{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:34:07Z","timestamp":1790760847685,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Catholic Medical Center Research Foundation","award":["5-2018-B0001-00214"],"award-info":[{"award-number":["5-2018-B0001-00214"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.cyto.2020.155343","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T09:13:38Z","timestamp":1603876418000},"page":"155343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Interleukin 8 may predict surgical necrotizing enterocolitis in infants born less than 1500\u00a0g"],"prefix":"10.1016","volume":"137","author":[{"given":"Yu-mi","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Kuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Ah","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Kyung","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-2414","authenticated-orcid":false,"given":"Young-Ah","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.cyto.2020.155343_b0005","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/jp.2010.193","article-title":"The age of necrotizing enterocolitis onset: an application of Sartwell\u2019s incubation period model","volume":"31","author":"Rosbel Gonz\u00e1lez-Rivera","year":"2011","journal-title":"J. Perinatol."},{"issue":"5","key":"10.1016\/j.cyto.2020.155343_b0010","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s11894-008-0084-x","article-title":"A roadmap for understanding and preventing necrotizing enterocolitis","volume":"10","author":"Neu","year":"2008","journal-title":"Curr. Gastroenterol. Rep."},{"issue":"147","key":"10.1016\/j.cyto.2020.155343_b0015","first-page":"e1","article-title":"Trends in neonatal morbidity and mortality for very low birthweight infants","volume":"196","author":"Fanaroff","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cyto.2020.155343_b0020","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.cyto.2020.155343_b0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/jp.2011.65","article-title":"Characteristics of patients who die of necrotizing enterocolitis","volume":"32","author":"Clark","year":"2012","journal-title":"J. Perinatol."},{"key":"10.1016\/j.cyto.2020.155343_b0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0095-5108(18)30341-5","article-title":"Epidemiology of necrotizing enterocolitis","volume":"21","author":"Stoll","year":"1994","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.cyto.2020.155343_b0035","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis","volume":"364","author":"Neu","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2020.155343_b0040","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3748\/wjg.14.2142","article-title":"Necrotizing enterocolitis: a multifactorial disease with no cure","volume":"14","author":"Schnabl","year":"2008","journal-title":"World J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.cyto.2020.155343_b0045","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2165\/00003495-200868090-00004","article-title":"Necrotizing enterocolitis in newborns: pathogenesis, prevention and management","volume":"68","author":"Thompson","year":"2008","journal-title":"Drugs"},{"key":"10.1016\/j.cyto.2020.155343_b0050","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jpeds.2014.11.005","article-title":"50 Years Ago in The Journal of Pediatrics: Necrotizing Enterocolitis in Premature Infants","volume":"166","author":"Toltzis","year":"2015","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cyto.2020.155343_b0055","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3345\/kjp.2014.57.12.505","article-title":"Necrotizing enterocolitis in newborns: update in pathophysiology and newly emerging therapeutic strategies","volume":"57","author":"Choi","year":"2014","journal-title":"Korean J. Pediatr."},{"issue":"1","key":"10.1016\/j.cyto.2020.155343_b0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.semperi.2016.09.018","article-title":"Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis","volume":"41","author":"MohanKumara","year":"2017","journal-title":"Semin. Perinatol."},{"issue":"3","key":"10.1016\/j.cyto.2020.155343_b0065","doi-asserted-by":"crossref","first-page":"e0122234","DOI":"10.1371\/journal.pone.0122234","article-title":"Difference in the breast milk proteome between allergic and non-allergic mothers","volume":"10","author":"Hettinga","year":"2015","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.cyto.2020.155343_b0070","first-page":"40","article-title":"The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis","volume":"3","author":"Hodzic","year":"2017","journal-title":"Front. Pediatr."},{"issue":"10","key":"10.1016\/j.cyto.2020.155343_b0075","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nrgastro.2016.119","article-title":"Necrotizing enterocolitis: new insights into pathogenesis and mechanisms","volume":"13","author":"Nino","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.cyto.2020.155343_b0080","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2249.2011.04523.x","article-title":"Enterocytes: active cells in tolerance to food and microbial antigens in the gut","volume":"167","author":"Miron","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cyto.2020.155343_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","author":"Bell","year":"1978","journal-title":"Ann. Surg."},{"issue":"06","key":"10.1016\/j.cyto.2020.155343_b0090","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0022-3476(97)70279-8","article-title":"Changes in gastric emptying in early postnatal life","volume":"130","author":"Carlos","year":"1997","journal-title":"J. Pediatr."},{"issue":"4","key":"10.1016\/j.cyto.2020.155343_b0095","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage in premature infants: a study of infants","volume":"92","author":"Papile","year":"1978","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cyto.2020.155343_b0100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1056\/NEJMoa1403489","article-title":"Causes and timing of death in extremely premature infants from 2000 through 2011","volume":"372","author":"Patel","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2020.155343_b0105","doi-asserted-by":"crossref","unstructured":"Michael S. Caplan, Mark A. Underwood, Neena Modi, Ravi Patel, Phillip V. Gordon, Karl G. Sylvester, Steven McElroy, Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes, J Pediatr. 