{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:55:11Z","timestamp":1790553311647,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007365","name":"Fondazione IRCCS Policlinico San Matteo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004769","name":"Universit\u00e0 degli Studi di Pavia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.cyto.2019.154947","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T23:17:44Z","timestamp":1575415064000},"page":"154947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Adipose tissue dysfunction and metabolic disorders: Is it possible to predict who will develop type 2 diabetes mellitus? Role of markErs in the progreSsion of dIabeteS in obese paTIeNts (The RESISTIN trial)"],"prefix":"10.1016","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-4760","authenticated-orcid":false,"given":"Giuseppe","family":"Derosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Catena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Maffioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2019.154947_b0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.beem.2013.02.005","article-title":"Adipose tissue dysfunction contributes to obesity related metabolic diseases","volume":"27","author":"Bluher","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2019.154947_b0010","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.physbeh.2007.10.010","article-title":"The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance","volume":"94","author":"Goossens","year":"2008","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.cyto.2019.154947_b0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000321319","article-title":"Brown versus white adipose tissue: a mini-review","volume":"58","author":"Saely","year":"2012","journal-title":"Gerontology"},{"issue":"4","key":"10.1016\/j.cyto.2019.154947_b0020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/ncb2922","article-title":"Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source","volume":"16","author":"Chau","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.cyto.2019.154947_b0025","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s10753-013-9620-4","article-title":"Adipocytokine levels in obese and non-obese subjects: an observational study","volume":"36","author":"Derosa","year":"2013","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.cyto.2019.154947_b0030","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00380-007-0989-6","article-title":"Comparison between metalloproteinases-2 and -9 in healthy subjects, diabetics, and subjects with acute coronary syndrome","volume":"22","author":"Derosa","year":"2007","journal-title":"Heart Vessels"},{"key":"10.1016\/j.cyto.2019.154947_b0035","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/39335","article-title":"Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function","volume":"389","author":"Uysal","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2019.154947_b0040","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1046\/j.1365-2796.1999.00490.x","article-title":"The role of TNF-alpha and TNF receptors in obesity and insulin resistance","volume":"245","author":"Hotamisligil","year":"1999","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.cyto.2019.154947_b0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.cyto.2019.154947_b0050","unstructured":"World Health Organization, Obesity: Preventing and Managing the Global Epidemic, Report of WHO Consultation on Obesity, Geneva, WHO, 1997."},{"key":"10.1016\/j.cyto.2019.154947_b0055","doi-asserted-by":"crossref","unstructured":"American Diabetes Association, Screening for diabetes (Position Statement), Diabetes Care, 2001; 24: S21-S24.uns.","DOI":"10.2337\/diacare.25.2007.S21"},{"key":"10.1016\/j.cyto.2019.154947_b0060","doi-asserted-by":"crossref","unstructured":"European Diabetes Policy Group 1999, A desktop guide to Type 2 diabetes mellitus, Diabet. Med., 16(9) (1999) 716\u2013730.","DOI":"10.1046\/j.1464-5491.1999.00166.x"},{"issue":"4","key":"10.1016\/j.cyto.2019.154947_b0065","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/BF01225569","article-title":"Determination of total serum insulin (IRI) in insulin-treated diabetic patients","volume":"8","author":"Heding","year":"1972","journal-title":"Diabetologia"},{"key":"10.1016\/j.cyto.2019.154947_b0070","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.cyto.2019.154947_b0075","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cyto.2019.154947_b0080","first-page":"121","article-title":"Enzymatische Bestimmung des Gesamtcholesterins mit dem [Enzymatic dosage of total cholesterolemia by Greiner Selective Analyzer (GSA II)]","volume":"15","author":"Klose","year":"1978","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.cyto.2019.154947_b0085","series-title":"Methods of Enzymatic Analysis","first-page":"18","article-title":"Triglycerides determination after enzymatic hydrolysis","author":"Wahlefeld","year":"1974"},{"key":"10.1016\/j.cyto.2019.154947_b0090","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI103182","article-title":"The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum","volume":"34","author":"Havel","year":"1955","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2019.154947_b0095","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low density lipoprotein in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cyto.2019.154947_b0100","first-page":"249","article-title":"Lipoprotein (a): structure, biology and clinical relevance","volume":"36","author":"Scanu","year":"1991","journal-title":"Adv. Intern. Med."