{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:26:49Z","timestamp":1786987609994,"version":"build-2736575974"},"reference-count":165,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.cyto.2024.156560","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:54:40Z","timestamp":1709600080000},"page":"156560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Cytokine storm in human monkeypox: A possible involvement of purinergic signaling"],"prefix":"10.1016","volume":"177","author":[{"given":"Gilnei Bruno","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u00f3rgia","family":"de Carvalho Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Le\u00e3o Batista","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniela Pinto","family":"Kempka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete Dulce","family":"Bagatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2024.156560_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109108","article-title":"The resurgence of a neglected orthopoxvirus: immunologic and clinical aspects of monkeypox virus infections over the past six decades","volume":"243","author":"Al-Musa","year":"2022","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0010","doi-asserted-by":"crossref","first-page":"e0010141","DOI":"10.1371\/journal.pntd.0010141","article-title":"The changing epidemiology of human monkeypox\u2014A potential threat? A systematic review","volume":"16","author":"Bunge","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.cyto.2024.156560_b0015","doi-asserted-by":"crossref","first-page":"16262","DOI":"10.1073\/pnas.1005769107","article-title":"Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo","volume":"107","author":"Rimoin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cyto.2024.156560_b0020","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/biomedicines9070765","article-title":"Battle royale: innate recognition of poxviruses and viral immune evasion","volume":"9","author":"Yu","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.cyto.2024.156560_b0025","doi-asserted-by":"crossref","first-page":"e15615","DOI":"10.1371\/journal.pone.0015615","article-title":"Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus","volume":"6","author":"Rubins","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cyto.2024.156560_b0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.virol.2011.07.013","article-title":"Cowpox virus infection of cynomolgus macaques as a model of hemorrhagic smallpox","volume":"418","author":"Johnson","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.cyto.2024.156560_b0035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jcv.2014.12.001","article-title":"Cytokine modulation correlates with severity of monkeypox disease in humans","volume":"63","author":"Johnston","year":"2015","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0040","doi-asserted-by":"crossref","first-page":"14567","DOI":"10.1073\/pnas.0800589105","article-title":"Monkeypox virus evades antiviral CD4\u00a0+\u00a0and CD8\u00a0+\u00a0T cell responses by suppressing cognate T cell activation","volume":"105","author":"Hammarlund","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cyto.2024.156560_b0045","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/art.40071","article-title":"Review: cytokine storm syndrome: looking toward the precision medicine era","volume":"69","author":"Behrens","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cyto.2024.156560_b0050","doi-asserted-by":"crossref","first-page":"316","DOI":"10.7150\/thno.49713","article-title":"Immunopathogenesis and treatment of cytokine storm in COVID-19","volume":"11","author":"Kim","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.cyto.2024.156560_b0055","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jmv.26232","article-title":"The cytokine storm and COVID-19","volume":"93","author":"Hu","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0060","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2024.156560_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108150","article-title":"Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue","volume":"100","author":"Le\u00e3o Batista Sim\u00f5es","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2024.156560_b0070","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s11010-021-04130-4","article-title":"Possible role of purinergic signaling in COVID-19","volume":"476","author":"Franciosi","year":"2021","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.cyto.2024.156560_b0075","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/08923973.2021.1988102","article-title":"Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19","volume":"43","author":"Zarei","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.cyto.2024.156560_b0080","first-page":"C832","article-title":"Purinergic signaling, DAMPs, and inflammation","volume":"318","author":"Di Virgilio","year":"2020","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.cyto.2024.156560_b0085","doi-asserted-by":"crossref","unstructured":"G. Burnstock, A. Verkhratsky, Purinergic Signalling and the Nervous System. Springer Berlin Heidelberg, Berlin, Heidelberg (2012). https:\/\/doi.org\/10.1007\/978-3-642-28863-0.","DOI":"10.1007\/978-3-642-28863-0"},{"key":"10.1016\/j.cyto.2024.156560_b0090","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11302-014-9427-2","article-title":"Purinergic signalling and immune cells","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic Signall."},{"key":"10.1016\/j.cyto.2024.156560_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11302-017-9593-0","article-title":"The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression","volume":"14","author":"Burnstock","year":"2018","journal-title":"Purinergic Signall."