{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:12:48Z","timestamp":1778584368072,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["APQ- 1703-2.11\/15"],"award-info":[{"award-number":["APQ- 1703-2.11\/15"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["441584\/2014-4"],"award-info":[{"award-number":["441584\/2014-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.cyto.2019.154784","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T23:43:09Z","timestamp":1563838989000},"page":"154784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Study of association of the rs2275913 IL-17A single nucleotide polymorphism and susceptibility to cutaneous leishmaniasis caused by Leishmania braziliensis"],"prefix":"10.1016","volume":"123","author":[{"given":"Su\u00eania da Cunha","family":"Gon\u00e7alves de Albuquerque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00edntia Nascimento","family":"da Costa Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Vaitkevicius-Ant\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carla","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Feitosa","family":"Luna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virg\u00ednia Maria Barros","family":"de Lorena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"de Paiva-Cavalcanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cyto.2019.154784_b0005","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2019.154784_b0010","first-page":"587","article-title":"Cutaneous leishmaniasis","volume":"7","author":"Reithinger","year":"2007","journal-title":"Lancet Infect. Dies."},{"issue":"3","key":"10.1016\/j.cyto.2019.154784_b0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4269\/ajtmh.2012.11-0378","article-title":"Epidemiological and clinical changes in American tegumentary leishmaniasis in an area of Leishmania (viannia) braziliensis transmission over a 20-year period","volume":"86","author":"Jirmanus","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.cyto.2019.154784_b0020","first-page":"1","article-title":"Cutaneous leishmaniasis: immune responses in protection and pathogenesis","volume":"7","author":"Scott","year":"2016","journal-title":"Nat Rev Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2019.154784_b0025","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00281-012-0350-8","article-title":"Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis","volume":"34","author":"Soong","year":"2012","journal-title":"Semm. Immunopathol."},{"issue":"2","key":"10.1016\/j.cyto.2019.154784_b0030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1084\/jem.20061886","article-title":"CD4+CD25-Foxp3- Th1 cells are source of IL-10 \u2013 mediated immune suppression in chronic cutaneous leishmaniasis","volume":"204","author":"Anderson","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2019.154784_b0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1155\/2010\/719361","article-title":"The prominent role of neutrophils during the initial phase of infection by leishmania parasites","volume":"2010","author":"Charmoy","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"issue":"3","key":"10.1016\/j.cyto.2019.154784_b0040","doi-asserted-by":"crossref","first-page":"e1003243","DOI":"10.1371\/journal.ppat.1003243","article-title":"IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection","volume":"9","author":"Gonzalez-Lombana","year":"2013","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.cyto.2019.154784_b0045","first-page":"1","article-title":"Th17 cells in human disease","volume":"23","author":"Tesmer","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cyto.2019.154784_b0050","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.cyto.2019.154784_b0055","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.4049\/jimmunol.0804024","article-title":"IL-27 regulates IL-10 and IL-17 from CD4+ cells in non-healing Leishmania major infection","volume":"183","author":"Anderson","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0060","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.4049\/jimmunol.180.11.7537","article-title":"Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses","volume":"180","author":"Vargas-inchaustegui","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0065","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-3024.2010.01256.x","article-title":"IL-17 and regulatory cytokines (IL-10 and IL-27) in L. braziliensis infection","volume":"33","author":"Novoa","year":"2011","journal-title":"Paras. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2019.154784_b0070","doi-asserted-by":"crossref","first-page":"e1006587","DOI":"10.1371\/journal.pgen.1006587","article-title":"Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease","volume":"13","author":"Soderquest","year":"2017","journal-title":"PLoS Genet."},{"issue":"50","key":"10.1016\/j.cyto.2019.154784_b0075","doi-asserted-by":"crossref","first-page":"52762","DOI":"10.1074\/jbc.M405764200","article-title":"Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17","volume":"279","author":"Liu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2019.154784_b0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.alit.2017.05.010","article-title":"IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy","volume":"67","author":"Holster","year":"2018","journal-title":"Allergol. Int."