{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:17:50Z","timestamp":1790320670691,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.cyto.2021.155457","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T18:55:13Z","timestamp":1612983313000},"page":"155457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Trauma-induced lung injury is associated with infiltration of activated TLR expressing myeloid cells"],"prefix":"10.1016","volume":"141","author":[{"given":"Meenakshi","family":"Rani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-8877","authenticated-orcid":false,"given":"Shannon R","family":"Sayyadioskoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-2605","authenticated-orcid":false,"given":"Eva M.","family":"Galvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah E.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Schwacha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6 Suppl","key":"10.1016\/j.cyto.2021.155457_b0005","first-page":"S3","article-title":"Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations","volume":"60","author":"Kauvar","year":"2006","journal-title":"J. Trauma"},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4187\/respcare.04716","article-title":"Past and Present ARDS Mortality Rates: A Systematic Review","volume":"62","author":"Maca","year":"2017","journal-title":"Respir. Care"},{"issue":"2","key":"10.1016\/j.cyto.2021.155457_b0015","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1164\/rccm.201409-1598OC","article-title":"Timing of low tidal volume ventilation and intensive care unit mortality in acute respiratory distress syndrome. A prospective cohort study","volume":"191","author":"Needham","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.cyto.2021.155457_b0020","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00000658-199905000-00007","article-title":"Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection","volume":"229","author":"Angele","year":"1999","journal-title":"Ann. Surg."},{"issue":"7","key":"10.1016\/j.cyto.2021.155457_b0025","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/ppul.21433","article-title":"IL-10 inhibits inflammatory cytokines released by fetal mouse lung fibroblasts exposed to mechanical stretch","volume":"46","author":"Hawwa","year":"2011","journal-title":"Pediatr. Pulmonol."},{"issue":"12","key":"10.1016\/j.cyto.2021.155457_b0030","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1097\/00000478-200212000-00004","article-title":"Usual interstitial pneumonia: histologic study of biopsy and explant specimens","volume":"26","author":"Katzenstein","year":"2002","journal-title":"American J. Surg. Pathol."},{"issue":"5","key":"10.1016\/j.cyto.2021.155457_b0035","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00063198-200109000-00002","article-title":"Bronchoalveolar lavage in interstitial lung disease","volume":"7","author":"Costabel","year":"2001","journal-title":"Current Opin. Pulmonary Med."},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.bcr.0000188325.71515.19","article-title":"T-cells of the \u03b3\u03b4 T-cell receptor lineage play an important role in the postburn wound healing process","volume":"27","author":"Alexander","year":"2006","journal-title":"J. Burn Care Res."},{"issue":"3","key":"10.1016\/j.cyto.2021.155457_b0045","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/shk.0b013e318034264c","article-title":"Regulation of the postburn wound inflammatory response by gammadelta T-cells","volume":"28","author":"Daniel","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.cyto.2021.155457_b0050","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.intimp.2018.03.002","article-title":"Toll-like receptors in immunity and inflammatory diseases: Past, present, and future","volume":"59","author":"Vijay","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155457_b0055","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s10753-015-0127-z","article-title":"Esculin Inhibits the Inflammation of LPS-Induced Acute Lung Injury in Mice Via Regulation of TLR\/NF-kappaB Pathways","volume":"38","author":"Tianzhu","year":"2015","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.cyto.2021.155457_b0060","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/00003246-198910000-00010","article-title":"Hemorrhage in mice induces alterations in immunoglobulin-secreting B cells","volume":"17","author":"Abraham","year":"1989","journal-title":"Crit. Care Med."},{"issue":"6","key":"10.1016\/j.cyto.2021.155457_b0065","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/SHK.0000000000000358","article-title":"Gamma delta T cells regulate inflammatory cell infiltration of the lung after trauma-hemorrhage","volume":"43","author":"Rani","year":"2015","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.cyto.2021.155457_b0070","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/S0002-9440(10)64504-X","article-title":"Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4\/FasL deficiency","volume":"161","author":"Ayala","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.cyto.2021.155457_b0075","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.bcp.2005.03.007","article-title":"Prevention of hemorrhagic shock-induced lung injury by heme arginate treatment in rats","volume":"69","author":"Maeshima","year":"2005","journal-title":"Biochem. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.cyto.2021.155457_b0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1385\/IR:26:1-3:063","article-title":"Gender dimorphism in immune responses following trauma and hemorrhage","volume":"26","author":"Yokoyama","year":"2002","journal-title":"Immunol. Res."},{"issue":"8","key":"10.1016\/j.cyto.2021.155457_b0085","doi-asserted-by":"crossref","first-page":"L709","DOI":"10.1152\/ajplung.00341.2013","article-title":"Diverse macrophage populations mediate acute lung inflammation and resolution","volume":"306","author":"Aggarwal","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"11","key":"10.1016\/j.cyto.2021.155457_b0090","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1172\/JCI0217302","article-title":"Neutrophils and lung injury: getting it right","volume":"110","author":"Martin","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.cyto.2021.155457_b0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/thoraxjnl-2017-211253","article-title":"Friend or foe? The dual role of neutrophils in lung injury and repair","volume":"73","author":"Grudzinska","year":"2018","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.cyto.2021.155457_b0100","first-page":"1004","article-title":"Propofol Protects Rats and Human Alveolar Epithelial Cells Against Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting HMGB1 Expression","volume":"39","author":"Wang","year":"2016","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.cyto.2021.155457_b0105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1164\/ajrccm\/144.2.251","article-title":"Neutrophils and adult respiratory distress syndrome: two interlocking perspectives in 