{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T06:05:35Z","timestamp":1794204335805,"version":"4.8.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.cyto.2024.156568","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T16:53:39Z","timestamp":1710176019000},"page":"156568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Pepsin-mediated inflammation in laryngopharyngeal reflux via the ROS\/NLRP3\/IL-1\u03b2 signaling pathway"],"prefix":"10.1016","volume":"178","author":[{"given":"Jia-Jie","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Feng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Hong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2024.156568_b0005","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/MOO.0000000000000486","article-title":"Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018","volume":"26","author":"Lechien","year":"2018","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.cyto.2024.156568_b0010","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1007\/s00405-020-06045-0","article-title":"An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China","volume":"277","author":"Xiao","year":"2020","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.cyto.2024.156568_b0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1067\/mhn.2000.109935","article-title":"Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders","volume":"123","author":"Koufman","year":"2000","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.cyto.2024.156568_b0020","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jvoice.2019.05.005","article-title":"Proton pump inhibitors for the treatment of laryngopharyngeal reflux. A Systematic Review","volume":"34","author":"Spantideas","year":"2020","journal-title":"J. Voice."},{"issue":"6","key":"10.1016\/j.cyto.2024.156568_b0025","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ajg.2013.69","article-title":"High economic burden of caring for patients with suspected extraesophageal reflux","volume":"108","author":"Francis","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.cyto.2024.156568_b0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/lary.20665","article-title":"Laryngeal mucosa: its susceptibility to damage by acid and pepsin","volume":"120","author":"Bulmer","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cyto.2024.156568_b0035","doi-asserted-by":"crossref","first-page":"13778","DOI":"10.1038\/s41598-019-50360-4","article-title":"Pepsin triggers neutrophil migration across acid damaged lung epithelium","volume":"9","author":"Hurley","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cyto.2024.156568_b0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.otohns.2009.08.022","article-title":"Pepsin as a causal agent of inflammation during nonacidic reflux","volume":"141","author":"Samuels","year":"2009","journal-title":"Otolaryngol. Otolaryngol.\u2013head Neck Surg."},{"key":"10.1016\/j.cyto.2024.156568_b0045","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MOO.0000000000000664","article-title":"Pepsin in gastroesophageal and extraesophageal reflux: molecular pathophysiology and diagnostic utility","volume":"28","author":"Samuels","year":"2020","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.cyto.2024.156568_b0050","doi-asserted-by":"crossref","unstructured":"R.C. Orlando, Pathophysiology of gastroesophageal reflux disease, J. Clin. Gastroenterol. 443 42 (2008) 584\u2013588 [doi:10.1097\/MCG.0b013e31815d0628] [Pubmed: 18364588].","DOI":"10.1097\/MCG.0b013e31815d0628"},{"key":"10.1016\/j.cyto.2024.156568_b0055","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1001\/jama.2016.5657","article-title":"Association of Acute Gastroesophageal Reflux Disease with Esophageal Histologic Changes","volume":"315","author":"Dunbar","year":"2016","journal-title":"JAMA."},{"key":"10.1016\/j.cyto.2024.156568_b0060","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1053\/j.gastro.2009.07.055","article-title":"Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury","volume":"137","author":"Souza","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2024.156568_b0065","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14022","article-title":"Mucosal pathogenesis in gastro-esophageal reflux disease","volume":"32","author":"Ustaoglu","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.cyto.2024.156568_b0070","doi-asserted-by":"crossref","first-page":"E479","DOI":"10.1002\/lary.28482","article-title":"Gastroesophageal reflux in laryngopharyngeal reflux patients: clinical features and therapeutic response","volume":"130","author":"Lechien","year":"2020","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cyto.2024.156568_b0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.coph.2017.10.004","article-title":"A new paradigm for GERD pathogenesis. not acid injury, but cytokine-mediated inflammation driven by HIF-2\u03b1: a potential role for targeting HIF-2\u03b1 to prevent and treat reflux esophagitis","volume":"37","author":"Souza","year":"2017","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.cyto.2024.156568_b0080","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/rccm.200706-895OC","article-title":"The mucosal immune response to laryngopharyngeal reflux","volume":"177","author":"Rees","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cyto.2024.156568_b0085","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41590-021-00869-6","article-title":"Inflammasomes and adaptive immune responses","volume":"22","author":"Deets","year":"2021","journal-title":"Nat. Immunol."