{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:08:03Z","timestamp":1725062883948},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.cyto.2024.156722","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:21:50Z","timestamp":1723101710000},"page":"156722","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intragastric administration of transamidated gliadin interferes with the systemic and intestinal immune responses to wheat gliadin in DQ8 transgenic mice"],"prefix":"10.1016","volume":"182","author":[{"given":"Lucia","family":"Treppiccione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Maurano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diomira","family":"Luongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cyto.2024.156722_b0005","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1136\/gutjnl-2021-326257","article-title":"Immunopathogenesis and environmental triggers in coeliac disease","volume":"71","author":"Levescot","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.cyto.2024.156722_b0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathmechdis-031521-032634","article-title":"The Immunobiology and Pathogenesis of Celiac Disease","volume":"18","author":"Iversen","year":"2023","journal-title":"Annu. Rev. Pathol."},{"issue":"1","key":"10.1016\/j.cyto.2024.156722_b0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2249.2010.04317.x","article-title":"Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin","volume":"164","author":"Rauhavirta","year":"2011","journal-title":"A. Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2024.156722_b0020","doi-asserted-by":"crossref","first-page":"e17039","DOI":"10.1371\/journal.pone.0017039","article-title":"Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular trafficking","volume":"6","author":"Vittoria Barone","year":"2011","journal-title":"PLoS. One"},{"issue":"4","key":"10.1016\/j.cyto.2024.156722_b0025","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","volume":"161","author":"van de Wal","year":"1998","journal-title":"J. Immunol"},{"key":"10.1016\/j.cyto.2024.156722_b0030","doi-asserted-by":"crossref","unstructured":"V. Abadie, S. M. Kim, T. Lejeune, B. A. Palanski, J. D. Ernest, O. Tastet, J. Voisine, V. Discepolo, E. V. Marietta, M. B. F. Hawash, C. Ciszewski, R. Bouziat, K. Panigrahi, I. Horwath, M. A. Zurenski, I. Lawrence, A. Dumaine, V. Yotova, J. C. Grenier, J. A. Murray, C. Khosla, L. B. Barreiro, B. Jabri, IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease, Nature. 578 (7796) (2020), 600-604. doi: 10.1038\/s41586-020-2003-8.","DOI":"10.1038\/s41586-020-2003-8"},{"issue":"3","key":"10.1016\/j.cyto.2024.156722_b0035","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1053\/j.gastro.2007.06.023","article-title":"Transamidation of wheat flour inbits the response to gliadin of intestinal T cells in Celiac Disease","volume":"133","author":"Gianfrani","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cyto.2024.156722_b0040","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm0698-713","article-title":"Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease","volume":"4","author":"Molberg","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2024.156722_b0045","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1039\/D2FO02032G","article-title":"Mauro Rossi, Transamidated wheat gliadin induces differential antigen recognition in the small intestine of HLA\/DQ8 transgenic mice","volume":"13","author":"Treppiccione","year":"2022","journal-title":"Food. Funct."},{"key":"10.1016\/j.cyto.2024.156722_b0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1365-3083.1999.00578.x","article-title":"In mice, intravenous or intranasal administration of gliadin is able to down-regulate the specific immune response","volume":"50","author":"Rossi","year":"1999","journal-title":"Scandinavian. J. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2024.156722_b0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0165-2478(03)00069-5","article-title":"Intranasal administration of a recombinant \u03b1-gliadin down-regulates the immune response to wheat gliadin in DQ8 transgenic mice","volume":"88","author":"Senger","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cyto.2024.156722_b0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/jcrs.1995.0058","article-title":"RP\u2013HPLC and Capillary Electrophoresis of Subunits from Glutenin Isolated by SDS and Osborne Fractionation","volume":"22","author":"Weegels","year":"1995","journal-title":"J. Cereal. Sci."},{"issue":"3","key":"10.1016\/j.cyto.2024.156722_b0065","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/foods5030049","article-title":"Effects of two-step transamidation of wheat semolina on the technological properties of gluten","volume":"5","author":"Moscaritolo","year":"2016","journal-title":"Foods."},{"key":"10.1016\/j.cyto.2024.156722_b0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.imlet.2017.05.004","article-title":"Immunomodulatory activity of recombinant \u03b1-gliadin conjugated to cholera toxin in DQ8 transgenic mice","volume":"187","author":"Rossi","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cyto.2024.156722_b0075","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1046\/j.1365-3083.2001.00869.x","article-title":"Intranasal administration of one alpha gliadin can downregulate the immune response to whole gliadin in mice","volume":"53","author":"Maurano","year":"2001","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.cyto.2024.156722_b0080","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/QCO.0000000000000165","article-title":"Breast milk and its impact on maturation of the neonatal immune system","volume":"28","author":"Turfkruyer","year":"2015","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"4","key":"10.1016\/j.cyto.2024.156722_b0085","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s10620-010-1383-2","article-title":"Adult patients with eosinophilic esophagitis do not show an increased frequency of the HLA-DQ2\/DQ8 genotypes predisposing to celiac disease","volume":"56","author":"Lucendo","year":"2011","journal-title":"Dig. Dis. Sci."