1991","volume":"144","author":"Repine","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0110","first-page":"1","article-title":"Neutrophil activation and acute lung injury","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Crit. Care"},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1172\/JCI118009","article-title":"Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms","volume":"96","author":"Folkesson","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0120","doi-asserted-by":"crossref","first-page":"L25","DOI":"10.1152\/ajplung.2000.279.1.L25","article-title":"Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome","volume":"279","author":"Rosseau","year":"2000","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"5","key":"10.1016\/j.cyto.2021.155457_b0125","doi-asserted-by":"crossref","first-page":"L447","DOI":"10.1152\/ajplung.00415.2010","article-title":"TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia","volume":"302","author":"Standiford","year":"2012","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"10","key":"10.1016\/j.cyto.2021.155457_b0130","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.intimp.2011.05.013","article-title":"Toll like receptors in diseases of the lung","volume":"11","author":"Kovach","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2021.155457_b0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2017.01.015","article-title":"MyD88 gene knockout attenuates paraquat-induced acute lung injury","volume":"269","author":"Shen","year":"2017","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.cyto.2021.155457_b0140","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.3892\/etm.2016.3154","article-title":"Penehyclidine ameliorates acute lung injury by inhibiting Toll-like receptor 2\/4 expression and nuclear factor-kappaB activation","volume":"11","author":"Wang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cyto.2021.155457_b0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fimmu.2016.00095","article-title":"Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis","volume":"7","author":"Ferreira","year":"2016","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12026-015-8639-z","article-title":"PTEN-Foxo1 signaling triggers HMGB1-mediated innate immune responses in acute lung injury","volume":"62","author":"Zhou","year":"2015","journal-title":"Immunol. Res."},{"issue":"6813","key":"10.1016\/j.cyto.2021.155457_b0155","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.cyto.2021.155457_b0160","doi-asserted-by":"crossref","first-page":"L665","DOI":"10.1152\/ajplung.00232.2013","article-title":"Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction","volume":"305","author":"Herold","year":"2013","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"5","key":"10.1016\/j.cyto.2021.155457_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064375","article-title":"Toll-like receptor 4 mediates acute lung injury induced by high mobility group box-1","volume":"8","author":"Deng","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cyto.2021.155457_b0170","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1465-9921-12-149","article-title":"Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease","volume":"12","author":"Nadigel","year":"2011","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5056\/jnm.2011.17.1.28","article-title":"Basic and translational understandings of microbial recognition by toll-like receptors in the intestine","volume":"17","author":"Rhee","year":"2011","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.cyto.2021.155457_b0180","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1423-0127-21-20","article-title":"Inhibition of the phosphoinositide 3-kinase pathway decreases innate resistance to lipopolysaccharide toxicity in TLR4 deficient mice","volume":"21","author":"Yang","year":"2014","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0185","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2567.2006.02485.x","article-title":"Toll-like receptor interactions: tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-beta production","volume":"120","author":"Broad","year":"2007","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.cyto.2021.155457_b0190","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/1753425908100016","article-title":"Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms","volume":"14","author":"Flohe","year":"2008","journal-title":"Innate. Immun"},{"issue":"5","key":"10.1016\/j.cyto.2021.155457_b0195","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/1753425912437981","article-title":"The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death","volume":"18","author":"Beyer","year":"2012","journal-title":"Innate. Immun"},{"issue":"7285","key":"10.1016\/j.cyto.2021.155457_b0200","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"issue":"48","key":"10.1016\/j.cyto.2021.155457_b0205","doi-asserted-by":"crossref","first-page":"20388","DOI":"10.1073\/pnas.0908698106","article-title":"Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome","volume":"106","author":"Iyer","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"6","key":"10.1016\/j.cyto.2021.155457_b0210","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1189\/jlb.0703328","article-title":"Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses","volume":"75","author":"Collins","year":"2004","journal-title":"J Leukoc. Biol"},{"issue":"1","key":"10.1016\/j.cyto.2021.155457_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0305-4179(02)00187-0","article-title":"Macrophages and post-burn immune dysfunction","volume":"29","author":"Schwacha","year":"2003","journal-title":"Burns"},{"issue":"3","key":"10.1016\/j.cyto.2021.155457_b0220","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1189\/jlb.0503233","article-title":"Injury, sepsis, and the regulation of Toll-like receptor responses","volume":"75","author":"Murphy","year":"2004","journal-title":"J. Leukoc. Biol"},{"issue":"12","key":"10.1016\/j.cyto.2021.155457_b0225","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.4049\/jimmunol.180.12.7847","article-title":"Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages","volume":"180","author":"Henning","year":"2008","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2021.155457_b0230","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1164\/rccm.200907-1002OC","article-title":"The role of surfactant protein A in bleomycin-induced acute lung injury","volume":"181","author":"Goto","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621000375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621000375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:59:41Z","timestamp":1760907581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466621000375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":46,"alternative-id":["S1043466621000375"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155457","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trauma-induced lung injury is associated with infiltration of activated TLR expressing myeloid cells","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155457"}}