},{"key":"10.1016\/j.cyto.2024.156560_b0100","series-title":"Smallpox and Its Eradication","author":"Fenner","year":"1988"},{"key":"10.1016\/j.cyto.2024.156560_b0105","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3390\/v10050252","article-title":"Genome sequences of Akhmeta virus, an early divergent old world orthopoxvirus","volume":"10","author":"Gao","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0110","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1699-0463.1959.tb00328.x","article-title":"A pox-like disease in cynomolgus monkeys","volume":"46","author":"Magnus","year":"2009","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.cyto.2024.156560_b0115","doi-asserted-by":"crossref","first-page":"taz002","DOI":"10.1093\/jtm\/taz002","article-title":"Monkeypox transmission among international travellers\u2014serious monkey business?","volume":"26","author":"Angelo","year":"2019","journal-title":"J. Travel Med."},{"key":"10.1016\/j.cyto.2024.156560_b0120","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/v12111257","article-title":"Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution","volume":"12","author":"Alakunle","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/br.37.1.1-18.1973","article-title":"Monkeypox virus","volume":"37","author":"Cho","year":"1973","journal-title":"Bacteriol. Rev."},{"key":"10.1016\/j.cyto.2024.156560_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102855","article-title":"The 2022 outbreak and the pathobiology of the monkeypox virus","volume":"131","author":"Kumar","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.cyto.2024.156560_b0135","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/v4050688","article-title":"Poxvirus cell entry: how many proteins does it take?","volume":"4","author":"Moss","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/smim.2000.0296","article-title":"Immunology 101 at poxvirus U: immune evasion genes","volume":"13","author":"Moss","year":"2001","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0145","doi-asserted-by":"crossref","DOI":"10.3201\/eid2002.130118","article-title":"Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo","volume":"20","author":"Kugelman","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.cyto.2024.156560_b0150","doi-asserted-by":"crossref","first-page":"1132250","DOI":"10.3389\/fimmu.2023.1132250","article-title":"Insights into monkeypox pathophysiology, global prevalence, clinical manifestation and treatments","volume":"14","author":"Niu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109364","article-title":"Poxviruses and the immune system: implications for monkeypox virus","volume":"113","author":"Saghazadeh","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cyto.2024.156560_b0160","doi-asserted-by":"crossref","first-page":"a010199","DOI":"10.1101\/cshperspect.a010199","article-title":"Poxvirus DNA replication","volume":"5","author":"Moss","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cyto.2024.156560_b0165","doi-asserted-by":"crossref","first-page":"9899","DOI":"10.1128\/JVI.05446-11","article-title":"Expression profiling of the intermediate and late stages of poxvirus replication","volume":"85","author":"Yang","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcdb.2016.07.015","article-title":"Membrane fusion during poxvirus entry","volume":"60","author":"Moss","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cyto.2024.156560_b0175","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.coviro.2011.11.007","article-title":"Poxvirus host cell entry","volume":"2","author":"Schmidt","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0180","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1073\/pnas.0601025103","article-title":"Ligand-induced and nonfusogenic dissolution of a viral membrane","volume":"103","author":"Law","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cyto.2024.156560_b0185","first-page":"707","article-title":"Conserved oligomeric Golgi (COG) complex proteins facilitate orthopoxvirus entry","volume":"12","author":"Realegeno","year":"2020","journal-title":"Fusion and Spread. Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0190","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00011-17","article-title":"Monkeypox virus host factor screen using haploid cells identifies essential role of GARP complex in extracellular virus formation","volume":"91","author":"Realegeno","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0195","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41577-022-00775-4","article-title":"Monkeypox: disease epidemiology, host immunity and clinical interventions","volume":"22","author":"Lum","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0200","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1128\/JVI.00304-15","article-title":"Evasion of the innate immune type I interferon system by monkeypox virus","volume":"89","author":"Arndt","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0205","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.3390\/v14102155","article-title":"Monkeypox: a comprehensive review","volume":"14","author":"Harapan","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/524743","article-title":"Orthopoxvirus genes that mediate disease virulence and host tropism","volume":"2012","author":"Shchelkunov","year":"2012","journal-title":"Adv. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0215","first-page":"599","article-title":"Isolation and properties of the causal agent of a new variola-like disease (monkeypox) in man","volume":"46","author":"Marennikova","year":"1972","journal-title":"Bull. World Health Org."