{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:35:45Z","timestamp":1762324545933,"version":"build-2065373602"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"DST-SERB","doi-asserted-by":"publisher","award":["SB-YS-LS-60\/2013"],"award-info":[{"award-number":["SB-YS-LS-60\/2013"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Genotypic Technology Pvt. Ltd, Bangalore-India"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.cyto.2019.154815","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T12:46:24Z","timestamp":1567169184000},"page":"154815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["TNF-alpha regulates alternative splicing of genes participating in pathways of crucial metabolic syndromes; a transcriptome wide study"],"prefix":"10.1016","volume":"125","author":[{"given":"Jiss Maria","family":"Louis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candida","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Advait","family":"Balaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Tanavde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9444-630X","authenticated-orcid":false,"given":"Indrani","family":"Talukdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2019.154815_b0005","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2019.154815_b0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.cyto.2019.154815_b0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2337\/diab.46.1.3","article-title":"Role of fatty acids in the pathogenesis of insulin resistance and NIDDM","volume":"46","author":"Boden","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2019.154815_b0020","doi-asserted-by":"crossref","first-page":"50230","DOI":"10.1074\/jbc.M200958200","article-title":"Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle","volume":"277","author":"Yu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2019.154815_b0025","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2019.154815_b0030","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/diabetes.48.6.1270","article-title":"Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade","volume":"48","author":"Griffin","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2019.154815_b0035","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1172\/JCI200422230","article-title":"PKC-\u03b8 knockout mice are protected from fat-induced insulin resistance","volume":"114","author":"Kim","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2019.154815_b0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","article-title":"Erratum: absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","author":"Um","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2019.154815_b0045","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","article-title":"Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of ikkbeta","volume":"293","author":"Yuan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cyto.2019.154815_b0050","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","author":"Guilherme","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cyto.2019.154815_b0055","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1016\/S0021-9258(18)42251-X","article-title":"Transcriptional repression of the C\/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis","volume":"267","author":"Stephens","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2019.154815_b0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/039463201302600106","article-title":"CD1d-associated expression of NF-\u03baB and cardiac dysfunction in diabetic and obese mice","volume":"26","author":"Madonna","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.cyto.2019.154815_b0065","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0301-0082(01)00007-7","article-title":"Alternative RNA splicing in the nervous system","volume":"65","author":"Grabowski","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cyto.2019.154815_b0070","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cyto.2019.154815_b0075","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060614-034316","article-title":"Mechanisms and regulation of alternative pre-mRNA splicing","volume":"84","author":"Lee","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cyto.2019.154815_b0080","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2777","article-title":"Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches","volume":"10","author":"Chen","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cyto.2019.154815_b0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1261\/rna.043893.113","article-title":"SR proteins control a complex network of RNA-processing events","volume":"21","author":"Bradley","year":"2015","journal-title":"RNA"},{"key":"10.1016\/j.cyto.2019.154815_b0090","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/jc.2002-020666","article-title":"Tumor necrosis factor-\u03b1-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-\u03baB activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression","volume":"88","author":"Sakamoto","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2019.154815_b0095","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/jcb.21562","article-title":"Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression","volume":"103","author":"Yang","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cyto.2019.154815_b0100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-0042-116157","article-title":"Elevated steroid hormone production in the db\/db mouse model of obesity and type 2 diabetes","volume":"49","author":"Hofmann","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.cyto.2019.154815_b0105","first-page":"1","article-title":"Comparative analysis and classification of cassette exons and constitutive exons","volume":"2017","author":"Cui","year":"2017","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.cyto.2019.154815_b0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13073-015-0168-9","article-title":"Widespread intron retention diversifies most cancer transcriptomes","volume":"7","author":"Dvinge","year":"2015","journal-title":"Genome Med."},{"issue":"1","key":"10.1016\/j.cyto.2019.154815_b0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-07238-0","article-title":"T2DiACoD: a gene atlas of type 2 diabetes mellitus associated complex disorders","volume":"7","author":"Rani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2019.154815_b0120","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db14-0703","article-title":"Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk","volume":"64","author":"Segr\u00e8","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2019.154815_b0125","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/mt.2008.85","article-title":"An endogenous TNF-\u03b1 antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models","volume":"16","author":"Graziewicz","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cyto.2019.154815_b0130","doi-asserted-by":"crossref","first-page":"R162","DOI":"10.1093\/hmg\/ddl181","article-title":"RNA-dominant diseases","volume":"15","author":"Osborne","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cyto.2019.154815_b0135","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nature Biotechnol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:56:23Z","timestamp":1760907383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466619302443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":27,"alternative-id":["S1043466619302443"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154815","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TNF-alpha regulates alternative splicing of genes participating in pathways of crucial metabolic syndromes; a transcriptome wide study","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154815","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154815"}}