{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:56:00Z","timestamp":1787165760609,"version":"build-2736575974"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.cyto.2022.155852","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T12:46:47Z","timestamp":1646830007000},"page":"155852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Plasma secretome analyses identify IL-8 and nitrites as predictors of poor prognosis in nasopharyngeal carcinoma patients"],"prefix":"10.1016","volume":"153","author":[{"given":"Ahmed Amine","family":"Zergoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle S.","family":"Draleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faycal","family":"Chettibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chafia","family":"Touil-Boukoffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamel","family":"Djennaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Merghoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Bourouba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10192","key":"10.1016\/j.cyto.2022.155852_b0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"The Lancet"},{"key":"10.1016\/j.cyto.2022.155852_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1100\/2012\/632910","article-title":"Clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area","volume":"2012","author":"Li","year":"2012","journal-title":"Sci. World J."},{"issue":"27","key":"10.1016\/j.cyto.2022.155852_b0015","doi-asserted-by":"crossref","first-page":"24511","DOI":"10.18632\/oncotarget.4312","article-title":"Distant metastasis risk and patterns of nasopharyngeal carcinoma in the era of IMRT: long-term results and benefits of chemotherapy","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.cyto.2022.155852_b0020","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41422-020-0374-x","article-title":"Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma","volume":"30","author":"Chen","year":"2020","journal-title":"Cell Res."},{"issue":"12","key":"10.1016\/j.cyto.2022.155852_b0025","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/ijc.31279","article-title":"Prognostic significance of tumor-infiltrating lymphocytes in nondisseminated nasopharyngeal carcinoma: A large-scale cohort study","volume":"142","author":"Wang","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12943-020-01292-5","article-title":"Unraveling tumour microenvironment heterogeneity in nasopharyngeal carcinoma identifies biologically distinct immune subtypes predicting prognosis and immunotherapy responses","volume":"20","author":"Chen","year":"2021","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.cyto.2022.155852_b0035","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.31557\/APJCP.2020.21.9.2763","article-title":"Transcriptome Profile of Next Generation Sequence Data Related to Inflammation on Nasopharyngeal Carcinoma Cases in Indonesia","volume":"21","author":"Sudigyo","year":"2020","journal-title":"Asian Pacific J. Cancer Prevent.: APJCP"},{"key":"10.1016\/j.cyto.2022.155852_b0040","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/149185","article-title":"Chronic inflammation and cytokines in the tumor microenvironment","volume":"2014","author":"Landskron","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.cyto.2022.155852_b0045","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fimmu.2018.00563","article-title":"Immunological approaches towards cancer and inflammation: a cross talk","volume":"9","author":"Qu","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0050","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/CBM-201687","article-title":"Serum interleukin-8 as a potential diagnostic biomarker in esophageal squamous cell carcinoma","volume":"29","author":"Huang","year":"2020","journal-title":"Cancer Biomarkers: Sect. A Disease Markers"},{"issue":"12","key":"10.1016\/j.cyto.2022.155852_b0055","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1158\/1541-7786.MCR-11-0271","article-title":"IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway","volume":"9","author":"Yadav","year":"2011","journal-title":"Mol. Cancer Res.: MCR"},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0060","doi-asserted-by":"crossref","first-page":"1898104","DOI":"10.1080\/2162402X.2021.1898104","article-title":"Association of circulating protein biomarkers with clinical outcomes of durvalumab in head and neck squamous cell carcinoma","volume":"10","author":"Arends","year":"2021","journal-title":"Oncoimmunology"},{"issue":"5","key":"10.1016\/j.cyto.2022.155852_b0065","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41419-020-2627-5","article-title":"The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12883-019-1286-6","article-title":"Selected serum cytokines and nitric oxide as potential multi-marker biosignature panels for Parkinson disease of varying durations: a case-control study","volume":"19","author":"Rathnayake","year":"2019","journal-title":"BMC Neurol."