00483.x","article-title":"Evaluation of the humoral immune response to the cytolethal distending toxin of Aggregatibacter actinomycetemcomitans Y4 in subjects with localized aggressive periodontitis","volume":"24","author":"Xynogala","year":"2009","journal-title":"Oral Microbiol. Immun."},{"key":"10.1016\/j.cyto.2018.12.019_b0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/0022034509353397","article-title":"Hyper-responsive phenotype in localized aggressive periodontitis","volume":"89","author":"Shaddox","year":"2010","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cyto.2018.12.019_b0055","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1177\/0022034516631973","article-title":"Inflammatory response influences treatment of localized aggressive periodontitis","volume":"95","author":"Cruz-Almeida","year":"2016","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cyto.2018.12.019_b0060","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1590\/1679-775720130252","article-title":"Leukotoxicity of Aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in Brazilians and their family members","volume":"21","author":"Silveira","year":"2013","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.cyto.2018.12.019_b0065","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/jcpe.12299","article-title":"Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial","volume":"41","author":"Guerrero","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0070","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/jcpe.12296","article-title":"IgG sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross-sectional study of selected pocket sites","volume":"41","author":"Saraiva","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0075","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/00016357.2017.1372623","article-title":"Cytokine profile in gingival crevicular fluid and plasma of patients with aggressive periodontitis","volume":"75","author":"Zein Elabdeen","year":"2017","journal-title":"Acta Odontol. Scand"},{"key":"10.1016\/j.cyto.2018.12.019_b0080","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1902\/jop.1990.61.3.180","article-title":"Neutrophil surface protein markers as indicators of defective chemotaxis in LJP","volume":"61","author":"DykeTE","year":"1990","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0085","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.12659\/MSM.896979","article-title":"Evaluation of ICAM-1 and VCAM-1 Gene polymorphisms in patients with periodontal disease","volume":"22","author":"Wang","year":"2016","journal-title":"Med. Sci. Monit."},{"issue":"7 Suppl","key":"10.1016\/j.cyto.2018.12.019_b0090","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2007.060264","article-title":"Case definitions for use in population-based surveillance of periodontitis","volume":"78","author":"Page","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0095","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1902\/jop.2012.110664","article-title":"Update of the case definitions for population-based surveillance of periodontitis","volume":"83","author":"Eke","year":"2012","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0100","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1177\/0022034513495242","article-title":"LPS-induced inflammatory response after therapy of aggressiveperiodontitis","volume":"92","author":"Shaddox","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cyto.2018.12.019_b0105","doi-asserted-by":"crossref","DOI":"10.1002\/JPER.17-0687","article-title":"Immunological and microbiological periodontal profiles in isolated growth hormone deficiency","author":"Ara\u00fajo","year":"2018","journal-title":"J. Periodontol."},{"issue":"Suppl 1","key":"10.1016\/j.cyto.2018.12.019_b0110","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/JPER.17-0719","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0115","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/jcpe.12853","article-title":"Definition of aggressive periodontitis in periodontal research. A systematic review","volume":"45","author":"Ram\u00edrez","year":"2018","journal-title":"J. Clin. Periodontol."},{"issue":"65","key":"10.1016\/j.cyto.2018.12.019_b0120","first-page":"79","article-title":"Host response in aggressive periodontitis","volume":"2014","author":"Kulkarni","year":"2000","journal-title":"Periodontol"},{"issue":"65","key":"10.1016\/j.cyto.2018.12.019_b0125","first-page":"107","article-title":"Treatment of aggressive periodontitis","volume":"2014","author":"Teughels","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.cyto.2018.12.019_b0130","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/IAI.27.1.124-132.1980","article-title":"Neutrophil chemotaxis dysfunction in human periodontitis","volume":"27","author":"Van Dyke","year":"1980","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cyto.2018.12.019_b0135","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1902\/jop.2003.74.4.475","article-title":"Mutations of F110 and C126 of the formyl peptide receptor interfere with G-protein coupling and chemotaxis","volume":"74","author":"Jones","year":"2003","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0140","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.4049\/jimmunol.172.3.1856","article-title":"A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage","volume":"172","author":"Gronert","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2018.12.019_b0145","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1902\/jop.1998.69.11.1299","article-title":"The correlation of gingival crevicular fluid interleukin-8 levels and periodontal status in localized juvenile periodontitis","volume":"69","author":"Ozmeri\u00e7","year":"1998","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0150","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nri2356","article-title":"Colony-stimulating factors in inflammation and autoimmunity","volume":"8","author":"Hamilton","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2018.12.019_b0155","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1189\/jlb.3RU0316-144R","article-title":"Biologicalrole