{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:24:17Z","timestamp":1794317057065,"version":"4.9.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012434","name":"Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi","doi-asserted-by":"publisher","award":["2023KY0115"],"award-info":[{"award-number":["2023KY0115"]}],"id":[{"id":"10.13039\/501100012434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.cyto.2023.156446","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:13:11Z","timestamp":1700259191000},"page":"156446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Exploring the causal relationship between inflammatory cytokines and inflammatory arthritis: A Mendelian randomization study"],"prefix":"10.1016","volume":"173","author":[{"given":"Shixin","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2479-3001","authenticated-orcid":false,"given":"Chong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2023.156446_b0005","first-page":"CD008886","article-title":"Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)","volume":"10","author":"Ramiro","year":"2011","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.cyto.2023.156446_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.565275","article-title":"Innate Lymphocytes in Inflammatory Arthritis","volume":"11","author":"Wu","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.cyto.2023.156446_b0015","article-title":"Diagnosis and early management of inflammatory arthritis","volume":"358","author":"Ledingham","year":"2017","journal-title":"BMJ."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0020","first-page":"464","article-title":"Osteoimmunology: The Nexus between bone and immune system","volume":"23","author":"Dar","year":"2018","journal-title":"Front Biosci (landmark Ed)."},{"issue":"8","key":"10.1016\/j.cyto.2023.156446_b0025","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41584-019-0243-5","article-title":"Systemic effects of IL-17 in inflammatory arthritis","volume":"15","author":"Beringer","year":"2019","journal-title":"Nat Rev Rheumatol."},{"issue":"8","key":"10.1016\/j.cyto.2023.156446_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080818","article-title":"Cartilage and Bone Destruction in Arthritis: Pathogenesis and Treatment Strategy: A Literature Review","volume":"8","author":"Tateiwa","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cyto.2023.156446_b0035","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cyto.2017.04.012","article-title":"Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines","volume":"98","author":"Kim","year":"2017","journal-title":"Cytokine."},{"key":"10.1016\/j.cyto.2023.156446_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104473","article-title":"Biological and synthetic target DMARDs in psoriatic arthritis","volume":"149","author":"Silvagni","year":"2019","journal-title":"Pharmacol Res."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0045","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/cei.12670","article-title":"The interleukin (IL)-23\/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment","volume":"183","author":"Jethwa","year":"2016","journal-title":"Clin Exp Immunol."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13933","article-title":"Targeting tumor necrosis factor receptors in ankylosing spondylitis","volume":"1442","author":"Lata","year":"2019","journal-title":"Ann N Y Acad Sci."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat Rev Rheumatol."},{"issue":"4","key":"10.1016\/j.cyto.2023.156446_b0060","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00281-017-0619-z","article-title":"Selected cytokine pathways in rheumatoid arthritis","volume":"39","author":"Noack","year":"2017","journal-title":"Semin Immunopathol."},{"issue":"10136","key":"10.1016\/j.cyto.2023.156446_b0065","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"391","author":"Veale","year":"2018","journal-title":"Lancet."},{"issue":"14","key":"10.1016\/j.cyto.2023.156446_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411662","article-title":"Inflammatory Cytokines in Psoriatic Arthritis: Understanding Pathogenesis and Implications for Treatment","volume":"24","author":"Lee","year":"2023","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.berh.2017.08.003","article-title":"Genetic and environmental risk factors for rheumatoid arthritis","volume":"31","author":"Deane","year":"2017","journal-title":"Best Pract Res Clin Rheumatol."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010111","article-title":"The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis?","volume":"9","author":"Keewan","year":"2020","journal-title":"Cells."},{"key":"10.1016\/j.cyto.2023.156446_b0085","article-title":"Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: A Mendelian randomization","volume":"13","author":"Xiang","year":"2022","journal-title":"Front Immunol."},{"issue":"11","key":"10.1016\/j.cyto.2023.156446_b0090","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/sim.6835","article-title":"Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods","volume":"35","author":"Burgess","year":"2016","journal-title":"Stat Med."