},{"issue":"6","key":"10.1016\/j.cyto.2022.155852_b0075","first-page":"3169","article-title":"Serum nitric oxide as a predictive biomarker for bevacizumab in non-small cell lung cancer patients","volume":"37","author":"Muto","year":"2017","journal-title":"Anticancer Res."},{"issue":"2","key":"10.1016\/j.cyto.2022.155852_b0080","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4103\/ccd.ccd_11_18","article-title":"Significance of serum nitric oxide and superoxide dismutase in oral submucous fibrosis and squamous cell carcinoma: A comparative study","volume":"9","author":"Sadaksharam","year":"2018","journal-title":"Contemp. Clin. Dentistry"},{"issue":"3","key":"10.1016\/j.cyto.2022.155852_b0085","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jop.12670","article-title":"Proinflammatory cytokines as serum biomarker in oral carcinoma\u2014A prospective multi-biomarker approach","volume":"47","author":"Schiegnitz","year":"2018","journal-title":"J. Oral Pathol. Med."},{"issue":"7","key":"10.1016\/j.cyto.2022.155852_b0090","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/08820139.2017.1360342","article-title":"Serum IL-6 and IL-8 correlate with prognostic factors in ovarian cancer","volume":"46","author":"Sanguinete","year":"2017","journal-title":"Immunol. Invest."},{"issue":"2","key":"10.1016\/j.cyto.2022.155852_b0095","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2217\/bmm.13.122","article-title":"Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients","volume":"8","author":"Visconti","year":"2014","journal-title":"Biomark. Med."},{"issue":"3","key":"10.1016\/j.cyto.2022.155852_b0100","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1007\/s13277-015-4186-4","article-title":"IL-6\/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients","volume":"37","author":"Zergoun","year":"2016","journal-title":"Tumor. Biol."},{"issue":"7","key":"10.1016\/j.cyto.2022.155852_b0105","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3109\/1354750X.2012.706643","article-title":"Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma","volume":"17","author":"Bourouba","year":"2012","journal-title":"Biomarkers: Biochem. Indicators Exposure, Response, Susceptibility Chem."},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cyto.2015.04.003","article-title":"TNFalpha antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth","volume":"74","author":"Bourouba","year":"2015","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.cyto.2022.155852_b0115","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/annonc\/mdu549","article-title":"Cytokine profile determined by data-mining analysis set into clusters of non-small-cell lung cancer patients according to prognosis","volume":"26","author":"Barrera","year":"2015","journal-title":"Ann. Oncol.: Off. J. Europ. Soc. Med. Oncol."},{"issue":"4","key":"10.1016\/j.cyto.2022.155852_b0120","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1200\/CCI.20.00072","article-title":"Machine Learning in Oncology: Methods, Applications, and Challenges","author":"Bertsimas","year":"2020","journal-title":"JCO Clin. Cancer Inform."},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02587.x","article-title":"Cancer immunoediting from immune surveillance to immune escape","volume":"121","author":"Kim","year":"2007","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.cyto.2022.155852_b0130","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/hed.21557","article-title":"Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival","volume":"33","author":"Chang","year":"2011","journal-title":"Head Neck"},{"issue":"9","key":"10.1016\/j.cyto.2022.155852_b0135","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1158\/1055-9965.EPI-11-0221","article-title":"Evaluation of multiplexed cytokine and inflammation marker measurements: a methodologic study","volume":"20","author":"Chaturvedi","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"9","key":"10.1016\/j.cyto.2022.155852_b0140","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jamaoncol.2020.1808","article-title":"Efficacy and Safety of Locoregional Radiotherapy With Chemotherapy vs Chemotherapy Alone in De Novo Metastatic Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial","volume":"6","author":"You","year":"2020","journal-title":"JAMA Oncol."},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0145","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1477-7819-11-118","article-title":"Nitric oxide and cancer: a review","volume":"11","author":"Choudhari","year":"2013","journal-title":"World J. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.cyto.2022.155852_b0150","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1172\/JCI31537","article-title":"A cytokine-mediated link between innate immunity, inflammation, and cancer","volume":"117","author":"Lin","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cyto.2022.155852_b0155","doi-asserted-by":"crossref","unstructured":"Y.B. Jin, G.Y. Zhang, K.R. Lin, X.P. Chen, J.H. Cui, Y.J. Wang, W. Luo, Changes of plasma cytokines and chemokines expression level in nasopharyngeal carcinoma patients after treatment with definitive intensity-modulated radiotherapy (IMRT), PLoS One 12(2) (2017) e0172264.","DOI":"10.1371\/journal.pone.0172264"},{"key":"10.1016\/j.cyto.2022.155852_b0160","doi-asserted-by":"crossref","first-page":"3939720","DOI":"10.1155\/2019\/3939720","article-title":"Analysis of Plasma EBV-DNA and Soluble Checkpoint Proteins in Nasopharyngeal Carcinoma Patients after Definitive Intensity-Modulated Radiotherapy","volume":"2019","author":"Ruan","year":"2019","journal-title":"Biomed Res. Int."