{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:09:54Z","timestamp":1792537794653,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.cyto.2024.156595","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T17:39:08Z","timestamp":1712338748000},"page":"156595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Low expression of interleukin-1 receptor antagonist correlates with poor prognosis via promoting proliferation and migration and inhibiting apoptosis in oral squamous cell carcinoma"],"prefix":"10.1016","volume":"179","author":[{"given":"Yujie","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1962-1512","authenticated-orcid":false,"given":"Zhida","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cyto.2024.156595_b0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.soc.2019.08.010","article-title":"Oral cancer: genetics and the role of precision medicine","volume":"29","author":"Li","year":"2020","journal-title":"Surg. Oncol. Clin. N Am."},{"issue":"2","key":"10.1016\/j.cyto.2024.156595_b0010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1368-8375(98)00101-8","article-title":"Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan","volume":"35","author":"Chen","year":"1999","journal-title":"Oral Oncol."},{"issue":"3","key":"10.1016\/j.cyto.2024.156595_b0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-A Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.cyto.2024.156595_b0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"Ca-A Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.cyto.2024.156595_b0025","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/elps.1150191103","article-title":"Proteome and proteomics: new technologies, new concepts, and new words","volume":"19","author":"Anderson","year":"1998","journal-title":"Electrophoresis"},{"issue":"10","key":"10.1016\/j.cyto.2024.156595_b0030","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201700448","article-title":"Discovery and validation of clinical biomarkers of cancer: a review combining metabolomics and proteomics","volume":"19","author":"Srivastava","year":"2019","journal-title":"Proteomics"},{"issue":"10","key":"10.1016\/j.cyto.2024.156595_b0035","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1039\/C4CS00370E","article-title":"Cancer biomarker detection: recent achievements and challenges","volume":"44","author":"Wu","year":"2015","journal-title":"Chem. Soc. Rev."},{"issue":"3","key":"10.1016\/j.cyto.2024.156595_b0040","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/bib\/bbx158","article-title":"Computer-aided biomarker discovery for precision medicine: data resources, models and applications","volume":"20","author":"Lin","year":"2019","journal-title":"Brief Bioinform"},{"issue":"1","key":"10.1016\/j.cyto.2024.156595_b0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/imr.12614","article-title":"IL-1 and IL-1 regulatory pathways in cancer progression and therapy","volume":"281","author":"Mantovani","year":"2018","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.cyto.2024.156595_b0050","doi-asserted-by":"crossref","first-page":"396","DOI":"10.4149\/neo_2011_05_396","article-title":"The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro","volume":"58","author":"Huang","year":"2011","journal-title":"Neoplasma"},{"key":"10.1016\/j.cyto.2024.156595_b0055","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1007\/s10875-012-9847-0","article-title":"Cancer-related inflammation","volume":"33","author":"Candido","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.cyto.2024.156595_b0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.immunol.16.1.27","article-title":"Interleukin-1 receptor antagonist: role in biology","volume":"16","author":"Arend","year":"1998","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.cyto.2024.156595_b0065","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","article-title":"The interleukin-1 family: back to the future","volume":"39","author":"Garlanda","year":"2013","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.cyto.2024.156595_b0070","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.3892\/ijo.2015.2917","article-title":"Interleukin-1 receptor antagonist (IL1RN) is associated with suppression of early carcinogenic events in human oral malignancies","volume":"46","author":"Shiiba","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.cyto.2024.156595_b0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0090-8258(02)00154-3","article-title":"Clinical significance of interleukin-1 receptor antagonist in patients with cervical carcinoma","volume":"89","author":"Fujiwaki","year":"2003","journal-title":"Gynecol. Oncol."},{"issue":"4","key":"10.1016\/j.cyto.2024.156595_b0080","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/mc.1031","article-title":"Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesis","volume":"30","author":"La","year":"2001","journal-title":"Mol. Carcinog."},{"issue":"11","key":"10.1016\/j.cyto.2024.156595_b0085","first-page":"3519","article-title":"Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC","volume":"7","author":"Hu","year":"2001","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.cyto.2024.156595_b0090","first-page":"794","article-title":"The production of interleukin-1 receptor antagonist by human bronchogenic carcinoma","volume":"143","author":"Smith","year":"1993","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.cyto.2024.156595_b0095","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/archotol.1996.01890190047012","article-title":"Interleukin-1 receptor antagonist in head and neck squamous cell carcinoma","volume":"122","author":"von Biberstein","year":"1996","journal-title":"Arch. Otolaryngol.