{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:05:00Z","timestamp":1791374700839,"version":"4.3.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cyto.2020.155394","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T01:41:23Z","timestamp":1607478083000},"page":"155394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Carvedilol prevents pancreatic \u03b2-cell damage and the development of type 1 diabetes in mice by the inhibition of proinflammatory cytokines, NF-\u03baB, COX-2, iNOS and oxidative stress"],"prefix":"10.1016","volume":"138","author":[{"given":"Keyvan","family":"Amirshahrokhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zohouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2020.155394_b0005","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.cyto.2012.07.029","article-title":"Thalidomide attenuates multiple low-dose streptozotocin-induced diabetes in mice by inhibition of proinflammatory cytokines","volume":"60","author":"Amirshahrokhi","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2020.155394_b0010","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.coi.2011.10.001","article-title":"Diabetogenic T lymphocytes in human Type 1 diabetes","volume":"23","author":"Roep","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cyto.2020.155394_b0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2018.04.581","article-title":"The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes","volume":"125","author":"Feduska","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cyto.2020.155394_b0020","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1734-1140(09)70111-2","article-title":"Role of NF-kappa B in the pathogenesis of diabetes and its associated complications","volume":"61","author":"Patel","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cyto.2020.155394_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105884","article-title":"Febuxostat attenuates ulcerative colitis by the inhibition of NF-\u03baB, proinflammatory cytokines, and oxidative stress in mice","volume":"76","author":"Amirshahrokhi","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2020.155394_b0030","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.diabres.2008.11.029","article-title":"NO-mediated cytotoxicity contributes to multiple low-dose streptozotocin-induced diabetes but not to NOD diabetes","volume":"83","author":"Yasuda","year":"2009","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.cyto.2020.155394_b0035","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1006\/bbrc.2000.2959","article-title":"COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice","volume":"273","author":"Tabatabaie","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cyto.2020.155394_b0040","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.2337\/diacare.28.6.1371","article-title":"Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation","volume":"28","author":"Basu","year":"2005","journal-title":"Diabetes Care."},{"key":"10.1016\/j.cyto.2020.155394_b0045","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.biopha.2018.07.090","article-title":"Withaferin-A attenuates multiple low doses of Streptozotocin (MLD-STZ) induced type 1 diabetes","volume":"106","author":"Tekula","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cyto.2020.155394_b0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.taap.2012.04.012","article-title":"New therapeutic aspect for carvedilol: antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage","volume":"261","author":"Hamdy","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cyto.2020.155394_b0055","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.2147\/DDDT.S210797","article-title":"Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice","volume":"13","author":"Wu","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.cyto.2020.155394_b0060","doi-asserted-by":"crossref","first-page":"H83","DOI":"10.1152\/ajpheart.00536.2003","article-title":"Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property","volume":"286","author":"Yuan","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cyto.2020.155394_b0065","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/1440-1681.12447","article-title":"Anti-oxidative effect of the \u03b2-blocker carvedilol on diabetic nephropathy in non-obese type 2 diabetic rats","volume":"42","author":"Yonekura","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cyto.2020.155394_b0070","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.yjmcc.2004.05.024","article-title":"Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro","volume":"37","author":"Spallarossa","year":"2004","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.cyto.2020.155394_b0075","first-page":"479","article-title":"Carvedilol alleviates diabetic cardiomyopathy in diabetic rats","volume":"17","author":"Zheng","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cyto.2020.155394_b0080","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cyto.2016.09.004","article-title":"Carvedilol attenuates paraquat-induced lung injury by inhibition of proinflammatory cytokines, chemokine MCP-1, NF-\u03baB activation and oxidative stress mediators","volume":"88","author":"Amirshahrokhi","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2020.155394_b0085","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.intimp.2016.03.006","article-title":"Gastroprotective effect of 2-mercaptoethane sulfonate against acute gastric mucosal damage induced by ethanol","volume":"34","author":"Amirshahrokhi","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2020.155394_b0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.taap.2018.12.011","article-title":"Modulating impacts of quercetin\/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats","volume":"365","author":"Eitah","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cyto.2020.155394_b0095","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.peptides.2010.11.017","article-title":"Anti-hyperglycemic, antioxidant and anti-inflammatory effects of VIP and a VPAC1 agonist on streptozotocin-induced diabetic mice","volume":"32","author":"Yu","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.cyto.2020.155394_b0100","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s00125-004-1367-x","article-title":"Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL\/6 mice are associated with diabetes induced by multiple low doses of streptozotocin","volume":"47","author":"Friesen","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.cyto.2020.155394_b0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/BST0360343","article-title":"Oxidative stress: the vulnerable beta-cell","volume":"36","author":"Lenzen","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.cyto.2020.155394_b0110","first-page":"896","article-title":"Effect of Methylsulfonylmethane Pretreatment on Aceta-minophen Induced Hepatotoxicity in Rats","volume":"16","author":"Bohlooli","year":"2013","journal-title":"Iran J. Basic Med. Sci."