},{"key":"10.1016\/j.cyto.2019.154784_b0085","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/rheumatology\/ken512","article-title":"Association analysis of the interleukin 17A gene in caucasian rheumatoid arthritis patients from Norway and New Zealand","volume":"48","author":"Gry","year":"2009","journal-title":"Rheumatol."},{"key":"10.1016\/j.cyto.2019.154784_b0090","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10875-007-9125-8","article-title":"The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis","volume":"28","author":"Arisawa","year":"2008","journal-title":"J. Clin. Immunol."},{"issue":"10","key":"10.1016\/j.cyto.2019.154784_b0095","doi-asserted-by":"crossref","first-page":"e26229","DOI":"10.1371\/journal.pone.0026229","article-title":"A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation","volume":"6","author":"Espinoza","year":"2011","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.cyto.2019.154784_b0100","doi-asserted-by":"crossref","first-page":"e0147814","DOI":"10.1371\/journal.pone.0147814","article-title":"Single nucleotide polymorphisms in IL17A and IL6 are associated with decreased risk for pulmonary tuberculosis in southern Brazilian population","volume":"11","author":"Milano","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cyto.2019.154784_b0105","doi-asserted-by":"crossref","first-page":"40666","DOI":"10.1038\/srep40666","article-title":"The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina","volume":"7","author":"Rolandelli","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cyto.2019.154784_b0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11684-015-0388-9","article-title":"Th17 Cells in autoimmune diseases","volume":"9","author":"Han","year":"2015","journal-title":"Front. Med."},{"issue":"8","key":"10.1016\/j.cyto.2019.154784_b0115","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/gene.2015.42","article-title":"Investigation of the role of IL17A gene variants in Chagas disease","volume":"16","author":"Rodriguez","year":"2015","journal-title":"Genes Immun."},{"key":"10.1016\/j.cyto.2019.154784_b0120","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.3389\/fimmu.2017.01437","article-title":"The equivocal role of Th17 cells and neutrophils on immunopathogenesis of Leishmaniasis","volume":"8","author":"Gon\u00e7alves-de-Albuquerque","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0125","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13578-015-0021-2","article-title":"Leishmaniases diagnosis: an update on the use of immunological and molecular tools","volume":"5","author":"Paiva-Cavalcanti","year":"2015","journal-title":"Cell Biosci."},{"key":"10.1016\/j.cyto.2019.154784_b0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1678-9199-20-16","volume":"20","author":"Gon\u00e7alves-de-Albuquerque","year":"2014","journal-title":"J. Ven. Anim. Tox. incl. Trop. Dis."},{"key":"10.1016\/j.cyto.2019.154784_b0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.mcp.2013.01.003","article-title":"Quantitative real time PCR assays for the detection of Leishmania (Viannia) braziliensis in animals and humans","volume":"27","author":"Paiva-Cavalcanti","year":"2013","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.cyto.2019.154784_b0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/ijc.25027","article-title":"Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer","volume":"127","author":"Wu","year":"2010","journal-title":"Int. J. Cancer"},{"issue":"5","key":"10.1016\/j.cyto.2019.154784_b0145","doi-asserted-by":"crossref","first-page":"e92708","DOI":"10.1371\/journal.pone.0092708","article-title":"In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis","volume":"9","author":"Chamakh-Ayari","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cyto.2019.154784_b0150","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cyto.2019.154784_b0155","series-title":"Epi Info, Version 6.04, a word processing, database, and statistics program for public health on IBM-compatible microcomputers","first-page":"1","author":"Dean","year":"1996"},{"key":"10.1016\/j.cyto.2019.154784_b0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00038-008-7068-3","article-title":"When to use the odds ratio or the relative risk?","volume":"53","author":"Schmidt","year":"2008","journal-title":"Int. J. Public Health"},{"issue":"8","key":"10.1016\/j.cyto.2019.154784_b0165","first-page":"2379","article-title":"IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani","volume":"119","author":"Pitta","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.cyto.2019.154784_b0170","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/infdis\/jis771","article-title":"Successful therapy of visceral leishmaniasis with curdlan involves T-helper 17 cytokines","volume":"207","author":"Ghosh","year":"2013","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cyto.2019.154784_b0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1086\/599380","article-title":"Interleukin 17 production among patients with American cutaneous leishmaniasis","volume":"200","author":"Bacellar","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cyto.2019.154784_b0180","first-page":"519","article-title":"IL6 174 G\/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil","volume":"194","author":"Castellucci","year":"2006","journal-title":"J. Ven Anim. Tox. Incl. Trop. Dis."