\u2013Head Neck Surg."},{"issue":"4","key":"10.1016\/j.cyto.2024.156595_b0100","first-page":"429","article-title":"In-house cDNA microarray analysis of gene expression profiles involved in SCC cell lines","volume":"12","author":"Moriya","year":"2003","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.cyto.2024.156595_b0105","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.252080","article-title":"The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype","volume":"134","author":"Niklander","year":"2021","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.cyto.2024.156595_b0110","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.cyto.2024.156595_b0115","doi-asserted-by":"crossref","unstructured":"S.H. Huang, B. O'Sullivan, Overview of the 8th Edition TNM Classification for Head and Neck Cancer. Curr. Treat. Options Oncol., 2017. 18(7): p. 40.","DOI":"10.1007\/s11864-017-0484-y"},{"issue":"4","key":"10.1016\/j.cyto.2024.156595_b0120","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1158\/1940-6207.CAPR-11-0502","article-title":"Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions","volume":"5","author":"Vitale-Cross","year":"2012","journal-title":"Cancer Prev. Res. (phila)"},{"key":"10.1016\/j.cyto.2024.156595_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2021.722676","article-title":"IL-1\/IL-1R signaling in head and neck cancer","volume":"2","author":"Niklander","year":"2021","journal-title":"Front. Oral Health"},{"issue":"5","key":"10.1016\/j.cyto.2024.156595_b0130","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.cyto.2024.156595_b0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/odi.12971","article-title":"Discovery and preclinical validation of proteomic biomarkers in saliva for early detection of oral squamous cell carcinomas","volume":"25","author":"Shan","year":"2019","journal-title":"Oral. Dis."},{"issue":"8","key":"10.1016\/j.cyto.2024.156595_b0140","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/odi.13704","article-title":"Oral potentially malignant disorders: a consensus report from an international seminar on nomenclature and classification, convened by the WHO collaborating Centre for Oral Cancer","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"issue":"1","key":"10.1016\/j.cyto.2024.156595_b0145","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jobcr.2020.11.009","article-title":"Quality of life among oral potentially malignant disorder (OPMD) patients: a prospective study","volume":"11","author":"Kumar","year":"2021","journal-title":"J. Oral. Biol. Craniofac. Res."},{"issue":"5","key":"10.1016\/j.cyto.2024.156595_b0150","first-page":"584","article-title":"Cytokine status and neutrophil phenotype in the progression of cervical cancer","volume":"60","author":"Gening","year":"2014","journal-title":"Vopr. Onkol."},{"key":"10.1016\/j.cyto.2024.156595_b0155","doi-asserted-by":"crossref","unstructured":"A. Bugshan, I. Farooq, Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis. F1000Res, 2020. 9: p. 229.","DOI":"10.12688\/f1000research.22941.1"},{"issue":"6","key":"10.1016\/j.cyto.2024.156595_b0160","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5125\/jkaoms.2018.44.6.282","article-title":"Clinical analysis of neck node metastasis in oral cavity cancer","volume":"44","author":"Sharma","year":"2018","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"issue":"11","key":"10.1016\/j.cyto.2024.156595_b0165","doi-asserted-by":"crossref","first-page":"e0259529","DOI":"10.1371\/journal.pone.0259529","article-title":"Quantitative nuclear phenotype signatures predict nodal disease in oral squamous cell carcinoma","volume":"16","author":"Liu","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cyto.2024.156595_b0170","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.7150\/thno.51777","article-title":"Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.cyto.2024.156595_b0175","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-65768-0_1","article-title":"Glucose metabolism in cancer: the Warburg effect and beyond","volume":"1311","author":"Bose","year":"2021","journal-title":"Adv. Experiment. Med. Biol."},{"issue":"4","key":"10.1016\/j.cyto.2024.156595_b0180","doi-asserted-by":"crossref","first-page":"e14960","DOI":"10.1016\/j.heliyon.2023.e14960","article-title":"Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas","volume":"9","author":"Ding","year":"2023","journal-title":"Heliyon"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346662400098X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346662400098X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T17:59:32Z","timestamp":1718733572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104346662400098X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":36,"alternative-id":["S104346662400098X"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156595","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3742357\/v1","asserted-by":"object"}]},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low expression of interleukin-1 receptor antagonist correlates with poor prognosis via promoting proliferation and migration and inhibiting apoptosis in oral squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156595","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"156595"}}