},{"issue":"6","key":"10.1016\/j.cyto.2023.156446_b0095","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/jbmr.2434","article-title":"Mendelian randomization analysis to examine for a causal effect of urate on bone mineral density","volume":"30","author":"Dalbeth","year":"2015","journal-title":"J Bone Miner Res."},{"issue":"10","key":"10.1016\/j.cyto.2023.156446_b0100","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/ijc.34214","article-title":"Causal relationships between inflammatory factors and multiple myeloma: A bidirectional Mendelian randomization study","volume":"151","author":"Wang","year":"2022","journal-title":"Int J Cancer."},{"key":"10.1016\/j.cyto.2023.156446_b0105","doi-asserted-by":"crossref","first-page":"1131198","DOI":"10.3389\/fgene.2023.1131198","article-title":"Genetically predicted circulating levels of cytokines and the risk of osteoarthritis: A mendelian randomization study","volume":"14","author":"Su","year":"2023","journal-title":"Front Genet."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0110","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/EDE.0000000000000081","article-title":"Methodological challenges in mendelian randomization","volume":"25","author":"VanderWeele","year":"2014","journal-title":"Epidemiology."},{"issue":"16","key":"10.1016\/j.cyto.2023.156446_b0115","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0120","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajhg.2016.11.007","article-title":"Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors","volume":"100","author":"Ahola-Olli","year":"2017","journal-title":"Am J Hum Genet."},{"issue":"7944","key":"10.1016\/j.cyto.2023.156446_b0125","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature."},{"key":"10.1016\/j.cyto.2023.156446_b0130","doi-asserted-by":"crossref","first-page":"1088778","DOI":"10.3389\/fimmu.2023.1088778","article-title":"Systemic inflammatory regulators and proliferative diabetic retinopathy: A bidirectional Mendelian randomization study","volume":"14","author":"Shi","year":"2023","journal-title":"Front Immunol."},{"issue":"7","key":"10.1016\/j.cyto.2023.156446_b0135","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two-sample Mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol."},{"issue":"7","key":"10.1016\/j.cyto.2023.156446_b0140","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol."},{"key":"10.1016\/j.cyto.2023.156446_b0145","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife."},{"issue":"7571","key":"10.1016\/j.cyto.2023.156446_b0150","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Genomes Project C","year":"2015","journal-title":"Nature."},{"key":"10.1016\/j.cyto.2023.156446_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.569323","article-title":"No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis","volume":"12","author":"Mensah-Kane","year":"2021","journal-title":"Front Genet."},{"key":"10.1016\/j.cyto.2023.156446_b0160","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res."},{"issue":"4","key":"10.1016\/j.cyto.2023.156446_b0165","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol."},{"issue":"2","key":"10.1016\/j.cyto.2023.156446_b0170","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol."},{"issue":"21","key":"10.1016\/j.cyto.2023.156446_b0175","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1002\/sim.6522","article-title":"Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome","volume":"34","author":"Greco","year":"2015","journal-title":"Stat Med."},{"issue":"5","key":"10.1016\/j.cyto.2023.156446_b0180","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0185","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1189\/jlb.3RU0316-144R","article-title":"Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage","volume":"100","author":"Ushach","year":"2016","journal-title":"J Leukoc Biol."},{"issue":"6","key":"10.1016\/j.cyto.2023.156446_b0190","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrc.2017.28","article-title":"Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy","volume":"17","author":"von Karstedt","year":"2017","journal-title":"Nat Rev Cancer."},{"issue":"9","key":"10.1016\/j.cyto.2023.156446_b0195","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1515\/hsz-2016-0280","article-title":"beta-NGF and beta-NGF receptor upregulation in blood and synovial fluid in osteoarthritis","volume":"398","author":"Montagnoli","year":"2017","journal-title":"Biol Chem."},{"issue":"6","key":"10.1016\/j.cyto.2023.156446_b0200","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in Signaling and Disease: Beyond Discovery and Development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell."},{"key":"10.1016\/j.cyto.2023.156446_b0205","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cyto.2018.05.019","article-title":"Emerging IL-12 family cytokines in the fight against fungal infections","volume":"111","author":"Thompson","year":"2018","journal-title":"Cytokine."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0210","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat Rev Immunol."},{"issue":"11","key":"10.1016\/j.cyto.2023.156446_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113000","article-title":"Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis","volume":"10","author":"Iwaszko","year":"2021","journal-title":"Cells."