{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:53:09Z","timestamp":1772729589068,"version":"3.50.1"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cyto.2020.155398","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T23:06:33Z","timestamp":1608159993000},"page":"155398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3530-4536","authenticated-orcid":false,"given":"Maha","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa H.","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lobna A.","family":"Abdelzaher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally A.","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Mali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit A","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-3970","authenticated-orcid":false,"given":"Eman","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10173","key":"10.1016\/j.cyto.2020.155398_b0005","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0140-6736(18)32822-8","article-title":"The global syndemic of obesity, undernutrition, and climate change: the lancet commission report","volume":"393","author":"Swinburn","year":"2019","journal-title":"The Lancet"},{"issue":"2","key":"10.1016\/j.cyto.2020.155398_b0010","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/11026480310007953","article-title":"Dietary fat and obesity: lack of an important role","volume":"47","author":"Willett","year":"2003","journal-title":"Scandinavian J. Nutr."},{"issue":"5","key":"10.1016\/j.cyto.2020.155398_b0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/07853890.2014.891802","article-title":"Personalized nutrition and obesity","volume":"46","author":"Qi","year":"2014","journal-title":"Ann. Med."},{"issue":"22","key":"10.1016\/j.cyto.2020.155398_b0020","article-title":"Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease","volume":"7","author":"Chait","year":"2020","journal-title":"Front. Cardiovascular Med."},{"key":"10.1016\/j.cyto.2020.155398_b0025","doi-asserted-by":"crossref","first-page":"535918","DOI":"10.1155\/2010\/535918","article-title":"Inflammation, a link between obesity and cardiovascular disease","volume":"2010","author":"Wang","year":"2010","journal-title":"Mediators Inflamm.."},{"key":"10.1016\/j.cyto.2020.155398_b0030","doi-asserted-by":"crossref","first-page":"3407306","DOI":"10.1155\/2018\/3407306","article-title":"The impact of obesity on the cardiovascular system","volume":"2018","author":"Csige","year":"2018","journal-title":"J. Diabetes Res."},{"issue":"11","key":"10.1016\/j.cyto.2020.155398_b0035","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.2337\/db10-0367","article-title":"A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease","volume":"59","author":"Mori","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.cyto.2020.155398_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2013.00037","article-title":"Beta cell dysfunction and insulin resistance","volume":"4","author":"Cerf","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0045","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbrc.2010.11.127","article-title":"Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans","volume":"404","author":"Gauthier","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7432","key":"10.1016\/j.cyto.2020.155398_b0050","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature11862","article-title":"Metabolism of inflammation limited by AMPK and pseudo-starvation","volume":"493","author":"O'Neill","year":"2013","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0055","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00011.2008","article-title":"AMPK in Health and Disease","volume":"89","author":"Steinberg","year":"2009","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.cyto.2020.155398_b0060","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.diabet.2007.10.004","article-title":"Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders","volume":"33","author":"Viollet","year":"2007","journal-title":"Diabetes Metab."},{"issue":"6","key":"10.1016\/j.cyto.2020.155398_b0065","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1210\/endo.143.6.8841","article-title":"Lisofylline, a novel antiinflammatory agent, protects pancreatic beta-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism","volume":"143","author":"Chen","year":"2002","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.cyto.2020.155398_b0070","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.4049\/jimmunol.163.12.6567","article-title":"Selective pharmacologic inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling","volume":"163","author":"Coon","year":"1999","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0075","first-page":"3","article-title":"Effect of trental on indices kidney function in diabetes mellitus","volume":"28","author":"Blagosklonnaia Ia","year":"1982","journal-title":"Problemy endokrinologii"},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0080","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13098-015-0060-1","article-title":"Effects of pentoxifylline on proteinuria and glucose control in patients with type 2 diabetes: a prospective randomized double-blind multicenter study","volume":"7","author":"Han","year":"2015","journal-title":"Diabetology Metab. Syndrome"},{"issue":"13","key":"10.1016\/j.cyto.2020.155398_b0085","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1016\/j.bmcl.2006.04.036","article-title":"Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes","volume":"16","author":"Cui","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2004.08.012","article-title":"Lisofylline: a potential lead for the treatment of diabetes","volume":"69","author":"Yang","year":"2005","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.cyto.2020.155398_b0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4236\/jdm.2012.22040","article-title":"Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline","volume":"2","author":"Tersey","year":"2012","journal-title":"J. Diabetes Mellitus"},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0100","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1073\/pnas.91.9.3857","article-title":"Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid","volume":"91","author":"Rice","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.cyto.2020.155398_b0105","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.181.2.569","article-title":"Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice","volume":"181","author":"Abraham","year":"1995","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0110","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/0885066606287045","article-title":"Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome","volume":"21","author":"Cepkova","year":"2006","journal-title":"J. Intensive Care Med."