{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:39:57Z","timestamp":1765546797176,"version":"build-2065373602"},"reference-count":316,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.cyto.2021.155628","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T11:34:38Z","timestamp":1628249678000},"page":"155628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["COVID-19, what could sepsis, severe acute pancreatitis, gender differences, and aging teach us?"],"prefix":"10.1016","volume":"148","author":[{"given":"Claudio G.","family":"Gallo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirio","family":"Fiorino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Posabella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donato","family":"Antonacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Tropeano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Pausini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Pausini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-9022","authenticated-orcid":false,"given":"Tommaso","family":"Guarniero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-4252","authenticated-orcid":false,"given":"Wandong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Giampieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-1978","authenticated-orcid":false,"given":"Ivan","family":"Corazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lari","family":"Federico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"de Biase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Zippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zancanaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.cyto.2021.155628_b0005","first-page":"ofaa286","article-title":"The Course of Mild and Moderate COVID-19 Infections-The Unexpected Long-Lasting Challenge, Open Forum","volume":"7","author":"Xia","year":"2020","journal-title":"Infect Dis"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40425-018-0343-9","article-title":"Cytokine release syndrome","volume":"6","author":"Shimabukuro-Vornhagen","year":"2018","journal-title":"J. ImmunoTher. Cancer"},{"key":"10.1016\/j.cyto.2021.155628_b0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0020","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.cyto.2021.155628_b0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fimmu.2015.00422","article-title":"DAMPs from Cell Death to New Life","volume":"6","author":"Venereau","year":"2015","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0035","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.coviro.2011.10.006","article-title":"Toll-like receptors: key players in antiviral immunity","volume":"1","author":"Arpaia","year":"2011","journal-title":"Curr Opin Virol"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0040","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.cyto.2021.155628_b0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/bja\/77.1.110","article-title":"Sepsis and cytokines: current status","volume":"77","author":"Blackwell","year":"1996","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.cyto.2021.155628_b0055","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0060","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/eji.201545911","article-title":"IRF5 and IRF8 modulate the CAL-1 human plasmacytoid dendritic cell line response following TLR9 ligation","volume":"46","author":"Steinhagen","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0065","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2147\/JIR.S178084","article-title":"Inflammasomes: Pandora's box for sepsis","volume":"11","author":"Kumar","year":"2018","journal-title":"J Inflamm Res"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0070","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin Immunopathol"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0075","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/17471060500435662","article-title":"Inflammatory mediators in sepsis: Cytokines, chemokines, adhesion molecules and gases","volume":"2","author":"Ramnath","year":"2006","journal-title":"Journal of Organ Dysfunction"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0080","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1479-666X(03)80018-5","article-title":"Surgical sepsis: dysregulation of immune function and therapeutic implications","volume":"1","author":"Boontham","year":"2003","journal-title":"Surgeon"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.5455\/msm.2013.25.277-281","article-title":"The importance of serum procalcitonin in diagnosis and treatment of serious bacterial infections and sepsis","volume":"25","author":"Mehanic","year":"2013","journal-title":"Mater Sociomed"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0090","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3349\/ymj.2016.57.5.1139","article-title":"Serum Procalcitonin as a Useful Serologic Marker for Differential Diagnosis between Acute Gouty Attack and Bacterial Infection","volume":"57","author":"Choi","year":"2016","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.cyto.2021.155628_b0095","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4236\/abb.2013.49114","article-title":"Cytokine release in sepsis","volume":"4","author":"Burkovskiy","year":"2013","journal-title":"Advances in Bioscience and Biotechnology"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0100","first-page":"1","article-title":"Pro-Inflammatory Cytokines in Sepsis: Biological Studies and Prospects From In Silico Research, Biological Systems: Open","volume":"5","author":"Gomes","year":"2015","journal-title":"Access"},{"issue":"9","key":"10.1016\/j.cyto.2021.155628_b0105","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1097\/00003246-199609000-00004","article-title":"Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis","volume":"24","author":"Miller","year":"1996","journal-title":"Crit. Care Med."},{"issue":"5\u20136","key":"10.1016\/j.cyto.2021.155628_b0110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist","volume":"16","author":"Dinarello","year":"1998","journal-title":"Int. Rev. Immunol."},{"issue":"10141","key":"10.1016\/j.cyto.2021.155628_b0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0120","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","volume":"20","year":"1992","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0125","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"Sccm\/Esicm\/Accp\/Ats\/Sis, 2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit. Care Med."},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0130","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0135","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.cyto.2021.155628_b0140","doi-asserted-by":"crossref","unstructured":"M. Shankar-Hari, G.S. Phillips, M.L. Levy, C.W. Seymour, V.X. Liu, C.S. Deutschman, D.C. Angus, G.D. Rubenfeld, M. Singer, F. Sepsis Definitions Task, Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), JAMA 315(8) (2016) 775-87.","DOI":"10.1001\/jama.2016.0289"},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0145","first-page":"707","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure","volume":"22","author":"Vincent","year":"1996","journal-title":"On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine, Intensive Care Med"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0150","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s15010-008-8203-z","article-title":"Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry","volume":"37","author":"Beale","year":"2009","journal-title":"Infection"},{"issue":"11","key":"10.1016\/j.cyto.2021.155628_b0155","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.molmed.2020.06.007","article-title":"JAK-STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis","volume":"26","author":"Clere-Jehl","year":"2020","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0160","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/bja\/aep128","article-title":"Immunomodulation in the critically ill","volume":"103","author":"Webster","year":"2009","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1684\/ecn.2011.0281","article-title":"Pro- and anti-inflammatory responses are regulated simultaneously from the first moments of septic shock","volume":"22","author":"Tamayo","year":"2011","journal-title":"Eur. Cytokine Netw."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0170","doi-asserted-by":"crossref","first-page":"R237","DOI":"10.1186\/cc9392","article-title":"Genome-wide transcription profiling of human sepsis: a systematic review","volume":"14","author":"Tang","year":"2010","journal-title":"Crit. Care"},{"issue":"13","key":"10.1016\/j.cyto.2021.155628_b0175","first-page":"2581","article-title":"Inflammation, P","volume":"208","author":"Xiao","year":"2011","journal-title":"Host Response to Injury Large-Scale Collaborative Research, A genomic storm in critically injured humans, J Exp Med"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0180","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ajem.2015.12.075","article-title":"Artemisinin protects mice against burn sepsis through inhibiting NLRP3 inflammasome activation","volume":"34","author":"Long","year":"2016","journal-title":"Am. J. Emerg. Med."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.intimp.2014.02.017","article-title":"Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1","volume":"20","author":"Luo","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.cyto.2021.155628_b0190","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/mnfr.201500316","article-title":"Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock","volume":"59","author":"Gong","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b0195","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1007\/s40520-020-01669-y","article-title":"Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy","volume":"32","author":"Fiorino","year":"2020","journal-title":"Aging Clin Exp Res"},{"issue":"12","key":"10.1016\/j.cyto.2021.155628_b0200","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.cyto.2021.155628_b0205","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.thromres.2014.03.014","article-title":"Crosstalk between the coagulation and complement systems in sepsis","volume":"133","author":"Lupu","year":"2014","journal-title":"Thromb. Res."},{"issue":"16","key":"10.1016\/j.cyto.2021.155628_b0210","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1002\/1873-3468.13881","article-title":"Complement in sepsis-when science meets clinics","volume":"594","author":"Mollnes","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cyto.2021.155628_b0215","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/382463","article-title":"Activated Complement Factors as Disease Markers for Sepsis","volume":"2015","author":"Charchaflieh","year":"2015","journal-title":"Dis. Markers"},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0220","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41577-019-0168-x","article-title":"New insights into the immune functions of complement","volume":"19","author":"Reis","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0225","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0230","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2010.024","article-title":"Sepsis-associated disseminated intravascular coagulation and thromboembolic disease","volume":"2","author":"Semeraro","year":"2010","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.cyto.2021.155628_b0235","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fimmu.2016.00236","article-title":"The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis","volume":"7","author":"Kimball","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0240","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.thromres.2018.08.005","article-title":"The role of neutrophils in thrombosis","volume":"170","author":"Kapoor","year":"2018","journal-title":"Thromb. Res."