},{"issue":"6","key":"10.1016\/j.cyto.2023.156446_b0220","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s15010-015-0837-z","article-title":"Bacteremic pneumococcal pneumonia: clinical outcomes and preliminary results of inflammatory response","volume":"43","author":"Bordon","year":"2015","journal-title":"Infection."},{"key":"10.1016\/j.cyto.2023.156446_b0225","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cca.2019.06.026","article-title":"Elevated circulating IL-17 level is associated with inflammatory arthritis and disease activity: A meta-analysis","volume":"496","author":"Zhang","year":"2019","journal-title":"Clin Chim Acta."},{"key":"10.1016\/j.cyto.2023.156446_b0230","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fimmu.2019.00003","article-title":"Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10\/STAT3 Mechanism","volume":"10","author":"Degboe","year":"2019","journal-title":"Front Immunol."},{"issue":"R1","key":"10.1016\/j.cyto.2023.156446_b0235","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010120","article-title":"Role of Synovial Exosomes in Osteoclast Differentiation in Inflammatory Arthritis","volume":"10","author":"Song","year":"2021","journal-title":"Cells."},{"issue":"5","key":"10.1016\/j.cyto.2023.156446_b0245","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2177\/jsci.40.367","article-title":"Inflammation and osteoclasts","volume":"40","author":"Yokota","year":"2017","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi."},{"issue":"12","key":"10.1016\/j.cyto.2023.156446_b0250","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1136\/ard.2006.054874","article-title":"Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis","volume":"65","author":"Yang","year":"2006","journal-title":"Ann Rheum Dis."},{"issue":"2","key":"10.1016\/j.cyto.2023.156446_b0255","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2567.2009.03058.x","article-title":"Following TRAIL's path in the immune system","volume":"127","author":"Falschlehner","year":"2009","journal-title":"Immunology."},{"key":"10.1016\/j.cyto.2023.156446_b0260","doi-asserted-by":"crossref","first-page":"4521324","DOI":"10.1155\/2017\/4521324","article-title":"TNF-alpha Induced the Enhanced Apoptosis of Mesenchymal Stem Cells in Ankylosing Spondylitis by Overexpressing TRAIL-R2","volume":"2017","author":"Liu","year":"2017","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.cyto.2023.156446_b0265","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/798060","article-title":"Patients with ankylosing spondylitis and low disease activity because of anti-TNF-alpha therapy have higher TRAIL levels than controls: a potential compensatory effect","volume":"2014","author":"Genre","year":"2014","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0270","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0002-9610(83)90427-0","article-title":"Continuous direct tissue oxygen tension measurement by a new method using an implantable silastic tonometer and oxygen polarography","volume":"146","author":"Gottrup","year":"1983","journal-title":"Am J Surg."},{"issue":"2","key":"10.1016\/j.cyto.2023.156446_b0275","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1302\/2046-3758.122.BJR-2022-0195.R1","article-title":"Cytokines and regulatory T cells in ankylosing spondylitis","volume":"12","author":"Liao","year":"2023","journal-title":"Bone Joint Res."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0280","doi-asserted-by":"crossref","first-page":"e0117320","DOI":"10.1128\/mSystems.01173-20","article-title":"The Salivary Microbiota, Cytokines, and Metabolome in Patients with Ankylosing Spondylitis Are Altered and More Proinflammatory than Those in Healthy Controls","volume":"6","author":"Lv","year":"2021","journal-title":"mSystems."},{"issue":"4","key":"10.1016\/j.cyto.2023.156446_b0285","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrrheum.2017.22","article-title":"Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases","volume":"13","author":"Croft","year":"2017","journal-title":"Nat Rev Rheumatol."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0290","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s002960050111","article-title":"Serum levels of IL-10, IL-6, IL-1ra, and sIL-2R in patients with psoriatic arthritis","volume":"19","author":"Elkayam","year":"2000","journal-title":"Rheumatol Int."},{"key":"10.1016\/j.cyto.2023.156446_b0295","doi-asserted-by":"crossref","first-page":"1133435","DOI":"10.3389\/fimmu.2023.1133435","article-title":"Characterization of the inflammatory proteome of synovial fluid from patients with psoriatic arthritis: Potential treatment targets","volume":"14","author":"Barbarroja","year":"2023","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2023.156446_b0300","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/ard.61.2.174","article-title":"Interleukin 13 in synovial fluid and serum of patients with psoriatic arthritis","volume":"61","author":"Spadaro","year":"2002","journal-title":"Ann Rheum Dis."