{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:41:20Z","timestamp":1790808080733,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["062.01954\/2015"],"award-info":[{"award-number":["062.01954\/2015"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.cyto.2019.154788","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T17:00:50Z","timestamp":1564160450000},"page":"154788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["A polymorphism in the IL1B gene (rs16944 T\/C) is associated with cutaneous leishmaniasis caused by Leishmania guyanensis and plasma cytokine interleukin receptor antagonist"],"prefix":"10.1016","volume":"123","author":[{"given":"George Allan Villarouco","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirza Gabrielle Ramos","family":"de Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helia Valeria","family":"de Souza Encarna\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"do Esp\u00edrito Santo Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"da Costa Sabino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"de Aguiar Neres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim Assad","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara L\u00facia Gomes","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u00e9sio","family":"Talhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-1996","authenticated-orcid":false,"given":"Rajendranath","family":"Ramasawmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2019.154788_b0005","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/0974-777X.62881","article-title":"Leishmaniasis vaccine: where are we today?","volume":"2","author":"Kedzierski","year":"2010","journal-title":"J Glob. Infect. Dis."},{"key":"10.1016\/j.cyto.2019.154788_b0010","unstructured":"Center for Disease Control and Prevention. Parasites- Leishmaniasis: Epidemiology and Risk Factors. CDC Web site. Updated January 10, 2013.Accessed November 20, 2016. <http:\/\/www.cdc.gov\/parasites\/leishmaniasis\/epi.html>."},{"key":"10.1016\/j.cyto.2019.154788_b0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.0105-2896.2004.00185.x","article-title":"Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice","volume":"201","author":"Sacks","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cyto.2019.154788_b0020","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1172\/JCI79526","article-title":"An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis","volume":"125","author":"Gurung","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2019.154788_b0025","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nm.3221","article-title":"Inflammasome-derived IL-1\u00df production induces nitric oxide-mediated resistance to Leishmania","volume":"19","author":"Lima-Junior","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2019.154788_b0030","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/eji.201546015","article-title":"The Nlrp3 inflammasome, IL-1\u00df, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL\/6 mice","volume":"46","author":"Charmoy","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0035","doi-asserted-by":"crossref","first-page":"e1006196","DOI":"10.1371\/journal.ppat.1006196","article-title":"CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1\u00df production","volume":"13","author":"Novais","year":"2017","journal-title":"Plos Pathog."},{"key":"10.1016\/j.cyto.2019.154788_b0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/jid.2014.305","article-title":"Genomic profiling of human Leishmaniabrasilienzis lesions identifies transcriptional modules associated with cutaneous immunopathology","volume":"135","author":"Novais","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cyto.2019.154788_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001533","article-title":"Disease severity in patients infected with Leishmaniamexicana relates to IL-1\u00df","volume":"6","author":"Fern\u00e1ndez-Figueroa","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cyto.2019.154788_b0050","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2019.154788_b0055","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Ann. Rev. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0060","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1365-2362.1992.tb01480.x","article-title":"A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro","volume":"22","author":"Pociot","year":"1992","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.cyto.2019.154788_b0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-3083.1998.00300.x","article-title":"Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1beta production in vitro","volume":"47","author":"Santtila","year":"1998","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0070","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/molehr\/gag076","article-title":"In-vitro secretion of proinflammatory cytokines by human amniochorion carrying hyper-responsive gene polymorphisms of tumour necrosis factor-alpha and interleukin-1beta","volume":"9","author":"Hernandez-Guerrero","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.cyto.2019.154788_b0075","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.gene.6364128","article-title":"Cis-acting effect of the IL1B C-31T polymorphism on IL-1 beta mRNA expression","volume":"5","author":"Kimura","year":"2004","journal-title":"Genes Immun."},{"key":"10.1016\/j.cyto.2019.154788_b0080","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1046\/j.1365-3083.2002.01161.x","article-title":"Polymorphisms in interleukin-1beta and interleukin-1 receptor antagonist genes and malaria in Ghanaian children","volume":"56","author":"Gyan","year":"2002","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0085","first-page":"985","article-title":"Lack of association between the IL1B (-511 and +3954), IL1RN VNTR polymorphisms and tuberculosis risk: A meta-analysis","volume":"193","author":"Huang","year":"2015","journal-title":"Lug."