},{"key":"10.1016\/j.cyto.2021.155628_b0245","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.610696","article-title":"Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0250","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/SHK.0000000000000221","article-title":"Neutrophil extracellular traps in sepsis","volume":"42","author":"Camicia","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.cyto.2021.155628_b0255","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fcvm.2019.00085","article-title":"Platelet-Neutrophil Interplay: Insights Into Neutrophil Extracellular Trap (NET)-Driven Coagulation in Infection","volume":"6","author":"Zucoloto","year":"2019","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0260","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","article-title":"NETosis, complement, and coagulation: a triangular relationship","volume":"16","author":"de Bont","year":"2019","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0265","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.4049\/jimmunol.2000644","article-title":"COVID-19: Complement, Coagulation, and Collateral Damage","volume":"205","author":"Lo","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0270","doi-asserted-by":"crossref","first-page":"4235909","DOI":"10.1155\/2020\/4235909","article-title":"Monocytes Undergo Functional Reprogramming to Generate Immunosuppression through HIF-1alpha Signaling Pathway in the Late Phase of Sepsis","volume":"2020","author":"Li","year":"2020","journal-title":"Mediators Inflamm."},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b0275","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.it.2009.07.009","article-title":"Endotoxin tolerance: new mechanisms, molecules and clinical significance","volume":"30","author":"Biswas","year":"2009","journal-title":"Trends Immunol."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0280","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/cc5055","article-title":"Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis","volume":"10","author":"Cavaillon","year":"2006","journal-title":"Crit. Care"},{"issue":"8899","key":"10.1016\/j.cyto.2021.155628_b0285","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0140-6736(94)91584-9","article-title":"Interleukin-10 production during septicaemia","volume":"343","author":"Marchant","year":"1994","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.cyto.2021.155628_b0290","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1286-4579(02)01613-1","article-title":"Toll receptors, CD14, and macrophage activation and deactivation by LPS","volume":"4","author":"Dobrovolskaia","year":"2002","journal-title":"Microbes Infect."},{"issue":"7147","key":"10.1016\/j.cyto.2021.155628_b0295","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nature05836","article-title":"Gene-specific control of inflammation by TLR-induced chromatin modifications","volume":"447","author":"Foster","year":"2007","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b0300","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.4049\/jimmunol.0803350","article-title":"Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients","volume":"182","author":"del Fresno","year":"2009","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.cyto.2021.155628_b0305","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1172\/JCI3877","article-title":"Regulation of an essential innate immune response by the p50 subunit of NF-kappaB","volume":"102","author":"Bohuslav","year":"1998","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0310","first-page":"13","article-title":"Molecular mechanism in tolerance to lipopolysaccharide","volume":"45","author":"Ziegler-Heitbrock","year":"1995","journal-title":"J. Inflamm."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0315","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1164\/ajrccm.162.5.2003058","article-title":"NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance","volume":"162","author":"Adib-Conquy","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0320","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1172\/JCI116306","article-title":"Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome","volume":"91","author":"McCall","year":"1993","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0325","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2249.2008.03737.x","article-title":"Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression","volume":"154","author":"Danikas","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0330","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1067\/mlc.2000.104306","article-title":"Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patients","volume":"135","author":"Manjuck","year":"2000","journal-title":"J. Lab. Clin. Med."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0335","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1172\/JCI114542","article-title":"Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages","volume":"85","author":"Mathison","year":"1990","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0340","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1128\/iai.63.6.2109-2112.1995","article-title":"High levels of interleukin 10 in serum are associated with fatality in meningococcal disease","volume":"63","author":"Lehmann","year":"1995","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0345","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.imlet.2004.07.009","article-title":"The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration","volume":"95","author":"Monneret","year":"2004","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0350","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/infdis\/172.2.433","article-title":"Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections","volume":"172","author":"van Deuren","year":"1995","journal-title":"J. Infect. Dis."},{"issue":"9107","key":"10.1016\/j.cyto.2021.155628_b0355","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0140-6736(05)60606-X","article-title":"Anti-inflammatory cytokine profile and mortality in febrile patients","volume":"351","author":"van Dissel","year":"1998","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0360","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.intimp.2011.01.003","article-title":"Myeloid derived suppressor cells in human diseases","volume":"11","author":"Greten","year":"2011","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0365","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/CJI.0b013e318242169f","article-title":"Myeloid-derived suppressor cells in cancer patients: a clinical perspective","volume":"35","author":"Montero","year":"2012","journal-title":"J. Immunother."},{"key":"10.1016\/j.cyto.2021.155628_b0370","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3389\/fimmu.2019.00327","article-title":"Myeloid-Derived Suppressor Cells in Sepsis","volume":"10","author":"Schrijver","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0375","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0380","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/CCM.0000000000002074","article-title":"Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome","volume":"45","author":"Mira","year":"2017","journal-title":"Crit. Care Med."},{"issue":"23","key":"10.1016\/j.cyto.2021.155628_b0385","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"Boomer","year":"2011","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0390","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/SHK.0000000000000234","article-title":"Persistent lymphopenia after diagnosis of sepsis predicts mortality","volume":"42","author":"Drewry","year":"2014","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0395","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/TA.0b013e318256e000","article-title":"Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care","volume":"72","author":"Gentile","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.cyto.2021.155628_b0400","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jcrc.2018.01.013","article-title":"Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis - A meta-analysis","volume":"45","author":"Krautz","year":"2018","journal-title":"J. Crit. Care"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0405","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2362.1990.tb01883.x","article-title":"Endotoxin-stimulated peritoneal macrophages obtained from continuous ambulatory peritoneal dialysis patients show an increased capacity to release interleukin-1 beta in vitro during infectious peritonitis","volume":"20","author":"Fieren","year":"1990","journal-title":"Eur. J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0410","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/CCM.0000000000003685","article-title":"Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559)","volume":"47","author":"Hotchkiss","year":"2019","journal-title":"Crit. Care Med."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0415","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1164\/ajrccm\/140.6.1686","article-title":"Elevated interleukin-1 release by human alveolar macrophages during the adult respiratory distress syndrome","volume":"140","author":"Jacobs","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"issue":"1\u20132","key":"10.1016\/j.cyto.2021.155628_b0420","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cyto.2006.04.007","article-title":"Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis","volume":"34","author":"Suzuki","year":"2006","journal-title":"Cytokine"},{"issue":"Suppl 4","key":"10.1016\/j.cyto.2021.155628_b0425","first-page":"7","article-title":"Biomarkers for Sepsis: What Is and What Might Be?","volume":"10","author":"Biron","year":"2015","journal-title":"Biomark Insights"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0430","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1160\/TH08-07-0421","article-title":"Compensatory anti-inflammatory response syndrome","volume":"101","author":"Adib-Conquy","year":"2009","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0435","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1203\/00006450-199810000-00002","article-title":"Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis","volume":"44","author":"Berner","year":"1998","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0440","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3233\/NPM-1364112","article-title":"Cytokines patterns in newborn infants with late onset sepsis","volume":"6","author":"Lusyati","year":"2013","journal-title":"J Neonatal Perinatal Med"},{"key":"10.1016\/j.cyto.2021.155628_b0445","article-title":"Neonatal sepsis and inflammatory mediators","volume":"2014","author":"Machado","year":"2014","journal-title":"Mediators Inflamm."