{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:23:37Z","timestamp":1787495017784,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.cyto.2022.156115","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T05:20:48Z","timestamp":1672636848000},"page":"156115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Disruption of IDO signaling pathway alleviates chronic unpredictable mild stress-induced depression-like behaviors and tumor progression in mice with breast cancer"],"prefix":"10.1016","volume":"162","author":[{"given":"Jun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10286","key":"10.1016\/j.cyto.2022.156115_b0005","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.cyto.2022.156115_b0010","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1038\/s41380-020-00865-6","article-title":"Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients","volume":"25","author":"Wang","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"13","key":"10.1016\/j.cyto.2022.156115_b0015","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.3390\/cancers13133368","article-title":"Physical comorbidities and depression in recent and long-term adult cancer survivors: NHANES 2007-2018","volume":"13","author":"Petrova","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cyto.2022.156115_b0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ctrv.2016.11.004","article-title":"Depression in cancer: The many biobehavioral pathways driving tumor progression","volume":"52","author":"Bortolato","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.cyto.2022.156115_b0025","first-page":"CD011246","article-title":"Prevention of depression in adults with long-term physical conditions","volume":"3","author":"Kampling","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7","key":"10.1016\/j.cyto.2022.156115_b0030","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41380-019-0595-x","article-title":"Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies","volume":"25","author":"Wang","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.cyto.2022.156115_b0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/pon.3409","article-title":"Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments","volume":"23","author":"Krebber","year":"2014","journal-title":"Psychooncology"},{"issue":"1","key":"10.1016\/j.cyto.2022.156115_b0040","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41398-021-01744-6","article-title":"Moderators of inflammation-related depression: a prospective study of breast cancer survivors","volume":"11","author":"Manigault","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"11","key":"10.1016\/j.cyto.2022.156115_b0045","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/jamasurg.2020.3325","article-title":"Association of breast cancer surgery with quality of life and psychosocial well-being in young breast cancer survivors","volume":"155","author":"Rosenberg","year":"2020","journal-title":"JAMA Surg."},{"issue":"1","key":"10.1016\/j.cyto.2022.156115_b0050","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1186\/s12885-021-08615-9","article-title":"Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study","volume":"21","author":"Hajj","year":"2021","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.cyto.2022.156115_b0055","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00281-020-00815-y","article-title":"Stress reduction strategies in breast cancer: review of pharmacologic and non-pharmacologic based strategies","volume":"42","author":"Gosain","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.cyto.2022.156115_b0060","article-title":"Investigation of the relationship among cortisol, pro-inflammatory cytokines, and the degradation of tryptophan into kynurenine in patients with major depression and suicidal behavior","author":"Messaoud","year":"2021","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.cyto.2022.156115_b0065","doi-asserted-by":"crossref","first-page":"107746","DOI":"10.1016\/j.pharmthera.2020.107746","article-title":"Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets","volume":"221","author":"Dolsak","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.cyto.2022.156115_b0070","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.18632\/oncotarget.6467","article-title":"Understanding the role of the kynurenine pathway in human breast cancer immunobiology","volume":"7","author":"Heng","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.cyto.2022.156115_b0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13058-020-01351-1","article-title":"Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression","volume":"22","author":"Heng","year":"2020","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cyto.2022.156115_b0080","doi-asserted-by":"crossref","first-page":"106506","DOI":"10.1016\/j.intimp.2020.106506","article-title":"Prognosis significance of indoleamine 2, 3-dioxygenase, programmed death ligand-1 and tumor-infiltrating immune cells in microenvironment of breast cancer","volume":"84","author":"Wei","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2022.156115_b0085","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbr.2015.04.052","article-title":"Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice","volume":"291","author":"Deng","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.cyto.2022.156115_b0090","first-page":"965","article-title":"The effect of interpersonal psychotherapy on quality of life among breast cancer patients with common mental health disorder: a randomized control trial at Tikur Anbessa Specialized Hospital","volume":"30","author":"Belay","year":"2022","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.cyto.2022.156115_b0095","doi-asserted-by":"crossref","first-page":"13003","DOI":"10.2147\/CMAR.S279800","article-title":"Resatorvid relieves breast cancer complicated with depression by inactivating hippocampal microglia through TLR4\/NF-kappaB\/NLRP3 signaling pathway","volume":"12","author":"Luo","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"9","key":"10.1016\/j.cyto.2022.156115_b0100","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","article-title":"Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity","volume":"25","author":"Yang","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cyto.2022.156115_b0105","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1038\/s41467-018-05283-5","article-title":"Modulation of anti-tumor immunity by the brain's reward system","volume":"9","author":"Ben-Shaanan","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cyto.2022.156115_b0110","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41380-021-01224-9","article-title":"The