{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:05:52Z","timestamp":1783109152428,"version":"3.54.6"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.cyto.2020.155120","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T23:08:46Z","timestamp":1591916926000},"page":"155120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Vascular endothelial growth factor (VEGF), tissue inhibitors of metalloproteinase-1 (TIMP-1) and nail fold capillaroscopy changes in children and adolescents with Gaucher disease; relation to residual disease severity"],"prefix":"10.1016","volume":"133","author":[{"given":"Nouran Yousef","family":"Salah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2020.155120_b0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.smim.2018.02.006","article-title":"An unexpected player in Gaucher disease: the multiple roles of complement in disease development","volume":"37","author":"Pandey","year":"2018","journal-title":"Seminars Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2020.155120_b0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejmhg.2015.02.001","article-title":"Cytokines in Gaucher disease: role in the pathogenesis of bone and pulmonary disease","volume":"16","author":"Tantawy","year":"2015","journal-title":"Egyptian J. Med. Human Genet."},{"key":"10.1016\/j.cyto.2020.155120_b0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.pmbts.2017.01.001","article-title":"The balance between metalloproteinases and TIMPs: critical regulator of microvascular endothelial cell function in health and disease","volume":"147","author":"Masciantonio","year":"2017","journal-title":"Progr. Mol. Biol. Translat. Sci."},{"key":"10.1016\/j.cyto.2020.155120_b0020","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41598-017-00671-1","article-title":"TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice","volume":"7","author":"Thiele","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cyto.2020.155120_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028777","article-title":"Alteration of gene expression profile in Niemann-Pick Type C mice correlates with tissue damage and oxidative stress","volume":"6","author":"V\u00e1zquez","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.cyto.2020.155120_b0030","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.18632\/oncotarget.23832","article-title":"TIMP-1 downregulation modulates miR-125a-5p expression and triggers the apoptotic pathway","volume":"9","author":"Ghoshal-Gupta","year":"2018","journal-title":"Oncotarget."},{"issue":"15","key":"10.1016\/j.cyto.2020.155120_b0035","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000010415","article-title":"VEGF levels in plasma in relation to metabolic control, inflammation, and microvascular complications in type-2 diabetes: a cohort study","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cyto.2020.155120_b0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bcmd.2016.10.009","article-title":"Aberrant bone marrow vascularization patterns in untreated patients with Gaucher disease type 1","volume":"68","author":"Klimkowska","year":"2018","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.cyto.2020.155120_b0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mvr.2016.09.001","article-title":"Capillary density: an important parameter in nailfold capillaroscopy","volume":"109","author":"Emrani","year":"2017","journal-title":"Microvascular Res."},{"issue":"11","key":"10.1016\/j.cyto.2020.155120_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(17)35437-2","article-title":"Nail fold capillaroscopy for the identification of microvascular disease in African-Americans","volume":"69","author":"Khan","year":"2017","journal-title":"J. Am. College Cardiol."},{"issue":"4","key":"10.1016\/j.cyto.2020.155120_b0055","first-page":"1037","article-title":"Nailfold capillaroscopy a non-invasive tool for direct observation of microvascular damage in diabetes mellitus: review","volume":"2","author":"Maldonado","year":"2017","journal-title":"JSM Atheroscler."},{"key":"10.1016\/j.cyto.2020.155120_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-42584-1","article-title":"Gene expression profile in patients with Gaucher disease indicates activation of inflammatory processes","volume":"9","author":"\u0141ugowska","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cyto.2020.155120_b0065","first-page":"31","article-title":"Recurrent wheezing in children","volume":"5","author":"Tenero","year":"2016","journal-title":"Transl. Pediatr."},{"key":"10.1016\/j.cyto.2020.155120_b0070","series-title":"WHO child growth standards: training course on child growth assessment","author":"World Health Organization","year":"2008"},{"key":"10.1016\/j.cyto.2020.155120_b0075","doi-asserted-by":"crossref","first-page":"209","DOI":"10.7863\/jum.1997.16.3.209","article-title":"Accuracy of ultrasonography in assessing spleen and liver size in patients with Gaucher disease: comparison to computed tomographic measurements","volume":"16","author":"Elstein","year":"1997","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.cyto.2020.155120_b0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0049-0172(99)80036-5","article-title":"Nail fold capillaroscopy: Normal findings in children and adolescents","volume":"29","author":"Terreri","year":"1999","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.cyto.2020.155120_b0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1024\/0301-1526\/a000159","article-title":"Qualitative and quantitative assessment of nailfold capillaries by capillaroscopy in healthy volunteers","volume":"41","author":"Hoerth","year":"2012","journal-title":"Vasa"},{"key":"10.1016\/j.cyto.2020.155120_b0090","unstructured":"E. Beutler, G.A. Grabowski, Gaucher Disease. The Metabolic and Molecular Bases of Inherited Diseases. Volume III, McGraw-Hill, New York, 2001, pp. 3635\u20133668."