{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:55:58Z","timestamp":1790488558970,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H27-nanchitou[nan]-ippan-033"],"award-info":[{"award-number":["H27-nanchitou[nan]-ippan-033"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.cyto.2022.155901","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T17:58:11Z","timestamp":1652291891000},"page":"155901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan"],"prefix":"10.1016","volume":"155","author":[{"given":"Yoshihiro","family":"Miyake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Andoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Imaeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kakimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nunoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiyuu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakiko","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitarou","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Higashiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Hokari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teru","family":"Kumagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"Hato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Sayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Hiasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2022.155901_b0005","doi-asserted-by":"crossref","unstructured":"M. Gajendran, P. Loganathan, G. Jimenez, A.P. Catinella, N. Ng, C. Umapathy, N. Ziade, J.G. Hashash, A comprehensive review and update on ulcerative colitis, Disease-a-Month. 65 (2019) 100851. https:\/\/doi.org\/10.1016\/j.disamonth.2019.02.004.","DOI":"10.1016\/j.disamonth.2019.02.004"},{"key":"10.1016\/j.cyto.2022.155901_b0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. Rev. Disease Primers."},{"key":"10.1016\/j.cyto.2022.155901_b0015","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/ibd.20894","article-title":"Interleukin-23\/Th17 pathways and inflammatory bowel disease","volume":"15","author":"Abraham","year":"2009","journal-title":"Inflammat. Bowel Diseases."},{"issue":"3","key":"10.1016\/j.cyto.2022.155901_b0020","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1007\/s10620-021-06932-4","article-title":"Effectiveness and safety of ustekinumab in inflammatory bowel disease: a systematic review and meta-analysis","volume":"67","author":"Honap","year":"2022","journal-title":"Digest. Diseases Sci."},{"key":"10.1016\/j.cyto.2022.155901_b0025","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/ibd.20463","article-title":"IL23R and IL12B polymorphisms in spanish IBD patients: No evidence of interaction","volume":"14","author":"M\u00e1rquez","year":"2008","journal-title":"Inflammat. Bowel Diseases."},{"key":"10.1016\/j.cyto.2022.155901_b0030","doi-asserted-by":"crossref","unstructured":"J. Glas, J. Seiderer, J. Wagner, T. Olszak, C. Fries, C. Tillack, M. Friedrich, F. Beigel, J. Stallhofer, C. Steib, M. Wetzke, B. G\u00f6ke, T. Ochsenk\u00fchn, J. Diegelmann, D. Czamara, S. Brand, Analysis of IL12B gene variants in inflammatory bowel disease, PLoS ONE. 7 (2012) e34349. https:\/\/doi.org\/10.1371\/journal.pone.0034349.","DOI":"10.1371\/journal.pone.0034349"},{"key":"10.1016\/j.cyto.2022.155901_b0035","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/jgh.12214","article-title":"Genetic variants in the IL12B gene are associated with inflammatory bowel diseases in the Korean population","volume":"28","author":"Moon","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cyto.2022.155901_b0040","doi-asserted-by":"crossref","unstructured":"S. Bank, P.S. Andersen, J. Burisch, N. Pedersen, S. Roug, J. Galsgaard, S. Ydegaard Turino, J. Broder Brodersen, S. Rashid, B. Kaiser Rasmussen, S. Avlund, T. Bastholm Olesen, H.J. Hoffmann, B. Andersen Nex\u00f8, J. Sode, U. Vogel, V. Andersen, Polymorphisms in the toll-like receptor and the IL-23\/IL-17 pathways were associated with susceptibility to inflammatory bowel disease in a Danish cohort, PLOS ONE. 10 (2015) e0145302. https:\/\/doi.org\/10.1371\/journal.pone.0145302.","DOI":"10.1371\/journal.pone.0145302"},{"key":"10.1016\/j.cyto.2022.155901_b0045","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s00535-017-1322-5","article-title":"Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn\u2019s disease is a risk factor for disease relapse in Japanese patients","volume":"52","author":"Kakuta","year":"2017","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.cyto.2022.155901_b0050","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23472","article-title":"Interleukin-12B gene rs6887695 and rs2288831 polymorphisms are associated with an increased risk of ulcerative colitis development in Chinese Han population: a case-control study","volume":"34","author":"Zhao","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.cyto.2022.155901_b0055","article-title":"Dietary intake of vegetables, fruit, and antioxidants and risk of ulcerative colitis: a case-control study in Japan","volume":"91\u201392","author":"Miyake","year":"2021","journal-title":"Nutrition."},{"key":"10.1016\/j.cyto.2022.155901_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155296","article-title":"Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: a meta-analysis","volume":"136","author":"Wu","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2022.155901_b0065","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/08820139.2020.1863981","article-title":"The Polymorphisms of interleukin-12B gene and susceptibility to inflammatory bowel diseases: a meta-analysis and trial sequential analysis","volume":"50","author":"Wang","year":"2021","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.cyto.2022.155901_b0070","article-title":"IL12p40 regulates functional development of human CD4+ T Cells","volume":"94","author":"Wang","year":"2015","journal-title":"Medicine."},{"key":"10.1016\/j.cyto.2022.155901_b0075","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/cei.13446","article-title":"Immunorelated gene polymorphisms associated with acute myeloid leukemia","volume":"201","author":"Liu","year":"2020","journal-title":"Clin. Exp. Immunol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622001107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622001107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:58:15Z","timestamp":1779721095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466622001107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":15,"alternative-id":["S1043466622001107"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155901","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155901","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155901"}}