{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:18:30Z","timestamp":1761581910658,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.cyto.2019.154962","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T03:44:56Z","timestamp":1577936696000},"page":"154962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Association between IL-27 and Tr1 cells in severe form of paracoccidioidomycosis"],"prefix":"10.1016","volume":"127","author":[{"given":"L\u00edvia Moreira","family":"Genaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian de Oliveira","family":"Coser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amauri da Silva","family":"Justo-Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia Furquim","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Karine Fel\u00edcio","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Eug\u00eania","family":"Rizzato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pl\u00ednio","family":"Trabasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronei Luciano","family":"Mamoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Mendes","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Let\u00edcia","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Nunes","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Pereira","family":"Ruas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Heloisa de Souza Lima","family":"Blotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cyto.2019.154962_b0005","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1590\/0037-8682-0230-2017","article-title":"Brazilian guidelines for the clinical management of paracoccidioidomycosis","volume":"50","author":"Shikanai-Yasuda","year":"2017","journal-title":"Rev. Soc. Bras. Med. Trop."},{"issue":"3","key":"10.1016\/j.cyto.2019.154962_b0010","doi-asserted-by":"crossref","first-page":"390","DOI":"10.4269\/ajtmh.1999.61.390","article-title":"Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region","volume":"61","author":"Blotta","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"2","key":"10.1016\/j.cyto.2019.154962_b0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CMR.6.2.89","article-title":"Paracoccidioidomycosis: an update","volume":"6","author":"Brummer","year":"1993","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.cyto.2019.154962_b0020","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1590\/S0102-311X2002000500037","article-title":"Paracoccidioidomycosis mortality in Brazil (1980\u20131995)","volume":"18","author":"Coutinho","year":"2002","journal-title":"Cad Saude Publica"},{"issue":"2","key":"10.1016\/j.cyto.2019.154962_b0025","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1286-4579(01)01521-0","article-title":"Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls","volume":"4","author":"Oliveira","year":"2002","journal-title":"Microbes and infection\/Institut Pasteur"},{"issue":"2","key":"10.1016\/j.cyto.2019.154962_b0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/mmy.40.2.153.159","article-title":"Enhanced production of specific IgG4, IgE, IgA and TGF-beta in sera from patients with the juvenile form of paracoccidioidomycosis","volume":"40","author":"Mamoni","year":"2002","journal-title":"Med. Mycology"},{"issue":"4","key":"10.1016\/j.cyto.2019.154962_b0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/cyto.2000.0824","article-title":"Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis","volume":"13","author":"Benard","year":"2001","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.cyto.2019.154962_b0040","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jinf.2013.07.019","article-title":"Characterization of the immune response in human paracoccidioidomycosis","volume":"67","author":"de Castro","year":"2013","journal-title":"J. Infect."},{"issue":"4\u20135","key":"10.1016\/j.cyto.2019.154962_b0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11046-007-9065-0","article-title":"An overview of the immunopathology of human paracoccidioidomycosis","volume":"165","author":"Benard","year":"2008","journal-title":"Mycopathologia"},{"issue":"1","key":"10.1016\/j.cyto.2019.154962_b0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cyto.2005.07.006","article-title":"Kinetics of cytokines and chemokines gene expression distinguishes Paracoccidioides brasiliensis infection from disease","volume":"32","author":"Mamoni","year":"2005","journal-title":"Cytokine"},{"issue":"3\u20134","key":"10.1016\/j.cyto.2019.154962_b0055","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cyto.2006.08.005","article-title":"Flow-cytometric analysis of cytokine production in human paracoccidioidomycosis","volume":"35","author":"Mamoni","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2019.154962_b0060","unstructured":"Bennett, Macp, Dolin, Blaser, Martin, Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases, Elsevier, 2020."},{"issue":"6","key":"10.1016\/j.cyto.2019.154962_b0065","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3109\/13693786.2011.654135","article-title":"Treatment of severe forms of paracoccidioidomycosis: is there a role for corticosteroids?","volume":"50","author":"Benard","year":"2012","journal-title":"Med. Mycol."