{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:32:16Z","timestamp":1768807936156,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/09038\u20131"],"award-info":[{"award-number":["2017\/09038\u20131"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/17646\u20131"],"award-info":[{"award-number":["2017\/17646\u20131"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/00855\u20132"],"award-info":[{"award-number":["2019\/00855\u20132"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/17058\u20138"],"award-info":[{"award-number":["2019\/17058\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301279\/2019\u20135"],"award-info":[{"award-number":["301279\/2019\u20135"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.cyto.2021.155494","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T08:22:12Z","timestamp":1616487732000},"page":"155494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Interleukin-6 ablation does not alter morphofunctional heart characteristics but modulates physiological and inflammatory markers after strenuous exercise"],"prefix":"10.1016","volume":"142","author":[{"given":"Alisson L.","family":"da Rocha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael L.","family":"Rovina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana P.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno B.","family":"Marafon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian E.C.M.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-9686","authenticated-orcid":false,"given":"Fernando M.","family":"Simabuco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiani G.","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 R.","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro P.","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7954-5630","authenticated-orcid":false,"given":"Dennys E.","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo R.","family":"Ropelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo T.","family":"Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen C.","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4500-6233","authenticated-orcid":false,"given":"Donato A.","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelino S.R.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cyto.2021.155494_b0005","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/00005768-200107000-00008","article-title":"Cardiac performance in endurance-trained and moderately active young women","volume":"33","author":"Ferguson","year":"2001","journal-title":"Med. Sci. Sports Exerc."},{"issue":"1","key":"10.1016\/j.cyto.2021.155494_b0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00005768-199801000-00008","article-title":"Oxygen transport: air to muscle cell","volume":"30","author":"Richardson","year":"1998","journal-title":"Med. Sci. Sports Exerc."},{"issue":"21","key":"10.1016\/j.cyto.2021.155494_b0015","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1073\/pnas.1934654100","article-title":"Phosphoinositide 3-kinase (p110\u03b1) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy","volume":"100","author":"McMullen","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.cyto.2021.155494_b0020","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/jcp.21197","article-title":"Activation or inactivation of cardiac Akt\/mTOR signaling diverges physiological from pathological hypertrophy","volume":"214","author":"Kemi","year":"2008","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155494_b0025","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.yjmcc.2006.03.251","article-title":"Phosphorylation of regulatory proteins CaMK, PLN and AKT precedes cardiomyocyte adaptation to exercise training","volume":"40","author":"Kemi","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cyto.2021.155494_b0030","article-title":"Exercise and Health\u2013emerging roles of IL-6, Current Opinion","author":"Ellingsgaard","year":"2019","journal-title":"Physiology"},{"key":"10.1016\/j.cyto.2021.155494_b0035","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev-physiol-020518-114339","article-title":"The physiology of optimizing health with a focus on exercise as medicine","volume":"81","author":"Pedersen","year":"2019","journal-title":"Annu. Rev. Physiol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155494_b0040","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tips.2007.02.002","article-title":"Beneficial health effects of exercise\u2013the role of IL-6 as a myokine","volume":"28","author":"Pedersen","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.cyto.2021.155494_b0045","first-page":"878","article-title":"The pro-and anti-inflammatory properties of the cytokine interleukin-6, Biochimica et Biophysica Acta (BBA)-Molecular Cell","volume":"1813","author":"Scheller","year":"2011","journal-title":"Research"},{"issue":"2","key":"10.1016\/j.cyto.2021.155494_b0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1536\/jhj.45.183","article-title":"Interleukin-6 and cardiovascular diseases","volume":"45","author":"Kanda","year":"2004","journal-title":"Jpn. Heart J."