{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:54:57Z","timestamp":1791550497240,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2022R1F1A1075097"],"award-info":[{"award-number":["NRF-2022R1F1A1075097"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.cyto.2023.156439","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T23:47:25Z","timestamp":1703116045000},"page":"156439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38"],"prefix":"10.1016","volume":"174","author":[{"given":"Jeong Hee","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geunyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Sook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran-Sook","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juram","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6555","key":"10.1016\/j.cyto.2023.156439_b0005","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/378386a0","article-title":"Multiple essential functions of neuregulin in development","volume":"378","author":"Meyer","year":"1995","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cyto.2023.156439_b0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0014-4827(02)00102-7","article-title":"Neuregulins: functions, forms, and signaling strategies","volume":"284","author":"Falls","year":"2003","journal-title":"Exp. Cell Res."},{"issue":"23","key":"10.1016\/j.cyto.2023.156439_b0015","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1523\/JNEUROSCI.5317-10.2011","article-title":"Specific regulation of NRG1 isoform expression by neuronal activity","volume":"31","author":"Liu","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cyto.2023.156439_b0020","article-title":"Integrative Analysis of Neuregulin Family Members-Related Tumor Microenvironment for Predicting the Prognosis in Gliomas","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.cyto.2023.156439_b0025","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.tim.2017.04.009","article-title":"The Role of ErbB Receptors in Infection","volume":"25","author":"Ho","year":"2017","journal-title":"Trends Microbiol."},{"issue":"6","key":"10.1016\/j.cyto.2023.156439_b0030","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn2392","article-title":"Neuregulin 1 in neural development, synaptic plasticity and schizophrenia","volume":"9","author":"Mei","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cyto.2023.156439_b0035","doi-asserted-by":"crossref","first-page":"31692","DOI":"10.1038\/srep31692","article-title":"Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2023.156439_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.662474","article-title":"Neuregulins in Neurodegenerative Diseases","volume":"13","author":"Ou","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.cyto.2023.156439_b0045","first-page":"326","article-title":"Neuregulin 1 enhances cell adhesion molecule L1 like expression levels and promotes malignancy in human glioma","volume":"20","author":"Lin","year":"2020","journal-title":"Oncol. Lett."},{"issue":"19","key":"10.1016\/j.cyto.2023.156439_b0050","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1042\/CS20200230","article-title":"Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease","volume":"134","author":"Geissler","year":"2020","journal-title":"Clin. Sci. (Lond.)"},{"issue":"4","key":"10.1016\/j.cyto.2023.156439_b0055","first-page":"1255","article-title":"Neuregulin-1 protects cardiac function in septic rats through multiple targets based on endothelial cells","volume":"44","author":"Kang","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"14","key":"10.1016\/j.cyto.2023.156439_b0060","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"10023","key":"10.1016\/j.cyto.2023.156439_b0065","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2023.156439_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.943640","article-title":"Atopic dermatitis: Is innate or adaptive immunity in control? A clinical perspective","volume":"13","author":"Ong","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2023.156439_b0075","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.cyto.2023.156439_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105318","article-title":"Revisiting the Roles of Filaggrin in Atopic Dermatitis","volume":"23","author":"Moosbrugger-Martinz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cyto.2023.156439_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031455","article-title":"The Discovery and Function of Filaggrin","volume":"23","author":"Hoober","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2023.156439_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.646316","article-title":"Pathogenic Mechanism of Der p 38 as a Novel Allergen Homologous to RipA and RipB Proteins in Atopic Dermatitis","volume":"12","author":"Jeon","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2023.156439_b0095","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3389\/fimmu.2020.01258","article-title":"S100A8 and S100A9 Promote Apoptosis of Chronic Eosinophilic Leukemia Cells","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.cyto.2023.156439_b0100","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.4049\/jimmunol.2001144","article-title":"Der p 38 Is a Bidirectional Regulator of Eosinophils and Neutrophils in Allergy","volume":"207","author":"Hong","year":"2021","journal-title":"J. Immunol."},{"issue":"6555","key":"10.1016\/j.cyto.2023.156439_b0105","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/378390a0","article-title":"Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor","volume":"378","author":"Gassmann","year":"1995","journal-title":"Nature"},{"issue":"6555","key":"10.1016\/j.cyto.2023.156439_b0110","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/378394a0","article-title":"Requirement for neuregulin receptor ErbB2 in neural and cardiac development","volume":"378","author":"Lee","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2023.156439_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101643","article-title":"Neuregulin-1\/ErbB network: An emerging modulator of nervous system injury and repair","volume":"180","author":"Kataria","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cyto.2023.156439_b0120","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.neuro.20.1.429","article-title":"ARIA: a neuromuscular junction