},{"issue":"9","key":"10.1016\/j.cyto.2019.154962_b0070","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.4049\/jimmunol.177.9.5811","article-title":"Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans","volume":"177","author":"Cavassani","year":"2006","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.cyto.2019.154962_b0075","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1128\/IAI.00487-10","article-title":"Involvement of regulatory T cells in the immunosuppression characteristic of patients with paracoccidioidomycosis","volume":"78","author":"Ferreira","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cyto.2019.154962_b0080","first-page":"1","article-title":"Regulatory T cells in paracoccidioidomycosis","author":"Calich","year":"2018","journal-title":"Virulence"},{"issue":"12","key":"10.1016\/j.cyto.2019.154962_b0085","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/myc.12226","article-title":"The relation between FoxP3(+) regulatory T cells and fungal density in oral paracoccidioidomycosis: a preliminary study","volume":"57","author":"Cardoso","year":"2014","journal-title":"Mycoses"},{"issue":"5","key":"10.1016\/j.cyto.2019.154962_b0090","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.4049\/jimmunol.180.5.3049","article-title":"CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression","volume":"180","author":"Moreira","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2019.154962_b0095","first-page":"S327","article-title":"Regulatory T cells in hepatitis C virus infection","author":"C. KM","year":"2007","journal-title":"Hepatology Res.: Official J. Japan Soc. Hepatology"},{"issue":"12","key":"10.1016\/j.cyto.2019.154962_b0100","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1089\/aid.2014.0356","article-title":"Increased frequency of CD49b\/LAG-3(+) Type 1 regulatory T cells in HIV-infected individuals","volume":"31","author":"Koch","year":"2015","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.cyto.2019.154962_b0105","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.4049\/jimmunol.172.10.5986","article-title":"IL-10- secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells","author":"Vieira PL","year":"2004","journal-title":"J. Immunology (Baltimore, Md : 1950)"},{"issue":"6652","key":"10.1016\/j.cyto.2019.154962_b0110","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","article-title":"A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis","volume":"389","author":"Groux","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2019.154962_b0115","first-page":"39","article-title":"Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications","volume":"380","author":"Roncarolo","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"5","key":"10.1016\/j.cyto.2019.154962_b0120","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/cmi.2015.44","article-title":"Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance","volume":"12","author":"Zeng","year":"2015","journal-title":"Cell. Mol. Immunol."},{"issue":"8","key":"10.1016\/j.cyto.2019.154962_b0125","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ni.2366","article-title":"IL-12 family cytokines: immunological playmakers","volume":"13","author":"Vignali","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2019.154962_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2018.05.019","article-title":"Emerging IL-12 family cytokines in the fight against fungal infections","author":"Thompson","year":"2018","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.cyto.2019.154962_b0135","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1074-7613(03)00300-5","article-title":"The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection","volume":"19","author":"Villarino","year":"2003","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.cyto.2019.154962_b0140","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni1375","article-title":"Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells","volume":"7","author":"Batten","year":"2006","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2019.154962_b0145","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/ni1541","article-title":"A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells","volume":"8","author":"Awasthi","year":"2007","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2019.154962_b0150","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/ni1537","article-title":"Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10","volume":"8","author":"Stumhofer","year":"2007","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2019.154962_b0155","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.4049\/jimmunol.0900568","article-title":"IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells","volume":"183","author":"Murugaiyan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2019.154962_b0160","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.0900735","article-title":"Differential effect of IL-27 on developing versus committed Th17 cells","volume":"183","author":"El-behi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2019.154962_b0165","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.smim.2011.08.003","article-title":"Induction of regulatory Tr1 cells and inhibition of Th17 cells by IL-27","volume":"23","author":"Pot","year":"2011","journal-title":"Semin. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2019.154962_b0170","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1086\/589774","article-title":"Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis","volume":"198","author":"Robinson","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"9","key":"10.1016\/j.cyto.2019.154962_b0175","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1084\/jem.20141520","article-title":"Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection","volume":"212","author":"Torrado","year":"2015","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.cyto.2019.154962_b0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/IAI.01091-13","article-title":"IL-27 receptor signaling regulates memory CD4+ T cell populations and suppresses rapid inflammatory responses during secondary malaria infection","volume":"82","author":"Gwyer Findlay","year":"2014","journal-title":"Infect. Immun."},{"issue":"6","key":"10.1016\/j.cyto.2019.154962_b0185","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.immuni.2012.11.003","article-title":"Interleukin-27: balancing protective and pathological immunity","volume":"37","author":"Hunter","year":"2012","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.cyto.2019.154962_b0190","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4049\/jimmunol.1501204","article-title":"IL-27 induced by select Candida spp. via TLR7\/NOD2 signaling and IFN-beta production inhibits fungal clearance","volume":"197","author":"Patin","year":"2016","journal-title":"J. Immunology (Baltimore, Md. : 1950)"},{"issue":"3","key":"10.1016\/j.cyto.2019.154962_b0195","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00437630","article-title":"In vivo and in vitro characteristics of six Paracoccidioides brasiliensis strains","volume":"92","author":"Kashino","year":"1985","journal-title":"Mycopathologia"},{"issue":"6","key":"10.1016\/j.cyto.2019.154962_b0200","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.4049\/jimmunol.174.6.3534","article-title":"The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis","volume":"174","author":"Holscher","year":"2005","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2019.154962_b0205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1074-7613(01)00206-0","article-title":"WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection","volume":"15","author":"Yoshida","year":"2001","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.cyto.2019.154962_b0210","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/imm.12095","article-title":"Neonatal macrophages express elevated levels of interleukin-27 that oppose immune responses","volume":"139","author":"Kraft","year":"2013","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.cyto.2019.154962_b0215","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2567.2010.03401.x","article-title":"EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation","volume":"132","author":"Dokmeci","year":"2011","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.cyto.2019.154962_b0220","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1074-7613(03)00298-X","article-title":"WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production","volume":"19","author":"Hamano","year":"2003","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.cyto.2019.154962_b0225","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.179.7.4415","article-title":"IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation","volume":"179","author":"Yoshimoto","year":"2007","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2019.154962_b0230","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4049\/jimmunol.150.2.353","article-title":"Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production","volume":"150","author":"Del Prete","year":"1993","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2019.154962_b0235","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1128\/jb.101.3.675-680.1970","article-title":"Cell wall glucans of the yeast and mycelial forms of Paracoccidioides brasiliensis","volume":"101","author":"Kanetsuna","year":"1970","journal-title":"J. Bacteriol."},{"issue":"2","key":"10.1016\/j.cyto.2019.154962_b0240","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1128\/iai.15.2.343-346.1977","article-title":"Host-parasite relationships in the yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9","volume":"15","author":"San-Blas","year":"1977","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.cyto.2019.154962_b0245","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01259396","article-title":"Paracoccidioides brasiliensis: cell wall structure and virulence. A review","volume":"62","author":"San-Blas","year":"1977","journal-title":"Mycopathologia"},{"key":"10.1016\/j.cyto.2019.154962_b0250","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.3389\/fmicb.2019.02445","article-title":"New role of P. brasiliensis alpha-Glucan: Differentiation of non-conventional dendritic cells","volume":"10","author":"Souza","year":"2019","journal-title":"Front. Microbiol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619303916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466619303916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:57:22Z","timestamp":1760907442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466619303916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":50,"alternative-id":["S1043466619303916"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154962","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between IL-27 and Tr1 cells in severe form of paracoccidioidomycosis","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2019.154962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"154962"}}