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0450","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/bjs.5290","article-title":"Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis","volume":"93","author":"Mofidi","year":"2006","journal-title":"Br. J. Surg."},{"issue":"11","key":"10.1016\/j.cyto.2021.155628_b0455","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.cgh.2009.08.012","article-title":"Early systemic inflammatory response syndrome is associated with severe acute pancreatitis","volume":"7","author":"Singh","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0460","first-page":"507","article-title":"Involvement of the exocrine pancreas during COVID-19 infection and possible pathogenetic hypothesis: a concise review","volume":"28","author":"Zippi","year":"2020","journal-title":"Infez Med"},{"key":"10.1016\/j.cyto.2021.155628_b0465","doi-asserted-by":"crossref","first-page":"1294951","DOI":"10.1155\/2018\/1294951","article-title":"NLRP3 Deficiency Alleviates Severe Acute Pancreatitis and Pancreatitis-Associated Lung Injury in a Mouse Model","volume":"2018","author":"Fu","year":"2018","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.cyto.2021.155628_b0470","doi-asserted-by":"crossref","unstructured":"S.M. van Dijk, N.D.L. Hallensleben, H.C. van Santvoort, P. Fockens, H. van Goor, M.J. Bruno, M.G. Besselink, G. Dutch Pancreatitis Study, Acute pancreatitis: recent advances through randomised trials, Gut 66(11) (2017) 2024-2032.","DOI":"10.1136\/gutjnl-2016-313595"},{"issue":"28","key":"10.1016\/j.cyto.2021.155628_b0475","doi-asserted-by":"crossref","first-page":"14717","DOI":"10.1074\/jbc.M116.718999","article-title":"Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis","volume":"291","author":"Sendler","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2021.155628_b0480","doi-asserted-by":"crossref","unstructured":"M. Sendler, C. van den Brandt, J. Glaubitz, A. Wilden, J. Golchert, F.U. Weiss, G. Homuth, L.L. De Freitas Chama, N. Mishra, U.M. Mahajan, L. Bossaller, U. Volker, B.M. Broker, J. Mayerle, M.M. Lerch, NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis, Gastroenterology 158(1) (2020) 253-269 e14.","DOI":"10.1053\/j.gastro.2019.09.040"},{"key":"10.1016\/j.cyto.2021.155628_b0485","doi-asserted-by":"crossref","unstructured":"N. Zhu, D. Zhang, W. Wang, X. Li, B. Yang, J. Song, X. Zhao, B. Huang, W. Shi, R. Lu, P. Niu, F. Zhan, X. Ma, D. Wang, W. Xu, G. Wu, G.F. Gao, W. Tan, I. China Novel Coronavirus, T. Research, A Novel Coronavirus from Patients with Pneumonia in China, 2019, N Engl J Med 382(8) (2020) 727-733.","DOI":"10.1056\/NEJMoa2001017"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0490","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s15010-020-01401-y","article-title":"2019 Novel coronavirus: where we are and what we know","volume":"48","author":"Cheng","year":"2020","journal-title":"Infection"},{"issue":"13","key":"10.1016\/j.cyto.2021.155628_b0495","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0500","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10030446","article-title":"Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations","volume":"10","author":"Thakur","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.cyto.2021.155628_b0505","doi-asserted-by":"crossref","unstructured":"Z. Zhou, L. Ren, L. Zhang, J. Zhong, Y. Xiao, Z. Jia, L. Guo, J. Yang, C. Wang, S. Jiang, D. Yang, G. Zhang, H. Li, F. Chen, Y. Xu, M. Chen, Z. Gao, J. Yang, J. Dong, B. Liu, X. Zhang, W. Wang, K. He, Q. Jin, M. Li, J. Wang, Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients, Cell Host Microbe 27(6) (2020) 883-890 e2.","DOI":"10.1016\/j.chom.2020.04.017"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0510","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0515","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fpubh.2020.00152","article-title":"Gender Differences in Patients With COVID-19: Focus on Severity and Mortality","volume":"8","author":"Jin","year":"2020","journal-title":"Front. Public Health"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0520","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008520","article-title":"Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients","volume":"16","author":"Meng","year":"2020","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0525","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0530","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0535","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.1901046","article-title":"Monocyte-Derived Cells in Tissue-Resident Memory T Cell Formation","volume":"204","author":"Chu","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0540","doi-asserted-by":"crossref","unstructured":"E.J. Giamarellos-Bourboulis, M.G. Netea, N. Rovina, K. Akinosoglou, A. Antoniadou, N. Antonakos, G. Damoraki, T. Gkavogianni, M.E. Adami, P. Katsaounou, M. Ntaganou, M. Kyriakopoulou, G. Dimopoulos, I. Koutsodimitropoulos, D. Velissaris, P. Koufargyris, A. Karageorgos, K. Katrini, V. Lekakis, M. Lupse, A. Kotsaki, G. Renieris, D. Theodoulou, V. Panou, E. Koukaki, N. Koulouris, C. Gogos, A. Koutsoukou, Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure, Cell Host Microbe 27(6) (2020) 992-1000 e3.","DOI":"10.1016\/j.chom.2020.04.009"},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0545","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41591-020-0944-y","article-title":"A single-cell atlas of the peripheral immune response in patients with severe COVID-19","volume":"26","author":"Wilk","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2021.155628_b0550","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fcvm.2017.00080","article-title":"Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation","volume":"4","author":"Buscher","year":"2017","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0555","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.4049\/jimmunol.1601281","article-title":"Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface","volume":"198","author":"Chimen","year":"2017","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0560","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41419-018-0327-1","article-title":"The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence","volume":"9","author":"Ong","year":"2018","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0565","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s11357-020-00213-0","article-title":"Severe COVID-19 and aging: are monocytes the key?","volume":"42","author":"Pence","year":"2020","journal-title":"Geroscience"},{"key":"10.1016\/j.cyto.2021.155628_b0570","article-title":"Monocyte class switch and hyperinflammation characterise severe COVID-19 in type 2 diabetes","author":"Alzaid","year":"2020","journal-title":"MedRxiv"},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0575","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.4049\/jimmunol.168.7.3536","article-title":"The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF","volume":"168","author":"Belge","year":"2002","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0580","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1182\/blood.V87.1.373.373","article-title":"Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis","volume":"87","author":"Frankenberger","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2021.155628_b0585","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fimmu.2013.00339","article-title":"Phenotypic characterization of human intermediate monocytes","volume":"4","author":"Hijdra","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0590","doi-asserted-by":"crossref","first-page":"13886","DOI":"10.1038\/srep13886","article-title":"Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous","volume":"5","author":"Mukherjee","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2021.155628_b0595","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40169-014-0040-3","article-title":"Clinical significance of monocyte heterogeneity","volume":"4","author":"Stansfield","year":"2015","journal-title":"Clin Transl Med"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0600","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2021.155628_b0605","doi-asserted-by":"crossref","unstructured":"I. Sanchez-Cerrillo, P. Landete, B. Aldave, S. Sanchez-Alonso, A. Sanchez-Azofra, A. Marcos-Jimenez, E. Avalos, A. Alcaraz-Serna, I. de Los Santos, T. Mateu-Albero, L. Esparcia, C. Lopez-Sanz, P. Martinez-Fleta, L. Gabrie, L. Del Campo Guerola, H. de la Fuente, M.J. Calzada, I. Gonzalez-Alvaro, A. Alfranca, F. Sanchez-Madrid, C. Munoz-Calleja, J.B. Soriano, J. Ancochea, E. Martin-Gayo, C. Reinmun, E. groups, COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes, J Clin Invest 130(12) (2020) 6290-6300.","DOI":"10.1172\/JCI140335"},{"issue":"10238","key":"10.1016\/j.cyto.2021.155628_b0610","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(20)30854-0","article-title":"Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study","volume":"395","author":"Banerjee","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0615","doi-asserted-by":"crossref","first-page":"199","DOI":"10.20945\/2359-3997000000256","article-title":"Type 2 diabetes as a major risk factor for COVID-19 severity: a meta-analysis","volume":"64","author":"Pinto","year":"2020","journal-title":"Arch Endocrinol Metab"},{"key":"10.1016\/j.cyto.2021.155628_b0620","unstructured":"T. Takahashi, P. Wong, M.K. Ellingson, C. Lucas, J. Klein, B. Israelow, J. Silva, J.E. Oh, T. Mao, M. Tokuyama, P. Lu, A. Venkataraman, A. Park, F. Liu, A. Meir, J. Sun, E.Y. Wang, A.L. Wyllie, C.B.F. Vogels, R. Earnest, S. Lapidus, I.M. Ott, A.J. Moore, A. Casanovas-Massana, C.D. Cruz, J.B. Fournier, C.D. Odio, S. Farhadian, N.D. Grubaugh, W.L. Schulz, A.I. Ko, A.M. Ring, S.B. Omer, A. Iwasaki, I.r.t. Yale, Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes, medRxiv (2020)."