},{"issue":"34","key":"10.1016\/j.cyto.2024.156722_b0090","doi-asserted-by":"crossref","first-page":"7542","DOI":"10.1021\/acs.jafc.7b02557","article-title":"Abrogation of immunogenic properties of gliadin peptides through transamidation by microbial transglutaminase is acyl-acceptor dependent","volume":"65","author":"Zhou","year":"2017","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.cyto.2024.156722_b0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.imlet.2022.03.007","article-title":"Oral tolerance: an updated review","volume":"245","author":"Rezende","year":"2022","journal-title":"Immunol. Lett."},{"issue":"13","key":"10.1016\/j.cyto.2024.156722_b0100","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.3390\/ijms22137019","article-title":"Transamidation down-regulates intestinal immunity of recombinant \u03b1-gliadin in HLA-DQ8 transgenic mice","volume":"22","author":"Rossi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cyto.2024.156722_b0105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nm1718","article-title":"Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma","volume":"14","author":"Verhasselt","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.cyto.2024.156722_b0110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/mi.2010.23","article-title":"Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development","volume":"3","author":"Mosconi","year":"2010","journal-title":"Mucosal. Immunol."},{"issue":"9","key":"10.1016\/j.cyto.2024.156722_b0115","article-title":"Breastfeeding contributes to physiological immune programming in the newborn","volume":"21","author":"Camacho-Morales","year":"2021","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.cyto.2024.156722_b0120","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1399-3038.2008.00718.x","article-title":"The importance of early complementary feeding in the development of oral tolerance: concerns and controversies","volume":"19","author":"Prescott","year":"2008","journal-title":"Pediatr. Allergy. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2024.156722_b0125","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/mi.2015.114","article-title":"Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency","volume":"9","author":"Turfkruyer","year":"2016","journal-title":"Mucosal. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2024.156722_b0130","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/mi.2014.111","article-title":"Cholera toxin adjuvant promotes a balanced Th1\/Th2\/Th17 response independently of IL-12 and IL-17 by acting on Gsalpha in CD11b(+) DCs","volume":"8","author":"Mattsson","year":"2015","journal-title":"Mucosal. Immunol"},{"issue":"1","key":"10.1016\/j.cyto.2024.156722_b0135","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2249.1998.00477.x","article-title":"Effects of adjuvants on the immune response to allergens in a murine model of allergen inhalation: cholera toxin induces a Th1-like response to Bet v 1, the major birch pollen allergen","volume":"111","author":"Wiedermann","year":"1998","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.cyto.2024.156722_b0140","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.immuni.2013.12.012","article-title":"Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1+ macrophages to CD103+ dendritic cells","volume":"40","author":"Mazzini","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.cyto.2024.156722_b0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri.2016.116","article-title":"Dendritic cell migration in health and disease","volume":"17","author":"Worbs","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cyto.2024.156722_b0150","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1126\/science.aac5560","article-title":"Jun Young Lee, Minji Lee, Charles D Surh, Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine","volume":"351","author":"Kim","year":"2016","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.cyto.2024.156722_b0155","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro-and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim. Biophys., Acta-Mol. Cell. Res."},{"issue":"7","key":"10.1016\/j.cyto.2024.156722_b0160","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/eji.201040391","article-title":"IL-6: regulator of Treg\/Th17 balance","volume":"40","author":"Kimura","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.cyto.2024.156722_b0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/intimm\/dxp003","article-title":"GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid producing capacity","volume":"21","author":"Yokota","year":"2009","journal-title":"Int. Immunol"},{"issue":"3","key":"10.1016\/j.cyto.2024.156722_b0170","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/gene.2011.9","article-title":"LIF in the regulation of T-cell fate and as a potential therapeutic","volume":"12","author":"Metcalfe","year":"2011","journal-title":"Genes. Immun."},{"key":"10.1016\/j.cyto.2024.156722_b0175","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.4049\/jimmunol.162.8.4928","article-title":"Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils","volume":"15","author":"Gasperini","year":"1999","journal-title":"J. Immunol."}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624002254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466624002254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T21:00:29Z","timestamp":1725051629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466624002254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":35,"alternative-id":["S1043466624002254"],"URL":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156722","relation":{},"ISSN":["1043-4666"],"issn-type":[{"type":"print","value":"1043-4666"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intragastric administration of transamidated gliadin interferes with the systemic and intestinal immune responses to wheat gliadin in DQ8 transgenic mice","name":"articletitle","label":"Article Title"},{"value":"Cytokine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cyto.2024.156722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156722"}}