},{"issue":"2","key":"10.1016\/j.cyto.2023.156446_b0305","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/cei.12449","article-title":"Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different contribution to systemic and joint inflammation","volume":"179","author":"Scrivo","year":"2015","journal-title":"Clin Exp Immunol."},{"issue":"3","key":"10.1016\/j.cyto.2023.156446_b0310","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/rheumatology\/kel306","article-title":"Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system","volume":"46","author":"Szodoray","year":"2007","journal-title":"Rheumatology (oxford)."},{"issue":"23","key":"10.1016\/j.cyto.2023.156446_b0315","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N Engl J Med."},{"issue":"4","key":"10.1016\/j.cyto.2023.156446_b0320","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10456-015-9477-2","article-title":"The pathogenic role of angiogenesis in rheumatoid arthritis","volume":"18","author":"Elshabrawy","year":"2015","journal-title":"Angiogenesis."},{"issue":"11","key":"10.1016\/j.cyto.2023.156446_b0325","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/ncprheum0647","article-title":"Mechanisms of Disease: angiogenesis in inflammatory diseases","volume":"3","author":"Szekanecz","year":"2007","journal-title":"Nat Clin Pract Rheumatol."},{"issue":"4","key":"10.1016\/j.cyto.2023.156446_b0330","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/cvr\/cvab096","article-title":"Clinical efficacy and safety of angiogenesis inhibitors: sex differences and current challenges","volume":"118","author":"Cignarella","year":"2022","journal-title":"Cardiovasc Res."},{"issue":"5","key":"10.1016\/j.cyto.2023.156446_b0335","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s004280050472","article-title":"Mig, GRO alpha and RANTES messenger RNA expression in lining layer, infiltrates and different leucocyte populations of synovial tissue from patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis","volume":"436","author":"Konig","year":"2000","journal-title":"Virchows Arch."},{"issue":"6","key":"10.1016\/j.cyto.2023.156446_b0340","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1136\/ard.2007.073825","article-title":"Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors","volume":"67","author":"Jorgensen","year":"2008","journal-title":"Ann Rheum Dis."},{"key":"10.1016\/j.cyto.2023.156446_b0345","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.802464","article-title":"Genetically Determined Circulating Levels of Cytokines and the Risk of Rheumatoid Arthritis","volume":"13","author":"Qian","year":"2022","journal-title":"Front Genet."},{"issue":"8","key":"10.1016\/j.cyto.2023.156446_b0350","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12082781","article-title":"Rheumatoid Arthritis from Easy to Complex Disease: From the \u201c2022 GISEA International Symposium\u201d","volume":"12","author":"Perniola","year":"2023","journal-title":"J Clin Med."},{"issue":"1","key":"10.1016\/j.cyto.2023.156446_b0355","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/ar4439","article-title":"ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial","volume":"16","author":"Seegobin","year":"2014","journal-title":"Arthritis Res Ther."},{"issue":"2","key":"10.1016\/j.cyto.2023.156446_b0360","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/annrheumdis-2015-208873","article-title":"Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naive patients classified according to the 2010 ACR\/EULAR criteria","volume":"76","author":"Nordberg","year":"2017","journal-title":"Ann Rheum Dis."},{"issue":"2","key":"10.1016\/j.cyto.2023.156446_b0365","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/art.27186","article-title":"Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis","volume":"62","author":"Kokkonen","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cyto.2023.156446_b0370","doi-asserted-by":"crossref","first-page":"26021","DOI":"10.1038\/srep26021","article-title":"Analysis of serum immune markers in seropositive and seronegative rheumatoid arthritis and in high-risk seropositive arthralgia patients","volume":"6","author":"Chalan","year":"2016","journal-title":"Sci Rep."},{"issue":"5","key":"10.1016\/j.cyto.2023.156446_b0375","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/1759720X10378372","article-title":"The role of interleukin 6 in the pathophysiology of rheumatoid arthritis","volume":"2","author":"Srirangan","year":"2010","journal-title":"Ther Adv Musculoskelet Dis."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466623003241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466623003241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T10:10:45Z","timestamp":1736417445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466623003241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":75,"alternative-id":["S1043466623003241"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2023.156446","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the causal relationship between inflammatory cytokines and inflammatory arthritis: A Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2023.156446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"156446"}}