},{"issue":"1","key":"10.1016\/j.cyto.2021.155494_b0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.physiol.63.1.391","article-title":"Cytoplasmic signaling pathways that regulate cardiac hypertrophy","volume":"63","author":"Molkentin","year":"2001","journal-title":"Annu. Rev. Physiol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155494_b0060","doi-asserted-by":"crossref","first-page":"C1256","DOI":"10.1152\/ajpcell.00338.2010","article-title":"mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy","volume":"299","author":"Song","year":"2010","journal-title":"American J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.cyto.2021.155494_b0065","article-title":"Deletion of interleukin-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction","author":"Zhao","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.cyto.2021.155494_b0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cyto.2019.02.016","article-title":"The proinflammatory effects of chronic excessive exercise","volume":"119","author":"da Rocha","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2021.155494_b0075","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.26799","article-title":"Excessive training induces molecular signs of pathologic cardiac hypertrophy","author":"da Rocha","year":"2018","journal-title":"J. Cell Physiol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155494_b0080","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.cell.2012.08.012","article-title":"Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits","volume":"150","author":"Andreux","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cyto.2021.155494_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117107","article-title":"Tlr4 participates in the responses of markers of apoptosis, inflammation, and ER stress to different acute exercise intensities in mice hearts","volume":"240","author":"de Vicente","year":"2020","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.cyto.2021.155494_b0090","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bbrc.2016.03.159","article-title":"Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle","volume":"473","author":"Ikeda","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cyto.2021.155494_b0095","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3389\/fimmu.2017.01378","article-title":"Treadmill Slope Modulates Inflammation Fiber Type Composition, Androgen, and Glucocorticoid Receptors in the Skeletal Muscle of Overtrained Mice","volume":"8","author":"da Rocha","year":"2017","journal-title":"Front Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2021.155494_b0100","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1016\/j.bbadis.2017.08.022","article-title":"Interleukin-6 deficiency facilitates myocardial dysfunction during high fat diet-induced obesity by promoting lipotoxicity and inflammation","volume":"1863","author":"Chen","year":"2017","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol. Basis Disease"},{"issue":"12","key":"10.1016\/j.cyto.2021.155494_b0105","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1089\/jir.2017.0049","article-title":"Interleukin-6 Affects Aging-Related Changes of the PPAR\u03b1-PGC-1\u03b1 Axis in the Myocardium","volume":"37","author":"Bonda","year":"2017","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.cyto.2021.155494_b0110","doi-asserted-by":"crossref","unstructured":"J. F\u00e4ldt, I. Wernstedt, S.M. Fitzgerald, K. Wallenius, G.r. Bergstr\u00f6m, J.-O. Jansson, Reduced exercise endurance in interleukin-6-deficient mice, Endocrinology 145(6) (2004) 2680-2686.","DOI":"10.1210\/en.2003-1319"},{"issue":"14","key":"10.1016\/j.cyto.2021.155494_b0115","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1055\/s-0035-1555851","article-title":"Skeletal muscle response to endurance training in IL-6\u2212\/\u2212 mice","volume":"36","author":"Wojewoda","year":"2015","journal-title":"Int. J. Sports Med."},{"issue":"6","key":"10.1016\/j.cyto.2021.155494_b0120","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1073\/pnas.95.6.3251","article-title":"Sympathetic neurons can produce and respond to interleukin 6","volume":"95","author":"M\u00e4rz","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.cyto.2021.155494_b0125","doi-asserted-by":"crossref","first-page":"H1423","DOI":"10.1152\/ajpheart.00850.2014","article-title":"Interleukin-6 mediates exercise preconditioning against myocardial ischemia reperfusion injury","volume":"308","author":"McGinnis","year":"2015","journal-title":"American J. Physiol.-Heart Circulatory Physiol."},{"key":"10.1016\/j.cyto.2021.155494_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(03)00841-2","article-title":"Tumor necrosis factor-\u03b1: molecular and cellular mechanisms in skeletal pathology","volume":"321","author":"Nanes","year":"2003","journal-title":"Gene"},{"issue":"5249","key":"10.1016\/j.cyto.2021.155494_b0135","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-\u03b1-and obesity-induced insulin resistance","volume":"271","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.cyto.2021.155494_b0140","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1152\/japplphysiol.00629.2001","article-title":"Raised plasma G-CSF and IL-6 after exercise may play a role in neutrophil mobilization into the circulation","volume":"92","author":"Yamada","year":"2002","journal-title":"J. Appl. Physiol."},{"issue":"10","key":"10.1016\/j.cyto.2021.155494_b0145","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nrm1488","article-title":"Molecular mechanisms of translational control","volume":"5","author":"Gebauer","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cyto.2021.155494_b0150","doi-asserted-by":"crossref","unstructured":"F. Patin, T. Baranek, P. Vourc\u2019h, L. Nadal-Desbarats, J.