},{"key":"10.1016\/j.cyto.2024.156560_b0220","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0035-9203(75)90122-4","article-title":"Relevance of some poxvirus infections in monkeys to smallpox eradication","volume":"69","author":"Gispen","year":"1975","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.cyto.2024.156560_b0225","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/ije\/17.3.643","article-title":"The transmission potential of monkeypox virus in human populations","volume":"17","author":"Fine","year":"1988","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.cyto.2024.156560_b0230","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1056\/NEJMoa032299","article-title":"The detection of monkeypox in humans in the Western hemisphere","volume":"350","author":"Reed","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2024.156560_b0235","unstructured":"UK Health Security Agency (UKHSA), Monkeypox Cases Confirmed in England \u2013Latest Updates, UKHSA, London, 2022. Available at: https:\/\/www.gov.uk\/government\/news\/monkeypox-cases-confirmed-in-england-latest-update."},{"key":"10.1016\/j.cyto.2024.156560_b0240","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jinf.2022.07.005","article-title":"Monkeypox outbreak in Madrid (Spain): clinical and virological aspects","volume":"85","author":"Orviz","year":"2022","journal-title":"J. Infect."},{"key":"10.1016\/j.cyto.2024.156560_b0245","unstructured":"Multi-country Monkeypox outbreak: Situation Update. World Health Organization, 2022. Available at: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON396."},{"key":"10.1016\/j.cyto.2024.156560_b0250","unstructured":"World Health Organization (WHO). WHO Director-General declares the ongoing monkeypox outbreak a public health emergency of international concern (2022). Accessed in December 2023. Available at: https:\/\/www.who.int\/ europe\/news\/item\/23-07-2022-who-director-general-declares-the-ongoingmonkeypox-outbreak-a-public-health-event-of-international-concern."},{"key":"10.1016\/j.cyto.2024.156560_b0255","unstructured":"Centers for Disease Control and Prevention (CDC), Monkeypox. Accessed in December 2023. Available at: https:\/\/www.cdc.gov\/poxvirus\/mpox\/index.html#:\u223c:text=CDC%20recommends%20people%20with%20the,with%20them%2C%20regardless%20of%20gender."},{"key":"10.1016\/j.cyto.2024.156560_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.lana.2023.100639","article-title":"Wastewater analysis of Mpox virus in a city with low prevalence of Mpox disease: an environmental surveillance study","volume":"28","author":"Oghuan","year":"2023","journal-title":"Lancet Regional Health \u2013 Americas"},{"key":"10.1016\/j.cyto.2024.156560_b0265","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3390\/medicina59061096","article-title":"Monkeypox outbreak in Peru","volume":"59","author":"Ram\u00edrez-Soto","year":"2023","journal-title":"Medicina"},{"key":"10.1016\/j.cyto.2024.156560_b0270","unstructured":"World Health Organization (WHO). 2022-23 Mpox (Monkeypox) Outbreak: Global Trends. Accessed in December 2023. Available at: https:\/\/worldhealthorg.shinyapps.io\/mpx_global\/."},{"key":"10.1016\/j.cyto.2024.156560_b0275","doi-asserted-by":"crossref","first-page":"e00092","DOI":"10.1128\/cmr.00092-22","article-title":"Monkeypox virus infections in humans","volume":"35","author":"Elsayed","year":"2022","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.cyto.2024.156560_b0280","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/tropicalmed1010008","article-title":"Human monkeypox: current state of knowledge and implications for the future","volume":"1","author":"Brown","year":"2016","journal-title":"TropicalMed"},{"key":"10.1016\/j.cyto.2024.156560_b0285","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2471\/BLT.19.242347","article-title":"Modelling human-to-human transmission of monkeypox","volume":"98","author":"Grant","year":"2020","journal-title":"Bull. World Health Org."},{"key":"10.1016\/j.cyto.2024.156560_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2022.106762","article-title":"Should not airborne transmission be ignored in the 2022 monkeypox outbreak?","volume":"104","author":"Saied","year":"2022","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.cyto.2024.156560_b0295","unstructured":"Monkeypox: background information. UK Health Security Agency, 2018. Available at: https:\/\/www.gov.uk\/guidance\/monkeypox#transmission."},{"key":"10.1016\/j.cyto.2024.156560_b0300","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMoa2207323","article-title":"Monkeypox virus infection in humans across 16 countries \u2014 April\u2013June 2022","volume":"387","author":"Thornhill","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2024.156560_b0305","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.15585\/mmwr.mm7132e3","article-title":"Epidemiologic and clinical characteristics of monkeypox cases \u2014 United States, may 17\u2013July 22, 2022","volume":"71","author":"Philpott","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.cyto.2024.156560_b0310","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0140-6736(22)01436-2","article-title":"Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study","volume":"400","author":"Tar\u00edn-Vicente","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.cyto.2024.156560_b0315","series-title":"Human Monkeypox, Monographs in Virology","author":"Je\u017eek","year":"1988"},{"key":"10.1016\/j.cyto.2024.156560_b0320","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1473-3099(03)00856-9","article-title":"Human monkeypox: an emerging zoonosis","volume":"4","author":"Di Giulio","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cyto.2024.156560_b0325","doi-asserted-by":"crossref","first-page":"D54","DOI":"10.1016\/j.vaccine.2011.04.014","article-title":"Status of human monkeypox: clinical disease, epidemiology and research","volume":"29","author":"Damon","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.cyto.2024.156560_b0330","first-page":"13","article-title":"Human monkeypox","volume":"27","author":"Jezek","year":"1983","journal-title":"J. Hyg. Epidemiol. Microbiol. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0335","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12941-022-00527-1","article-title":"Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis","volume":"21","author":"Benites-Zapata","year":"2022","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.cyto.2024.156560_b0340","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1086\/498115","article-title":"Clinical characteristics of human monkeypox, and risk factors for severe disease","volume":"41","author":"Huhn","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cyto.2024.156560_b0345","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13568-023-01517-y","article-title":"Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspective","volume":"13","author":"Al-Kuraishy","year":"2023","journal-title":"AMB Expr."},{"key":"10.1016\/j.cyto.2024.156560_b0350","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jcv.2006.03.012","article-title":"Detection of monkeypox virus with real-time PCR assays","volume":"36","author":"Li","year":"2006","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0355","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jviromet.2011.05.002","article-title":"Species-specific identification of variola, monkeypox, cowpox, and vaccinia viruses by multiplex real-time PCR assay","volume":"175","author":"Shchelkunov","year":"2011","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.cyto.2024.156560_b0360","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nm1273","article-title":"Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox","volume":"11","author":"Hammarlund","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2024.156560_b0365","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1080\/22221751.2022.2095309","article-title":"Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters","volume":"11","author":"Xiang","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.cyto.2024.156560_b0370","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1128\/AAC.49.8.3153-3162.2005","article-title":"Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate","volume":"49","author":"Magee","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cyto.2024.156560_b0375","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1128\/JVI.79.20.13139-13149.2005","article-title":"An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus challenge","volume":"79","author":"Yang","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0380","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s40265-022-01742-y","article-title":"Prevention and treatment of monkeypox","volume":"82","author":"Rizk","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.cyto.2024.156560_b0385","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.3390\/v14112496","article-title":"Prevention and treatment of monkeypox: a systematic review of preclinical studies","volume":"14","author":"Sudarmaji","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0390","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMoa1705688","article-title":"Oral tecovirimat for the treatment of smallpox","volume":"379","author":"Grosenbach","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cyto.2024.156560_b0395","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/milmed\/167.7.546","article-title":"The cause of death in smallpox: an examination of the pathology record","volume":"167","author":"Martin","year":"2002","journal-title":"Mil. Med."},{"key":"10.1016\/j.cyto.2024.156560_b0400","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1128\/jvi.70.10.7103-7107.1996","article-title":"Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo","volume":"70","author":"Sharma","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0405","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5500\/wjt.v3.i4.91","article-title":"Role of IL-10 in the progression of kidney disease","volume":"3","author":"Sinuani","year":"2013","journal-title":"WJT"},{"key":"10.1016\/j.cyto.2024.156560_b0410","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of Foxp3+ T regulatory cell-mediated suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2024.156560_b0415","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/intimm\/dxn147","article-title":"GM-CSF-induced CD11c+CD8a\u2013dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis","volume":"21","author":"Ganesh","year":"2009","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0420","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1099\/vir.0.036905-0","article-title":"Intrabronchial inoculation of cynomolgus macaques with cowpox virus","volume":"93","author":"Smith","year":"2012","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0425","doi-asserted-by":"crossref","first-page":"15190","DOI":"10.1073\/pnas.0405759101","article-title":"The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model","volume":"101","author":"Rubins","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cyto.2024.156560_b0430","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1073\/pnas.0405954101","article-title":"Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox","volume":"101","author":"Jahrling","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cyto.2024.156560_b0435","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1161\/01.RES.0000146672.10582.17","article-title":"Chemokines