neuregulin","volume":"20","author":"Fischbach","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.cyto.2023.156439_b0125","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1165\/rcmb.2009-0018OC","article-title":"Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium","volume":"42","author":"Kettle","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.cyto.2023.156439_b0130","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1159\/000430169","article-title":"Inflammasome Inhibition Suppresses Alveolar Cell Permeability Through Retention of Neuregulin-1 (NRG-1)","volume":"36","author":"Venugopal","year":"2015","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.cyto.2023.156439_b0135","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12974-015-0283-y","article-title":"Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury","volume":"12","author":"Li","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.cyto.2023.156439_b0140","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12974-016-0703-7","article-title":"Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway","volume":"13","author":"Simmons","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.cyto.2023.156439_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106912","article-title":"Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease","volume":"32","author":"Chambliss","year":"2023","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"3","key":"10.1016\/j.cyto.2023.156439_b0150","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/jcmm.16287","article-title":"Neuregulin-1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3\/caspase-1 in myocardial ischaemia-reperfusion injury","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cyto.2023.156439_b0155","article-title":"Neuregulin-1, a potential therapeutic target for cardiac repair","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.cyto.2023.156439_b0160","first-page":"2311","article-title":"Neuregulin-1: An underlying protective force of cardiac dysfunction in sepsis (Review)","volume":"21","author":"Kang","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.cyto.2023.156439_b0165","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1007\/s10787-022-01031-w","article-title":"Role of the NRG1\/ErbB4 and PI3K\/AKT\/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats","volume":"30","author":"Nawwar","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.cyto.2023.156439_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135803","article-title":"Nrg1\/ErbB2 regulates differentiation and apoptosis of neural stem cells in the cochlear nucleus through PI3K\/Akt pathway","volume":"751","author":"Lu","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.cyto.2023.156439_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084130","article-title":"Molecular Mechanisms of Atopic Dermatitis Pathogenesis","volume":"22","author":"Sroka-Tomaszewska","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.cyto.2023.156439_b0180","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cyto.2023.156439_b0185","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.3389\/fimmu.2018.02727","article-title":"Leveraging Multilayered \u201cOmics\u201d Data for Atopic Dermatitis: A Road Map to Precision Medicine","volume":"9","author":"Ghosh","year":"2018","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.cyto.2023.156439_b0190","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20212397","article-title":"A dysregulated sebum-microbial metabolite-IL-33 axis initiates skin inflammation in atopic dermatitis","volume":"219","author":"Qiu","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cyto.2023.156439_b0195","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3389\/fimmu.2020.00752","article-title":"IL-37 Ameliorating Allergic Inflammation in Atopic Dermatitis Through Regulating Microbiota and AMPK-mTOR Signaling Pathway-Modulated Autophagy Mechanism","volume":"11","author":"Hou","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2023.156439_b0200","doi-asserted-by":"crossref","unstructured":"N. Dhingra, M. Suarez-Farinas, J. Fuentes-Duculan, J.K. Gittler, A. Shemer, A. Raz, V.A. Fischetti, J.G. Krueger, E. Guttman-Yassky, Attenuated neutrophil axis in atopic dermatitis compared to psoriasis reflects TH17 pathway differences between these diseases, J. Allergy Clin. Immunol. 132(2) (2013) 498-501 e3.","DOI":"10.1016\/j.jaci.2013.04.043"},{"key":"10.1016\/j.cyto.2023.156439_b0205","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48448","article-title":"Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis","volume":"8","author":"Walsh","year":"2019","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.cyto.2023.156439_b0210","doi-asserted-by":"crossref","first-page":"498","DOI":"10.7150\/ijms.37833","article-title":"Suppressive effects of S100A8 and S100A9 on neutrophil apoptosis by cytokine release of human bronchial epithelial cells in asthma","volume":"17","author":"Kim","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.cyto.2023.156439_b0215","doi-asserted-by":"crossref","unstructured":"M.C. Peters, K.W. McGrath, G.A. Hawkins, A.T. Hastie, B.D. Levy, E. Israel, B.R. Phillips, D.T. Mauger, S.A. Comhair, S.C. Erzurum, M.W. Johansson, N.N. Jarjour, A.M. Coverstone, M. Castro, F. Holguin, S.E. Wenzel, P.G. Woodruff, E.R. Bleecker, J.V. Fahy, L. National Heart, P. Blood Institute Severe Asthma Research, Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts, Lancet Respir Med 4(7) (2016) 574-584.","DOI":"10.1016\/S2213-2600(16)30048-0"},{"issue":"1","key":"10.1016\/j.cyto.2023.156439_b0220","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1523-1755.1998.00741.x","article-title":"Interleukin-8 delays spontaneous and tumor necrosis factor-alpha-mediated apoptosis of human neutrophils","volume":"53","author":"Kettritz","year":"1998","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.cyto.2023.156439_b0225","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1128\/IAI.72.7.3823-3828.2004","article-title":"In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis","volume":"72","author":"Asensi","year":"2004","journal-title":"Infect. Immun."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466623003174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466623003174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T04:46:45Z","timestamp":1736311605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466623003174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":45,"alternative-id":["S1043466623003174"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2023.156439","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2023.156439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"156439"}}