212 (2019) 208-215.e1, doi: 10.1016\/j.jpeds.2019.05.032. Epub 2019 Jun 22.","DOI":"10.1016\/j.jpeds.2019.05.032"},{"key":"10.1016\/j.cyto.2020.155343_b0110","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.3346\/jkms.2015.30.S1.S75","article-title":"Necrotizing enterocolitis among very-low-birth-weight infants in Korea","volume":"30","author":"Youn","year":"2015","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.cyto.2020.155343_b0115","doi-asserted-by":"crossref","first-page":"e443","DOI":"10.1542\/peds.2012-3847","article-title":"Epidemiology and trends of necrotizing enterocolitis in Sweden: 1987\u20132009","volume":"132","author":"Ahle","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.cyto.2020.155343_b0120","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1542\/peds.2011-2022","article-title":"Canadian Neonatal Network. Incidence and timing of presentation of necrotizing enterocolitis in preterm infants","volume":"129","author":"Yee","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.cyto.2020.155343_b0125","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1442-200X.2006.02282.x","article-title":"Gastrointestinal perforation in very low-birthweight infants","volume":"48","author":"Kawase","year":"2006","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.cyto.2020.155343_b0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jss.2008.11.008","article-title":"State-based analysis of necrotizing enterocolitis outcomes","volume":"157","author":"Guner","year":"2009","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.cyto.2020.155343_b0135","doi-asserted-by":"crossref","unstructured":"T. Benkoe, S. Baumann, M. Weninger, M. Pones, C. Reck, W. Rebhandl, R. Oehler, Comprehensive Evaluation of 11 Cytokines in Premature Infants with Surgical Necrotizing Enterocolitis, PLoS One. 8(3) (2013) e58720. doi: 10.1371\/journal.pone.0058720. Epub 2013 Mar 5.","DOI":"10.1371\/journal.pone.0058720"},{"issue":"4 Pt 1","key":"10.1016\/j.cyto.2020.155343_b0140","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1542\/peds.103.4.766","article-title":"Circulating pro- and counterinflammatory cytokine levels and severity","volume":"103","author":"Edelson","year":"1999","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.cyto.2020.155343_b0145","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.amjsurg.2011.08.016","article-title":"Role of interleukin-10 in the pathogenesis of necrotizing enterocolitis","volume":"203","author":"Emami","year":"2012","journal-title":"Am. J. Surg."},{"issue":"13","key":"10.1016\/j.cyto.2020.155343_b0150","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1055\/s-0037-1603329","article-title":"The role of interleukin-6 and interleukin-8 circulating cytokines in differentiating between feeding intolerance and necrotizing enterocolitis in preterm infants","volume":"34","author":"Lodha","year":"2017","journal-title":"Am. J. Perinatol."},{"issue":"02","key":"10.1016\/j.cyto.2020.155343_b0155","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.semperi.2008.01.001","article-title":"The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis","volume":"32","author":"Frost","year":"2008","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.cyto.2020.155343_b0160","first-page":"997","article-title":"Expression of interleu kin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation","volume":"5","author":"Mazzucchelli","year":"1994","journal-title":"Am. J. Pathol."},{"issue":"04","key":"10.1016\/j.cyto.2020.155343_b0165","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jpeds.2005.04.037","article-title":"Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing entercolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortality","volume":"147","author":"Harris","year":"2005","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cyto.2020.155343_b0170","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0039-6060(97)90020-9","article-title":"Interleukin-10 reduces the systemic inflammatory response in a murine model of intestinal ischemia\/reperfusion","volume":"122","author":"Lane","year":"1997","journal-title":"Surgery"},{"key":"10.1016\/j.cyto.2020.155343_b0175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/PL00008445","article-title":"Plasma levels of interleukin-6 and interleukin-10 in preterm neonates evaluated for sepsis","volume":"160","author":"Romagnoli","year":"2001","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.cyto.2020.155343_b0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/14767050410001702186","article-title":"Second-trimester amniotic fluid interleukin-10 concentration predicts preterm delivery","volume":"15","author":"Apuzzio","year":"2004","journal-title":"J. Matern Fetal Neonatal Med."},{"key":"10.1016\/j.cyto.2020.155343_b0185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10- deficient mice develop chronic enterocolitis","volume":"75","author":"Kuhn","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2020.155343_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60449-6","article-title":"Properties and functions of interleukin-10","volume":"56","author":"Mosmann","year":"1994","journal-title":"Adv. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2020.155343_b0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/pr.2014.48","article-title":"Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants","volume":"76","author":"Maheshwari","year":"2014","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cyto.2020.155343_b0200","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/15513819709168731","article-title":"Inflammatory cytokine mRNAs in surgical specimens of necrotizing enterocolitis and normal newborn intestine","volume":"17","author":"Viscardi","year":"1997","journal-title":"Pediatr. Pathol. Lab. Med."},{"key":"10.1016\/j.cyto.2020.155343_b0205","doi-asserted-by":"crossref","first-page":"F209","DOI":"10.1136\/fn.88.3.F209","article-title":"Proinflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infections","volume":"88","author":"Ng","year":"2003","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"1","key":"10.1016\/j.cyto.2020.155343_b0210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.semperi.2016.09.018","article-title":"Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis","volume":"41","author":"MohanKumara","year":"2017","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.cyto.2020.155343_b0215","first-page":"e125","article-title":"Historical perspective: necrotizing enterocolitis: an inherited or acquired condition?","volume":"7","author":"Stevenson","year":"2006","journal-title":"Neo Reviews"},{"key":"10.1016\/j.cyto.2020.155343_b0220","first-page":"324","article-title":"Postnatal intestinal disturbances in small for gestational age premature infants after prenatal haemodynamic disturbances","volume":"89","author":"Robel-Tillig","year":"2000","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.cyto.2020.155343_b0225","series-title":"Principles and practice of pediatric infectious disease","first-page":"383","article-title":"Necrotizing enterocolitis","author":"Israel","year":"2003"},{"key":"10.1016\/j.cyto.2020.155343_b0230","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1542\/peds.2004-0569","article-title":"Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis","volume":"115","author":"Hintz","year":"2005","journal-title":"Pediatrics"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620303598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620303598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:59:29Z","timestamp":1760907569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466620303598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":46,"alternative-id":["S1043466620303598"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155343","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin 8 may predict surgical necrotizing enterocolitis in infants born less than 1500\u00a0g","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155343"}}