},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0625","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41590-018-0136-9","article-title":"Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells","volume":"19","author":"Rodrigues","year":"2018","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0630","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2018587118","article-title":"Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity","volume":"118","author":"Kvedaraite","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0635","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144734","article-title":"Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity","volume":"131","author":"Falck-Jones","year":"2021","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b0640","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41419-020-03125-1","article-title":"Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome","volume":"11","author":"Sacchi","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cyto.2021.155628_b0645","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.586765","article-title":"Can Natural Killer Cells Be a Principal Player in Anti-SARS-CoV-2 Immunity?","volume":"11","author":"Ahmed","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0650","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2020.00827","article-title":"Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0655","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.580237","article-title":"Elevated Exhaustion Levels of NK and CD8(+) T Cells as Indicators for Progression and Prognosis of COVID-19 Disease","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0660","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-019-0224-6","article-title":"TIM3 comes of age as an inhibitory receptor","volume":"20","author":"Wolf","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0665","first-page":"3641939","article-title":"Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 (+) T Cells","author":"Meckiff","year":"2020","journal-title":"SSRN"},{"key":"10.1016\/j.cyto.2021.155628_b0670","doi-asserted-by":"crossref","unstructured":"N. Kaneko, J. Boucau, H.H. Kuo, C. Perugino, V.S. Mahajan, J.R. Farmer, H. Liu, T.J. Diefenbach, A. Piechocka-Trocha, K. Lefteri, M.T. Waring, K.R. Premo, B.D. Walker, J.Z. Li, G. Gaiha, X.G. Yu, M. Lichterfeld, R.F. Padera, S. Pillai, Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19, medRxiv (2021).","DOI":"10.2139\/ssrn.3813278"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0675","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1182\/blood-2005-02-0456","article-title":"IL-6 blocks a discrete early step in lymphopoiesis","volume":"106","author":"Maeda","year":"2005","journal-title":"Blood"},{"issue":"49","key":"10.1016\/j.cyto.2021.155628_b0680","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaw2262","article-title":"TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity","volume":"5","author":"Harbour","year":"2020","journal-title":"Sci. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0685","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1183\/09031936.01.00057901","article-title":"Peripheral blood neutrophils are hyperresponsive to IL-8 and Gro-alpha in cryptogenic fibrosing alveolitis","volume":"18","author":"Glynn","year":"2001","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cyto.2021.155628_b0690","doi-asserted-by":"crossref","unstructured":"A. Ciccullo, A. Borghetti, L. Zileri Dal Verme, A. Tosoni, F. Lombardi, M. Garcovich, F. Biscetti, M. Montalto, R. Cauda, S. Di Giambenedetto, G.A.C. Group, Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line, Int J Antimicrob Agents 56(2) (2020) 106017.","DOI":"10.1016\/j.ijantimicag.2020.106017"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0695","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.13698","article-title":"Neutrophil\/lymphocyte ratio-A marker of COVID-19 pneumonia severity","volume":"75","author":"Imran","year":"2021","journal-title":"Int. J. Clin. Pract."},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0700","first-page":"466","article-title":"Rationale Use of Neutrophil-to-lymphocyte ratio for early diagnosis and stratification of COVID-19","volume":"121","author":"Zahorec","year":"2020","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.cyto.2021.155628_b0705","doi-asserted-by":"crossref","unstructured":"T. Sekine, A. Perez-Potti, O. Rivera-Ballesteros, K. Stralin, J.B. Gorin, A. Olsson, S. Llewellyn-Lacey, H. Kamal, G. Bogdanovic, S. Muschiol, D.J. Wullimann, T. Kammann, J. Emgard, T. Parrot, E. Folkesson, C.-S.G. Karolinska, O. Rooyackers, L.I. Eriksson, J.I. Henter, A. Sonnerborg, T. Allander, J. Albert, M. Nielsen, J. Klingstrom, S. Gredmark-Russ, N.K. Bjorkstrom, J.K. Sandberg, D.A. Price, H.G. Ljunggren, S. Aleman, M. Buggert, Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19, Cell 183(1) (2020) 158-168 e14.","DOI":"10.1101\/2020.06.29.174888"},{"key":"10.1016\/j.cyto.2021.155628_b0710","first-page":"71","article-title":"Interaction between the coagulation and complement system","volume":"632","author":"Amara","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0715","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/shk.0b013e3180342439","article-title":"Role of the alternative pathway in the early complement activation following major trauma","volume":"28","author":"Ganter","year":"2007","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0720","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nm1419","article-title":"Generation of C5a in the absence of C3: a new complement activation pathway","volume":"12","author":"Huber-Lang","year":"2006","journal-title":"Nat. Med."},{"issue":"15","key":"10.1016\/j.cyto.2021.155628_b0725","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1016\/S0021-9258(18)81901-9","article-title":"Complement proteins C5b\u20139 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface","volume":"264","author":"Hattori","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0730","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.4049\/jimmunol.1601121","article-title":"Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis","volume":"199","author":"Bettoni","year":"2017","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0735","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1182\/blood-2014-06-585430","article-title":"von Willebrand factor is a cofactor in complement regulation","volume":"125","author":"Feng","year":"2015","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0740","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1182\/blood.V100.2.517","article-title":"C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils","volume":"100","author":"Wojta","year":"2002","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0745","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1399-3089.2012.00704.x","article-title":"Increased human tumor necrosis factor-alpha levels induce procoagulant change in porcine endothelial cells in vitro","volume":"19","author":"Lee","year":"2012","journal-title":"Xenotransplantation"},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b0750","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.4049\/jimmunol.177.7.4794","article-title":"A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways","volume":"177","author":"Ritis","year":"2006","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.cyto.2021.155628_b0755","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.306853","article-title":"Cross Talk Pathways Between Coagulation and Inflammation","volume":"118","author":"Foley","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.cyto.2021.155628_b0760","first-page":"81","article-title":"Platelet mediated complement activation","volume":"632","author":"Peerschke","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b0765","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1182\/blood.V68.4.875.875","article-title":"Complement proteins C5b\u20139 stimulate procoagulant activity through platelet prothrombinase","volume":"68","author":"Wiedmer","year":"1986","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.cyto.2021.155628_b0770","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140711","article-title":"The complement system in COVID-19: friend and foe?","volume":"5","author":"Java","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.cyto.2021.155628_b0775","doi-asserted-by":"crossref","unstructured":"J. Carvelli, O. Demaria, F. Vely, L. Batista, N. Chouaki Benmansour, J. Fares, S. Carpentier, M.L. Thibult, A. Morel, R. Remark, P. Andre, A. Represa, C. Piperoglou, C.-I.P.H.g. Explore, C.-M.I.g. Explore, P.Y. Cordier, E. Le Dault, C. Guervilly, P. Simeone, M. Gainnier, Y. Morel, M. Ebbo, N. Schleinitz, E. Vivier, Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis, Nature 588(7836) (2020) 146-150.","DOI":"10.1038\/s41586-020-2600-6"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0780","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jaci.2020.05.006","article-title":"Complement activation in patients with COVID-19: A novel therapeutic target","volume":"146","author":"Cugno","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0785","volume":"9","author":"Gralinski","year":"2018","journal-title":"Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis, mBio"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0790","doi-asserted-by":"crossref","DOI":"10.3390\/v11010039","article-title":"Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV","volume":"11","author":"Jiang","year":"2019","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0795","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.kint.2020.05.013","article-title":"The case of complement activation in COVID-19 multiorgan impact","volume":"98","author":"Noris","year":"2020","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.cyto.2021.155628_b0800","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1172\/JCI141374","article-title":"Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis","volume":"130","author":"Skendros","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cyto.2021.155628_b0805","doi-asserted-by":"crossref","DOI":"10.1038\/s41573-019-0055-y","article-title":"Therapeutic targeting of the complement system","author":"Ricklin","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.cyto.2021.155628_b0810","doi-asserted-by":"crossref","first-page":"954","DOI":"10.3389\/fimmu.2019.00954","article-title":"Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer","volume":"10","author":"Kleczko","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0815","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-0039-3402731","article-title":"Traps N' Clots: NET-Mediated Thrombosis and Related Diseases","volume":"120","author":"Stakos","year":"2020","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.cyto.2021.155628_b0820","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.molimm.2019.07.030","article-title":"Compendium of current complement therapeutics","volume":"114","author":"Zelek","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0825","unstructured":"P. Bastard, L.B. Rosen, Q. Zhang, E. Michailidis, H.H. Hoffmann, Y. Zhang, K. Dorgham, Q. Philippot, J. Rosain, V. Beziat, J. Manry, E. Shaw, L. Haljasmagi, P. Peterson, L. Lorenzo, L. Bizien, S. Trouillet-Assant, K. Dobbs, A.A. de Jesus, A. Belot, A. Kallaste, E. Catherinot, Y. Tandjaoui-Lambiotte, J. Le Pen, G. Kerner, B. Bigio, Y. Seeleuthner, R. Yang, A. Bolze, A.N. Spaan, O.M. Delmonte, M.S. Abers, A. Aiuti, G. Casari, V. Lampasona, L. Piemonti, F. Ciceri, K. Bilguvar, R.P. Lifton, M. Vasse, D.M. Smadja, M. Migaud, J. Hadjadj, B. Terrier, D. Duffy, L. Quintana-Murci, D. van de Beek, L. Roussel, D.C. Vinh, S.G. Tangye, F. Haerynck, D. Dalmau, J. Martinez-Picado, P. Brodin, M.C. Nussenzweig, S. Boisson-Dupuis, C. Rodriguez-Gallego, G. Vogt, T.H. Mogensen, A.J. Oler, J. Gu, P.D. Burbelo, J.I. Cohen, A. Biondi, L.R. Bettini, M. D'Angio, P. Bonfanti, P. Rossignol, J. Mayaux, F. Rieux-Laucat, E.S. Husebye, F. Fusco, M.V. Ursini, L. Imberti, A. Sottini, S. Paghera, E. Quiros-Roldan, C. Rossi, R. Castagnoli, D. Montagna, A. Licari, G.L. Marseglia, X. Duval, J. Ghosn, H. Lab, N.-U.I.R.t.C. Group, C. Clinicians, C.-S. Clinicians, C.G. Imagine, C.C.S.G. French, C. Milieu Interieur, V.C.C. Co, U.M.C.C.