{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:09:40Z","timestamp":1787238580107,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2019R1A6A3A01096410"],"award-info":[{"award-number":["2019R1A6A3A01096410"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2019R1F1A1062687"],"award-info":[{"award-number":["2019R1F1A1062687"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cyto.2022.156018","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T17:46:34Z","timestamp":1661881594000},"page":"156018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["RANKL down-regulates the mast cell proliferation through inducing senescence"],"prefix":"10.1016","volume":"159","author":[{"given":"Jin-Ho","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Yun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Geun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ja","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.cyto.2022.156018_b0005","doi-asserted-by":"crossref","first-page":"11270","DOI":"10.3390\/ijms222011270","article-title":"Mastocytosis and mast cell activation disorders: clearing the air","volume":"22","author":"Jackson","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2022.156018_b0010","doi-asserted-by":"crossref","first-page":"S1001","DOI":"10.1016\/j.dsx.2017.07.029","article-title":"Review of various molecular targets on mast cells and its relation to obesity: a future perspective","volume":"11","author":"Bais","year":"2017","journal-title":"Diabetes Metab. Syndr."},{"issue":"10","key":"10.1016\/j.cyto.2022.156018_b0015","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/jid.2014.198","article-title":"TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6","volume":"134","author":"Han","year":"2014","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.cyto.2022.156018_b0020","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.autrev.2017.04.001","article-title":"Mast cells in rheumatoid arthritis: friends or foes?","volume":"16","author":"Rivellese","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cyto.2022.156018_b0025","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00020.2018","article-title":"Cellular Senescence: Aging, Cancer, and Injury","volume":"99","author":"Calcinotto","year":"2019","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.cyto.2022.156018_b0030","doi-asserted-by":"crossref","first-page":"L1164","DOI":"10.1152\/ajplung.00220.2017","article-title":"IPF lung fibroblasts have a senescent phenotype","volume":"313","author":"\u00c1lvarez","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.cyto.2022.156018_b0035","doi-asserted-by":"crossref","first-page":"e00512","DOI":"10.1128\/MCB.00512-20","article-title":"Translational control during cellular senescence","volume":"41","author":"Payea","year":"2021","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.cyto.2022.156018_b0040","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1182\/blood-2017-07-746396","article-title":"DNA damage responses and p53 in the aging process","volume":"131","author":"Ou","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.cyto.2022.156018_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype","volume":"9","author":"Kumari","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.cyto.2022.156018_b0050","doi-asserted-by":"crossref","first-page":"H693","DOI":"10.1152\/ajpheart.00378.2012","article-title":"Aging-associated shifts in functional status of mast cells located by adult and aged mesenteric lymphatic vessels","volume":"303","author":"Chatterjee","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.cyto.2022.156018_b0055","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.179.2.1080","article-title":"TLR3-and Th2 cytokinedependent production of thymic stromal lymphopoietin in human airway epithelial cells","volume":"179","author":"Kato","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2022.156018_b0060","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.20051745","article-title":"Thymic stromal lymphopoietin: master switch for allergic inflammation","volume":"203","author":"Liu","year":"2006","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.cyto.2022.156018_b0065","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.cyto.2011.03.007","article-title":"Thymic stromal lymphopoietin is expressed and produced by caspase-1\/NF-\u03baB pathway in mast cells","volume":"54","author":"Moon","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.cyto.2022.156018_b0070","doi-asserted-by":"crossref","first-page":"L479","DOI":"10.1152\/ajplung.00301.2009","article-title":"Essential role of NF-kB and AP-1 transcription factors in TNF-a-induced TSLP expression in human airway smooth muscle cells","volume":"300","author":"Redhu","year":"2011","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.cyto.2022.156018_b0075","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00011-019-01239-7","article-title":"Chrysophanol, an anthraquinone from AST2017-01, possesses the anti-proliferative effect through increasing p53 protein levels in human mast cells","volume":"68","author":"Han","year":"2019","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.cyto.2022.156018_b0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.cyto.2022.156018_b0085","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bone.2015.08.008","article-title":"Proliferation-coupled osteoclast differentiation by RANKL: cell density as a determinant of osteoclast formation","volume":"81","author":"Rahman","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.cyto.2022.156018_b0090","first-page":"1664","article-title":"An osteoclastogenesis system, the RANKL\/RANK signalling pathway, contributes to aggravated allergic inflammation, British","volume":"176","author":"Nam","year":"2019","journal-title":"J. Pharmacol."},{"key":"10.1016\/j.cyto.2022.156018_b0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.intimp.2017.11.019","article-title":"Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models","volume":"54","author":"Jeong","year":"2018","journal-title":"Int. Immunopharm."},{"issue":"4","key":"10.1016\/j.cyto.2022.156018_b0100","doi-asserted-by":"crossref","first-page":"e19528","DOI":"10.1371\/journal.pone.0019528","article-title":"C-Kit binding properties of hesperidin a major component of KMP6 as a potential anti-allergic agent","volume":"6","author":"Jeong","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.cyto.2022.156018_b0105","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13152","article-title":"Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome","volume":"19","author":"Mu","year":"2020","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.cyto.2022.156018_b0110","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jaci.2013.03.033","article-title":"Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3","volume":"132","author":"Junttila","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cyto.2022.156018_b0115","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1398-9995.2006.01139.x","article-title":"Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression","volume":"61","author":"Kaur","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.cyto.2022.156018_b0120","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neubiorev.2017.05.001","article-title":"Mast