{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T22:12:04Z","timestamp":1760911924414,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.cyto.2022.155924","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T05:07:44Z","timestamp":1655010464000},"page":"155924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection"],"prefix":"10.1016","volume":"157","author":[{"given":"Caio Cesar Henriques","family":"Mendes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Rodrigues","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Alves","family":"Ol\u00edmpio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz F\u00e1bio Magno","family":"Falc\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Luiz Gaia","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeferson","family":"da Costa Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo Jorge","family":"Martins Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"do Socorro Cabral Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lais Carneiro","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fellipe Souza","family":"da Silva Vilacoert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Costa Alves","family":"Gal\u00facio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimunda","family":"do Socorro da Silva Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia Caricio","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Irma Seixas","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Fernando","family":"da Costa Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juarez Ant\u00f4nio Sim\u00f5es","family":"Quaresma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2022.155924_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2021.708140","article-title":"Role of Th22 cells in human viral diseases","volume":"8","author":"Gong","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.cyto.2022.155924_b0010","doi-asserted-by":"crossref","unstructured":"M.S. Ferreira, P.S. Bezerra J\u00fanior, V.D. Cerqueira, G.R.C. Rivero, C.A. Oliveira J\u00fanior, P.H.G. Castro, G.A. da Silva, W.B. da Silva, A.A. Imbeloni, J.R. Sousa, A.P.S. Ara\u00fajo, F. de A. E Silva, R.B. Tesh, J.A.S. Quaresma, P.F. da C. Vasconcelos, Experimental yellow fever virus infection in the squirrel monkey (Saimiri spp.) I: Gross anatomical and histopathological findings in organs at necropsy, Memorias Do Instituto Oswaldo Cruz. 115 (2020) 1\u20138, doi: 10.1590\/0074-02760190501.","DOI":"10.1590\/0074-02760190501"},{"key":"10.1016\/j.cyto.2022.155924_b0015","doi-asserted-by":"crossref","unstructured":"E. Rodaniche, P. Galindo Isolation of yellow fever virus from Haemagogus mesodentatus, H. equinus and Sabethes chloropterus captured in Guatemala in 1956. Am. J. Tropical Med. Hygiene 6 (1957) 232\u2013237, doi: 10.4269\/ajtmh.1957.6.232.","DOI":"10.4269\/ajtmh.1957.6.232"},{"issue":"1","key":"10.1016\/j.cyto.2022.155924_b0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-05186-3","article-title":"Potential risk of re-emergence of urban transmission of Yellow Fever virus in Brazil facilitated by competent Aedes populations","volume":"7","author":"Couto-Lima","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2022.155924_b0025","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.jaci.2012.05.003","article-title":"T H17 and T H22 cells: a confusion of antimicrobial response with tissue inflammation versus protection","volume":"129","author":"Akdis","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cyto.2022.155924_b0030","doi-asserted-by":"crossref","DOI":"10.1007\/s40629-015-0039-3","article-title":"Th22 cells in allergic disease","volume":"24","author":"Eyerich","year":"2015","journal-title":"Allergo J. Int."},{"key":"10.1016\/j.cyto.2022.155924_b0035","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17765-5","article-title":"In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus","volume":"8","author":"Azevedo","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2022.155924_b0040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/mi.2016.38","article-title":"IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice","volume":"10","author":"Moyat","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.cyto.2022.155924_b0045","first-page":"942","article-title":"Bacterial pneumonia","volume":"7","author":"Ramya","year":"2014","journal-title":"Res. J. Pharm. Technol."},{"key":"10.1016\/j.cyto.2022.155924_b0050","first-page":"1","article-title":"The role of IL-22 in viral infections: paradigms and paradoxes","volume":"7","author":"Brias","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2022.155924_b0055","first-page":"1","article-title":"The pathogenic role of interleukin-22 and its receptor during UVB-induced skin inflammation","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cyto.2022.155924_b0060","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/jid.2012.463","article-title":"IL-22 promotes fibroblast-mediated wound repair in the skin","volume":"133","author":"McGee","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cyto.2022.155924_b0065","doi-asserted-by":"crossref","unstructured":"M. Furue, M. Furue, Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation, Exploration Immunol. (2021) 37\u201347, doi: 10.37349\/ei.2021.00005.","DOI":"10.37349\/ei.2021.00005"},{"key":"10.1016\/j.cyto.2022.155924_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/v12121349","article-title":"The absence of yellow fever in asia: History, hypotheses, vector dispersal, possibility of yf in asia, and other enigmas","volume":"12","author":"Kuno","year":"2020","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.cyto.2022.155924_b0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/ETLS20200187","article-title":"Re-emergence of yellow fever in the neotropics - Quo vadis?","volume":"4","author":"Low","year":"2020","journal-title":"Emerg. Topics Life Sci."