-B. Amsterdam, C.H.G. Effort, J.S. Tsang, R. Goldbach-Mansky, K. Kisand, M.S. Lionakis, A. Puel, S.Y. Zhang, S.M. Holland, G. Gorochov, E. Jouanguy, C.M. Rice, A. Cobat, L.D. Notarangelo, L. Abel, H.C. Su, J.L. Casanova, Autoantibodies against type I IFNs in patients with life-threatening COVID-19, Science 370(6515) (2020)."},{"key":"10.1016\/j.cyto.2021.155628_b0830","unstructured":"Q. Zhang, P. Bastard, Z. Liu, J. Le Pen, M. Moncada-Velez, J. Chen, M. Ogishi, I.K.D. Sabli, S. Hodeib, C. Korol, J. Rosain, K. Bilguvar, J. Ye, A. Bolze, B. Bigio, R. Yang, A.A. Arias, Q. Zhou, Y. Zhang, F. Onodi, S. Korniotis, L. Karpf, Q. Philippot, M. Chbihi, L. Bonnet-Madin, K. Dorgham, N. Smith, W.M. Schneider, B.S. Razooky, H.H. Hoffmann, E. Michailidis, L. Moens, J.E. Han, L. Lorenzo, L. Bizien, P. Meade, A.L. Neehus, A.C. Ugurbil, A. Corneau, G. Kerner, P. Zhang, F. Rapaport, Y. Seeleuthner, J. Manry, C. Masson, Y. Schmitt, A. Schluter, T. Le Voyer, T. Khan, J. Li, J. Fellay, L. Roussel, M. Shahrooei, M.F. Alosaimi, D. Mansouri, H. Al-Saud, F. Al-Mulla, F. Almourfi, S.Z. Al-Muhsen, F. Alsohime, S. Al Turki, R. Hasanato, D. van de Beek, A. Biondi, L.R. Bettini, M. D'Angio, P. Bonfanti, L. Imberti, A. Sottini, S. Paghera, E. Quiros-Roldan, C. Rossi, A.J. Oler, M.F. Tompkins, C. Alba, I. Vandernoot, J.C. Goffard, G. Smits, I. Migeotte, F. Haerynck, P. Soler-Palacin, A. Martin-Nalda, R. Colobran, P.E. Morange, S. Keles, F. Colkesen, T. Ozcelik, K.K. Yasar, S. Senoglu, S.N. Karabela, C. Rodriguez-Gallego, G. Novelli, S. Hraiech, Y. Tandjaoui-Lambiotte, X. Duval, C. Laouenan, C.-S. Clinicians, C. Clinicians, C.G. Imagine, C.C.S.G. French, V.C.C. Co, U.M.C.C.-B. Amsterdam, C.H.G. Effort, N.-U.T.C.I. Group, A.L. Snow, C.L. Dalgard, J.D. Milner, D.C. Vinh, T.H. Mogensen, N. Marr, A.N. Spaan, B. Boisson, S. Boisson-Dupuis, J. Bustamante, A. Puel, M.J. Ciancanelli, I. Meyts, T. Maniatis, V. Soumelis, A. Amara, M. Nussenzweig, A. Garcia-Sastre, F. Krammer, A. Pujol, D. Duffy, R.P. Lifton, S.Y. Zhang, G. Gorochov, V. Beziat, E. Jouanguy, V. Sancho-Shimizu, C.M. Rice, L. Abel, L.D. Notarangelo, A. Cobat, H.C. Su, J.L. Casanova, Inborn errors of type I IFN immunity in patients with life-threatening COVID-19, Science 370(6515) (2020)."},{"key":"10.1016\/j.cyto.2021.155628_b0835","unstructured":"P.D. Monk, R.J. Marsden, V.J. Tear, J. Brookes, T.N. Batten, M. Mankowski, F.J. Gabbay, D.E. Davies, S.T. Holgate, L.P. Ho, T. Clark, R. Djukanovic, T.M.A. Wilkinson, C.-S.G. Inhaled Interferon Beta, Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial, Lancet Respir Med 9(2) (2021) 196-206."},{"key":"10.1016\/j.cyto.2021.155628_b0840","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106903","article-title":"Interferon beta-1b in treatment of severe COVID-19: A randomized clinical trial","volume":"88","author":"Rahmani","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.cyto.2021.155628_b0845","article-title":"SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant","volume":"32","author":"Y. Konno, I. Kimura, K. Uriu, M. Fukushi, T. Irie, Y. Koyanagi, D. Sauter, R.J. Gifford, U.-C. Consortium, S. Nakagawa, K. Sato","year":"2020","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0850","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1038\/s41467-020-17665-9","article-title":"Activation and evasion of type I interferon responses by SARS-CoV-2","volume":"11","author":"Lei","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0855","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108234","article-title":"Evasion of Type I Interferon by SARS-CoV-2","volume":"33","author":"Xia","year":"2020","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0860","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chom.2016.01.007","article-title":"Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice","volume":"19","author":"Channappanavar","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cyto.2021.155628_b0865","doi-asserted-by":"crossref","unstructured":"N. Wang, Y. Zhan, L. Zhu, Z. Hou, F. Liu, P. Song, F. Qiu, X. Wang, X. Zou, D. Wan, X. Qian, S. Wang, Y. Guo, H. Yu, M. Cui, G. Tong, Y. Xu, Z. Zheng, Y. Lu, P. Hong, Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients, Cell Host Microbe 28(3) (2020) 455-464 e2.","DOI":"10.1016\/j.chom.2020.07.005"},{"key":"10.1016\/j.cyto.2021.155628_b0870","doi-asserted-by":"crossref","unstructured":"T.T. Brehm, M. van der Meirschen, A. Hennigs, K. Roedl, D. Jarczak, D. Wichmann, D. Frings, A. Nierhaus, T. Oqueka, W. Fiedler, M. Christopeit, C. Kraef, A. Schultze, M. Lutgehetmann, M.M. Addo, S. Schmiedel, S. Kluge, J. Schulze Zur Wiesch, Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza, Sci Rep 11(1) (2021) 5803.","DOI":"10.1038\/s41598-021-85081-0"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b0875","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41590-020-00840-x","article-title":"Untuned antiviral immunity in COVID-19 revealed by temporal type I\/III interferon patterns and flu comparison","volume":"22","author":"Galani","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b0880","doi-asserted-by":"crossref","unstructured":"I.E. Galani, V. Triantafyllia, E.E. Eleminiadou, O. Koltsida, A. Stavropoulos, M. Manioudaki, D. Thanos, S.E. Doyle, S.V. Kotenko, K. Thanopoulou, E. Andreakos, Interferon-lambda Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness, Immunity 46(5) (2017) 875-890 e6.","DOI":"10.1016\/j.immuni.2017.04.025"},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0885","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jiac.2020.05.005","article-title":"Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship","volume":"26","author":"Kato","year":"2020","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.cyto.2021.155628_b0890","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijid.2020.06.026","article-title":"Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years","volume":"98","author":"Li","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"10229","key":"10.1016\/j.cyto.2021.155628_b0895","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.cyto.2021.155628_b0900","first-page":"1","article-title":"The activation of bystander CD8(+) T cells and their roles in viral infection","volume":"51","author":"Kim","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b0905","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20031051","article-title":"Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen","volume":"198","author":"Berg","year":"2003","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b0910","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.166.2.1097","article-title":"Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens","volume":"166","author":"Lertmemongkolchai","year":"2001","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.cyto.2021.155628_b0915","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.4049\/jimmunol.173.11.6873","article-title":"Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18","volume":"173","author":"Raue","year":"2004","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0920","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2012.05.029","article-title":"Inflammatory monocytes activate memory CD8(+) T and innate NK lymphocytes independent of cognate antigen during microbial pathogen invasion","volume":"37","author":"Soudja","year":"2012","journal-title":"Immunity"},{"issue":"5270","key":"10.1016\/j.cyto.2021.155628_b0925","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1126\/science.272.5270.1947","article-title":"Induction of bystander T cell proliferation by viruses and type I interferon in vivo","volume":"272","author":"Tough","year":"1996","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0930","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nri.2016.69","article-title":"Immune responses and immunopathology in acute and chronic viral hepatitis","volume":"16","author":"Shin","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0935","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1084\/jem.191.8.1269","article-title":"The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection","volume":"191","author":"Maini","year":"2000","journal-title":"J. Exp. Med."},{"issue":"7847","key":"10.1016\/j.cyto.2021.155628_b0940","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41586-020-03148-w","article-title":"Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia","volume":"590","author":"Grant","year":"2021","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.cyto.2021.155628_b0945","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1056\/NEJMoa2004500","article-title":"Covid-19 in Critically Ill Patients in the Seattle Region - Case Series","volume":"382","author":"Bhatraju","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0950","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1056\/NEJMc2011400","article-title":"Multiorgan and Renal Tropism of SARS-CoV-2","volume":"383","author":"Puelles","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10235","key":"10.1016\/j.cyto.2021.155628_b0955","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0140-6736(20)30920-X","article-title":"SARS-CoV-2 and viral sepsis: observations and hypotheses","volume":"395","author":"Li","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b0960","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rmv.2141","article-title":"Interleukin-6 in Covid-19: A systematic review and meta-analysis","volume":"30","author":"Coomes","year":"2020","journal-title":"Rev. Med. Virol."},{"issue":"12","key":"10.1016\/j.cyto.2021.155628_b0965","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S2213-2600(20)30404-5","article-title":"Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes","volume":"8","author":"Leisman","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b0970","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1053\/j.gastro.2020.07.014","article-title":"Lipotoxicity and Cytokine Storm in Severe Acute Pancreatitis and COVID-19","volume":"159","author":"Hegyi","year":"2020","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b0975","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S2213-2600(20)30217-4","article-title":"Immunotherapies for COVID-19: lessons learned from sepsis","volume":"8","author":"Remy","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.cyto.2021.155628_b0980","doi-asserted-by":"crossref","first-page":"11355","DOI":"10.1038\/srep11355","article-title":"Cytokine profile in severe Gram-positive and Gram-negative abdominal sepsis","volume":"5","author":"Surbatovic","year":"2015","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b0985","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105954","article-title":"Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality","volume":"55","author":"Zhang","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.cyto.2021.155628_b0990","doi-asserted-by":"crossref","unstructured":"T. Herold, V. Jurinovic, C. Arnreich, B.J. Lipworth, J.C. Hellmuth, M. von Bergwelt-Baildon, M. Klein, T. Weinberger, Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19, J Allergy Clin Immunol 146(1) (2020) 128-136 e4.","DOI":"10.1016\/j.jaci.2020.05.008"},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b0995","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/cid\/ciaa449","article-title":"Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019","volume":"71","author":"Chen","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cyto.2021.155628_b1000","doi-asserted-by":"crossref","unstructured":"M. Hoffmann, H. Kleine-Weber, S. Schroeder, N. Kruger, T. Herrler, S. Erichsen, T.S. Schiergens, G. Herrler, N.H. Wu, A. Nitsche, M.A. Muller, C. Drosten, S. Pohlmann, SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell 181(2) (2020) 271-280 e8.","DOI":"10.1016\/j.cell.2020.02.052"},{"issue":"10234","key":"10.1016\/j.cyto.2021.155628_b1005","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2021.155628_b1010","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiab136","article-title":"Complement Induced Endotheliopathy Associated Vascular Microthrombosis in Coronavirus 2019 Disease","author":"Hawley","year":"2021","journal-title":"J. Infect. Dis."