{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:27:06Z","timestamp":1791548826641,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.cyto.2023.156280","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T17:32:57Z","timestamp":1687627977000},"page":"156280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Clinical significance of serum cytokine profiles for differentiating between Kawasaki disease and its mimickers"],"prefix":"10.1016","volume":"169","author":[{"given":"Shuya","family":"Kaneko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Shimbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Irabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Furuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Akamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Nakagishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Minato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Morio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2023.156280_b0005","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1161\/01.CIR.0000145143.19711.78","article-title":"Diagnosis, treatment and long-term management of Kawasaki disease","volume":"110","author":"Newburger","year":"2004","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.cyto.2023.156280_b0010","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/01.CIR.94.6.1379","article-title":"Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients","volume":"94","author":"Kato","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.cyto.2023.156280_b0015","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/ped.14326","article-title":"Revision of diagnostic guidelines for Kawasaki disease","volume":"62","author":"Kobayashi","year":"2020","journal-title":"Pediatr Int"},{"issue":"5","key":"10.1016\/j.cyto.2023.156280_b0020","doi-asserted-by":"crossref","first-page":"e783","DOI":"10.1542\/peds.2008-1871","article-title":"Recognition of a Kawasaki disease shock syndrome","volume":"123","author":"Kanegaye","year":"2009","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.cyto.2023.156280_b0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/01.bor.0000381996.69261.71","article-title":"Macrophage activation syndrome: advances towards understanding pathogenesis","volume":"22","author":"Grom","year":"2010","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"10.1016\/j.cyto.2023.156280_b0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.semarthrit.2014.07.007","article-title":"Macrophage activation syndrome in Kawasaki disease: more common than we thought?","volume":"44","author":"Wang","year":"2015","journal-title":"Semin Athritis Reum"},{"key":"10.1016\/j.cyto.2023.156280_b0035","doi-asserted-by":"crossref","unstructured":"P. Jin, Y. Luo, X. Liu, J. Xu, C. Liu. Kawasaki disease complicated with macrophage activation syndrome: case reports and literature review. Front Pediatr, 7(2019), pp423.","DOI":"10.3389\/fped.2019.00423"},{"issue":"7","key":"10.1016\/j.cyto.2023.156280_b0040","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1093\/rheumatology\/keaa715","article-title":"Macrophage activation syndrome in children with Kawasaki disease: an experience from a tertiary care hospital in northwest India","volume":"60","author":"Pilania","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.cyto.2023.156280_b0045","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-0702","article-title":"Epidemiology of COVID-19 among children in China","volume":"145","author":"Dong","year":"2020","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.cyto.2023.156280_b0050","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1097\/INF.0000000000003393","article-title":"An update on multisystem inflammatory syndrome in children related to SARS-CoV-2","volume":"41","author":"Dionne","year":"2022","journal-title":"Pediatr Infect Dis J"},{"issue":"40","key":"10.1016\/j.cyto.2023.156280_b0055","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.15585\/mmwr.mm6940e1","article-title":"Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection\u2014United Kingdom and United States, March\u2013August 2020","volume":"69","author":"Morris","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"Suppl 1","key":"10.1016\/j.cyto.2023.156280_b0060","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/S0163-4453(17)30206-2","article-title":"Toxic shock syndrome - the seven Rs of management and treatment","volume":"74","author":"Wilkins","year":"2017","journal-title":"J Infect"},{"issue":"6","key":"10.1016\/j.cyto.2023.156280_b0065","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1128\/JCM.42.6.2866-2869.2004","article-title":"Fatal case of toxic shock-like syndrome due to Group C streptococcus associated with superantigen exotoxin","volume":"42","author":"Korman","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.cyto.2023.156280_b0070","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/jama.1993.03500030088038","article-title":"Defining the Group A streptococcal toxic shock syndrome. Rationale and consensus definition. The Working Group on Severe Streptococcal Infections","volume":"269","author":"Breiman","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.cyto.2023.156280_b0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000100859","article-title":"Yersinia pseudotuberculosis superantigens","volume":"93","author":"Donadini","year":"2007","journal-title":"Chem Immunol Allergy"},{"key":"10.1016\/j.cyto.2023.156280_b0080","unstructured":"Centers for Disease Control and Prevention. Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). 2020. URL: https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp."},{"key":"10.1016\/j.cyto.2023.156280_b0085","unstructured":"World Health Organization. Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19. 2020. URL: https:\/\/www.who.int\/news-room\/commentaries\/detail\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19."},{"key":"10.1016\/j.cyto.2023.156280_b0090","first-page":"1","article-title":"Case definitions for infectious conditions under public health surveillance","volume":"46","author":"Centres for Disease Control and Prevention","year":"1997","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.cyto.2023.156280_b0095","doi-asserted-by":"crossref","unstructured":"J. Suzuki, K. Abe, T. Matsui, T. Honda, K. Yasukawa, J.I.Takanashi,et al. Kawasaki Disease Shock Syndrome in Japan and Comparison With Multisystem Inflammatory Syndrome in Children in European countries. Front Pediatr, 9(2021), 625456.","DOI":"10.3389\/fped.2021.625456"},{"issue":"6","key":"10.1016\/j.cyto.2023.156280_b0100","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1084\/jem.164.6.1958","article-title":"Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome","volume":"164","author":"Leung","year":"1986","journal-title":"Journal of experimental medicine"},{"issue":"12","key":"10.1016\/j.cyto.2023.156280_b0105","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1136\/annrheumdis-2012-201658","article-title":"A child with severe relapsing Kawasaki disease