},{"issue":"3","key":"10.1016\/j.cyto.2022.155852_b0165","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejca.2010.09.025","article-title":"Serum CCL2 and serum TNF-alpha\u2013two new biomarkers predict bone invasion, post-treatment distant metastasis and poor overall survival in nasopharyngeal carcinoma","volume":"47","author":"Lu","year":"2011","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"10.1016\/j.cyto.2022.155852_b0170","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00405-013-2580-3","article-title":"Prognostic value of interleukin-8 and MMP-9 in nasopharyngeal carcinoma","volume":"271","author":"Cheng","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"4","key":"10.1016\/j.cyto.2022.155852_b0175","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/(SICI)1097-0215(19990820)84:4<396::AID-IJC11>3.0.CO;2-#","article-title":"Elevated serum levels of transforming growth factor \u03b21 in Epstein-Barr virus-associated nasopharyngeal carcinoma patients","volume":"84","author":"Xu","year":"1999","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.cyto.2022.155852_b0180","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<255::AID-CNCR2>3.0.CO;2-N","article-title":"Elevation of serum vascular endothelial growth factor in male patients with metastatic nasopharyngeal carcinoma","volume":"88","author":"Qian","year":"2000","journal-title":"Cancer: Interdisciplinary Int. J. Am. Cancer Soc."},{"issue":"4","key":"10.1016\/j.cyto.2022.155852_b0185","first-page":"813","article-title":"The elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma","volume":"10","author":"Chow","year":"2003","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.cyto.2022.155852_b0190","first-page":"265","article-title":"Interleukin-10 levels in Epstein-Barr virus-associated nasopharyngeal carcinoma","volume":"35","author":"Budiani","year":"2002","journal-title":"J. Microbiol., Immunol., Infect. = Wei mian yu gan ran za zhi"},{"issue":"12","key":"10.1016\/j.cyto.2022.155852_b0195","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3109\/00016480902849427","article-title":"Clinical significance of measuring levels of tumor necrosis factor-alpha and soluble interleukin-2 receptor in nasopharyngeal carcinoma","volume":"129","author":"Hsiao","year":"2009","journal-title":"Acta Otolaryngol."},{"issue":"1","key":"10.1016\/j.cyto.2022.155852_b0200","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/1471-2407-6-227","article-title":"Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-\u03b21 and stem cell factor in plasma of patients with nasopharyngeal carcinoma","volume":"6","author":"Tan","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cyto.2022.155852_b0205","first-page":"1","article-title":"Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27","volume":"2010","author":"Xu","year":"2010","journal-title":"Clin. Dev. Immunol."},{"issue":"8","key":"10.1016\/j.cyto.2022.155852_b0210","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/sj.bjc.6605891","article-title":"Human Th17 cells can be induced through head and neck cancer and have a functional impact on HNSCC development","volume":"103","author":"Kesselring","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.cyto.2022.155852_b0215","first-page":"359","article-title":"Ability of systemic interleukin-12 to hamper progressive stages of mammary carcinogenesis in HER2\/neu transgenic mice","volume":"60","author":"Boggio","year":"2000","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.cyto.2022.155852_b0220","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00262-020-02681-x","article-title":"Anti-PD-1 antibody increases NK cell cytotoxicity towards nasopharyngeal carcinoma cells in the context of chemotherapy-induced upregulation of PD-1 and PD-L1","volume":"70","author":"Makowska","year":"2021","journal-title":"Cancer Immunol., Immunotherapy: CII"},{"issue":"12","key":"10.1016\/j.cyto.2022.155852_b0225","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.4049\/jimmunol.164.12.6237","article-title":"Gender-dependent IL-12 secretion by APC is regulated by IL-10","volume":"164","author":"Wilcoxen","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2022.155852_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108479","article-title":"Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism","volume":"690","author":"Sellam","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cyto.2022.155852_b0235","doi-asserted-by":"crossref","unstructured":"D.S. Dace, A.A. Khan, J. Kelly, R.S. Apte, Interleukin-10 promotes pathological