{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:58:26Z","timestamp":1793656706720,"version":"4.5.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.cyto.2019.154829","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T13:43:10Z","timestamp":1566999790000},"page":"154829","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"C","title":["Thermal stability of cytokines: A review"],"prefix":"10.1016","volume":"125","author":[{"given":"Samantha","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Kaislasuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Guller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2019.154829_b0005","series-title":"Human Cytokines: Their Role in Disease and Therapy","author":"Aggarwal","year":"1995"},{"key":"10.1016\/j.cyto.2019.154829_b0010","first-page":"8","article-title":"Cytokines and signaling molecules predict clinical outcomes in sepsis","volume":"14","author":"Fjell","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2019.154829_b0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0920-9964(98)00034-6","article-title":"The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6","volume":"32","author":"Lin","year":"1998","journal-title":"Schizophrenia Res."},{"key":"10.1016\/j.cyto.2019.154829_b0020","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF03339794","article-title":"Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer\u2019s disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increase serum interleukin-6 in DAT","volume":"10","author":"Bonaccorso","year":"1998","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.cyto.2019.154829_b0025","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.2215\/CJN.11051011","article-title":"Derivation and validation of a cytokine-based assay to screen for acute rejection in renal transplant recipients","volume":"7","author":"De Serres","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cyto.2019.154829_b0030","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0196-0644(05)80051-4","article-title":"Utility of interleukin-6 for diagnosis of invasive bacterial disease","volume":"21","author":"Saladino","year":"1992","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.cyto.2019.154829_b0035","unstructured":"M. Dy, A. Vazquez, J. Bertoglio, J. Th\u00e9ze, General aspects of cytokine properties and functions. The cytokine network and immune functions, Jacques Th\u00e9ze, Oxford University Press, Oxford, 1999."},{"key":"10.1016\/j.cyto.2019.154829_b0040","unstructured":"A. Wuyts, S. Struyf, P. Proost, J. Van Damme, \u201cChemokines.\u201d The cytokine network and immune functions, Jacques Th\u00e9ze, Oxford University Press, Oxford, 1999."},{"key":"10.1016\/j.cyto.2019.154829_b0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1383-5742(02)00090-X","article-title":"Biological sample collection and processing for molecular epidemiological studies","volume":"543","author":"Holland","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cyto.2019.154829_b0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ymeth.2013.01.003","article-title":"Utility, reliability and reproducibility of immunoassay multiplex kits","volume":"61","author":"Tighe","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.cyto.2019.154829_b0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ymeth.2013.04.005","article-title":"Cytokine assays: an assessment of the preparation and treatment of blood and tissue samples","volume":"61","author":"Keustermans","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.cyto.2019.154829_b0060","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/clinchem\/35.1.146","article-title":"Solving the problem of antibody interference in commercial sandwich immunoassays of carcinoembryonic antigen","volume":"35","author":"Hansen","year":"1989","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cyto.2019.154829_b0065","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2172-10-52","article-title":"Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays","volume":"10","author":"de Jager","year":"2009","journal-title":"BMC Immunol."},{"key":"10.1016\/j.cyto.2019.154829_b0070","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cyto.2017.05.014","article-title":"Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of the 27 multiplex assayed cytokines \u2013 consequences for defining reference values in healthy humans","volume":"97","author":"Henn\u00f8","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2019.154829_b0075","article-title":"Effect of storage duration on cytokine stability in human serum and plasma","author":"Vincent","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2019.154829_b0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2019.154829_b0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.smim.2016.10.010","article-title":"Blood coagulation in immunothrombosis \u2013 at the frontline of intravascular immunity","volume":"28","author":"Gartner","year":"2016","journal-title":"Sem. Immunol."