rescued by IL-1 receptor blockade and extracorporeal membrane oxygenation","volume":"71","author":"Cohen","year":"2012","journal-title":"Annals of the rheumatic diseases"},{"issue":"19","key":"10.1016\/j.cyto.2023.156280_b0110","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1056\/NEJMc1709609","article-title":"Coronary-artery aneurysm in tocilizumab-treated children with Kawasaki disease","volume":"377","author":"Nozawa","year":"2017","journal-title":"New Eng J Med"},{"issue":"9930","key":"10.1016\/j.cyto.2023.156280_b0115","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/S0140-6736(13)62298-9","article-title":"Infliximab for intensification of primary therapy for Kawasaki disease: a phase 3 randomised, double-blind, placebo-controlled trial","volume":"383","author":"Tremoulet","year":"2014","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.cyto.2023.156280_b0120","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jpeds.2010.10.012","article-title":"Infliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study","volume":"158","author":"Son","year":"2011","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.cyto.2023.156280_b0125","doi-asserted-by":"crossref","first-page":"pp1","DOI":"10.1186\/s12969-018-0303-4","article-title":"Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-\u03b3 as biomarkers for early recognition","volume":"17","author":"Li","year":"2019","journal-title":"Pediatr Rheum Online J"},{"key":"10.1016\/j.cyto.2023.156280_b0130","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cyto.2019.03.001","article-title":"Cytokine profile of macrophage activation syndrome associated with Kawasaki disease","volume":"119","author":"Jinkawa","year":"2019","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.cyto.2023.156280_b0135","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/rheumatology\/keaa299","article-title":"Comparison of serum cytokine profiles in macrophage activation syndrome complicating different background rheumatic diseases in children","volume":"60","author":"Mizuta","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.cyto.2023.156280_b0140","doi-asserted-by":"crossref","first-page":"ppe144554","DOI":"10.1172\/JCI144554","article-title":"Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease","volume":"131","author":"Esteve-Sole","year":"2021","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.cyto.2023.156280_b0145","doi-asserted-by":"crossref","first-page":"e574","DOI":"10.1016\/S2665-9913(21)00139-9","article-title":"Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study","volume":"3","author":"Rodriguez-Smith","year":"2021","journal-title":"Lancet. Rheumatol"},{"issue":"8","key":"10.1016\/j.cyto.2023.156280_b0150","doi-asserted-by":"crossref","first-page":"e632","DOI":"10.1111\/j.1365-2230.2009.03353.x","article-title":"Cytokine profile during the clinical course of toxic shock syndrome","volume":"34","author":"Seishima","year":"2009","journal-title":"Clin Exp Dermatol"},{"issue":"1","key":"10.1016\/j.cyto.2023.156280_b0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/toxsci\/kft099","article-title":"Toxic shock syndrome: characterization of human immune responses to TSST-1 and evidence for sensitivity thresholds","volume":"134","author":"Kimber","year":"2013","journal-title":"Toxicol Sci"},{"issue":"3","key":"10.1016\/j.cyto.2023.156280_b0160","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/art.39332","volume":"68","author":"Ravelli","year":"2016","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.cyto.2023.156280_b0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/icb.2010.158","article-title":"CXCR3 ligands: redundant, collaborative and antagonistic functions","volume":"89","author":"Groom","year":"2011","journal-title":"Immunol Cell Biol"},{"issue":"1","key":"10.1016\/j.cyto.2023.156280_b0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jim.2008.09.021","article-title":"MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines","volume":"340","author":"Berthoud","year":"2009","journal-title":"J Immunol Methods"},{"issue":"1\u20132","key":"10.1016\/j.cyto.2023.156280_b0175","first-page":"69","article-title":"Evaluation of measurement of human TNF in plasma by ELISA","volume":"10","author":"Engelberts","year":"1991","journal-title":"Lymphokine Cytokine Res"},{"issue":"2","key":"10.1016\/j.cyto.2023.156280_b0180","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/infdis\/169.2.420","article-title":"Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection\u2013correlations to clinical, immunologic, and virologic parameters","volume":"169","author":"Aukrust","year":"1994","journal-title":"The journal of infectious diseases"},{"issue":"2\u20133","key":"10.1016\/j.cyto.2023.156280_b0185","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-2478(94)90138-4","article-title":"Tumor necrosis factor alpha and soluble tumor necrosis factor receptors in individuals with human immunodeficiency virus infection","volume":"41","author":"Zangerle","year":"1994","journal-title":"Immunology letters"},{"key":"10.1016\/j.cyto.2023.156280_b0190","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cyto.2019.03.018","article-title":"Clinical significance of serum CXCL9 levels as a biomarker for systemic juvenile idiopathic arthritis associated macrophage activation syndrome","volume":"119","author":"Mizuta","year":"2019","journal-title":"Cytokine"},{"issue":"9","key":"10.1016\/j.cyto.2023.156280_b0195","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/ped.13614","article-title":"Kawasaki disease shock syndrome: Unique and severe subtype of Kawasaki disease","volume":"60","author":"Gamez-Gonzalez","year":"2018","journal-title":"Pediatr Int"},{"issue":"59","key":"10.1016\/j.cyto.2023.156280_b0200","doi-asserted-by":"crossref","first-page":"eabh1516","DOI":"10.1126\/sciimmunol.abh1516","article-title":"Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem inflammatory Syndrome in Children","volume":"6","author":"Moreews","year":"2021","journal-title":"Science immunol"},{"key":"10.1016\/j.cyto.2023.156280_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.108955","article-title":"Time course of peripheral immunophenotypes of multisystem inflammatory syndrome in children","volume":"236","author":"Morita","year":"2022","journal-title":"Clin Immunol"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466623001588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466623001588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:51:25Z","timestamp":1760910685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466623001588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":41,"alternative-id":["S1043466623001588"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2023.156280","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical significance of serum cytokine profiles for differentiating between Kawasaki disease and its mimickers","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2023.156280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"156280"}}