angiogenesis by regulating macrophage response to hypoxia during development, PloS One 3(10) (2008) e3381.","DOI":"10.1371\/journal.pone.0003381"},{"issue":"9","key":"10.1016\/j.cyto.2022.155852_b0240","doi-asserted-by":"crossref","first-page":"e1027473","DOI":"10.1080\/2162402X.2015.1027473","article-title":"IP-10\/CXCL10 attracts regulatory T cells: implication for pancreatic cancer","volume":"4","author":"Lunardi","year":"2015","journal-title":"Oncoimmunology"},{"issue":"5","key":"10.1016\/j.cyto.2022.155852_b0245","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/bjc.2016.172","article-title":"CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer","volume":"115","author":"Bronger","year":"2016","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.cyto.2022.155852_b0250","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/bjc.2015.193","article-title":"Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome","volume":"113","author":"Wightman","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cyto.2022.155852_b0255","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.676135","article-title":"IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment","volume":"11","author":"Clark","year":"2021","journal-title":"Front. Oncol."},{"issue":"1-2","key":"10.1016\/j.cyto.2022.155852_b0260","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cyto.2006.03.012","article-title":"Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing","volume":"34","author":"Antonelli","year":"2006","journal-title":"Cytokine"},{"issue":"10","key":"10.1016\/j.cyto.2022.155852_b0265","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/mc.23082","article-title":"Knockdown of Notch1 inhibits nasopharyngeal carcinoma cell growth and metastasis via downregulation of CCL2, CXCL16, and uPA","volume":"58","author":"Guo","year":"2019","journal-title":"Mol. Carcinog."},{"issue":"33","key":"10.1016\/j.cyto.2022.155852_b0270","doi-asserted-by":"crossref","first-page":"53217","DOI":"10.18632\/oncotarget.10676","article-title":"Correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.cyto.2022.155852_b0275","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.4049\/jimmunol.1302821","article-title":"CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2\/CCR2-dependent gene expression profile","volume":"192","author":"Sierra-Filardi","year":"2014","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2022.155852_b0280","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.it.2016.01.004","article-title":"The nature of myeloid-derived suppressor cells in the tumor microenvironment","volume":"37","author":"Kumar","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cyto.2022.155852_b0285","doi-asserted-by":"crossref","first-page":"6304851","DOI":"10.1155\/2019\/6304851","article-title":"Prognostic Value of Inducible Nitric Oxide Synthase (iNOS) in Human Cancer: A Systematic Review and Meta-Analysis","volume":"2019","author":"Liao","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.cyto.2022.155852_b0290","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3389\/fimmu.2018.01769","article-title":"Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report","volume":"9","author":"Merhi","year":"2018","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.cyto.2022.155852_b0295","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/s41416-020-1026-0","article-title":"Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer","volume":"123","author":"Yang","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"7","key":"10.1016\/j.cyto.2022.155852_b0300","first-page":"1946","article-title":"Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma","volume":"7","author":"Yoshizaki","year":"2001","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.cyto.2022.155852_b0305","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/00005537-200405000-00012","article-title":"Epstein-Barr Virus (EBV) Latent Membrane Protein 1 Induces Interleukin-8 through the Nuclear Factor-\u03baB Signaling Pathway in EBV-Infected Nasopharyngeal Carcinoma Cell Line","volume":"114","author":"Ren","year":"2004","journal-title":"Laryngoscope"},{"issue":"20","key":"10.1016\/j.cyto.2022.155852_b0310","first-page":"2159","article-title":"Neutrophil plasticity in the tumor microenvironment","volume":"133","author":"Giese","year":"2019","journal-title":"Blood, J. Am. Soc. Hematol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622000618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622000618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:44:04Z","timestamp":1760910244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466622000618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":62,"alternative-id":["S1043466622000618"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155852","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma secretome analyses identify IL-8 and nitrites as predictors of poor prognosis in nasopharyngeal carcinoma patients","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155852"}}