},{"key":"10.1016\/j.cyto.2022.155924_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10060693","article-title":"The usefulness of a duplex rt-qpcr during the recent yellow fever brazilian epidemic: surveillance of vaccine adverse events, epizootics and vectors","volume":"10","author":"Queiroz","year":"2021","journal-title":"Pathogens"},{"issue":"51","key":"10.1016\/j.cyto.2022.155924_b0085","doi-asserted-by":"crossref","first-page":"32648","DOI":"10.1073\/pnas.2014096117","article-title":"Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury","volume":"117","author":"Bailey","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cyto.2022.155924_b0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.virol.2005.09.058","article-title":"Revisiting the liver in human yellow fever: Virus-induced apoptosis in hepatocytes associated with TGF-\u03b2, TNF-\u03b1 and NK cells activity","volume":"345","author":"Quaresma","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.cyto.2022.155924_b0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/rmv.1752","article-title":"Immunity and immune response, pathology and pathologic changes: progress and challenges in the immunopathology of yellow fever","volume":"23","author":"Quaresma","year":"2013","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.cyto.2022.155924_b0100","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.mehy.2006.01.060","article-title":"Midzonal lesions in yellow fever: a specific pattern of liver injury caused by direct virus action and in situ inflammatory response","volume":"67","author":"Quaresma","year":"2006","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.cyto.2022.155924_b0105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.trstmh.2006.02.019","article-title":"Hepatocyte lesions and cellular immune response in yellow fever infection","volume":"101","author":"Quaresma","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.cyto.2022.155924_b0110","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-017-0637-x","article-title":"Molecular pathogenesis of viral hemorrhagic fever","volume":"39","author":"Basler","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.cyto.2022.155924_b0115","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-016-1391-6","article-title":"Biological and pathological activities of interleukin-22","volume":"94","author":"Perusina Lanfranca","year":"2016","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.cyto.2022.155924_b0120","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/infdis\/jit495","article-title":"Interleukin 22 inhibits intracellular growth of mycobacterium tuberculosis by enhancing calgranulin a expression","volume":"209","author":"Dhiman","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cyto.2022.155924_b0125","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jaad.2014.11.023","article-title":"New immunologic pathways in the pathogenesis of leprosy: Role for Th22 cytokines in the polar forms of the disease","volume":"72","author":"De Lima Silveira","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.cyto.2022.155924_b0130","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.actatropica.2016.01.008","article-title":"In situ expression of M2 macrophage subpopulation in leprosy skin lesions","volume":"157","author":"de Sousa","year":"2016","journal-title":"Acta Trop."},{"key":"10.1016\/j.cyto.2022.155924_b0135","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.actatropica.2017.03.016","article-title":"Response of iNOS and its relationship with IL-22 and STAT3 in macrophage activity in the polar forms of leprosy","volume":"171","author":"de Sousa","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.cyto.2022.155924_b0140","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing","volume":"206","author":"Pickert","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2022.155924_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1006839","article-title":"Viral manipulation of STAT3: evade, exploit, and injure","volume":"14","author":"Roca Suarez","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cyto.2022.155924_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.01448","article-title":"Fine-tuning of type I interferon response by STAT3","volume":"10","author":"Tsai","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2022.155924_b0155","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2147\/CEG.S173484","article-title":"A study of the circulating fibroblast growth factor 21 as a novel noninvasive biomarker of hepatic injury in genotype-4 chronic hepatitis C: egyptian patients and their response to direct-acting antiviral agents","volume":"11","author":"El Sagheer","year":"2018","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.1016\/j.cyto.2022.155924_b0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clim.2015.03.003","article-title":"Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C","volume":"158","author":"Wu","year":"2015","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cyto.2022.155924_b0165","first-page":"19574","article-title":"Interleukin-22 promotes macrophage M2 polarization via STAT3 pathway","volume":"9","author":"Luo","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.cyto.2022.155924_b0170","first-page":"3573","article-title":"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling","volume":"119","author":"Eyerich","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cyto.2022.155924_b0175","first-page":"5389","article-title":"Recruitment and significance of Th22 cells and Th17 cells in malignant ascites","volume":"16","author":"Yang","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cyto.2022.155924_b0180","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.4049\/jimmunol.1601480","article-title":"Th22 cells form a distinct Th lineage from Th17 cells in vitro with unique transcriptional properties and Tbet-dependent Th1 plasticity","volume":"198","author":"Plank","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2022.155924_b0185","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1165\/rcmb.2018-0053OC","article-title":"IL-13\u2013regulated macrophage polarization during granuloma formation in an in vitro human sarcoidosis model","volume":"60","author":"Locke","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cyto.2022.155924_b0190","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1074\/jbc.M110.169367","article-title":"The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor \u03b11 (IL13R\u03b11)","volume":"286","author":"Martinez-Nunez","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2022.155924_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2012.00116","article-title":"IL-13 signaling in liver fibrogenesis","volume":"3","author":"Liu","year":"2012","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.cyto.2022.155924_b0200","doi-asserted-by":"crossref","first-page":"e0168973","DOI":"10.1371\/journal.pone.0168973","article-title":"Peripheral organs of dengue fatal cases present strong pro-inflammatory response with participation of IFN-Gamma-, TNF-Alphaand RANTES-Producing cells","volume":"11","author":"P\u00f3voa","year":"2016","journal-title":"PLoS ONE"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622001338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622001338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:44:14Z","timestamp":1760910254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466622001338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":40,"alternative-id":["S1043466622001338"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155924","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2022.155924","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155924"}}