},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0115","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1164\/ajrccm.155.3.9117028","article-title":"The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs","volume":"155","author":"Hasegawa","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cyto.2020.155398_b0120","doi-asserted-by":"crossref","unstructured":"B.M. Hybertson, S.L. Bursten, J.A. Leff, Y.M. Lee, E.K. Jepson, C.R. Dewitt, J. Zagorski, H.G. Cho, J.E. Repine, Lisofylline prevents leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally, Journal of applied physiology (Bethesda, Md. : 1985) 82(1) (1997) 226-32.","DOI":"10.1152\/jappl.1997.82.1.226"},{"issue":"10","key":"10.1016\/j.cyto.2020.155398_b0125","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00210-017-1406-z","article-title":"PK\/PD studies on non-selective PDE inhibitors in rats using cAMP as a marker of pharmacological response","volume":"390","author":"\u015awierczek","year":"2017","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0130","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1210\/en.2010-0250","article-title":"Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors","volume":"151","author":"Frangioudakis","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.cyto.2020.155398_b0135","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1196\/annals.1288.069","article-title":"Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes","volume":"1005","author":"Yang","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.cyto.2020.155398_b0140","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1242\/dmm.009621","article-title":"Anti-obesity drugs: past, present and future","volume":"5","author":"Rodgers","year":"2012","journal-title":"Disease Models Mech."},{"issue":"Suppl. 3","key":"10.1016\/j.cyto.2020.155398_b0145","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.2337\/diabetes.53.suppl_3.S215","article-title":"The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes","volume":"53","author":"Winzell","year":"2004","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.TP.0000104844.48064.81","article-title":"The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation","volume":"77","author":"Yang","year":"2004","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0155","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1258\/002367707779399518","article-title":"Anthropometrical parameters and markers of obesity in rats","volume":"41","author":"Novelli","year":"2007","journal-title":"Lab. Anim."},{"issue":"11","key":"10.1016\/j.cyto.2020.155398_b0160","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1016\/j.ajpath.2017.07.021","article-title":"Essential role of IL-12 in angiogenesis in Type 2 diabetes","volume":"187","author":"Ali","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cyto.2020.155398_b0165","unstructured":"J.D. Bancroft, M. Gamble, Theory and practice of histological techniques, Elsevier health sciences, 2008."},{"key":"10.1016\/j.cyto.2020.155398_b0170","unstructured":"J.J. Bozzola, L.D. Russell, Electron microscopy principles and techniques for biologists, (1999)."},{"issue":"Suppl. 8A","key":"10.1016\/j.cyto.2020.155398_b0175","doi-asserted-by":"crossref","first-page":"37s","DOI":"10.1016\/j.amjmed.2003.08.012","article-title":"Obesity as a cardiovascular risk factor","volume":"115","author":"Sowers","year":"2003","journal-title":"Am. J. Med."},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0180","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2337\/diab.37.9.1163","article-title":"Diet-induced type II diabetes in C57BL\/6J mice","volume":"37","author":"Surwit","year":"1988","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0185","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0026-0495(97)90175-X","article-title":"Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL\/6J mice","volume":"46","author":"Ahren","year":"1997","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.cyto.2020.155398_b0190","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1210\/en.2002-220835","article-title":"Differential mechanisms and development of leptin resistance in A\/J versus C57BL\/6J mice during diet-induced obesity","volume":"144","author":"Prpic","year":"2003","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0195","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.metabol.2003.10.008","article-title":"Lisofylline, a novel anti-inflammatory agent, enhances glucose-stimulated insulin secretion in vivo and in vitro: studies in prediabetic and normal rats","volume":"53","author":"Striffler","year":"2004","journal-title":"Metab. \u2013 Clin. Exp."},{"issue":"4","key":"10.1016\/j.cyto.2020.155398_b0200","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1097\/00006676-200305000-00021","article-title":"The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice","volume":"26","author":"Yang","year":"2003","journal-title":"Pancreas"},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0205","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000163635.62927.34","article-title":"Adipose tissue, inflammation, and cardiovascular disease","volume":"96","author":"Berg","year":"2005","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2012.04.011","article-title":"Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway","volume":"59","author":"Lin","year":"2012","journal-title":"Cytokine"},{"issue":"11","key":"10.1016\/j.cyto.2020.155398_b0215","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1210\/endo.137.11.8895359","article-title":"Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1 beta-induced dysfunction in cultured