},{"issue":"16","key":"10.1016\/j.cyto.2021.155628_b1015","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/blood-2017-03-771501","article-title":"Complement and clot","volume":"129","author":"Afshar-Kharghan","year":"2017","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1016\/j.cyto.2021.155628_b1020","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1111\/jth.12950","article-title":"Reincarnation of ancient links between coagulation and complement","volume":"13","author":"Conway","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.cyto.2021.155628_b1025","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.4049\/jimmunol.0903678","article-title":"Molecular intercommunication between the complement and coagulation systems","volume":"185","author":"Amara","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b1030","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3389\/fmicb.2017.01117","article-title":"Complement Evasion Strategies of Viruses: An Overview","volume":"8","author":"Agrawal","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cyto.2021.155628_b1035","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/407324","article-title":"The role of complement system in septic shock","volume":"2012","author":"Charchaflieh","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"6A","key":"10.1016\/j.cyto.2021.155628_b1040","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1111\/j.1582-4934.2008.00504.x","article-title":"Complexity of complement activation in sepsis","volume":"12","author":"Markiewski","year":"2008","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cyto.2021.155628_b1045","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.616731","article-title":"Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome","volume":"8","author":"Raghunandan","year":"2020","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.cyto.2021.155628_b1050","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/962927","article-title":"Role of complement in multiorgan failure","volume":"2012","author":"Rittirsch","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"11","key":"10.1016\/j.cyto.2021.155628_b1055","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1172\/JCI142780","article-title":"Complement and coagulation: key triggers of COVID-19-induced multiorgan pathology","volume":"130","author":"Ghebrehiwet","year":"2020","journal-title":"J Clin Invest"},{"issue":"40","key":"10.1016\/j.cyto.2021.155628_b1060","doi-asserted-by":"crossref","first-page":"25018","DOI":"10.1073\/pnas.2010540117","article-title":"Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients","volume":"117","author":"Holter","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1065","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12575-021-00142-y","article-title":"Anatomical and Pathological Observation and Analysis of SARS and COVID-19: Microthrombosis Is the Main Cause of Death","volume":"23","author":"Chen","year":"2021","journal-title":"Biol Proced Online"},{"key":"10.1016\/j.cyto.2021.155628_b1070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2020.04.007","article-title":"Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases","volume":"220","author":"Magro","year":"2020","journal-title":"Transl Res"},{"key":"10.1016\/j.cyto.2021.155628_b1075","doi-asserted-by":"crossref","unstructured":"B. Shen, X. Yi, Y. Sun, X. Bi, J. Du, C. Zhang, S. Quan, F. Zhang, R. Sun, L. Qian, W. Ge, W. Liu, S. Liang, H. Chen, Y. Zhang, J. Li, J. Xu, Z. He, B. Chen, J. Wang, H. Yan, Y. Zheng, D. Wang, J. Zhu, Z. Kong, Z. Kang, X. Liang, X. Ding, G. Ruan, N. Xiang, X. Cai, H. Gao, L. Li, S. Li, Q. Xiao, T. Lu, Y. Zhu, H. Liu, H. Chen, T. Guo, Proteomic and Metabolomic Characterization of COVID-19 Patient Sera, Cell 182(1) (2020) 59-72 e15.","DOI":"10.1016\/j.cell.2020.05.032"},{"key":"10.1016\/j.cyto.2021.155628_b1080","unstructured":"F. Diurno, F.G. Numis, G. Porta, F. Cirillo, S. Maddaluno, A. Ragozzino, P. De Negri, C. Di Gennaro, A. Pagano, E. Allegorico, L. Bressy, G. Bosso, A. Ferrara, C. Serra, A. Montisci, M. D'Amico, S. Schiano Lo Morello, G. Di Costanzo, A.G. Tucci, P. Marchetti, U. Di Vincenzo, I. Sorrentino, A. Casciotta, M. Fusco, C. Buonerba, M. Berretta, M. Ceccarelli, G. Nunnari, Y. Diessa, S. Cicala, G. Facchini, Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience, Eur Rev Med Pharmacol Sci 24(7) (2020) 4040-4047."},{"key":"10.1016\/j.cyto.2021.155628_b1085","doi-asserted-by":"crossref","unstructured":"S. Ram Kumar Pandian, S. Arunachalam, V. Deepak, S. Kunjiappan, K. Sundar, Targeting complement cascade: an alternative strategy for COVID-19, 3 Biotech 10(11) (2020) 479.","DOI":"10.1007\/s13205-020-02464-2"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1090","article-title":"Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm","volume":"9","author":"Rabaan","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.cyto.2021.155628_b1095","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.cca.2020.06.009","article-title":"Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19","volume":"509","author":"Bao","year":"2020","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2020.08.009","article-title":"Immunopathology of Hyperinflammation in COVID-19","volume":"191","author":"Gustine","year":"2021","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b1105","first-page":"e594","article-title":"COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study, Lancet","volume":"2","author":"Manson","year":"2020","journal-title":"Rheumatol"},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b1110","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.23812\/20-1-E","article-title":"Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy","volume":"34","author":"Conti","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.cyto.2021.155628_b1115","unstructured":"C.-C. group, Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial, Lancet Respir Med 9(3) (2021) 295-304."},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b1120","first-page":"1569","article-title":"IL-1 Receptor Antagonist Anakinra in the Treatment of COVID-19 Acute Respiratory Distress Syndrome: A Retrospective","volume":"206","author":"Franzetti","year":"2021","journal-title":"Observational Study, J Immunol"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(21)00035-7","article-title":"The right place for IL-1 inhibition in COVID-19","volume":"9","author":"Cavalli","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1135","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell. Mol. Immunol."},{"issue":"14","key":"10.1016\/j.cyto.2021.155628_b1140","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1111\/febs.13775","article-title":"Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system","volume":"283","author":"Martin","year":"2016","journal-title":"FEBS J."},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b1145","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ni.3503","article-title":"Interleukin 1alpha and the inflammatory process","volume":"17","author":"Di Paolo","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b1150","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fimmu.2012.00315","article-title":"IL-1 family cytokines trigger sterile inflammatory disease","volume":"3","author":"Lukens","year":"2012","journal-title":"Front. Immunol."},{"issue":"32","key":"10.1016\/j.cyto.2021.155628_b1155","doi-asserted-by":"crossref","first-page":"18951","DOI":"10.1073\/pnas.2009017117","article-title":"Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19","volume":"117","author":"Cauchois","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1160","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s13054-020-03166-0","article-title":"Blocking IL-1 to prevent respiratory failure in COVID-19","volume":"24","author":"van de Veerdonk","year":"2020","journal-title":"Crit. Care"},{"issue":"20","key":"10.1016\/j.cyto.2021.155628_b1165","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1073\/pnas.2005615117","article-title":"Effective treatment of severe COVID-19 patients with tocilizumab","volume":"117","author":"Xu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cyto.2021.155628_b1170","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cytogfr.2020.05.003","article-title":"The cytokine storm in COVID-19: An overview of the involvement of the chemokine\/chemokine-receptor system","volume":"53","author":"Coperchini","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.cyto.2021.155628_b1175","article-title":"IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections","volume":"7","author":"Kimmig","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.cyto.2021.155628_b1180","article-title":"Tocilizumab for treatment of mechanically ventilated patients with COVID-19","author":"Somers","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cyto.2021.155628_b1185","doi-asserted-by":"crossref","unstructured":"P. Mehta, D.F. McAuley, M. Brown, E. Sanchez, R.S. Tattersall, J.J. Manson, U.K. Hlh Across Speciality Collaboration, COVID-19: consider cytokine storm syndromes and immunosuppression, Lancet 395(10229) (2020) 1033-1034.","DOI":"10.1016\/S0140-6736(20)30628-0"},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b1190","doi-asserted-by":"crossref","first-page":"e603","DOI":"10.1016\/S2665-9913(20)30277-0","article-title":"Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study","volume":"2","author":"Biran","year":"2020","journal-title":"Lancet Rheumatol"},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b1195","doi-asserted-by":"crossref","first-page":"e474","DOI":"10.1016\/S2665-9913(20)30173-9","article-title":"Tocilizumab in patients with severe COVID-19: a retrospective cohort study","volume":"2","author":"Guaraldi","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.cyto.2021.155628_b1200","doi-asserted-by":"crossref","unstructured":"C. Salvarani, G. Dolci, M. Massari, D.F. Merlo, S. Cavuto, L. Savoldi, P. Bruzzi, F. Boni, L. Braglia, C. Turra, P.F. Ballerini, R. Sciascia, L. Zammarchi, O. Para, P.G. Scotton, W.O. Inojosa, V. Ravagnani, N.D. Salerno, P.P. Sainaghi, A. Brignone, M. Codeluppi, E. Teopompi, M. Milesi, P. Bertomoro, N. Claudio, M. Salio, M. Falcone, G. Cenderello, L. Donghi, V. Del Bono, P.L. Colombelli, A. Angheben, A. Passaro, G. Secondo, R. Pascale, I. Piazza, N. Facciolongo, M. Costantini, R.