},{"key":"10.1016\/j.cyto.2019.154784_b0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2350-11-10","article-title":"CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study","volume":"11","author":"Castellucci","year":"2010","journal-title":"BMC Med. Gen."},{"key":"10.1016\/j.cyto.2019.154784_b0190","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1084\/jem.182.5.1259","article-title":"Polymorphism in tumor necrosis factor genes associated with mucocutaneous Leishmaniasis","volume":"182","author":"Cabrera","year":"1995","journal-title":"J. Exp. Med."},{"issue":"1159\u20131168","key":"10.1016\/j.cyto.2019.154784_b0195","first-page":"1995","article-title":"Human genetic susceptibility and Infection with Leishmania peruviana","volume":"57","author":"Shaw","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cyto.2019.154784_b0200","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00436-007-0562-3","article-title":"Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters","volume":"12","author":"Singh","year":"2007","journal-title":"Parasitol. Res."},{"issue":"5","key":"10.1016\/j.cyto.2019.154784_b0205","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s12603-014-0019-1","article-title":"Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity","volume":"18","author":"Addison","year":"2014","journal-title":"J. Nutr. Health. Ag."},{"issue":"3","key":"10.1016\/j.cyto.2019.154784_b0210","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1590\/S0074-02762004000300001","article-title":"Clinical and immunopathological spectrum of American cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review","volume":"99","author":"Silveira","year":"2004","journal-title":"Mem. Inst. Osw. Cruz"},{"issue":"2","key":"10.1016\/j.cyto.2019.154784_b0215","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4049\/jimmunol.0900047","article-title":"IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection","volume":"185","author":"Miyazaki","year":"2010","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2019.154784_b0220","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.imbio.2012.10.005","article-title":"IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment","volume":"218","author":"Erdmann","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/j.cyto.2019.154784_b0225","first-page":"46","article-title":"Alternative Th17 and CD4 CD25 FoxP3 cells frequency increase and correlate with worse cardiac function in Chagas cardiomyopathy","volume":"12","author":"Almeida","year":"2018","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0230","doi-asserted-by":"crossref","first-page":"33900","DOI":"10.1038\/srep33900","article-title":"IL-22 is rapidly induced by pathogen recognition receptors stimulation in bone-marrow-derived dendritic cells in the absence of IL-23","volume":"6","author":"Fumagalli","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2019.154784_b0235","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10875-010-9391-8","article-title":"The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis","volume":"30","author":"Chen","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0240","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1002\/eji.200940115","article-title":"Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines","volume":"40","author":"Boaventura","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0245","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fimmu.2012.00080","article-title":"T helper 1\/T helper 2 cells and resistance\/susceptibility to Leishmania infection: is this paradigm still relevant?","volume":"3","author":"Alexander","year":"2012","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2019.154784_b0250","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jaci.2005.12.1346","article-title":"IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity","volume":"117","author":"Kawaguchi","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0255","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1002\/eji.201040384","article-title":"Murine model of chronic L. (Viannia) panamensis infection: role of IL-13 in disease","volume":"40","author":"Castilho","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2019.154784_b0260","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.4049\/jimmunol.0713598","article-title":"IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice","volume":"182","author":"Lopez-Kostka","year":"2009","journal-title":"J. Immunol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:28:34Z","timestamp":1778581714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466619302133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":52,"alternative-id":["S1043466619302133"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154784","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study of association of the rs2275913 IL-17A single nucleotide polymorphism and susceptibility to cutaneous leishmaniasis caused by Leishmania braziliensis","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154784"}}