in the pathogenesis of vascular disease","volume":"95","author":"Charo","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.cyto.2024.156560_b0440","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1160\/TH07-08-0483","article-title":"Crosstalk between coagulation and inflammation during dengue virus infection","volume":"99","author":"Huerta-Zepeda","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.cyto.2024.156560_b0445","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cyto.2024.156560_b0450","doi-asserted-by":"crossref","first-page":"S357","DOI":"10.1086\/520611","article-title":"Cytokine and chemokine expression in humans infected with Sudan Ebola virus","volume":"196","author":"Hutchinson","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cyto.2024.156560_b0455","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1371\/journal.pntd.0000837","article-title":"Human fatal Zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis","volume":"4","author":"Wauquier","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.cyto.2024.156560_b0460","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1001\/archinte.1920.00100050087006","article-title":"Report of a case of hemorrhagic smallpox: a consideration of the r\u00f4le played by the hemolytic streptococcus","volume":"26","author":"Kempton","year":"1920","journal-title":"Arch. Intern. Med. (Chic.)"},{"key":"10.1016\/j.cyto.2024.156560_b0465","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1128\/JVI.01931-10","article-title":"Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route","volume":"85","author":"Johnson","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0470","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1099\/vir.0.010207-0","article-title":"Virulence and pathophysiology of the Congo Basin and west african strains of monkeypox virus in non-human primates","volume":"90","author":"Saijo","year":"2009","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0475","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3390\/v10120692","article-title":"A system based-approach to examine cytokine response in poxvirus-infected macrophages","volume":"10","author":"Wong","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0480","doi-asserted-by":"crossref","DOI":"10.2139\/ssrn.4213365","article-title":"Immunological signature in human cases of monkeypox infection in 2022 outbreak","author":"Agrati","year":"2022","journal-title":"SSRN J."},{"key":"10.1016\/j.cyto.2024.156560_b0485","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.1128\/JVI.00162-12","article-title":"Lethal monkeypox virus infection of CAST\/EIJ mice is associated with a deficient gamma interferon response","volume":"86","author":"Earl","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0490","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bcmd.2005.12.025","article-title":"Ecto-nucleotidases of the CD39\/NTPDase family modulate platelet activation and thrombus formation: potential as therapeutic targets","volume":"36","author":"Atkinson","year":"2006","journal-title":"Blood Cell Mol. Dis."},{"key":"10.1016\/j.cyto.2024.156560_b0495","series-title":"International Review of Cytology","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0074-7696(04)40002-3","article-title":"Cellular distribution and functions of P2 receptor subtypes in different systems","author":"Burnstock","year":"2004"},{"key":"10.1016\/j.cyto.2024.156560_b0500","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00109-022-02185-4","article-title":"High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity","volume":"100","author":"Da Silva","year":"2022","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.cyto.2024.156560_b0505","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/jid.2011.344","article-title":"Purinergic signaling in healthy and diseased skin","volume":"132","author":"Burnstock","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cyto.2024.156560_b0510","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbagen.2004.09.006","article-title":"Characterization of NTPDase (NTPDase1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5) activity in human lymphocytes","volume":"1721","author":"Leal","year":"2005","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Gen. Subj."},{"key":"10.1016\/j.cyto.2024.156560_b0515","doi-asserted-by":"crossref","DOI":"10.1177\/2398212818817494","article-title":"Purine and purinergic receptors","volume":"2","author":"Burnstock","year":"2018","journal-title":"Brain Neurosci. Adv."},{"key":"10.1016\/j.cyto.2024.156560_b0520","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1158\/0008-5472.CAN-12-1600","article-title":"Purines, purinergic receptors, and cancer","volume":"72","author":"Di Virgilio","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.cyto.2024.156560_b0525","first-page":"1","article-title":"The impact of purinergic system enzymes on noncommunicable, neurological, and degenerative diseases","volume":"2018","author":"Bagatini","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.cyto.2024.156560_b0530","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbamcr.2008.01.024","article-title":"Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade","volume":"1783","author":"Yegutkin","year":"2008","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Mol. Cell Res."