-T.-C.-S. Group, Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial, JAMA Intern Med 181(1) (2021) 24-31.","DOI":"10.1001\/jamainternmed.2020.6615"},{"key":"10.1016\/j.cyto.2021.155628_b1205","doi-asserted-by":"crossref","unstructured":"O. Hermine, X. Mariette, P.L. Tharaux, M. Resche-Rigon, R. Porcher, P. Ravaud, C.-C. Group, Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial, JAMA Intern Med 181(1) (2021) 32-40.","DOI":"10.1001\/jamainternmed.2021.2209"},{"issue":"24","key":"10.1016\/j.cyto.2021.155628_b1210","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1056\/NEJMoa2028836","article-title":"Efficacy of Tocilizumab in Patients Hospitalized with Covid-19","volume":"383","author":"Stone","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b1215","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41591-020-1051-9","article-title":"An inflammatory cytokine signature predicts COVID-19 severity and survival","volume":"26","author":"Del Valle","year":"2020","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b1220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048111","article-title":"Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition","volume":"7","author":"Keshari","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1225","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12929-020-00634-1","article-title":"Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-alpha therapy effectiveness","volume":"27","author":"Ruiz-Limon","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cyto.2021.155628_b1230","doi-asserted-by":"crossref","unstructured":"E.J. Brenner, R.C. Ungaro, R.B. Gearry, G.G. Kaplan, M. Kissous-Hunt, J.D. Lewis, S.C. Ng, J.F. Rahier, W. Reinisch, F.M. Ruemmele, F. Steinwurz, F.E. Underwood, X. Zhang, J.F. Colombel, M.D. Kappelman, Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry, Gastroenterology 159(2) (2020) 481-491 e3.","DOI":"10.1053\/j.gastro.2020.05.032"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1235","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3892\/ijo.2020.5159","article-title":"Immune-checkpoint inhibitors from cancer to COVID19: A promising avenue for the treatment of patients with COVID19 (Review)","volume":"58","author":"Vivarelli","year":"2021","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cyto.2021.155628_b1240","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119124","article-title":"SARS-CoV-2 infection: The role of PD-1\/PD-L1 and CTLA-4 axis","volume":"270","author":"Aghbash","year":"2021","journal-title":"Life Sci."},{"issue":"21","key":"10.1016\/j.cyto.2021.155628_b1245","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1128\/MCB.25.21.9543-9553.2005","article-title":"CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms","volume":"25","author":"Parry","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"18","key":"10.1016\/j.cyto.2021.155628_b1250","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1073\/pnas.1718217115","article-title":"Role of PD-1 during effector CD8 T cell differentiation","volume":"115","author":"Ahn","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1255","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9","article-title":"PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2","volume":"32","author":"Carter","year":"2002","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1260","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2567.1999.00888.x","article-title":"Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation","volume":"98","author":"Vandenborre","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.cyto.2021.155628_b1265","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","article-title":"CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer","volume":"37","author":"McLane","year":"2019","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cyto.2021.155628_b1270","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cyto.2018.03.041","article-title":"The regulation of JAKs in cytokine signaling and its breakdown in disease","volume":"118","author":"Hammaren","year":"2019","journal-title":"Cytokine"},{"issue":"5573","key":"10.1016\/j.cyto.2021.155628_b1275","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1071545","article-title":"A road map for those who don't know JAK-STAT","volume":"296","author":"Aaronson","year":"2002","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b1280","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/1947601910397187","article-title":"Jak\/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies","volume":"1","author":"Jatiani","year":"2010","journal-title":"Genes Cancer"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1285","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02981951","article-title":"Role of Jak kinases and STATs in cytokine signal transduction","volume":"73","author":"Leonard","year":"2001","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.cyto.2021.155628_b1290","first-page":"ii111-5","article-title":"Janus kinase inhibitors in autoimmune diseases","volume":"72 Suppl 2","author":"O'Shea","year":"2013","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1295","first-page":"685","article-title":"Evaluation of the Short-, Mid-, and Long-Term Effects of Tofacitinib on Lymphocytes in Patients With Rheumatoid Arthritis, Arthritis","volume":"71","author":"van Vollenhoven","year":"2019","journal-title":"Rheumatol"},{"key":"10.1016\/j.cyto.2021.155628_b1300","doi-asserted-by":"crossref","unstructured":"F. Sunzini, I. McInnes, S. Siebert, JAK inhibitors and infections risk: focus on herpes zoster, Ther Adv Musculoskelet Dis 12 (2020) 1759720X20936059.","DOI":"10.1177\/1759720X20936059"},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b1305","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1136\/annrheumdis-2019-216852","article-title":"Infections in baricitinib clinical trials for patients with active rheumatoid arthritis","volume":"79","author":"Winthrop","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b1310","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/phar.2438","article-title":"Baricitinib: A Review of Pharmacology, Safety, and Emerging Clinical Experience in COVID-19","volume":"40","author":"Jorgensen","year":"2020","journal-title":"Pharmacotherapy"},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b1315","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s40264-018-0651-5","article-title":"Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk?","volume":"41","author":"Scott","year":"2018","journal-title":"Drug Saf."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b1320","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s40264-017-0622-2","article-title":"Analysis of Spontaneous Postmarket Case Reports Submitted to the FDA Regarding Thromboembolic Adverse Events and JAK Inhibitors","volume":"41","author":"Verden","year":"2018","journal-title":"Drug Saf."},{"issue":"12","key":"10.1016\/j.cyto.2021.155628_b1325","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.1172\/JCI141772","article-title":"Baricitinib restrains the immune dysregulation in patients with severe COVID-19","volume":"130","author":"Bronte","year":"2020","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1330","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jinf.2020.04.017","article-title":"Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact","volume":"81","author":"Cantini","year":"2020","journal-title":"J. Infect."},{"key":"10.1016\/j.cyto.2021.155628_b1335","doi-asserted-by":"crossref","unstructured":"Y. Cao, J. Wei, L. Zou, T. Jiang, G. Wang, L. Chen, L. Huang, F. Meng, L. Huang, N. Wang, X. Zhou, H. Luo, Z. Mao, X. Chen, J. Xie, J. Liu, H. Cheng, J. Zhao, G. Huang, W. Wang, J. Zhou, Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial, J Allergy Clin Immunol 146(1) (2020) 137-146 e3.","DOI":"10.1016\/j.jaci.2020.05.019"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1340","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052449","article-title":"Thromboembolic Adverse Drug Reactions in Janus Kinase (JAK) Inhibitors: Does the Inhibitor Specificity Play a Role?","volume":"22","author":"Kotyla","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cyto.2021.155628_b1345","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s40266-020-00775-w","article-title":"Safety of Janus Kinase Inhibitors in Older Patients: A Focus on the Thromboembolic Risk","volume":"37","author":"Rajasimhan","year":"2020","journal-title":"Drugs Aging"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1350","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/rheumatology\/keaa587","article-title":"Baricitinib improves respiratory function in patients treated with corticosteroids for SARS-CoV-2 pneumonia: an observational cohort study","volume":"60","author":"Rodriguez-Garcia","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1355","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41584-020-0371-y","article-title":"Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases","volume":"16","author":"Hardy","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cyto.2021.155628_b1360","doi-asserted-by":"crossref","unstructured":"R.C. Group, P. Horby, W.S. Lim, J.R. Emberson, M. Mafham, J.L. Bell, L. Linsell, N. Staplin, C. Brightling, A. Ustianowski, E. Elmahi, B. Prudon, C. Green, T. Felton, D. Chadwick, K. Rege, C. Fegan, L.C. Chappell, S.N. Faust, T. Jaki, K. Jeffery, A. Montgomery, K. Rowan, E. Juszczak, J.K. Baillie, R. Haynes, M.J. Landray, Dexamethasone in Hospitalized Patients with Covid-19, N Engl J Med 384(8) (2021) 693-704.","DOI":"10.1056\/NEJMoa2021436"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1365","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0378-1119(92)90216-C","article-title":"Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase","volume":"122","author":"Steinhauer","year":"1992","journal-title":"Gene"},{"issue":"23","key":"10.1016\/j.cyto.2021.155628_b1370","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01246-20","article-title":"The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2","volume":"94","author":"Ogando","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2021.155628_b1375","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.10181","article-title":"Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation load","volume":"8","author":"Eskier","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.cyto.2021.155628_b1380","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cegh.2020.07.006","article-title":"Antivirals for COVID-19: A critical review","volume":"9","author":"Frediansyah","year":"2021","journal-title":"Clin Epidemiol Glob Health"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b1385","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/14787210.2021.1823832","article-title":"The effect of antivirals on COVID-19: a systematic review","volume":"19","author":"Hussain","year":"2021","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.2162","article-title":"The emerging role of ACE2 in physiology and disease","volume":"212","author":"Hamming","year":"2007","journal-title":"J. Pathol."