{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:05:10Z","timestamp":1787238310749,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["961069"],"award-info":[{"award-number":["961069"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.cyto.2021.155696","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T19:14:24Z","timestamp":1631128464000},"page":"155696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Evaluation of correlation between transcription factors and IL-17 in oral and cutaneous lichen planus lesions and Leukocytes"],"prefix":"10.1016","volume":"148","author":[{"given":"Reza","family":"Zare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nooshin","family":"Mohtasham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Ghazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Mosannen Mozafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Abdollahpoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Poursheikhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Mohajertehran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolreza","family":"Esmaeilzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cyto.2021.155696_b0005","first-page":"309","article-title":"Clinical variants of lichen planus. JDDG","volume":"11","author":"Wagner","year":"2013","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft."},{"issue":"1","key":"10.1016\/j.cyto.2021.155696_b0010","first-page":"e1","article-title":"Cutaneous, genital and oral lichen planus: a descriptive study of 274 patients","volume":"24","author":"Cassol-Spanemberg","year":"2019","journal-title":"Med. Oral. Patol. Oral. Cir. Bucal."},{"key":"10.1016\/j.cyto.2021.155696_b0015","first-page":"1","article-title":"Immunoexpression of Interleukin-22 and Interleukin-23 in oral and cutaneous lichen planus lesions: a preliminary study","volume":"2013","author":"Chen","year":"2013","journal-title":"Mediators Inflamm."},{"issue":"2","key":"10.1016\/j.cyto.2021.155696_b0020","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00784-019-02961-6","article-title":"Comparison of serum lipid parameters between patients with classic cutaneous lichen planus and oral lichen planus","volume":"24","author":"Ozbagcivan","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.cyto.2021.155696_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/742826","article-title":"Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis","volume":"2014","author":"Gorouhi","year":"2014","journal-title":"ScientificWorldJournal."},{"key":"10.1016\/j.cyto.2021.155696_b0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3389\/fimmu.2019.00577","article-title":"Antagonizing retinoic acid-related-orphan receptor gamma activity blocks the T helper 17\/interleukin-17 pathway leading to attenuated pro-inflammatory human keratinocyte and skin responses","volume":"10","author":"Ecoeur","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2021.155696_b0035","doi-asserted-by":"crossref","unstructured":"Chang MR, Rosen H, Griffin PR. RORs in autoimmune disease. Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases: Springer; 2014. p. 171-82.","DOI":"10.1007\/978-3-319-05879-5_8"},{"issue":"3","key":"10.1016\/j.cyto.2021.155696_b0040","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cyto.2008.07.017","article-title":"An overview of IL-17 function and signaling","volume":"43","author":"Gaffen","year":"2008","journal-title":"Cytokine"},{"issue":"9","key":"10.1016\/j.cyto.2021.155696_b0045","first-page":"989","article-title":"A significant increase in expression of FOXP3 and IL-17 genes in patients with allergic rhinitis underwent accelerated rush immunotherapy","volume":"22","author":"Salmani","year":"2019","journal-title":"Iranian J. Basic Med. Sci."},{"issue":"8","key":"10.1016\/j.cyto.2021.155696_b0050","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.drudis.2014.04.012","article-title":"Inhibiting ROR\u03b3t\/Th17 axis for autoimmune disorders","volume":"19","author":"Isono","year":"2014","journal-title":"Drug Discovery Today"},{"issue":"3","key":"10.1016\/j.cyto.2021.155696_b0055","first-page":"294","article-title":"Detection of Th17\/Treg cells and related factors in gingival tissues and peripheral blood of rats with experimental periodontitis","volume":"20","author":"Gao","year":"2017","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"23","key":"10.1016\/j.cyto.2021.155696_b0060","doi-asserted-by":"crossref","first-page":"14086","DOI":"10.1111\/jcmm.16020","article-title":"T cell\u2013derived exosomes induced macrophage inflammatory protein-1\u03b1\/\u03b2 drive the trafficking of CD8+ T cells in oral lichen planus","volume":"24","author":"Yang","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.cyto.2021.155696_b0065","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11596-012-0078-7","article-title":"Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus","volume":"32","author":"Xie","year":"2012","journal-title":"Journal of Huazhong University of Science and Technology [Medical Sciences]."