},{"key":"10.1016\/j.cyto.2024.156560_b0535","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.coi.2018.03.026","article-title":"Modulation of innate and adaptive immunity by P2X ion channels","volume":"52","author":"Di Virgilio","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0540","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","article-title":"The P2X7 receptor in infection and inflammation","volume":"47","author":"Di Virgilio","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.cyto.2024.156560_b0545","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.autneu.2015.04.011","article-title":"Purinergic signaling in the immune system","volume":"191","author":"Di Virgilio","year":"2015","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.cyto.2024.156560_b0550","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1748-1716.2009.01957.x","article-title":"Evolutionary origins of the purinergic signalling system","volume":"195","author":"Burnstock","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1016\/j.cyto.2024.156560_b0555","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1023\/A:1012388618693","article-title":"Purinergic signalling: ATP release","volume":"26","author":"Bodin","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cyto.2024.156560_b0560","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1093\/emboj\/20.22.6347","article-title":"Proteomic and functional evidence for a P2X7 receptor signalling complex","volume":"20","author":"Kim","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.cyto.2024.156560_b0565","series-title":"Advances in Immunology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(04)86001-2","article-title":"Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation","author":"Blackburn","year":"2005"},{"key":"10.1016\/j.cyto.2024.156560_b0570","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.neuro.24.1.31","article-title":"The role and regulation of adenosine in the central nervous system","volume":"24","author":"Dunwiddie","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.cyto.2024.156560_b0575","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5501\/wjv.v4.i3.285","article-title":"Purinergic signaling and human immunodeficiency virus\/acquired immune deficiency syndrome: from viral entry to therapy","volume":"4","author":"Passos","year":"2015","journal-title":"WJV"},{"key":"10.1016\/j.cyto.2024.156560_b0580","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3390\/v12030290","article-title":"Purinergic receptors: elucidating the role of these immune mediators in HIV-1 fusion","volume":"12","author":"Freeman","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.cyto.2024.156560_b0585","doi-asserted-by":"crossref","first-page":"11504","DOI":"10.1128\/JVI.01158-14","article-title":"P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection","volume":"88","author":"Swartz","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0590","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12974-019-1466-8","article-title":"HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K\/Akt and ERK MAPK pathways","volume":"16","author":"Zhou","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cyto.2024.156560_b0595","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3389\/fimmu.2020.01446","article-title":"The COVID-19 cytokine storm; what we know so far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0600","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/s41380-020-00965-3","article-title":"Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology","volume":"26","author":"Ribeiro","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cyto.2024.156560_b0605","doi-asserted-by":"crossref","first-page":"e1002115","DOI":"10.1371\/journal.ppat.1002115","article-title":"Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting","volume":"7","author":"Hagbom","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cyto.2024.156560_b0610","doi-asserted-by":"crossref","first-page":"eabc3621","DOI":"10.1126\/science.abc3621","article-title":"Rotavirus induces intercellular calcium waves through ADP signaling","volume":"370","author":"Chang-Graham","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cyto.2024.156560_b0615","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00229-17","article-title":"Contribution of the purinergic receptor P2X7 to development of lung immunopathology during influenza virus infection","volume":"8","author":"Leyva-Grado","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.cyto.2024.156560_b0620","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1111\/bph.14787","article-title":"Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection","volume":"176","author":"Rosli","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cyto.2024.156560_b0625","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1128\/JVI.01068-14","article-title":"Activation of a 1 -adenosine receptors promotes leukocyte recruitment to the lung and attenuates acute lung injury in mice infected with influenza A\/WSN\/33 (H1N1) virus","volume":"88","author":"Aeffner","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.cyto.2024.156560_b0630","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.4049\/jimmunol.1303343","article-title":"Type I IFNs and IL-18 regulate the antiviral response of primary human \u03b3\u03b4 T cells against dendritic cells infected with dengue virus","volume":"194","author":"Tsai","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0635","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.imbio.2016.02.003","article-title":"The