{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:16:34Z","timestamp":1773666994988,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.cyto.2019.154946","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T23:11:53Z","timestamp":1576019513000},"page":"154946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair"],"prefix":"10.1016","volume":"127","author":[{"given":"Priya","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogeshwar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-7280","authenticated-orcid":false,"given":"Sanjeev","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2019.154946_b0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cyto.2019.154946_b0010","doi-asserted-by":"crossref","first-page":"840","DOI":"10.4161\/auto.19693","article-title":"A new role for ATM: regulating mitochondrial function and mitophagy","volume":"8","author":"Valentin-Vega","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.cyto.2019.154946_b0015","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cyto.2019.154946_b0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2015.05.022","article-title":"Ataxia-telangiectasia \u2013 a historical review and a proposal for a new designation: ATM syndrome","volume":"355","author":"Teive","year":"2015","journal-title":"J. Neurol. Sci."},{"issue":"Mar","key":"10.1016\/j.cyto.2019.154946_b0025","article-title":"Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict hepatic regeneration","volume":"5","author":"Viswanathan","year":"2018","journal-title":"Cell Prolif."},{"key":"10.1016\/j.cyto.2019.154946_b0030","article-title":"Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells","author":"Yadav","year":"2018","journal-title":"Human Gene Therapy"},{"key":"10.1016\/j.cyto.2019.154946_b0035","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s10495-016-1295-5","article-title":"Mitochondrial dynamics during cell cycling","volume":"21","author":"Horbay","year":"2016","journal-title":"Apoptosis: Int. J. Program. Cell Death"},{"key":"10.1016\/j.cyto.2019.154946_b0040","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/MPG.0000000000001345","article-title":"Incidence of primary mitochondrial disease in children younger than 2 Years presenting with acute liver failure","volume":"63","author":"McKiernan","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.cyto.2019.154946_b0045","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ejmg.2016.08.012","article-title":"Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion","volume":"59","author":"Varma","year":"2016","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.cyto.2019.154946_b0050","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ajhg.2009.08.004","article-title":"Acute infantile liver failure due to mutations in the TRMU gene","volume":"85","author":"Zeharia","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cyto.2019.154946_b0055","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/MPG.0b013e31829ef4b4","article-title":"Reduced mitochondrial DNA content and heterozygous nuclear gene mutations in patients with acute liver failure","volume":"57","author":"Helbling","year":"2013","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.cyto.2019.154946_b0060","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1089\/adt.2014.571","article-title":"Evaluation of cytotoxicity and DNA damage response with analysis of intracellular ATM signaling pathways","volume":"12","author":"Bandi","year":"2014","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.cyto.2019.154946_b0065","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/CS20140100","article-title":"The ins and outs of fibroblast growth factor receptor signalling","volume":"127","author":"Coleman","year":"2014","journal-title":"Clin. Sci. (London, England: 1979)"},{"key":"10.1016\/j.cyto.2019.154946_b0070","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1038\/onc.2014.257","article-title":"VEGF drives cancer-initiating stem cells through VEGFR-2\/Stat3 signaling to upregulate Myc and Sox2","volume":"34","author":"Zhao","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.cyto.2019.154946_b0075","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1074\/jbc.RA118.002417","article-title":"Gain-of-function mutations in granulocyte colony-stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation","volume":"293","author":"Zhang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2019.154946_b0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12943-018-0796-y","article-title":"Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cyto.2019.154946_b0085","doi-asserted-by":"crossref","first-page":"T69","DOI":"10.1530\/JME-17-0311","article-title":"IGF1 receptor signaling pathways","volume":"61","author":"Hakuno","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.cyto.2019.154946_b0090","first-page":"764981","article-title":"Hepatic stellate cell coculture enables sorafenib resistance in Huh7 cells through HGF\/c-Met\/Akt and Jak2\/Stat3 pathways","volume":"2014","author":"Chen","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cyto.2019.154946_b0095","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1056\/NEJMoa1409002","article-title":"Ruxolitinib versus standard therapy for the treatment of polycythemia vera","volume":"372","author":"Vannucchi","year":"2015","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.cyto.2019.154946_b0100","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3835(98)00388-7","article-title":"Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines","volume":"136","author":"Gagandeep","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cyto.2019.154946_b0105","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1073\/pnas.062040199","article-title":"Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea","volume":"99","author":"Kubo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cyto.2019.154946_b0110","doi-asserted-by":"crossref","first-page":"e12445","DOI":"10.1111\/cpr.12445","article-title":"Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict liver regeneration","volume":"51","author":"Viswanathan","year":"2018","journal-title":"Cell Prolif."