neuroendocrinology of stress: the stress-related continuum of chronic disease development","volume":"27","author":"Agorastos","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.cyto.2022.156115_b0115","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/cac2.12198","article-title":"Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine\/beta2 -AR\/MACC1 axis","volume":"41","author":"Pan","year":"2021","journal-title":"Cancer Commun. (Lond)"},{"issue":"7","key":"10.1016\/j.cyto.2022.156115_b0120","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1007\/s11064-021-03316-y","article-title":"SRC-1 Deficiency increases susceptibility of mice to depressive-like behavior after exposure to CUMS","volume":"46","author":"Wu","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cyto.2022.156115_b0125","doi-asserted-by":"crossref","first-page":"135851","DOI":"10.1016\/j.neulet.2021.135851","article-title":"Depression promotes lung carcinoma progression by regulating the tumor microenvironment in tumor-bearing models of C57BL\/6J mice","volume":"754","author":"Cui","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cyto.2022.156115_b0130","doi-asserted-by":"crossref","first-page":"714163","DOI":"10.3389\/fphar.2021.714163","article-title":"Sini San Inhibits chronic psychological stress-induced breast cancer stemness by suppressing cortisol-mediated GRP78 activation","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.cyto.2022.156115_b0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/cns.13465","article-title":"Activation of dopaminergic VTA inputs to the mPFC ameliorates chronic stress-induced breast tumor progression","volume":"27","author":"Xu","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.cyto.2022.156115_b0140","doi-asserted-by":"crossref","first-page":"671864","DOI":"10.3389\/fnbeh.2021.671864","article-title":"Daidzein alleviates hypothalamic-pituitary-adrenal axis hyperactivity, ameliorates depression-like behavior, and partly rectifies circulating cytokine imbalance in two rodent models of depression","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.cyto.2022.156115_b0145","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","article-title":"Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala","volume":"91","author":"Zheng","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.cyto.2022.156115_b0150","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/eji.201847525","article-title":"Serotonin decreases the production of Th1\/Th17 cytokines and elevates the frequency of regulatory CD4(+) T-cell subsets in multiple sclerosis patients","volume":"48","author":"Sacramento","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cyto.2022.156115_b0155","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.intimp.2018.12.012","article-title":"Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress","volume":"67","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2022.156115_b0160","doi-asserted-by":"crossref","first-page":"738252","DOI":"10.3389\/fonc.2021.738252","article-title":"Chronic stress effects on tumor: Pathway and mechanism","volume":"11","author":"Hong","year":"2021","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.cyto.2022.156115_b0165","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00726-013-1602-1","article-title":"Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease","volume":"45","author":"Fatokun","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.cyto.2022.156115_b0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fncel.2020.00011","article-title":"Indoleamine-2,3-dioxygenase mediates emotional deficits by the kynurenine\/tryptophan pathway in the ethanol addiction\/withdrawal mouse model","volume":"14","author":"Jiang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.cyto.2022.156115_b0175","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-3-030-49844-3_13","article-title":"Indoleamine 2,3-dioxygenase activity-induced acceleration of tumor growth, and protein kinases-related novel therapeutics regimens","volume":"1275","author":"Engin","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"10.1016\/j.cyto.2022.156115_b0180","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.4049\/jimmunol.1400833","article-title":"Noncanonical NF-kappaB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer","volume":"193","author":"Yu","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2022.156115_b0185","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molimm.2021.06.013","article-title":"Regulatory t cells express tumor necrosis factor receptor 2 with the highest intensity among CD4(+) T cells in the draining lymph nodes of breast cancer","volume":"137","author":"Ghods","year":"2021","journal-title":"Mol. Immunol."},{"issue":"11","key":"10.1016\/j.cyto.2022.156115_b0190","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00109-021-02123-w","article-title":"Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions","volume":"99","author":"Salminen","year":"2021","journal-title":"J. Mol. Med. (Berl)"},{"issue":"10","key":"10.1016\/j.cyto.2022.156115_b0195","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nn.4113","article-title":"Neuroimmune mechanisms of depression","volume":"18","author":"Hodes","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cyto.2022.156115_b0200","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3389\/fnins.2018.00547","article-title":"Involvement of innate and adaptive immune systems alterations in the pathophysiology and treatment of depression","volume":"12","author":"Medina-Rodriguez","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cyto.2022.156115_b0205","doi-asserted-by":"crossref","first-page":"5537523","DOI":"10.1155\/2021\/5537523","article-title":"Depression induced by CUMS leads to bladder cancer development and local tumor immunosuppression in mice","volume":"2021","author":"Qian","year":"2021","journal-title":"J. Oncol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622003246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466622003246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:48:03Z","timestamp":1760910483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466622003246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":41,"alternative-id":["S1043466622003246"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2022.156115","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of IDO signaling pathway alleviates chronic unpredictable mild stress-induced depression-like behaviors and tumor progression in mice with breast cancer","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2022.156115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"156115"}}