rat islets","volume":"137","author":"Bleich","year":"1996","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.cyto.2020.155398_b0220","first-page":"L776","article-title":"Effects of lisofylline on hyperoxia-induced lung injury","volume":"276","author":"George","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0225","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1016\/j.transproceed.2004.09.083","article-title":"Inflammation blockade improves pancreatic islet function","volume":"36","author":"Yang","year":"2004","journal-title":"Transplant Proc"},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0230","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1097\/MPA.0b013e3181744b50","article-title":"Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats","volume":"37","author":"Zhang","year":"2008","journal-title":"Pancreas"},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0235","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3164\/jcbn.09-83","article-title":"A mouse model of metabolic syndrome: insulin resistance, fatty liver and non-alcoholic fatty pancreas disease (NAFPD) in C57BL\/6 mice fed a high fat diet","volume":"46","author":"Fraulob","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"7","key":"10.1016\/j.cyto.2020.155398_b0240","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/10520295.2015.1021380","article-title":"Histopathological changes in rat pancreas and skeletal muscle associated with high fat diet induced insulin resistance","volume":"90","author":"Ickin Gulen","year":"2015","journal-title":"Biotech. Histochem.: Off. Publ. Biol. Stain Commission"},{"key":"10.1016\/j.cyto.2020.155398_b0245","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1038\/onc.2016.487","article-title":"An integrated analysis identifies STAT4 as a key regulator of ovarian cancer metastasis","volume":"36","author":"Zhao","year":"2017","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.cyto.2020.155398_b0250","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11882-008-0077-8","article-title":"STAT4: genetics, mechanisms, and implications for autoimmunity","volume":"8","author":"Korman","year":"2008","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"8","key":"10.1016\/j.cyto.2020.155398_b0255","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrd4088","article-title":"Therapeutic modulators of STAT signalling for human diseases","volume":"12","author":"Miklossy","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0260","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/JOE-15-0098","article-title":"STAT4 contributes to adipose tissue inflammation and atherosclerosis","volume":"227","author":"Dobrian","year":"2015","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.cyto.2020.155398_b0265","doi-asserted-by":"crossref","first-page":"E175","DOI":"10.1152\/ajpendo.00203.2010","article-title":"Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats","volume":"300","author":"Chakrabarti","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.cyto.2020.155398_b0270","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2020.155398_b0275","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4103\/0972-124X.150876","article-title":"Evaluation of serum interleukin-10 levels as a predictor of glycemic alteration in chronic periodontitis and type 2 diabetes mellitus","volume":"19","author":"Acharya","year":"2015","journal-title":"J. Indian Soc. Periodontol."},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0280","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jdi.12579","article-title":"Adiponectin and pro-inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus","volume":"8","author":"Tong","year":"2017","journal-title":"J. Diabetes Investig."},{"issue":"7","key":"10.1016\/j.cyto.2020.155398_b0285","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4070\/kcj.2010.40.7.299","article-title":"Apoptosis in cardiovascular diseases: mechanism and clinical implications","volume":"40","author":"Kim","year":"2010","journal-title":"Korean Circulation J."},{"key":"10.1016\/j.cyto.2020.155398_b0290","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2018\/1875870","article-title":"Oxidative stress, apoptosis, and mitochondrial function in diabetic nephropathy","volume":"2018","author":"Sifuentes-Franco","year":"2018","journal-title":"Int. J. Endocrinol."},{"issue":"25","key":"10.1016\/j.cyto.2020.155398_b0295","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.jacc.2010.07.033","article-title":"Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy","volume":"56","author":"Rajesh","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.cyto.2020.155398_b0300","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s11745-017-4295-5","article-title":"Flaxseed Oil supplementation improve gene expression levels of PPAR-gamma, LP(a), IL-1 and TNF-alpha in Type 2 diabetic patients with coronary heart disease","volume":"52","author":"Hashemzadeh","year":"2017","journal-title":"Lipids"},{"issue":"8","key":"10.1016\/j.cyto.2020.155398_b0305","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/eci.12781","article-title":"Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease","volume":"47","author":"Pedersen","year":"2017","journal-title":"Eur. J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.cyto.2020.155398_b0310","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1074248409356557","article-title":"Targeting apoptosis in the heart of streptozotocin-induced diabetic rats","volume":"15","author":"Baraka","year":"2010","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0315","first-page":"311","article-title":"Lipotoxicity in the heart","volume":"1801","author":"Wende","year":"2010","journal-title":"BBA"},{"key":"10.1016\/j.cyto.2020.155398_b0320","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.biopha.2017.11.020","article-title":"Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts","volume":"97","author":"Feng","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0325","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ccr.2014.01.021","article-title":"Mutant p53 in cancer: new functions and therapeutic