},{"key":"10.1016\/j.cyto.2019.154947_b0105","first-page":"458","article-title":"Protein composition of lipoprotein (a)","volume":"80","author":"Uterman","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2019.154947_b0110","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2019.154947_b0115","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1210\/jc.2002-021604","article-title":"Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans","volume":"88","author":"Yannakoulia","year":"2003","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"12","key":"10.1016\/j.cyto.2019.154947_b0120","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/clinchem\/45.12.2136","article-title":"Clinical efficacy of an automated high-sensitivity C-reactive protein assay","volume":"45","author":"Rifai","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cyto.2019.154947_b0125","first-page":"540","article-title":"Leptin: its receptor and obesity","volume":"44","author":"Misra","year":"1996","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.cyto.2019.154947_b0130","series-title":"The Cytokine Handbook","author":"Zhang","year":"1988"},{"key":"10.1016\/j.cyto.2019.154947_b0135","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1210\/jc.2006-1249","article-title":"Retinol binding protein-4 and clinical features of type 2 diabetes patients","volume":"92","author":"Takebayashi","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2019.154947_b0140","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1073\/pnas.82.19.6480","volume":"82","author":"Cook","year":"1985","journal-title":"PNAS"},{"key":"10.1016\/j.cyto.2019.154947_b0145","doi-asserted-by":"crossref","first-page":"10610","DOI":"10.1073\/pnas.0504703102","article-title":"Visceral adipose tissue-derived serine protease inhibitor: a unique insulinsensitizing adipocytokine in obesity","volume":"102","author":"Hida","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cyto.2019.154947_b0150","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1210\/jc.2007-1304","article-title":"Molecular characteristics of serum visfatin and differential detection by immunoassays","volume":"92","author":"Korner","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.cyto.2019.154947_b0155","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/db06-1506","article-title":"Omentin plasma levels and gene expression are decreased in obesity","volume":"56","author":"De Souza Batista","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2019.154947_b0160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cmet.2007.08.010","article-title":"The rapidly expanding family of adipokines","volume":"6","author":"MacDougald","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.cyto.2019.154947_b0165","series-title":"Statistical Principles in Experimental Design","author":"Winer","year":"1971"},{"issue":"4","key":"10.1016\/j.cyto.2019.154947_b0170","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2337\/dc11-1659","article-title":"Screening for dysglycemia in overweight youth presenting for weight management","volume":"35","author":"Morrison","year":"2012","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.cyto.2019.154947_b0175","first-page":"S1041","article-title":"Serum level of orexin-A, leptin, adiponectin and insulin in north Indian obese women","volume":"11","author":"Mishra","year":"2017","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"2","key":"10.1016\/j.cyto.2019.154947_b0180","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2337\/dc08-1625","article-title":"Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts","volume":"32","author":"Chen","year":"2009","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1016\/j.cyto.2019.154947_b0185","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.2926","article-title":"The association between dysregulated adipocytokines in early pregnancy and development of Gestational Diabetes","volume":"33","author":"Abell","year":"2017","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"1","key":"10.1016\/j.cyto.2019.154947_b0190","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41598-017-18709-9","article-title":"Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.cyto.2019.154947_b0195","doi-asserted-by":"crossref","first-page":"e0182273","DOI":"10.1371\/journal.pone.0182273","article-title":"Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346661930376X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346661930376X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:55:11Z","timestamp":1760907311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104346661930376X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":39,"alternative-id":["S104346661930376X"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154947","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipose tissue dysfunction and metabolic disorders: Is it possible to predict who will develop type 2 diabetes mellitus? Role of markErs in the progreSsion of dIabeteS in obese paTIeNts (The RESISTIN trial)","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154947","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154947"}}