{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:40:18Z","timestamp":1786790418051,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004951","name":"Ataturk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.cyto.2022.155861","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T12:03:18Z","timestamp":1647604998000},"page":"155861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia\/reperfusion damage"],"prefix":"10.1016","volume":"153","author":[{"given":"Seda","family":"Askin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Askin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elifnur","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Palabiyik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handan","family":"Uguz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Cakmak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubra","family":"Koc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cyto.2022.155861_b0005","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.21873\/anticanres.13744","article-title":"Protective role of fucoidan on cisplatin-mediated ER stress in renal proximal tubule epithelial cells","volume":"39","author":"Kim","year":"2019","journal-title":"Anticancer Res."},{"key":"10.1016\/j.cyto.2022.155861_b0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00210-020-01984-1","article-title":"The targets of betasitosterol as a novel therapeutic against cardio-renal complications in acute renal ischemia\/reperfusion damage","volume":"394","author":"Koc","year":"2021","journal-title":"Naunyn-Schmiedeb. Arch. Pharmacol."},{"key":"10.1016\/j.cyto.2022.155861_b0015","first-page":"907","article-title":"Walnuts (Juglans), Genet. Res. Temperate Fruit Nut","volume":"290","author":"McGranahan","year":"1991","journal-title":"Crops"},{"key":"10.1016\/j.cyto.2022.155861_b0020","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.3390\/molecules24112133","article-title":"Comparative Review on the Extraction, Antioxidant Content and Antioxidant Potential of Different Parts of Walnut (Juglans regia L.) Fruit and Tree","volume":"24","author":"Esfahlan","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.cyto.2022.155861_b0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jfca.2008.10.016","article-title":"Antioxidant activity and phenolic content of fresh and dry nuts with or without the seed coat","volume":"22","author":"Arcan","year":"2009","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.cyto.2022.155861_b0030","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1021\/jf050721n","article-title":"Phenolic acids, syringaldehyde, and juglone in fruits of di_erent cultivars of Juglans regia L","volume":"53","author":"Colaric","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cyto.2022.155861_b0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1051\/fruits\/2016006","article-title":"Antioxidant activity, and phenolic and mineral contents of the walnut kernel (Juglans regia L.) as a function of the pellicle color","volume":"71","author":"Trandafir","year":"2016","journal-title":"Fruits"},{"issue":"1","key":"10.1016\/j.cyto.2022.155861_b0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jsfa.3799","article-title":"Antibacterial activities of essential oils and extracts of Turkish Achillea, Satureja and Thymus species against plant pathogenic bacteria","volume":"90","author":"Kotan","year":"2010","journal-title":"J. Sci. Food Agric."},{"issue":"1","key":"10.1016\/j.cyto.2022.155861_b0045","first-page":"10","article-title":"Effect of aqueous extract of walnut septum on blood glucose and pancreatic structure in streptozotocin-induced diabetic mouse","volume":"11","author":"Dehghani","year":"2012","journal-title":"I. J. Pharm. Ther."},{"key":"10.1016\/j.cyto.2022.155861_b0050","series-title":"Theory and Practice of Histologicaltechniques","author":"Bancroft","year":"1990"},{"key":"10.1016\/j.cyto.2022.155861_b0055","first-page":"13","volume":"258","author":"Shimkets","year":"2012","journal-title":"Methods in Molecular Biology. Gene Expression Profiling, Methods and Protocols"},{"key":"10.1016\/j.cyto.2022.155861_b0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s13643-019-1150-1","article-title":"The therapeutic effects of microRNAs in preclinical studies of acute kidney injury: a systematic review protocol","volume":"8","author":"Zankar","year":"2019","journal-title":"Syst Rev"},{"issue":"5","key":"10.1016\/j.cyto.2022.155861_b0065","doi-asserted-by":"crossref","first-page":"802","DOI":"10.4172\/pharmaceutical-sciences.1000425","article-title":"Antioxidant activities of aqueous extract from Iris taochia and identification of its natural chemical compounds pharmacognosy and phytochemistry","volume":"80","author":"Askin","year":"2018","journal-title":"Ind. J. Pharm. Sci."},{"key":"10.1016\/j.cyto.2022.155861_b0070","series-title":"Clinical Hepatology","first-page":"319","article-title":"Basic Laboratory Parameters","author":"Dancygier","year":"2010"},{"key":"10.1016\/j.cyto.2022.155861_b0075","first-page":"1","article-title":"Effects of aqueous extract of purslane (Portulaca oleracea) on hepatic enzymes in two models of renal ischemia-reperfusion injury in rats","volume":"18","author":"Askaripour","year":"2016","journal-title":"Zahedan J. Res. Med. Sci."