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1395","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10286-018-0572-5","article-title":"The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications","volume":"29","author":"Miller","year":"2019","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.cyto.2021.155628_b1400","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biopha.2017.07.091","article-title":"Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies","volume":"94","author":"Patel","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1405","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/fcp.12318","article-title":"Angiotensin-converting enzyme 2-Angiotensin 1\u20137\/1-9 system: novel promising targets for heart failure treatment","volume":"32","author":"Kittana","year":"2018","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.cyto.2021.155628_b1410","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117905","article-title":"Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications","volume":"256","author":"Banu","year":"2020","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b1415","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/jmv.25785","article-title":"Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19","volume":"92","author":"Cheng","year":"2020","journal-title":"J. Med. Virol."},{"issue":"5\u20136","key":"10.1016\/j.cyto.2021.155628_b1420","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2119\/molmed.2009.00160","article-title":"ACE2 activation promotes antithrombotic activity","volume":"16","author":"Fraga-Silva","year":"2010","journal-title":"Mol. Med."},{"key":"10.1016\/j.cyto.2021.155628_b1425","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.virusres.2014.03.010","article-title":"Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus","volume":"185","author":"Liu","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.cyto.2021.155628_b1430","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.1038\/srep07027","article-title":"Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury","volume":"4","author":"Yang","year":"2014","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b1435","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJMc2005396","article-title":"Association between Angiotensin Blockade and Incidence of Influenza in the United Kingdom","volume":"383","author":"Chung","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1440","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2015432","article-title":"Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19","volume":"383","author":"Ackermann","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b1445","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41577-020-0343-0","article-title":"COVID-19: the vasculature unleashed","volume":"20","author":"Teuwen","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"22","key":"10.1016\/j.cyto.2021.155628_b1450","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1073\/pnas.0711241105","article-title":"Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry","volume":"105","author":"Haga","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1455","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3892\/etm.2014.1566","article-title":"Severe sepsis: Low expression of the renin-angiotensin system is associated with poor prognosis","volume":"7","author":"Zhang","year":"2014","journal-title":"Exp Ther Med"},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1460","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3904\/kjim.2019.262","article-title":"Effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on the patients with sepsis","volume":"36","author":"Lee","year":"2021","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.cyto.2021.155628_b1465","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-015-0802-3","article-title":"Angiotensin II in septic shock","volume":"19","author":"Correa","year":"2015","journal-title":"Crit. Care"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1470","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1056\/NEJMoa1704154","article-title":"Angiotensin II for the Treatment of Vasodilatory Shock","volume":"377","author":"Khanna","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1475","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ccc.2018.11.002","article-title":"Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill","volume":"35","author":"Bitker","year":"2019","journal-title":"Crit. Care Clin."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1480","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1124\/jpet.102.037382","article-title":"Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome","volume":"303","author":"Raiden","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1485","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/SHK.0b013e318189017a","article-title":"Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases","volume":"31","author":"Shen","year":"2009","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1490","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s13054-017-1823-x","article-title":"A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome","volume":"21","author":"Khan","year":"2017","journal-title":"Crit. Care"},{"issue":"4","key":"10.1016\/j.cyto.2021.155628_b1495","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1113\/expphysiol.2013.074815","article-title":"Angiotensin-converting enzyme (ACE and ACE2) imbalance correlates with the severity of cerulein-induced acute pancreatitis in mice","volume":"99","author":"Liu","year":"2014","journal-title":"Exp. Physiol."},{"issue":"1\u20133","key":"10.1016\/j.cyto.2021.155628_b1500","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.regpep.2010.10.006","article-title":"Co-operative effects of angiotensin II and caerulein in NFkappaB activation in pancreatic acinar cells in vitro","volume":"166","author":"Chan","year":"2011","journal-title":"Regul. Pept."},{"issue":"2","key":"10.1016\/j.cyto.2021.155628_b1505","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1124\/jpet.108.148353","article-title":"Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells","volume":"329","author":"Chan","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.cyto.2021.155628_b1510","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1159\/000225906","article-title":"Use of angiotensin II receptor blockers and the risk of acute pancreatitis: a nested case-control study","volume":"9","author":"Sjoberg Bexelius","year":"2009","journal-title":"Pancreatology"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1515","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.pan.2012.07.017","article-title":"Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1\u20137)-Mas axis and promotes increased circulating angiotensin-(1\u20137)","volume":"12","author":"Wang","year":"2012","journal-title":"Pancreatology"},{"key":"10.1016\/j.cyto.2021.155628_b1520","doi-asserted-by":"crossref","unstructured":"A.C. Simoes e Silva, K.D. Silveira, A.J. Ferreira, M.M. Teixeira, ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis, Br J Pharmacol 169(3) (2013) 477-92.","DOI":"10.1111\/bph.12159"},{"key":"10.1016\/j.cyto.2021.155628_b1525","doi-asserted-by":"crossref","unstructured":"A. Zangrillo, G. Landoni, L. Beretta, F. Morselli, A. Serpa Neto, R. Bellomo, C.O.-B.S. Group, Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series, Crit Care 24(1) (2020) 227.","DOI":"10.1186\/s13054-020-02928-0"},{"issue":"10","key":"10.1016\/j.cyto.2021.155628_b1530","article-title":"Physiologic Response to Angiotensin II Treatment for Coronavirus Disease 2019-Induced Vasodilatory Shock: A Retrospective Matched Cohort Study","volume":"2","author":"Leisman","year":"2020","journal-title":"Crit Care Explor"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1535","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jacc.2020.06.003","article-title":"Renin-Angiotensin System Blockade in COVID-19: Good, Bad, or Indifferent?","volume":"76","author":"Bloch","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1540","doi-asserted-by":"crossref","first-page":"C279","DOI":"10.1152\/ajpcell.00478.2020","article-title":"Soluble ACE2 as a potential therapy for COVID-19","volume":"320","author":"Krishnamurthy","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.cyto.2021.155628_b1545","doi-asserted-by":"crossref","first-page":"10617","DOI":"10.1038\/s41598-021-89957-z","article-title":"A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection","volume":"11","author":"Miller","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2021.155628_b1550","doi-asserted-by":"crossref","unstructured":"N. Liu, J. Sun, X. Wang, T. Zhang, M. Zhao, H. Li, Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis, Int J Infect Dis 104 (2021) 58-64.","DOI":"10.1016\/j.ijid.2020.12.077"},{"issue":"3","key":"10.1016\/j.cyto.2021.155628_b1555","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1017\/S0007114520002913","article-title":"The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities","volume":"125","author":"Fiorino","year":"2021","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.cyto.2021.155628_b1560","doi-asserted-by":"crossref","unstructured":"C. Annweiler, B. Hanotte, C. Grandin de l'Eprevier, J.M. Sabatier, L. Lafaie, T. Celarier, Vitamin D and survival in COVID-19 patients: A quasi-experimental study, J Steroid Biochem Mol Biol 204 (2020) 105771.","DOI":"10.1016\/j.jsbmb.2020.105771"},{"issue":"11","key":"10.1016\/j.cyto.2021.155628_b1565","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113377","article-title":"Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study","volume":"12","author":"Annweiler","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.cyto.2021.155628_b1570","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.27075","article-title":"Vitamin D and COVID-19: Role of ACE2, age, gender, and ethnicity","author":"Getachew","year":"2021","journal-title":"J. Med. Virol."},{"issue":"7","key":"10.1016\/j.cyto.2021.155628_b1575","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00210-020-01911-4","article-title":"Vitamin D can prevent COVID-19 infection-induced multiple organ damage","volume":"393","author":"Aygun","year":"2020","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"5","key":"10.1016\/j.cyto.2021.155628_b1580","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2119","article-title":"A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19","volume":"30","author":"Malek Mahdavi","year":"2020","journal-title":"Rev. Med. Virol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621002143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621002143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:02:53Z","timestamp":1760907773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466621002143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":316,"alternative-id":["S1043466621002143"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155628","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COVID-19, what could sepsis, severe acute pancreatitis, gender differences, and aging teach us?","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155628","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"155628"}}