purinergic receptor P2X7 role in control of dengue virus-2 infection and cytokine\/chemokine production in infected human monocytes","volume":"221","author":"Corr\u00eaa","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.cyto.2024.156560_b0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104424","article-title":"The land-scape of immune response to monkeypox virus","volume":"87","author":"Li","year":"2023","journal-title":"eBioMedicine"},{"key":"10.1016\/j.cyto.2024.156560_b0645","doi-asserted-by":"crossref","first-page":"a006049","DOI":"10.1101\/cshperspect.a006049","article-title":"Signaling in innate immunity and inflammation","volume":"4","author":"Newton","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cyto.2024.156560_b0650","first-page":"1443","article-title":"P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation","volume":"S3","author":"Bours","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.cyto.2024.156560_b0655","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11302-021-09798-3","article-title":"Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile","volume":"17","author":"Merz","year":"2021","journal-title":"Purinergic Signall."},{"key":"10.1016\/j.cyto.2024.156560_b0660","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1038\/s41467-021-26134-w","article-title":"CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression","volume":"12","author":"Schneider","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cyto.2024.156560_b0665","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.591803","article-title":"Interplay between NLRP3 inflammasome and autophagy","volume":"11","author":"Biasizzo","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0670","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41419-022-04786-w","article-title":"Targeted P2X7\/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy","volume":"13","author":"Kong","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cyto.2024.156560_b0675","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11302-011-9271-6","article-title":"In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization","volume":"8","author":"Ford","year":"2012","journal-title":"Purinergic Signall."},{"key":"10.1016\/j.cyto.2024.156560_b0680","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.22-18-08139.2002","article-title":"Functional downregulation of P2X 3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain","volume":"22","author":"Barclay","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cyto.2024.156560_b0685","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11302-020-09718-x","article-title":"P2X3 receptors contribute to transition from acute to chronic muscle pain","volume":"16","author":"Jorge","year":"2020","journal-title":"Purinergic Signall."},{"key":"10.1016\/j.cyto.2024.156560_b0690","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.645834","article-title":"Structural and functional features of the P2X4 receptor: an immunological perspective","volume":"12","author":"Kanellopoulos","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0695","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coph.2019.02.011","article-title":"P2X4 receptors, immunity, and sepsis","volume":"47","author":"Antonioli","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.cyto.2024.156560_b0700","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1016\/j.febslet.2015.07.027","article-title":"CD73 and CD39 ectonucleotidases in T cell differentiation: beyond immunosuppression","volume":"589","author":"Bono","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cyto.2024.156560_b0705","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3389\/fimmu.2017.00727","article-title":"What else can CD39 tell us?","volume":"8","author":"Zhao","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0710","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1161\/ATVBAHA.115.306528","article-title":"Platelet P2Y 12 inhibitors reduce systemic inflammation and its prothrombotic effects in an experimental human model","volume":"35","author":"Thomas","year":"2015","journal-title":"ATVB"},{"key":"10.1016\/j.cyto.2024.156560_b0715","doi-asserted-by":"crossref","first-page":"17459","DOI":"10.1038\/s41598-021-95710-3","article-title":"P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells","volume":"11","author":"Siegel","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2024.156560_b0720","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/jth.12952","article-title":"P2Y12 receptors: structure and function","volume":"13","author":"Cattaneo","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.cyto.2024.156560_b0725","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jvs.2014.06.112","article-title":"P2Y 2 nucleotide receptor mediates arteriogenesis in a murine model of hind limb ischemia","volume":"63","author":"McEnaney","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.cyto.2024.156560_b0730","doi-asserted-by":"crossref","first-page":"11009","DOI":"10.3390\/ijerph182111009","article-title":"Role of the purinergic P2Y2 receptor in pulmonary hypertension","volume":"18","author":"Shihan","year":"2021","journal-title":"IJERPH"},{"key":"10.1016\/j.cyto.2024.156560_b0735","doi-asserted-by":"crossref","first-page":"27027","DOI":"10.1074\/jbc.M111.235176","article-title":"The P2Y2 nucleotide receptor mediates tissue factor expression in human coronary artery endothelial cells","volume":"286","author":"Ding","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cyto.2024.156560_b0740","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12185-020-03029-y","article-title":"COVID-19-associated coagulopathy and disseminated intravascular coagulation","volume":"113","author":"Asakura","year":"2021","journal-title":"Int J Hematol"},{"key":"10.1016\/j.cyto.2024.156560_b0745","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.3390\/ijms22147685","article-title":"Adenosine and inflammation: here, there and everywhere","volume":"22","author":"Pasquini","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.cyto.2024.156560_b0750","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11302-021-09814-6","article-title":"A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling","volume":"18","author":"Hasan","year":"2022","journal-title":"Purinergic Signall."