},{"issue":"13","key":"10.1016\/j.cyto.2024.156568_b0090","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"6","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2024.156568_b0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13080","article-title":"Airway reflux","volume":"1381","author":"Johnston","year":"2016","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.cyto.2024.156568_b0100","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1167\/iovs.13-12883","article-title":"Involvement of Nox2 NADPH oxidase in retinal neovascularization","volume":"54","author":"Chan","year":"2013","journal-title":"Invest. Ophthalmol. vis. Sci."},{"key":"10.1016\/j.cyto.2024.156568_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2020.102681","article-title":"Association of pepsin and DNA damage in laryngopharyngeal reflux-related vocal fold polyps","volume":"41","author":"Dai","year":"2020","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.cyto.2024.156568_b0110","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720908198","article-title":"Establishment of immortalized laryngeal epithelial cells transfected with Bmi1","volume":"29","author":"Tan","year":"2020","journal-title":"Cell Transplant."},{"key":"10.1016\/j.cyto.2024.156568_b0115","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.7150\/thno.43938","article-title":"An ultralow dose of the NADPH oxidase inhibitor diphenyleneiodonium (DPI) is an economical and effective therapeutic agent for the treatment of colitis-associated colorectal cancer","volume":"10","author":"Kuai","year":"2020","journal-title":"Theranostics."},{"key":"10.1016\/j.cyto.2024.156568_b0120","first-page":"1161","article-title":"Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts","volume":"37","author":"Bhardwaj","year":"2016","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.cyto.2024.156568_b0125","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2024.156568_b0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cyto.2024.156568_b0135","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2024.156568_b0140","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition","volume":"21","author":"Kawai","year":"2009","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cyto.2024.156568_b0145","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cyto.2024.156568_b0150","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cyto.2024.156568_b0155","doi-asserted-by":"crossref","first-page":"2183026","DOI":"10.1155\/2016\/2183026","article-title":"ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia\/Reperfusion Injury","author":"Minutoli","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.cyto.2024.156568_b0160","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1177\/000348940911800913","article-title":"Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cells","volume":"118","author":"Johnston","year":"2009","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.cyto.2024.156568_b0165","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/cells7120274","article-title":"The role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases","volume":"7","author":"Kausar","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.cyto.2024.156568_b0170","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mam.2016.01.002","article-title":"O2 sensing, mitochondria and ROS signaling: the fog is lifting","volume":"47\u201348","author":"Waypa","year":"2016","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.cyto.2024.156568_b0175","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.3390\/molecules18032821","article-title":"Apocynin: chemical and biophysical properties of a NADPH oxidase inhibitor","volume":"18","author":"Petr\u00f4nio","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.cyto.2024.156568_b0180","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cyto.2024.156568_b0185","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fimmu.2013.00514","article-title":"Thioredoxin\/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases","volume":"4","author":"Yoshihara","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cyto.2024.156568_b0190","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/nau.24271","article-title":"Cigarette smoke induces the pyroptosis of urothelial cells through ROS\/NLRP3\/caspase-1 signaling pathway","volume":"39","author":"Wu","year":"2020","journal-title":"Neurourol. Urodyn."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624000711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624000711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:49:36Z","timestamp":1760910576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466624000711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S1043466624000711"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156568","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pepsin-mediated inflammation in laryngopharyngeal reflux via the ROS\/NLRP3\/IL-1\u03b2 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"156568"}}