},{"key":"10.1016\/j.cyto.2019.154946_b0115","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1074\/jbc.M006190200","article-title":"Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia","volume":"276","author":"Gueven","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2019.154946_b0120","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2011.11.027","article-title":"Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure","volume":"142","author":"Garg","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2019.154946_b0125","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4049\/jimmunol.1500861","article-title":"G-CSF and GM-CSF in neutropenia","volume":"195","author":"Mehta","year":"2015","journal-title":"J. Immunol. (Baltimore, Md; 1950)"},{"key":"10.1016\/j.cyto.2019.154946_b0130","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/jnr.23362","article-title":"Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression","volume":"92","author":"Guo","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cyto.2019.154946_b0135","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/ajg.2014.154","article-title":"Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot study","volume":"109","author":"Singh","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.cyto.2019.154946_b0140","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai8710","article-title":"Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis","volume":"9","author":"Cao","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cyto.2019.154946_b0145","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature09493","article-title":"Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration","volume":"468","author":"Ding","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2019.154946_b0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yexmp.2013.10.017","article-title":"Nonselective inhibition of prostaglandin-endoperoxide synthases by naproxen ameliorates acute or chronic liver injury in animals","volume":"96","author":"Bahde","year":"2014","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.cyto.2019.154946_b0155","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1053\/j.gastro.2009.03.003","article-title":"Hepatic stellate cells promote hepatocyte engraftment in rat liver after prostaglandin-endoperoxide synthase inhibition","volume":"136","author":"Enami","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2019.154946_b0160","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41374-017-0010-7","article-title":"A humanized mouse model with liver fibrosis following expansion of transplanted hepatic stellate cells in injury and inflammation","volume":"98","author":"Benten","year":"2018","journal-title":"Lab Invest."},{"key":"10.1016\/j.cyto.2019.154946_b0165","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1002\/hep.29713","article-title":"Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure","volume":"67","author":"Kakabadze","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.cyto.2019.154946_b0170","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan1230","article-title":"TGFbeta inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence","volume":"10","author":"Bird","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cyto.2019.154946_b0175","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb3203","article-title":"Hepatic progenitor cells of biliary origin with liver repopulation capacity","volume":"17","author":"Lu","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cyto.2019.154946_b0180","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00204-011-0733-y","article-title":"Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism","volume":"86","author":"Lin","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cyto.2019.154946_b0185","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jhep.2016.11.017","article-title":"Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure","volume":"66","author":"Woolbright","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cyto.2019.154946_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051018","article-title":"Drug-induced liver injury: cascade of events leading to cell death, apoptosis or necrosis","volume":"18","author":"Iorga","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2019.154946_b0195","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.4049\/jimmunol.1600690","article-title":"Knockdown of RIPK1 markedly exacerbates murine immune-mediated liver injury through massive apoptosis of hepatocytes, independent of necroptosis and inhibition of NF-kappaB","volume":"197","author":"Suda","year":"2016","journal-title":"J. Immunol. (Baltimore, Md: 1950)"},{"key":"10.1016\/j.cyto.2019.154946_b0200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.toxlet.2014.01.005","article-title":"Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice","volume":"225","author":"Zhang","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cyto.2019.154946_b0205","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1046\/j.1365-2036.2002.01224.x","article-title":"Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose","volume":"16","author":"Schiodt","year":"2002","journal-title":"Aliment. Pharmacol. Therap."},{"key":"10.1016\/j.cyto.2019.154946_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2017.11.008","article-title":"E2F\/DP prevents cell-cycle progression in endocycling fat body cells by suppressing dATM expression","volume":"43","author":"Guarner","year":"2017","journal-title":"Develop. Cell"},{"key":"10.1016\/j.cyto.2019.154946_b0215","first-page":"104","article-title":"Portrait of the PI3K\/AKT pathway in colorectal cancer","volume":"1855","author":"Danielsen","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cyto.2019.154946_b0220","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1093\/hmg\/ddi333","article-title":"Impaired hepatocyte survival and liver regeneration in Atm-deficient mice","volume":"14","author":"Lu","year":"2005","journal-title":"Hum. Mol. Genet."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619303758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619303758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:55:51Z","timestamp":1760907351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466619303758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":44,"alternative-id":["S1043466619303758"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154946","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154946"}}