of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage","volume":"100","author":"Ushach","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cyto.2018.12.019_b0160","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/jir.2014.0149","article-title":"Dual role of GM-CSF as a pro-inflammatory and a regulatory cytokine: implications for immune therapy","volume":"35","author":"Bhattacharya","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.cyto.2018.12.019_b0165","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.168.4.1395","article-title":"Keratinocyte growth regulation by the products of immune cells","volume":"168","author":"HancockGE","year":"1988","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2018.12.019_b0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1734-1140(09)70004-0","article-title":"ICAM-1 signaling in endothelial cells","volume":"61","author":"Lawson","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cyto.2018.12.019_b0175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12866-014-0229-z","article-title":"TNF-\u03b1 augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1","volume":"14","author":"Kato","year":"2014","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.cyto.2018.12.019_b0180","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1902\/jop.2007.060286","article-title":"Influence of periodontal therapy on the regulation of soluble cell adhesion molecule expression in aggressive periodontitis patients","volume":"78","author":"Pischon","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0185","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fimmu.2015.00285","article-title":"CXCL8- The first chemokine","volume":"6","author":"Baggiolini","year":"2015","journal-title":"Front Immunol."},{"key":"10.1016\/j.cyto.2018.12.019_b0190","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1177\/0022034511413928","article-title":"Local inflammatory markers and systemic endotoxin inaggressive periodontitis","volume":"90","author":"Shaddox","year":"2011","journal-title":"J. Dent. Res."},{"issue":"75","key":"10.1016\/j.cyto.2018.12.019_b0195","first-page":"116","article-title":"Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later","volume":"2017","author":"Hajishengallis","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.cyto.2018.12.019_b0200","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0306-9877(92)90056-I","article-title":"A localized absence of interleukin-4 triggers periodontal disease activity: a novel hypothesis","volume":"39","author":"Shapira","year":"1992","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.cyto.2018.12.019_b0205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.cyto.2006.07.020","article-title":"Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: a preliminary report","volume":"35","author":"Bozkurt","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2018.12.019_b0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169870","article-title":"Functional haplotypes in interleukin 4 gene associated with periodontitis","volume":"12","author":"Anovazzi","year":"2017","journal-title":"Plos One"},{"key":"10.1016\/j.cyto.2018.12.019_b0215","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fimmu.2011.00057","article-title":"Modulation of macrophage efferocytosis in inflammation","volume":"2","author":"Korns","year":"2011","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2018.12.019_b0220","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1189\/jlb.0108014","article-title":"Characterization of CD4+ CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis","volume":"84","author":"Cardoso","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cyto.2018.12.019_b0225","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/154405910508400711","article-title":"Regulatory T-cells infiltrate periodontal disease tissues","volume":"84","author":"Nakajima","year":"2005","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cyto.2018.12.019_b0230","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.archoralbio.2016.08.020","article-title":"Biomarker levels in gingival crevicular fluid of subjects with different periodontal conditions: a cross-sectional study","volume":"72","author":"Zhang","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.cyto.2018.12.019_b0235","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.4049\/jimmunol.0804165","article-title":"IL-10 suppresses calcium-mediated costimulation of receptor activator NFkappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression","volume":"183","author":"Park-Min","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2018.12.019_b0240","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1902\/jop.2013.130002","article-title":"Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis","volume":"84","author":"Gon\u00e7alves","year":"2013","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0245","first-page":"811","article-title":"The use of 2 antibiotic regimens in aggressive periodontitis: comparison of changes in clinical parameters and gingival crevicular fluid biomarkers","volume":"39","author":"Machtei","year":"2008","journal-title":"Quintessence Int."},{"key":"10.1016\/j.cyto.2018.12.019_b0250","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1600-051X.2011.01817.x","article-title":"Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects","volume":"39","author":"de Lima Oliveira","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.cyto.2018.12.019_b0255","first-page":"281","article-title":"Amoxicillin\/metronidazole associated with nonsurgical therapy did not promote additional benefits in immunologic parameters in generalized aggressive periodontitis: a randomized controlled clinical trial","volume":"47","author":"Taiete","year":"2016","journal-title":"Quintessence Int."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619300079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619300079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T06:14:12Z","timestamp":1606198452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466619300079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":51,"alternative-id":["S1043466619300079"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2018.12.019","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2018.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}