},{"key":"10.1016\/j.cyto.2019.154829_b0090","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jpba.2004.05.024","article-title":"Development, validation, and the implementation of a multiplex immunoassay for the simultaneous determination of five cytokines in human serum","volume":"36","author":"Ray","year":"2005","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.cyto.2019.154829_b0095","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0022-1759(92)90313-I","article-title":"Measuring cytokine levels in blood","volume":"153","author":"Thavasu","year":"1992","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cyto.2019.154829_b0100","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.4155\/bio.15.57","article-title":"When close is not close enough: a comparison of endogenous and recombinant biomarker stability samples","volume":"7","author":"Fraser","year":"2015","journal-title":"Bioanalysis"},{"key":"10.1016\/j.cyto.2019.154829_b0105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-1759(92)90314-J","article-title":"Influence of collection and separation of blood samples on plasma IL-1, IL-6 and TNF-\u03b1 concentrations","volume":"153","author":"Riches","year":"1992","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cyto.2019.154829_b0110","doi-asserted-by":"crossref","first-page":"e38290","DOI":"10.1371\/journal.pone.0038290","article-title":"The effect of pre-analytical variability on the measurement of MRM-MS-Based mid- to high-abundance plasma protein biomarkers and a panel of cytokines","volume":"7","author":"Aguilar-Mahecha","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2019.154829_b0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CDLI.6.1.89-95.1999","article-title":"Variables that affect assays for plasma cytokines and soluble activation markers","volume":"6","author":"Aziz","year":"1999","journal-title":"Clin. Diag. Lab. Immunol."},{"key":"10.1016\/j.cyto.2019.154829_b0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cyto.2016.05.010","article-title":"Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions","volume":"84","author":"Aziz","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2019.154829_b0125","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/00365513.2016.1230882","article-title":"An evaluation of multiplex bead-based analysis of cytokines and soluble proteins in archived lithium heparin plasma, EDTA plasma, and serum samples","volume":"76","author":"Br\u00f8ndum","year":"2016","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.cyto.2019.154829_b0130","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1515\/CCLM.2007.160","article-title":"Serum biobank certification and the establishment of quality controls for biological fluids: examples of serum biomarker stability after temperature variation","volume":"45","author":"Chaigneau","year":"2007","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cyto.2019.154829_b0135","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1006\/cyto.2000.0764","article-title":"Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-\u03b1 and leptin","volume":"12","author":"Flower","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2019.154829_b0140","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.5858\/132.11.1802","article-title":"Stability of tumor necrosis factor \u03b1, interleukin 6, and interleukin 8 in blood samples of patients with systemic immune activation","volume":"132","author":"Friebe","year":"2008","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.cyto.2019.154829_b0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12967-017-1154-3","article-title":"Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies","volume":"15","author":"Graham","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cyto.2019.154829_b0150","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3892\/mmr.2013.1263","article-title":"Clinical evaluation of the levels of 12 cytokines in serum\/plasma under various storage conditions using evidence biochip arrays","volume":"7","author":"Guo","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cyto.2019.154829_b0155","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3109\/13547500903340570","article-title":"Stability and reproducibility of simultaneously detected plasma and serum cytokine levels in asymptomatic subjects","volume":"15","author":"Hosnijieh","year":"2010","journal-title":"Biomarkers"},{"key":"10.1016\/j.cyto.2019.154829_b0160","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cyto.2017.02.016","article-title":"Impact of freeze-thaw cycles on circulating inflammation marker measurements","volume":"95","author":"Huang","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2019.154829_b0165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1043-4666(02)91961-7","article-title":"Stability of interleukin 6, soluble interleukin 6 receptor, interleukin 10 and CC16 in human serum","volume":"19","author":"Kenis","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2019.154829_b0170","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/SHK.0000000000000805","article-title":"Effects of transport temperature on the stability of inflammatory, hemostasis, endothelial function, and oxidative stress plasma biomarker concentrations","volume":"47","author":"Palmer","year":"2017","journal-title":"Shock"},{"key":"10.1016\/j.cyto.2019.154829_b0175","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/890706","article-title":"Mulitplex cytokine concentration measurement: How much do the medium and handling matter?","author":"Parkitny","year":"2013","journal-title":"Mediators of Inflamm"},{"key":"10.1016\/j.cyto.2019.154829_b0180","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jim.2008.04.006","article-title":"Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples","volume":"336","author":"Skogstrand","year":"2008","journal-title":"J. Immunol. Methods"},{"issue":"6","key":"10.1016\/j.cyto.2019.154829_b0185","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1089\/bio.2017.0001","article-title":"Influence of storage and inter- and intra-assay variability on the measurement of inflammatory biomarkers in population-based biobanking","volume":"15","author":"van Waateringe","year":"2017","journal-title":"Biopres. Biobank"},{"key":"10.1016\/j.cyto.2019.154829_b0190","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1515\/cclm-2013-0705","article-title":"Effect of biobanking conditions on short-term stability of biomarkers in human serum and plasma","volume":"52","author":"Zander","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cyto.2019.154829_b0195","unstructured":"A. Mantovani, The interleukin-1 system. The cytokine network and immune functions, Jacques Th\u00e9ze, Oxford University Press, Oxford, 1999."