-F. Goossens, S. Marouillat, A.-F. Dessein, A. Descat, B.M. Hounoum, C. Bruno, Combined metabolomics and transcriptomics approaches to assess the IL-6 blockade as a therapeutic of ALS: deleterious alteration of lipid metabolism, Neurotherapeutics 13(4) (2016) 905-917.","DOI":"10.1007\/s13311-016-0461-3"},{"issue":"10","key":"10.1016\/j.cyto.2021.155494_b0155","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.4049\/jimmunol.0902456","article-title":"TRIF signaling stimulates translation of TNF-\u03b1 mRNA via prolonged activation of MK2","volume":"184","author":"Gais","year":"2010","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.cyto.2021.155494_b0160","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.4049\/jimmunol.173.5.2913","article-title":"Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not Toll\/IL-1 receptor domain-containing adaptor-inducing IFN-\u03b2 (TRIF)-dependent pathway in TLR signaling","volume":"173","author":"Gohda","year":"2004","journal-title":"J. Immunol."},{"issue":"20","key":"10.1016\/j.cyto.2021.155494_b0165","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1056\/NEJMra0800239","article-title":"Biomarkers in heart failure","volume":"358","author":"Braunwald","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.cyto.2021.155494_b0170","doi-asserted-by":"crossref","first-page":"E629","DOI":"10.1152\/ajpendo.00171.2003","article-title":"Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise","volume":"285","author":"Coven","year":"2003","journal-title":"American J. Physiol.-Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155494_b0175","doi-asserted-by":"crossref","first-page":"786","DOI":"10.2337\/db06-0187","article-title":"AMP-activated protein kinase \u03b12 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function","volume":"56","author":"Ath\u00e9a","year":"2007","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.cyto.2021.155494_b0180","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/01.RES.0000187458.77026.10","article-title":"AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart","volume":"97","author":"Li","year":"2005","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.cyto.2021.155494_b0185","article-title":"Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice","volume":"12","author":"Shen","year":"2017","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.cyto.2021.155494_b0190","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cmet.2006.11.005","article-title":"Tumor necrosis factor \u03b1-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling","volume":"4","author":"Steinberg","year":"2006","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.cyto.2021.155494_b0195","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1128\/MCB.18.6.3518","article-title":"Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy","volume":"18","author":"Nemoto","year":"1998","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155494_b0200","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1074\/jbc.273.4.2161","article-title":"Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family","volume":"273","author":"Wang","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cyto.2021.155494_b0205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.139.1.115","article-title":"A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression","volume":"139","author":"Zechner","year":"1997","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155494_b0210","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1161\/CIRCULATIONAHA.107.710434","article-title":"Apoptosis signal-regulating kinase 1\/p38 signaling pathway negatively regulates physiological hypertrophy","volume":"117","author":"Taniike","year":"2008","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.cyto.2021.155494_b0215","doi-asserted-by":"crossref","first-page":"H1269","DOI":"10.1152\/ajpheart.00550.2006","article-title":"Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK","volume":"292","author":"Watanabe","year":"2007","journal-title":"American J. Physiol.-Heart Circulatory Physiol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155494_b0220","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.physiol.62.1.289","article-title":"Genetic dissection of cardiac growth control pathways","volume":"62","author":"MacLellan","year":"2000","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155494_b0225","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.cyto.2021.155494_b0230","doi-asserted-by":"crossref","DOI":"10.1172\/JCI133572","article-title":"Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts","volume":"130","author":"Chowdhury","year":"2020","journal-title":"J. Clin. Investig."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621000740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621000740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:00:12Z","timestamp":1760907612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466621000740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":46,"alternative-id":["S1043466621000740"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155494","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-6 ablation does not alter morphofunctional heart characteristics but modulates physiological and inflammatory markers after strenuous exercise","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155494","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"155494"}}