cells in neuroinflammation and brain disorders","volume":"79","author":"Hendriksen","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"10.1016\/j.cyto.2022.156018_b0125","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2017.06.007","article-title":"Mast cell activation syndromes","volume":"140","author":"Akin","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cyto.2022.156018_b0130","doi-asserted-by":"crossref","unstructured":"D.A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M.J. Borowitz, M.M. Le Beau, C.D. Bloomfield, M. Cazzola, J.W. Vardiman, The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia, Blood 127 (2016) 2391-2405.","DOI":"10.1182\/blood-2016-03-643544"},{"issue":"13","key":"10.1016\/j.cyto.2022.156018_b0135","doi-asserted-by":"crossref","first-page":"16936","DOI":"10.18632\/oncotarget.7851","article-title":"ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells","volume":"7","author":"Kapur","year":"2016","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.cyto.2022.156018_b0140","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1111\/all.14808","article-title":"Transcriptome programming of IL-3-dependent bone marrow-derived cultured mast cells by stem cell factor","volume":"76","author":"Wang","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.cyto.2022.156018_b0145","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF01262332","article-title":"Transforming growth factor beta 1 inhibits IL-3- and IL-4-dependent mouse connective tissue-type mast cell proliferation","volume":"287","author":"Toyota","year":"1995","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.cyto.2022.156018_b0150","doi-asserted-by":"crossref","unstructured":"S. Kobashigawa, Y.M. Sakaguchi, S. Masunaga, E. Mori, Stress-induced cellular senescence contributes to chronic inflammation and cancer progression, Therm. Med. 35 (2019) 41-58.","DOI":"10.3191\/thermalmed.35.41"},{"key":"10.1016\/j.cyto.2022.156018_b0155","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/cancers10090297","article-title":"The p53 Pathway in Glioblastoma","volume":"10","author":"Zhang","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cyto.2022.156018_b0160","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1111\/cas.13792","article-title":"Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis","volume":"109","author":"Yogosawa","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cyto.2022.156018_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114651","article-title":"p53 regulated senescence mechanism and role of its modulators in age-related disorders","volume":"190","author":"Pawge","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cyto.2022.156018_b0170","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2174\/13894501113149990194","article-title":"Maerken, MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance","volume":"15","author":"Barone","year":"2014","journal-title":"Curr. Drug Targets"},{"issue":"2","key":"10.1016\/j.cyto.2022.156018_b0175","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/onc.2012.45","article-title":"Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells","volume":"32","author":"Yasaei","year":"2013","journal-title":"Oncogene"},{"issue":"6549","key":"10.1016\/j.cyto.2022.156018_b0180","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/377552a0","article-title":"Radiation-induced cell cycle arrest compromised by p21 deficiency","volume":"377","author":"Brugarolas","year":"1995","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.cyto.2022.156018_b0185","doi-asserted-by":"crossref","first-page":"e25412","DOI":"10.1371\/journal.pone.0025412","article-title":"Tumor Suppressor p53 Functions as a Negative Regulator in IgE-Mediated Mast Cell Activation","volume":"6","author":"Suzuki","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2022.156018_b0190","doi-asserted-by":"crossref","unstructured":"I. Shimizu, T. Minamino T, Cellularsenescencein cardiac diseases, J. Cardiol. 74 (2019) 313-319.","DOI":"10.1016\/j.jjcc.2019.05.002"},{"key":"10.1016\/j.cyto.2022.156018_b0195","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0301-472X(01)00659-2","article-title":"Interleukin-3 and stem cell factor modulate cell cycle regulatory factors in mast cells: negative regulation of p27Kip1 in proliferation of mast cells induced by interleukin-3 but not stem cell factor","volume":"29","author":"Itakura","year":"2001","journal-title":"Exp. Hematol."},{"issue":"2","key":"10.1016\/j.cyto.2022.156018_b0200","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2217\/rme.11.2","article-title":"Role of mechanical factors in fate decisions of stem cells","volume":"6","author":"Li","year":"2011","journal-title":"Regen. Med."},{"key":"10.1016\/j.cyto.2022.156018_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106872","article-title":"Blockade of RANKL\/RANK signaling pathway by epigallocatechin gallate alleviates mast cell-mediated inflammatory reactions","volume":"88","author":"Kim","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.cyto.2022.156018_b0210","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.bpj.2010.08.026","article-title":"Stiffening of human skin fibroblasts with age","volume":"99","author":"Schulze","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.cyto.2022.156018_b0215","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1586\/14789450.2013.814881","article-title":"Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis","volume":"10","author":"Indra","year":"2013","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.cyto.2022.156018_b0220","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2020.09.023","article-title":"Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope","volume":"496","author":"Zafar","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cyto.2022.156018_b0225","doi-asserted-by":"crossref","first-page":"425","DOI":"10.5603\/EP.a2020.0053","article-title":"MDM2 promotes the proliferation and inhibits the apoptosis of pituitary adenoma cells by directly interacting with p53","volume":"71","author":"Wang","year":"2020","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.cyto.2022.156018_b0230","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.2174\/092986707782793998","article-title":"Regulation of mast cell development by infammatory factors","volume":"14","author":"Hu","year":"2007","journal-title":"Curr. Med. Chem."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622002277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622002277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:46:10Z","timestamp":1760910370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466622002277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":46,"alternative-id":["S1043466622002277"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2022.156018","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RANKL down-regulates the mast cell proliferation through inducing senescence","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2022.156018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"156018"}}