},{"key":"10.1016\/j.cyto.2020.155120_b0095","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1182\/blood-2005-12-5072","article-title":"Superior effects of high-dose enzyme replacement therapy in type 1 Gaucher disease on bone marrow involvement and chitotriosidase levels: a 2-center retrospective analysis","volume":"108","author":"De Fost","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2020.155120_b0100","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0888-7543(92)90311-F","article-title":"Polymorphisms in the human glucocerebrosidase gene","volume":"12","author":"Beutler","year":"1992","journal-title":"Genomics"},{"issue":"3","key":"10.1016\/j.cyto.2020.155120_b0105","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1086\/367850","article-title":"Reciprocal and nonreciprocal recombination at the glucocerebrosidase gene region: implications for complexity in Gaucher disease","volume":"72","author":"Tayebi","year":"2003","journal-title":"Am. J. Human Genet."},{"key":"10.1016\/j.cyto.2020.155120_b0110","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00005792-199211000-00002","article-title":"Gaucher disease. Clinical, laboratory, radiologic, and genetic features of 53 patients","volume":"71","author":"Zimran","year":"1992","journal-title":"Medicine"},{"issue":"Suppl S1","key":"10.1016\/j.cyto.2020.155120_b0115","first-page":"S6","article-title":"Understanding the natural history of Gaucher disease","volume":"90","author":"Mistry","year":"2015","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.cyto.2020.155120_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2326409816650465","article-title":"Lysosomes, lysosomal storage diseases and inflammation","volume":"4","author":"Simonaro","year":"2016","journal-title":"J. Inborn Errors Metab. Screening"},{"issue":"4","key":"10.1016\/j.cyto.2020.155120_b0125","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2017.01.018","article-title":"The complicated relationship between Gaucher disease and Parkinsonism: insights from a rare disease","volume":"93","author":"Aflaki","year":"2017","journal-title":"Neuron"},{"issue":"18","key":"10.1016\/j.cyto.2020.155120_b0130","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/ijms18020441","article-title":"A review of Gaucher disease pathophysiology, clinical presentation and treatments","volume":"2017","author":"Stirnemann","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2020.155120_b0135","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41598-017-00671-1","article-title":"TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice","volume":"7","author":"Thiele","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.cyto.2020.155120_b0140","doi-asserted-by":"crossref","first-page":"e0137673","DOI":"10.1371\/journal.pone.0137673","article-title":"TIMP-1 inhibits apoptosis in lung adenocarcinoma cells via interaction with Bcl-2","volume":"10","author":"Nalluri","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cyto.2020.155120_b0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/path.4452","article-title":"Inhibition of UDP-glucosylceramide synthase in mice prevents Gaucher disease-associated B-cell malignancy","volume":"235","author":"Pavlova","year":"2015","journal-title":"J. Pathol."},{"issue":"4","key":"10.1016\/j.cyto.2020.155120_b0150","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3390\/ijms20040843","article-title":"Defective Sphingolipids metabolism and tumor associated macrophages as the possible links between Gaucher disease and blood cancer development","volume":"20","author":"W\u0105tek","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2020.155120_b0155","article-title":"TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K\/AKT and MAPK pathway","volume":"148","author":"Song","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.cyto.2020.155120_b0160","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0197-0186(03)00004-4","article-title":"Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer\u2019s disease","volume":"43","author":"Lorenzl","year":"2003","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.cyto.2020.155120_b0165","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1006\/jaut.2001.0505","article-title":"Multiple sclerosis: elevated expression of matrix metalloproteinases in blood monocytes","volume":"16","author":"Kouwenhoven","year":"2001","journal-title":"J. Autoimmunity"},{"key":"10.1016\/j.cyto.2020.155120_b0170","first-page":"100490","article-title":"Reversal of life-threatening hepatopulmonary syndrome in Gaucher disease by imiglucerase enzyme replacement therapy","volume":"20","author":"El Beshlawy","year":"2019","journal-title":"Mol Genet Metab Rep."},{"key":"10.1016\/j.cyto.2020.155120_b0175","doi-asserted-by":"crossref","unstructured":"M. Ivanova, R.P. Limgala, E. Changsila, R. Kamath, C. Ioanou, O. Goker-Alpan, Gaucheromas: When macrophages promote tumor formation and dissemination, 2018.","DOI":"10.1016\/j.bcmd.2016.10.018"},{"issue":"147","key":"10.1016\/j.cyto.2020.155120_b0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.pmbts.2017.01.001","article-title":"The balance between metalloproteinases and TIMPs: critical regulator of microvascular endothelial cell function in health and disease","volume":"2017","author":"Masciantonio","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.cyto.2020.155120_b0185","first-page":"87","article-title":"TIMP-1 promotes VEGF-induced neovascularization in the retina","volume":"16","author":"Yamada","year":"2001","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.cyto.2020.155120_b0190","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2018.07.006","article-title":"Bioactive lysolipids in cancer and angiogenesis","volume":"193","author":"Hisano","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.cyto.2020.155120_b0195","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/path.4992","article-title":"Reduced cerebral vascularization in experimental neuronopathic Gaucher disease","volume":"244","author":"Smith","year":"2018","journal-title":"J. Pathol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620301368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620301368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:58:32Z","timestamp":1760907512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466620301368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":39,"alternative-id":["S1043466620301368"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155120","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular endothelial growth factor (VEGF), tissue inhibitors of metalloproteinase-1 (TIMP-1) and nail fold capillaroscopy changes in children and adolescents with Gaucher disease; relation to residual disease severity","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155120"}}