},{"issue":"2","key":"10.1016\/j.cyto.2021.155696_b0070","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/exd.14226","article-title":"The inflammation in cutaneous lichen planus is dominated by IFN-\u03d2 and IL-21\u2014A basis for therapeutic JAK1 inhibition","volume":"30","author":"Pietschke","year":"2021","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.cyto.2021.155696_b0075","doi-asserted-by":"crossref","unstructured":"K. Venken, P. Jacques, C. Mortier, M.E. Labadia, T. Decruy, J. Coudenys, et al., Ror\u03b3t inhibition selectively targets IL-17 producing iNKT and \u03b3\u03b4-T cells enriched in spondyloarthritis patients. Nat. Commun. 2019;10(1):1-15.","DOI":"10.1038\/s41467-018-07911-6"},{"issue":"2","key":"10.1016\/j.cyto.2021.155696_b0080","first-page":"80","article-title":"Effects of interleukin-35 on the balance of helper T cell 17\/regulatory T cell in peripheral blood of patients with oral lichen planus. Zhonghua kou Qiang yi xue za zhi= Zhonghua Kouqiang Yixue Zazhi=","volume":"55","author":"Hu","year":"2020","journal-title":"Chinese J. Stomatol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155696_b0085","first-page":"384","article-title":"Correlations between the T helper cell 17\/regulatory T cells balance in peripheral blood of patients with oral lichen planus and clinical characteristics. Hua xi kou qiang yi xue za zhi= Huaxi kouqiang yixue zazhi= West China","volume":"36","author":"Jia","year":"2018","journal-title":"J. Stomatol."},{"key":"10.1016\/j.cyto.2021.155696_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00348","article-title":"Transcriptional regulators of T helper 17 cell differentiation in health and autoimmune diseases","volume":"11","author":"Capone","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2021.155696_b0095","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1159\/000447587","article-title":"Evaluation of cardiovascular risk factors, haematological and biochemical parameters, and serum endocan levels in patients with lichen planus","volume":"232","author":"Ozlu","year":"2016","journal-title":"Dermatology"},{"issue":"3","key":"10.1016\/j.cyto.2021.155696_b0100","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/1346-8138.13061","article-title":"Assessments of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in Korean patients with psoriasis vulgaris and psoriatic arthritis","volume":"43","author":"Kim","year":"2016","journal-title":"J. Dermatol."},{"issue":"6","key":"10.1016\/j.cyto.2021.155696_b0105","first-page":"2570","article-title":"The association between the lymphocyte-to-monocyte ratio and coronary artery disease severity in patients with stable coronary artery disease","volume":"23","author":"Kose","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.cyto.2021.155696_b0110","unstructured":"S. Xie, L. Feng, S. Zhu, L. Ding, Expressions of ROR\u03b3T; and FOXP3 and clinical significance in patients with oral lichen planus. Shanghai kou qiang yi xue= Shanghai journal of stomatology. 2014;23(4):472\u20136."},{"issue":"8","key":"10.1016\/j.cyto.2021.155696_b0115","first-page":"870","article-title":"Investigation of the relationship between the Th17\/IL-23 pathway and innate-adaptive immune system in TNBS-induced colitis in rats","volume":"20","author":"Karaboga","year":"2017","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"6","key":"10.1016\/j.cyto.2021.155696_b0120","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.abd.2019.01.006","article-title":"Evaluation of the Th17 pathway in psoriasis and geographic tongue","volume":"94","author":"Picciani","year":"2019","journal-title":"Anais brasileiros de dermatologia."},{"key":"10.1016\/j.cyto.2021.155696_b0125","doi-asserted-by":"crossref","unstructured":"F. Solimani, R. Pollmann, T. Schmidt, A. Schmidt, X. Zheng, R. Savai, et al. Therapeutic targeting of Th17\/Tc17 cells leads to clinical improvement of lichen planus. Front. Immunol. 2019;10:1808.","DOI":"10.3389\/fimmu.2019.01808"},{"issue":"1","key":"10.1016\/j.cyto.2021.155696_b0130","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190456","article-title":"Targeting the interleukin-17 immune axis for cancer immunotherapy","volume":"217","author":"Vitiello","year":"2020","journal-title":"J Exp Med"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621002854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466621002854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:29:38Z","timestamp":1778581778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466621002854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":26,"alternative-id":["S1043466621002854"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155696","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of correlation between transcription factors and IL-17 in oral and cutaneous lichen planus lesions and Leukocytes","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2021.155696","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155696"}}