},{"key":"10.1016\/j.cyto.2024.156560_b0755","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pharmthera.2006.08.003","article-title":"Shaping of monocyte and macrophage function by adenosine receptors","volume":"113","author":"Hask\u00f3","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cyto.2024.156560_b0760","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11596-022-2658-5","article-title":"Gefapixant, a novel P2X3 antagonist, protects against post myocardial infarction cardiac dysfunction and remodeling via suppressing NLRP3 inflammasome","volume":"43","author":"Wei","year":"2023","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.cyto.2024.156560_b0765","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12960","article-title":"The potential involvement of P2X7 receptor in COVID-19 pathogenesis: a new therapeutic target?","volume":"93","author":"Pacheco","year":"2021","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0770","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1111\/bph.15138","article-title":"A rationale for targeting the P2X7 receptor in coronavirus disease 19","volume":"177","author":"Di Virgilio","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cyto.2024.156560_b0775","doi-asserted-by":"crossref","first-page":"10649","DOI":"10.3390\/ijms221910649","article-title":"Novel P2X7 antagonist ameliorates the early phase of ALS disease and decreases inflammation and autophagy in SOD1-G93A mouse model","volume":"22","author":"Apolloni","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.cyto.2024.156560_b0780","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174545","article-title":"Clopidogrel treatment inhibits P2Y2-mediated constriction in the rabbit middle cerebral artery","volume":"911","author":"Kuszynski","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cyto.2024.156560_b0785","series-title":"Purinergic Signaling, Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-4939-9717-6_3","article-title":"Agonists and antagonists for purinergic receptors","author":"M\u00fcller","year":"2020"},{"key":"10.1016\/j.cyto.2024.156560_b0790","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/jama.2021.23605","article-title":"Effect of P2Y12 inhibitors on survival free of organ support among non-critically ill hospitalized patients with COVID-19: a randomized clinical trial","volume":"327","author":"Berger","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.cyto.2024.156560_b0795","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-10-21","article-title":"Inhibition of G protein-coupled P2Y 2 receptor induced analgesia in a rat model of trigeminal neuropathic pain","volume":"10","author":"Li","year":"2014","journal-title":"Mol. Pain"},{"key":"10.1016\/j.cyto.2024.156560_b0800","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/BST20200677","article-title":"Galectin-8, cytokines, and the storm","volume":"50","author":"Zick","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.cyto.2024.156560_b0805","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11302-015-9482-3","article-title":"Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury","volume":"12","author":"Winerdal","year":"2016","journal-title":"Purinergic Signall."},{"key":"10.1016\/j.cyto.2024.156560_b0810","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028548","article-title":"Targeting IL-10 family cytokines for the treatment of human diseases","volume":"11","author":"Wang","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cyto.2024.156560_b0815","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/cells9071739","article-title":"Adenosine receptors as neuroinflammation modulators: role of A1 agonists and A2A antagonists","volume":"9","author":"Mart\u00ed Navia","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.cyto.2024.156560_b0820","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4049\/jimmunol.164.1.436","article-title":"Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes","volume":"164","author":"Link","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.cyto.2024.156560_b0825","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1124\/jpet.105.096016","article-title":"Adenosine inhibits tumor necrosis factor-\u03b1 release from mouse peritoneal macrophages via a2A and a2B but not the a3 adenosine receptor","volume":"317","author":"Kreckler","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624000632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624000632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:50:16Z","timestamp":1760910616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466624000632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":165,"alternative-id":["S1043466624000632"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156560","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine storm in human monkeypox: A possible involvement of purinergic signaling","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"156560"}}