opportunities","volume":"25","author":"Muller","year":"2014","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.cyto.2020.155398_b0330","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2017.08.028","article-title":"Putting p53 in context","volume":"170","author":"Kastenhuber","year":"2017","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0335","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.3390\/ijms19092622","article-title":"p53 Functions in adipose tissue metabolism and homeostasis","volume":"19","author":"Krstic","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cyto.2020.155398_b0340","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/ijo.2013.163","article-title":"Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression","volume":"38","author":"Ortega","year":"2014","journal-title":"Int. J .Obes. (Lond)"},{"issue":"4","key":"10.1016\/j.cyto.2020.155398_b0345","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.celrep.2016.12.086","article-title":"Protection against high-fat-diet-induced obesity in MDM2(C305F) mice due to reduced p53 activity and enhanced energy expenditure","volume":"18","author":"Liu","year":"2017","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0350","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/nm.2014","article-title":"A crucial role for adipose tissue p53 in the regulation of insulin resistance","volume":"15","author":"Minamino","year":"2009","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.cyto.2020.155398_b0355","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1074\/jbc.M303857200","article-title":"12\/15-Lipoxygenase activity mediates inflammatory monocyte\/endothelial interactions and atherosclerosis in vivo","volume":"279","author":"Reilly","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cyto.2020.155398_b0360","doi-asserted-by":"crossref","first-page":"E1065","DOI":"10.1152\/ajpendo.90371.2008","article-title":"12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet","volume":"295","author":"Nunemaker","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cyto.2020.155398_b0365","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pharmthera.2018.10.010","article-title":"Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications","volume":"195","author":"Dobrian","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"16","key":"10.1016\/j.cyto.2020.155398_b0370","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1074\/jbc.RA118.007102","article-title":"Platelet-type 12-lipoxygenase deletion provokes a compensatory 12\/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet beta cells","volume":"294","author":"Conteh","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0375","doi-asserted-by":"crossref","first-page":"e7250","DOI":"10.1371\/journal.pone.0007250","article-title":"12\/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice","volume":"4","author":"Sears","year":"2009","journal-title":"PLoS ONE"},{"issue":"Suppl. 3","key":"10.1016\/j.cyto.2020.155398_b0380","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/dom.12161","article-title":"Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease","volume":"15","author":"Imai","year":"2013","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cyto.2020.155398_b0385","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.yjmcc.2018.03.004","article-title":"Genetic deletion of 12\/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction","volume":"118","author":"Kain","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5\u20136","key":"10.1016\/j.cyto.2020.155398_b0390","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1440-1681.2007.04851.x","article-title":"AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function","volume":"35","author":"Zou","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"9","key":"10.1016\/j.cyto.2020.155398_b0395","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/aps.2010.139","article-title":"AMPK in cardiovascular health and disease","volume":"31","author":"Shirwany","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"20","key":"10.1016\/j.cyto.2020.155398_b0400","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1007\/s00018-010-0454-z","article-title":"AMP-activated protein kinase and its downstream transcriptional pathways","volume":"67","author":"Canto","year":"2010","journal-title":"Cellular Mol. Life Sci.: CMLS"},{"issue":"12","key":"10.1016\/j.cyto.2020.155398_b0405","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.molmed.2008.09.007","article-title":"AMPK: a metabolic gauge regulating whole-body energy homeostasis","volume":"14","author":"Lage","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cyto.2020.155398_b0410","doi-asserted-by":"crossref","unstructured":"A.K. Wong, J. Howie, J.R. Petrie, C.C. Lang, AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease, Clinical science (London, England : 1979) 116(8) (2009) 607-20.","DOI":"10.1042\/CS20080066"},{"issue":"20","key":"10.1016\/j.cyto.2020.155398_b0415","doi-asserted-by":"crossref","first-page":"15346","DOI":"10.1074\/jbc.M110.102491","article-title":"Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin","volume":"285","author":"Liu","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"25","key":"10.1016\/j.cyto.2020.155398_b0420","doi-asserted-by":"crossref","first-page":"19051","DOI":"10.1074\/jbc.M110.123620","article-title":"Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1","volume":"285","author":"Yang","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.cyto.2020.155398_b0425","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.cyto.2020.155398_b0430","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1385\/ENDO:20:3:215","article-title":"Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome","volume":"20","author":"Akbar","year":"2003","journal-title":"Endocrine"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620304142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620304142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:58:43Z","timestamp":1760907523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466620304142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":86,"alternative-id":["S1043466620304142"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155398","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155398"}}