},{"key":"10.1016\/j.cyto.2020.155394_b0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopha.2017.08.040","article-title":"Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats","volume":"95","author":"Chandirasegaran","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cyto.2020.155394_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172569","article-title":"Nilotinib enhances \u03b2-islets integrity and secretory functions in a rat model of STZ-induced diabetes mellitus","volume":"860","author":"Samaha","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cyto.2020.155394_b0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0022-3565(25)10363-7","article-title":"Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger","volume":"263","author":"Yue","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cyto.2020.155394_b0130","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/HJH.0b013e3280127948","article-title":"Antioxidant activity of carvedilol in cardiovascular disease","volume":"25","author":"Dandona","year":"2007","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cyto.2020.155394_b0135","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2337\/diabetes.48.4.706","article-title":"Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes","volume":"48","author":"Flodstr\u00f6m","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2020.155394_b0140","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12079-017-0377-7","article-title":"Regulation of pancreatic \u03b2-cell function and mass dynamics by prostaglandin signaling","volume":"11","author":"Carboneau","year":"2017","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.cyto.2020.155394_b0145","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.2337\/diabetes.51.6.1772","article-title":"Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function","volume":"51","author":"Tran","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2020.155394_b0150","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.15252\/emmm.201404144","article-title":"Macrophages and \u03b2-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes","volume":"6","author":"Diana","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cyto.2020.155394_b0155","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2337\/db14-0443","article-title":"CXCR1\/2 inhibition blocks and reverses type 1 diabetes in mice","volume":"64","author":"Citro","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2020.155394_b0160","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejphar.2017.06.034","article-title":"Methylsulfonylmethane is effective against gastric mucosal injury","volume":"811","author":"Amirshahrokhi","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cyto.2020.155394_b0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2119\/2003-00016.Mabley","article-title":"Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes","volume":"9","author":"Mabley","year":"2003","journal-title":"Mol. Med."},{"key":"10.1016\/j.cyto.2020.155394_b0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2337\/diabetes.51.1.55","article-title":"Human pancreatic islets produce and secrete MCP-1\/CCL2: relevance in human islet transplantation","volume":"51","author":"Piemonti","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2020.155394_b0175","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00125-002-1017-0","article-title":"IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice","volume":"46","author":"Cardozo","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.cyto.2020.155394_b0180","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2174\/187152811795564046","article-title":"NF-\u03baB in type 1 diabetes","volume":"10","author":"Zhao","year":"2011","journal-title":"Inflamm. Allergy Drug Targets."},{"key":"10.1016\/j.cyto.2020.155394_b0185","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/jdi.12469","article-title":"Neutrophils in type 1 diabetes","volume":"7","author":"Huang","year":"2016","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.cyto.2020.155394_b0190","first-page":"183","article-title":"Apoptosis of pancreatic \u03b2-cells in Type 1 diabetes","volume":"17","author":"Tomita","year":"2017","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.cyto.2020.155394_b0195","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/jaut.2001.0506","article-title":"A transcriptional inhibitor of TNF-alpha prevents diabetes induced by multiple low-dose streptozotocin injections in mice","volume":"16","author":"Holstad","year":"2001","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.cyto.2020.155394_b0200","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.4049\/jimmunol.1000788","article-title":"IL-17 immunity in human type 1 diabetes","volume":"185","author":"Honkanen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2020.155394_b0205","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0006-2952(97)00492-9","article-title":"Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus","volume":"55","author":"Rabinovitch","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cyto.2020.155394_b0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1677\/JOE-07-0638","article-title":"Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells","volume":"197","author":"Souza","year":"2008","journal-title":"J. Endocrinol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620304105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620304105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:58:12Z","timestamp":1760907492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466620304105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":42,"alternative-id":["S1043466620304105"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155394","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carvedilol prevents pancreatic \u03b2-cell damage and the development of type 1 diabetes in mice by the inhibition of proinflammatory cytokines, NF-\u03baB, COX-2, iNOS and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155394"}}