},{"key":"10.1016\/j.cyto.2019.154788_b0090","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.humimm.2006.06.004","article-title":"Interleukin-1 gene cluster polymorphism in chagas disease in a Colombian case-control study","volume":"67","author":"Fl\u00f3rez","year":"2006","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0095","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3748\/wjg.v10.i12.1826","article-title":"Polymorphisms of interleukin-1B and interleukin-1 receptor antagonist genes in patients with chronic hepatitis B","volume":"10","author":"Zhang","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cyto.2019.154788_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humimm.2014.12.013","article-title":"Association between interleukin 1 receptor antagonist gene 86-bp VNTR polymorphism and sepsis: a meta-analysis","volume":"76","author":"Fang","year":"2015","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0105","doi-asserted-by":"crossref","first-page":"e1004572","DOI":"10.1371\/journal.pgen.1004572","article-title":"Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals","volume":"10","author":"Ruiz-Linares","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cyto.2019.154788_b0110","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1128\/JCM.41.7.3147-3153.2003","article-title":"Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysis","volume":"41","author":"Marfurt","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.cyto.2019.154788_b0115","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/JCM.42.5.2294-2297.2004","article-title":"Culture-independent species typing of neotropicalLeishmania for clinical validation of a PCR-based assay targeting heat shock protein 70 genes","volume":"42","author":"Garcia","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.cyto.2019.154788_b0120","series-title":"Molecular cloning: a laboratory manual. Cold Spring Harbor 2","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.cyto.2019.154788_b0125","unstructured":"TDR. Disease Watch Focus: Leishmaniasis, Nat. Rev. Microbiol. (internet), <www.who.int\/tdr\/publications\/disease_watch\/leish\/en\/>."},{"key":"10.1016\/j.cyto.2019.154788_b0130","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1371\/journal.pntd.0000313","article-title":"Complexities of assessing the disease burden attributable to leishmaniasis","volume":"2","author":"Bern","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cyto.2019.154788_b0135","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)61340-X","article-title":"Global, regional, and national disability-adjusted life years (DALYS) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990\u20132013: quantifying the epidemiological transition","volume":"386","author":"Murray","year":"2015","journal-title":"Lanc."},{"key":"10.1016\/j.cyto.2019.154788_b0140","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0145","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of Nod-like receptors in microbial recognition and host defense","volume":"227","author":"Franchi","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cyto.2019.154788_b0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0155","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1007\/s11033-012-1517-z","article-title":"IL-1\u00df (-511T\/C) gene polymorphism not IL-1\u00df (+3953T\/C) and LT-a (+252A\/G) gene variants confers susceptibility to visceral leishmaniasis","volume":"39","author":"Moravej","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.cyto.2019.154788_b0160","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/sj.ejhg.5201084","article-title":"Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study","volume":"12","author":"Walley","year":"2004","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.cyto.2019.154788_b0165","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1475-2875-4-38","article-title":"A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand","volume":"4","author":"Ohashi","year":"2005","journal-title":"Malar. J."},{"key":"10.1016\/j.cyto.2019.154788_b0170","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/sj.gene.6364393","article-title":"Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels","volume":"8","author":"Rafiq","year":"2007","journal-title":"Genes Immun."},{"key":"10.1016\/j.cyto.2019.154788_b0175","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.gene.6364133","article-title":"Interleukin-1beta polymorphisms in Colombian patients with autoimmune rheumatic diseases","volume":"5","author":"Camargo","year":"2004","journal-title":"Genes Immun."},{"key":"10.1016\/j.cyto.2019.154788_b0180","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1161\/01.ATV.0000150039.60906.02","article-title":"Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro","volume":"25","author":"Iacoviello","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cyto.2019.154788_b0185","doi-asserted-by":"crossref","first-page":"10791","DOI":"10.1038\/ncomms10791","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis","volume":"7","author":"Iannitti","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2019.154788_b0190","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/intimm\/dxq006","article-title":"IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB\/c mice","volume":"22","author":"Voronov","year":"2010","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cyto.2019.154788_b0195","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0625.2010.01172.x","article-title":"IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice","volume":"20","author":"Kautz-Neu","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.cyto.2019.154788_b0200","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.immuni.2010.07.018","article-title":"Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis","volume":"33","author":"Chou","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2019.154788_b0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/0976-237X.188560","article-title":"Interaction of IL1B and IL1RN polymorphisms, smoking habit, gender, and ethnicity with aggressive and chronic periodontitis susceptibility","volume":"7","author":"Ribeiro","year":"2016","journal-title":"Contemp. Clin. Dent."},{"key":"10.1016\/j.cyto.2019.154788_b0210","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1042\/bj3520913","article-title":"Cross-talk between interleukin 1beta (IL-1beta) and IL-6 signalling pathways: IL-1beta selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism","volume":"3","author":"Shen","year":"2000","journal-title":"Biochem. J."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:39:54Z","timestamp":1778794794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466619302170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":42,"alternative-id":["S1043466619302170"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154788","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A polymorphism in the IL1B gene (rs16944 T\/C) is associated with cutaneous leishmaniasis caused by Leishmania guyanensis and plasma cytokine interleukin receptor antagonist","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154788"}}