{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:41:07Z","timestamp":1760910067521,"version":"build-2065373602"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cyto.2020.155399","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T01:41:31Z","timestamp":1607478091000},"page":"155399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A nuclear factor kappa B reporter cell line used to evaluate ex vivo the net inflammatory effect of plasma samples from patients with rheumatoid arthritis, psoriasis, or COVID-19"],"prefix":"10.1016","volume":"138","author":[{"given":"Lelia","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter E.","family":"Haefeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Merle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanns-Martin","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Hohmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-9242","authenticated-orcid":false,"given":"Dirk","family":"Theile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2020.155399_b0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coi.2014.03.007","article-title":"Inflammation, ageing and chronic disease","volume":"29","author":"Pawelec","year":"2014","journal-title":"Curr. Opin. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.cyto.2020.155399_b0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 Years of NF-\u03baB: a blossoming of relevance to human pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2020.155399_b0015","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduction Targeted Therapy"},{"issue":"37","key":"10.1016\/j.cyto.2020.155399_b0020","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1038\/sj.onc.1206680","article-title":"Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation","volume":"22","author":"Criswell","year":"2003","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.cyto.2020.155399_b0025","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00411-010-0295-z","article-title":"Dose-rate effects of protons on in vivo activation of nuclear factor-kappa B and cytokines in mouse bone marrow cells","volume":"49","author":"Rithidech","year":"2010","journal-title":"Radiat. Environ. Biophys."},{"issue":"3","key":"10.1016\/j.cyto.2020.155399_b0030","first-page":"91","article-title":"Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings","volume":"11","author":"Dinarello","year":"1997","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.cyto.2020.155399_b0035","doi-asserted-by":"crossref","unstructured":"C. Chenevier-Gobeaux, S. Morin-Robinet, H. Lemarechal, S. Poiraudeau, J.C. Ekindjian, D. Borderie. 2004. Effects of pro- and anti-inflammatory cytokines and nitric oxide donors on hyaluronic acid synthesis by synovial cells from patients with rheumatoid arthritis, Clin. Sci. (London, England : 1979) 107(3), 291-296.","DOI":"10.1042\/CS20040104"},{"issue":"2","key":"10.1016\/j.cyto.2020.155399_b0040","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jacc.2006.07.071","volume":"49","author":"Liuzzo","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cyto.2020.155399_b0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1475-2875-11-191","article-title":"Activation of nuclear factor kappa B in peripheral blood mononuclear cells from malaria patients","volume":"11","author":"Punsawad","year":"2012","journal-title":"Malar. J."},{"issue":"11","key":"10.1016\/j.cyto.2020.155399_b0050","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1097\/01.CCM.0000089945.69588.18","article-title":"The effect of N-acetylcysteine on nuclear factor-kappa B activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis","volume":"31","author":"Paterson","year":"2003","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.cyto.2020.155399_b0055","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/00003246-200004000-00022","article-title":"Increased nuclear factor kappa B activation in critically ill patients who die","volume":"28","author":"Paterson","year":"2000","journal-title":"Crit. Care Med."},{"issue":"7","key":"10.1016\/j.cyto.2020.155399_b0060","doi-asserted-by":"crossref","first-page":"e0132496","DOI":"10.1371\/journal.pone.0132496","article-title":"Increased levels of NF-kB-dependent markers in cancer-associated deep venous thrombosis","volume":"10","author":"Malaponte","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cyto.2020.155399_b0065","doi-asserted-by":"crossref","first-page":"113646","DOI":"10.1016\/j.ab.2020.113646","article-title":"Reporter cell assay-based functional quantification of TNF-\u03b1-antagonists in serum \u2013 a proof-of-principle study for adalimumab","volume":"596","author":"Schuster","year":"2020","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cyto.2020.155399_b0070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/08916939808995367","article-title":"AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis","volume":"28","author":"Han","year":"1998","journal-title":"Autoimmunity"},{"issue":"4","key":"10.1016\/j.cyto.2020.155399_b0075","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/art.1780390407","article-title":"Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue","volume":"39","author":"Marok","year":"1996","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.cyto.2020.155399_b0080","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/rheumatology\/kem298","article-title":"Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation","volume":"47","author":"Simmonds","year":"2008","journal-title":"Rheumatology"},{"issue":"4","key":"10.1016\/j.cyto.2020.155399_b0085","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/rheumatology\/kes304","article-title":"Targeting monocytes\/macrophages in the treatment of rheumatoid arthritis","volume":"52","author":"Davignon","year":"2013","journal-title":"Rheumatology"},{"key":"10.1016\/j.cyto.2020.155399_b0090","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.12659\/MSM.895116","article-title":"Serum levels of IL-6 and TNF-\u03b1 may correlate with activity and severity of rheumatoid arthritis","volume":"21","author":"Wei","year":"2015","journal-title":"Med. Sci. Monitor: Int. Med. J. Exp. Clin. Res."},{"issue":"2","key":"10.1016\/j.cyto.2020.155399_b0095","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/bjd.12355","article-title":"Markers of systemic inflammation in psoriasis: a systematic review and meta-analysis","volume":"169","author":"Dowlatshahi","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.cyto.2020.155399_b0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cytogfr.2020.05.002","article-title":"COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons","volume":"53","author":"Nile","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"issue":"6","key":"10.1016\/j.cyto.2020.155399_b0105","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","article-title":"The pathogenesis and treatment of the \u2018Cytokine Storm' in COVID-19","volume":"80","author":"Ye","year":"2020","journal-title":"J. Infect."},{"key":"10.1016\/j.cyto.2020.155399_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-3-1","article-title":"Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)","volume":"3","author":"Grimm","year":"2006","journal-title":"J. Inflamm. (London, England)"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620304154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466620304154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:58:28Z","timestamp":1760907508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466620304154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":22,"alternative-id":["S1043466620304154"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155399","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A nuclear factor kappa B reporter cell line used to evaluate ex vivo the net inflammatory effect of plasma samples from patients with rheumatoid arthritis, psoriasis, or COVID-19","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2020.155399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155399"}}