},{"issue":"2","key":"10.1016\/j.cyto.2022.155861_b0080","first-page":"117","article-title":"Hypoglycemic and hepatoprotective activity of Eugenia jambolana in streptozotocin-diabetic rats","volume":"1","author":"Jasmine","year":"2007","journal-title":"I. J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cyto.2022.155861_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-30628-x","article-title":"Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease","volume":"8","author":"Honarpisheh","year":"2018","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.cyto.2022.155861_b0090","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1016\/j.transproceed.2010.09.008","article-title":"Liver injury following renal ischemia reperfusion in rats","volume":"42","author":"Wang","year":"2010","journal-title":"Transplant Proc."},{"issue":"8","key":"10.1016\/j.cyto.2022.155861_b0095","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/ki.2008.683","article-title":"Ischemic and non-ischemic acute kidney injury cause hepatic damage","volume":"75","author":"Golab","year":"2009","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.cyto.2022.155861_b0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1172\/JCI6974","article-title":"Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation","volume":"104","author":"Daemen","year":"1999","journal-title":"J Clin Invest."},{"issue":"6","key":"10.1016\/j.cyto.2022.155861_b0105","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1152\/ajpheart.00237.2019","article-title":"Cardiac ischemia\/reperfusion injury induces ROS-dependent loss of PKA regulatory subunit R\u0131\u03b1","volume":"317","author":"Haushalter","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cyto.2022.155861_b0110","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/MNM.0000000000001070","article-title":"Scintigraphic evaluation of renoprotective effects of coenzyme Q10 in a rat renal ischemia-reperfusion injury","volume":"40","author":"Akbulut","year":"2019","journal-title":"Nucl. Med. Commun."},{"issue":"3","key":"10.1016\/j.cyto.2022.155861_b0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.freeradbiomed.2010.04.004","article-title":"Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease","volume":"49","author":"Villanueva","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.cyto.2022.155861_b0120","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2011","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.cyto.2022.155861_b0125","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1172\/JCI9551","article-title":"Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training","volume":"105","author":"Fukai","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2022.155861_b0130","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/j.biopha.2018.11.116","article-title":"Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review","volume":"109","author":"Agarwal","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cyto.2022.155861_b0135","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phrs.2018.11.001","article-title":"Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents","volume":"139","author":"Tasneem","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.cyto.2022.155861_b0140","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.4049\/jimmunol.1101620","article-title":"Caspase-4 is required for activation of inflammasomes","volume":"188","author":"Sollberger","year":"2012","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2022.155861_b0145","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1097-2765(03)00054-6","article-title":"Mechanism of XIAP-mediated inhibition of caspase-9","volume":"11","author":"Shiozaki","year":"2003","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.cyto.2022.155861_b0150","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1083\/jcb.200310015","article-title":"Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and A\u03b2-induced cell death","volume":"165","author":"Hitomi","year":"2004","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.cyto.2022.155861_b0155","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1357-2725(99)00024-2","article-title":"Caspase-9, I","volume":"32","author":"Kuida","year":"2000","journal-title":"J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.cyto.2022.155861_b0160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-14-32","article-title":"Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis","volume":"14","author":"Brentnall","year":"2013","journal-title":"BMC Cell Biol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622000709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622000709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:45:10Z","timestamp":1760910310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466622000709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":32,"alternative-id":["S1043466622000709"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155861","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia\/reperfusion damage","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155861"}}