},{"key":"10.1016\/j.cyto.2019.154829_b0200","unstructured":"H. Okamura, M.T. Lotze, H. Tsutsui, S. Kashiwamura, H. Ueda, T. Yoshimoto, K. Nakanishi, \u201cInterleukin-18.\u201d The Cytokine Handbook. fourth ed. Michael T Lotze, Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0205","doi-asserted-by":"crossref","unstructured":"J. Vilcek, The cytokines: An overview, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50005-3"},{"key":"10.1016\/j.cyto.2019.154829_b0210","doi-asserted-by":"crossref","unstructured":"T. Enzler, G. Dranoff, Granulocyte-macrophage colony-stimulating factor, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50025-9"},{"key":"10.1016\/j.cyto.2019.154829_b0215","unstructured":"C.C. Kok, G.T. Schwenger, R.I.W. Osmond, D.L. Urwin, C.J. Sanderson, \u201cInterlekin-5.\u201d. The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0220","doi-asserted-by":"crossref","unstructured":"J.X. Lin, W.J., Leonard, \u201cInterleukin-2.\u201d, The Cytokine Handbook, 4th ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50012-0"},{"key":"10.1016\/j.cyto.2019.154829_b0225","doi-asserted-by":"crossref","unstructured":"H. Okada, J. Banchereau, M.T. Lotz, \u201cInterleukin-4.\u201d The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50014-4"},{"key":"10.1016\/j.cyto.2019.154829_b0230","doi-asserted-by":"crossref","unstructured":"P.K.E. Trinder, M.J. Maeurer, \u201cInterleukin-7.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50017-X"},{"key":"10.1016\/j.cyto.2019.154829_b0235","unstructured":"J.C. Renauld, J. Van Snick, Interleuin-9, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0240","doi-asserted-by":"crossref","unstructured":"M.R. Shurin, I.L. Tourkova, H. Hackstein, G.V. Shurin, Interleukin-15 and 21.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50022-3"},{"key":"10.1016\/j.cyto.2019.154829_b0245","unstructured":"G. Gr\u00fcnig, J.E. de Vries, R. de Waal Malefyt, \u201cInterleukin-13.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze. Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0250","unstructured":"P. Kalinski, W.J. Storkus, A.W. Thomson, M.T. Lotze, Interleukin-12 Family. The Cytokine Handbook. fourth ed., Michael T Lotze, Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0255","doi-asserted-by":"crossref","unstructured":"S.M. White, D.J. Tweardy, \u201cGranulocyte colony-stimulating factor.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze. Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50026-0"},{"key":"10.1016\/j.cyto.2019.154829_b0260","unstructured":"J.M. Soos, B.E. Szente, \u201cType I interferons.\u201d The Cytokine Handbook, fourth ed., Michael T Lotze. Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0265","doi-asserted-by":"crossref","unstructured":"G.H. Schreiber, R.D. Schreiber, \u201cInterferon-\u0263\u201d. The Cytokine Handbook, 4th ed., Michael T Lotze. Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50028-4"},{"key":"10.1016\/j.cyto.2019.154829_b0270","doi-asserted-by":"crossref","unstructured":"Y.Z. Ding, S. Fu, D. Zamarin, J. Bromberg, \u201cInterleukin-10.\u201d The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50029-6"},{"key":"10.1016\/j.cyto.2019.154829_b0275","doi-asserted-by":"crossref","unstructured":"H. Wang, C.J. Czura, K.J. Tracey. \u201cTumor necrosis factor.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50039-9"},{"key":"10.1016\/j.cyto.2019.154829_b0280","doi-asserted-by":"crossref","unstructured":"S.W. Granger, C.F. Ware, \u201cLymphotoxins.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50038-7"},{"key":"10.1016\/j.cyto.2019.154829_b0285","doi-asserted-by":"crossref","unstructured":"N. Mukaida, S.A. Ketlinsky, K. Matsushima, \u201cInterleukin-8 and other CXC chemokines.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50050-8"},{"key":"10.1016\/j.cyto.2019.154829_b0290","doi-asserted-by":"crossref","unstructured":"K.C. Wilson, D.M. Center, W.W. Cruikshank, \u201cInterleukin-16.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50023-5"},{"key":"10.1016\/j.cyto.2019.154829_b0295","unstructured":"T. Kishimoto, Interleukin-6 family, The Cytokine Handbook, 4th ed., Michael T Lotze. Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0300","doi-asserted-by":"crossref","unstructured":"D.C. Lee, C.L. Hinkle, L.F. Jackson, S. Li, S. Wohler Sunnarborg, \u201cEGF family ligands.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50045-4"},{"key":"10.1016\/j.cyto.2019.154829_b0305","unstructured":"M.A. Antonysamy, M. Numasaki, Interleukin-17, The Cytokine Handbook, fourth ed., Michael T Lotze. Academic Press, Chicago, 2003."},{"key":"10.1016\/j.cyto.2019.154829_b0310","unstructured":"R.J. Leichlader, A.B. Roberts, \u201cTransforming growth factor-\u03b2.\u201d, The cytokine network and immune functions. Jacques Th\u00e9ze. Oxford University Press, Oxford, 1999."},{"key":"10.1016\/j.cyto.2019.154829_b0315","doi-asserted-by":"crossref","unstructured":"D.I. Gabrilovich, M.M. Dikov, \u201cVascular endothelial growth factor.\u201d, The Cytokine Handbook, fourth ed., Michael T Lotze, Academic Press, Chicago, 2003.","DOI":"10.1016\/B978-012689663-3\/50048-X"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619302583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:56:02Z","timestamp":1760907362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466619302583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":63,"alternative-id":["S1043466619302583"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154829","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thermal stability of cytokines: A review","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154829","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"154829"}}